Cold-sensitive mutations in Salmonella typhimurium which affect ribosome synthesis.

Abstract:

:A number of mutations (45) expressed as cold-sensitive conditional lethal pheno-types were screened by transduction for their linkage to the streptomycin-resistance locus; 7 showed such linkage. Of these, two were studied in greater detail. The sedimentation profiles of ribosomes from cultures grown at low temperature differed from wild type and from one another. Both mutants lost ribonucleic acid control at low temperature. It is suggested that a high proportion of mutants expressing a cold-sensitive phenotype harbor mutations in genes affecting ribosome synthesis or regulation.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Tai PC,Kessler DP,Ingraham J

doi

10.1128/JB.97.3.1298-1304.1969

subject

Has Abstract

pub_date

1969-03-01 00:00:00

pages

1298-304

issue

3

eissn

0021-9193

issn

1098-5530

journal_volume

97

pub_type

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