Interactions of cholesterol esters with phospholipids: cholesteryl myristate and dimyristoyl lecithin.

abstract：:Serum amyloid A (SAA) is an acute phase reactant that can become the predominant apolipoprotein of high density lipoprotein (HDL) during severe inflammatory states. However, the function of SAA is unknown. To study the ability of SAA to form HDL in the absence of apolipoprotein A-I, we expressed the mouse SAA pI 6.15 ...

journal_title：Journal of lipid research

authors： Webb NR,de Beer MC,van der Westhuyzen DR,Kindy MS,Banka CL,Tsukamoto K,Rader DL,de Beer FC

更新日期：1997-08-01 00:00:00

abstract：:Mammalian spermatogenesis is a complex developmental program in which a diploid progenitor germ cell transforms into highly specialized spermatozoa. One intriguing aspect of sperm production is the dynamic change in membrane lipid composition that occurs throughout spermatogenesis. Cholesterol content, as well as its ...

journal_title：Journal of lipid research

authors： Keber R,Rozman D,Horvat S

更新日期：2013-01-01 00:00:00

abstract：:We have developed the technique of rapid (< 2 h) centrifugal ultrafiltration to measure the inter-mixed micellar/vesicular (non-lecithin-associated) bile salt (BS) concentrations (IMC) of individual BS in model biles. This methodology uses a centrifugal concentrator with a reinforced membrane, through which a small fr...

journal_title：Journal of lipid research

authors： Donovan JM,Jackson AA

更新日期：1993-07-01 00:00:00

abstract：:Membranes of mammalian cells contain lysophosphatidic acid acyltransferase (LPAAT) activities that catalyze the acylation of sn-1-acyl lysophosphatidic acid (lysoPA) to form phosphatidic acid. As the biological roles and biochemical properties of the six known LPAAT isoforms have yet to be fully elucidated, we have ch...

journal_title：Journal of lipid research

authors： Hollenback D,Bonham L,Law L,Rossnagle E,Romero L,Carew H,Tompkins CK,Leung DW,Singer JW,White T

更新日期：2006-03-01 00:00:00

abstract：:We studied the biogenesis of apolipoprotein B (apoB) in primary hepatocytes isolated from hamster liver, an animal model with striking resemblance to humans in lipoprotein metabolism. Hamster hepatocytes were found to assemble and secrete apoB-containing lipoproteins at a density of VLDL. Intracellular mechanisms of a...

journal_title：Journal of lipid research

authors： Taghibiglou C,Rudy D,Van Iderstine SC,Aiton A,Cavallo D,Cheung R,Adeli K

更新日期：2000-04-01 00:00:00

abstract：:The simultaneous exchange of (3h)tocopherol and (14C)cholesterol between rat plasma, rat plasma lipoproteins, and RBC was studied in vitro to compare quantitavely (a) the fractional exchange rates and (b) the half-times for isotope equilibration. In all incubations of RBC with plasma or with plasma lipoprotein fractio...

journal_title：Journal of lipid research

authors： Bjornson LK,Gniewkowski C,Kayden HJ

更新日期：1975-01-01 00:00:00

abstract：:The human retina is well-known to have unique lipid profiles enriched in long-chain polyunsaturated fatty acids (LC-PUFAs) and very long-chain polyunsaturated fatty acids (VLC-PUFAs) that appear to promote normal retinal structure and function, but the influence of diet on retinal lipid profiles in health and disease ...

journal_title：Journal of lipid research

authors： Gorusupudi A,Liu A,Hageman GS,Bernstein PS

更新日期：2016-03-01 00:00:00

abstract：:G protein-coupled receptor (GPR)120/FFA receptor (FFAR)4 (GPR120/FFAR4) activation by n-3 PUFAs attenuates inflammation, but its impact on atherosclerosis is unknown. We determined whether in vivo activation of leukocyte GPR120/FFAR4 by n-3 versus n-6 PUFAs is atheroprotective. Leukocyte GPR120/FFAR4 WT or KO mice in ...

journal_title：Journal of lipid research

authors： Shewale SV,Brown AL,Bi X,Boudyguina E,Sawyer JK,Alexander-Miller MA,Parks JS

更新日期：2017-01-01 00:00:00

abstract：:A device for the simultaneous evaporation of six samples under separately controlled streams of nitrogen is described. ...

journal_title：Journal of lipid research

authors： Komarek RJ

更新日期：1967-05-01 00:00:00

abstract：:A rapid and accurate method is described for the assay of cholesterol ester hydrolase (CEH) activity. Aliquots of the enzyme-substrate incubation mixture are extracted into isopropanol. The free cholesterol concentration in each extract is determined enzymatically using a single aqueous reagent containing cholesterol ...

journal_title：Journal of lipid research

authors： Gallo LL,Atasoy R,Vahouny GV,Treadwell CR

更新日期：1978-09-01 00:00:00

abstract：:Mitochondrial sterol 27-hydroxylase (EC 1.14.13.15) is an important enzyme, not only in the formation of bile acids from cholesterol intermediates in the liver but also in the removal of cholesterol by side chain hydroxylation in extrahepatic tissues. The enzyme has been assayed by complicated methods using radiolabel...

journal_title：Journal of lipid research

authors： Ota Y,Eto TA,Tanaka S,Sueta H,Shiotsuki H,Maeda Y,Une M,Chijiiwa K

更新日期：2003-12-01 00:00:00

abstract：:Taurocholate, a relatively hydrophobic bile salt, is a potent down-regulator of HMG-CoA reductase and cholesterol 7 alpha-hydroxylase (C7 alpha H), the rate-determining enzymes of the cholesterol and bile acid biosynthetic pathways, respectively. Inhibition of cholesterol synthesis with a bolus dose of mevinolin (lova...

journal_title：Journal of lipid research

authors： Pandak WM,Vlahcevic ZR,Chiang JY,Heuman DM,Hylemon PB

更新日期：1992-05-01 00:00:00

abstract：:Spontaneously transformed mouse fibroblasts (Balb/c 3T12-3 cells) displayed an increased adhesion when cultured in the presence of 10(-6) M all-trans retinol and acquired morphological characteristics of the normal phenotype. Thus it was of interest to investigate the metabolism of [15-(14)C]retinol in this system. Wi...

journal_title：Journal of lipid research

authors： Bhat PV,De Luca LM,Adamo S,Akalovsky I,Silverman-Jones CS,Peck GL

更新日期：1979-03-01 00:00:00

abstract：:Chiral phase high performance liquid chromatographic resolution of sn-1,2(2,3)- and X-1,3-diacylglycerols generated by partial Grignard degradation from natural triacylglycerols was carried out using a chiral column (25 cm x 4.6 mm i.d.) containing (R)-(+)-1-(1-napthyl)ethylamine polymer chemically bonded to 300A wide...

journal_title：Journal of lipid research

authors： Itabashi Y,Kukis A,Marai L,Takagi T

更新日期：1990-09-01 00:00:00

abstract：:We have reported the use of a retroviral vector to introduce the low density lipoprotein (LDL) receptor gene into receptor-deficient Watanabe heritable hyperlipidemic (WHHL) rabbit fibroblasts (Miyanohara, A., M. F. Sharkey, D. Steinberg, J. L. Witztum, and T. Friedmann. 1988. Proc. Natl. Acad. Sci. USA. 85: 6538-6542...

journal_title：Journal of lipid research

authors： Sharkey MF,Miyanohara A,Elam RL,Friedmann T,Witztum JL

更新日期：1990-12-01 00:00:00

abstract：:We have investigated the extent to which modifications in the essential fatty acid content of mammalian cells can affect prostaglandin production. Swiss mouse 3T3 cells stimulated with the calcium ionophore A23187 produced 1.7 to 7 times more prostaglandin E(2) (PGE(2)) when the cultures were supplemented with linolei...

journal_title：Journal of lipid research

authors： Denning GM,Figard PH,Spector AA

更新日期：1982-05-01 00:00:00

abstract：:High density lipoproteins (HDL) were isolated by a chromatographic procedure and subsequently fractionated on a DEAE cellulose (DE-52) column. Four fractions were separated and analyzed for lipid and protein composition and molecular weight. During ion exchange chromatography, one of the four fractions consistently co...

journal_title：Journal of lipid research

authors： Jahani M,Lacko AG

更新日期：1981-09-01 00:00:00

abstract：:Lysosomal acid lipase (LAL) is essential for the hydrolysis of triglycerides (TG) and cholesteryl esters (CE) in lysosomes. A mouse model created by gene targeting produces no LAL mRNA, protein, or enzyme activity. The lal-/- mice appear normal at birth, survive into adulthood, and are fertile. Massive storage of TG a...

journal_title：Journal of lipid research

authors： Du H,Heur M,Duanmu M,Grabowski GA,Hui DY,Witte DP,Mishra J

更新日期：2001-04-01 00:00:00

abstract：:Lipid droplet (LD) coating proteins are essential for the formation and stability of intracellular LDs. Plin2 is an abundant LD coating protein in skeletal muscle, but its importance for muscle function is unclear. We show that myotubes established from Plin2-/- mice contain reduced content of LDs and accumulate less ...

journal_title：Journal of lipid research

authors： Feng YZ,Lund J,Li Y,Knabenes IK,Bakke SS,Kase ET,Lee YK,Kimmel AR,Thoresen GH,Rustan AC,Dalen KT

更新日期：2017-11-01 00:00:00

abstract：:The major high density lipoprotein (HDL) apolipoprotein, apoA-I, was knocked out by gene targeting in ES cells to provide a model for the study of HDL metabolism and its relationship to plasma and tissue cholesterol metabolism. HDL and non-HDL cholesterol (HDL-C) were reduced in apoA-I-deficient mice. Feeding a high f...

journal_title：Journal of lipid research

authors： Plump AS,Azrolan N,Odaka H,Wu L,Jiang X,Tall A,Eisenberg S,Breslow JL

更新日期：1997-05-01 00:00:00

abstract：:Lysophospholipid (LP) research has experienced a period of renaissance with the discovery of the lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) receptors in the late 1990s. Vertebrate LP receptors regulate embryogenesis, vascular development, neurogenesis, uterine development, oocyte survival, immune ce...

journal_title：Journal of lipid research

authors： Skoura A,Hla T

更新日期：2009-04-01 00:00:00

abstract：:Scavenger receptor class B type I (SR-BI) mediates the selective uptake of HDL cholesteryl esters (CEs) and facilitates the efflux of unesterified cholesterol. SR-BI expression in macrophages presumably plays a role in atherosclerosis. The role of SR-BI for selective CE uptake and cholesterol efflux in macrophages was...

journal_title：Journal of lipid research

authors： Brundert M,Heeren J,Bahar-Bayansar M,Ewert A,Moore KJ,Rinninger F

更新日期：2006-11-01 00:00:00

abstract：:The acute-phase response (APR) leads to alterations in lipid metabolism and type II nuclear hormone receptors, which regulate lipid metabolism, are suppressed, in liver, heart, and kidney. Here, we examine the effect of the APR in adipose tissue. In mice, lipopolysaccharide produces a rapid, marked decrease in mRNA le...

journal_title：Journal of lipid research

authors： Lu B,Moser AH,Shigenaga JK,Feingold KR,Grunfeld C

更新日期：2006-10-01 00:00:00

abstract：:Rab GTPases require special machinery for protein prenylation, which include Rab escort protein (REP) and Rab geranylgeranyl transferase (RGGT). The current model of Rab geranylgeranylation proposes that REP binds Rab and presents it to RGGT. After geranylgeranylation of Rab C-terminal cysteines, REP delivers the pren...

journal_title：Journal of lipid research

authors： Leung KF,Baron R,Seabra MC

更新日期：2006-03-01 00:00:00

abstract：:Diseases such as obesity, diabetes, and atherosclerosis result from multiple genetic and environmental factors, and importantly, interactions between genetic and environmental factors. Identifying susceptibility genes for these diseases using genetic and genomic technologies is accelerating, and the expectation over t...

journal_title：Journal of lipid research

authors： Schadt EE,Lum PY

更新日期：2006-12-01 00:00:00

abstract：:A preparation of cerebral microvessels was used to demonstrate the presence of lipoprotein lipase and acid lipase activity in the microvasculature of rabbit brain. Microvessels, consisting predominantly of capillaries, small arterioles, and venules, were islated from rabbit brain. Homogenates were assayed for lipolyti...

journal_title：Journal of lipid research

authors： Brecher P,Kuan HT

更新日期：1979-05-01 00:00:00

abstract：:Lipogenesis in vitro from acetate-1-(14)C was studied in human preputial skin and abdominal skin. Radioactive lipids were separated by column chromatography on Florisil and by thin-layer chromatography on silica gel. Radioactivity was incorporated chiefly into the triglyceride, sterol, and polar lipid fractions, while...

journal_title：Journal of lipid research

authors： Vroman HE,Nemecek RA,Hsia SL

更新日期：1969-09-01 00:00:00

abstract：:Abdominal aortic aneurysm (AAA) is an important cause of death in older adults, which has no current drug therapy. Inflammation and abnormal redox status are believed to be key pathogenic mechanisms for AAA. In light of evidence correlating inflammation with aberrant fatty acid profiles, this study compared erythrocyt...

journal_title：Journal of lipid research

authors： Meital LT,Windsor MT,Ramirez Jewell RML,Young P,Schulze K,Magee R,O'Donnell J,Jha P,Perissiou M,Golledge J,Bailey TG,Brooks P,Askew CD,Russell FD

更新日期：2019-06-01 00:00:00

abstract：:Oxidative stress, hepatic steatosis, and mitochondrial dysfunction are key pathophysiological features of nonalcoholic fatty liver disease. A conjugated linoleic acid (CLA) mixture of cis9,trans11 (9,11-CLA) and trans10,cis12 (10,12-CLA) isomers enhanced the antioxidant/detoxifying mechanism via the activation of nucl...

journal_title：Journal of lipid research

authors： Mollica MP,Trinchese G,Cavaliere G,De Filippo C,Cocca E,Gaita M,Della-Gatta A,Marano A,Mazzarella G,Bergamo P

更新日期：2014-05-01 00:00:00

abstract：:An amino group of phosphatidylethanolamine (PE) is considered as a target for nonenzymatic glycation, and the potential involvement of lipid glycation in the pathogenesis of diabetic complications has generated interest. However, unlike an early glycation product of PE (Amadori-PE), the occurrence and roles of advance...

journal_title：Journal of lipid research

authors： Shoji N,Nakagawa K,Asai A,Fujita I,Hashiura A,Nakajima Y,Oikawa S,Miyazawa T

更新日期：2010-08-01 00:00:00