Abstract：
:The human retina is well-known to have unique lipid profiles enriched in long-chain polyunsaturated fatty acids (LC-PUFAs) and very long-chain polyunsaturated fatty acids (VLC-PUFAs) that appear to promote normal retinal structure and function, but the influence of diet on retinal lipid profiles in health and disease remains controversial. In this study, we examined two independent cohorts of donor eyes and related their retinal lipid profiles with systemic biomarkers of lipid intake. We found that serum and red blood cell lipids, and to a lesser extent orbital fat, are indeed excellent biomarkers of retinal lipid content and n-3/n-6 ratios in both the LC-PUFA and VLC-PUFA series. Eyes from age-related macular degeneration (AMD) donors have significantly decreased levels of VLC-PUFAs and low n-3/n-6 ratios. These results are consistent with the protective role of dietary n-3 LC-PUFAs against AMD and emphasize the importance of monitoring systemic biomarkers of lipid intake when undertaking clinical trials of lipid supplements for prevention and treatment of retinal disease.
journal_name
J Lipid Resjournal_title
Journal of lipid researchauthors
Gorusupudi A,Liu A,Hageman GS,Bernstein PSdoi
10.1194/jlr.P065540subject
Has Abstractpub_date
2016-03-01 00:00:00pages
499-508issue
3eissn
0022-2275issn
1539-7262pii
jlr.P065540journal_volume
57pub_type
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journal_title：Journal of lipid research
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journal_title：Journal of lipid research
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doi：
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journal_title：Journal of lipid research
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doi：
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journal_title：Journal of lipid research
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doi：
更新日期：1997-02-01 00:00:00
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doi：10.1194/jlr.M089714
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journal_title：Journal of lipid research
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
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journal_title：Journal of lipid research
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
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journal_title：Journal of lipid research
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
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journal_title：Journal of lipid research
pub_type： 杂志文章
doi：
更新日期：1999-04-01 00:00:00
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journal_title：Journal of lipid research
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doi：
更新日期：2000-12-01 00:00:00
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journal_title：Journal of lipid research
pub_type： 杂志文章
doi：
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journal_title：Journal of lipid research
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journal_title：Journal of lipid research
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doi：
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