abstract：:Oxidative stress promotes acute kidney injury (AKI). Higher concentrations of HDL cholesterol are associated with less AKI. To test the hypothesis that HDL antioxidant activity is associated with AKI after cardiac surgery, we quantified HDL particle size and number, paraoxonase-1 activity, and isofuran concentrations ...

journal_title：Journal of lipid research

authors： Smith LE,Smith DK,Yancey PG,Kon V,Remaley AT,Billings FT 4th,Linton MF

更新日期：2021-01-13 00:00:00

abstract：:Bacterial lipopolysaccharides (LPSs or endotoxins) can bind most proteins of the lipid transfer/LPS-binding protein (LT/LBP) family in host organisms. The LPS-bound LT/LBP proteins then trigger either an LPS-induced proinflammatory cascade or LPS binding to lipoproteins that are involved in endotoxin inactivation and ...

journal_title：Journal of lipid research

authors： Dusuel A,Deckert V,Pais de Barros JP,van Dongen K,Choubley H,Charron É,Le Guern N,Labbé J,Mandard S,Grober J,Lagrost L,Gautier T

更新日期：2020-12-15 00:00:00

abstract：:The LDL receptor-related protein-1 (LRP1) is highly expressed in numerous cell types, and its impairment is associated with obesity, diabetes, and fatty liver disease. However, the mechanisms linking LRP1 to metabolic disease are not completely understood. Here, we compared the metabolic phenotype of C57BL/6J wild typ...

journal_title：Journal of lipid research

authors： Jaeschke A,Haller A,Cash JG,Nam C,Igel E,Roebroek AJM,Hui DY

更新日期：2020-12-09 00:00:00

abstract：:Adiponectin, an adipocyte-derived protein, has antiatherogenic and antidiabetic effects, but how it confers the atherogenic effects is not well known. To study the antiatherogenic mechanisms of adiponectin, we examined whether it interacts with atherogenic low density lipoprotein (LDL) to attenuate LDL's atherogenicit...

journal_title：Journal of lipid research

authors： Kakino A,Fujita Y,Ke LY,Chan HC,Tsai MH,Dai CY,Chen CH,Sawamura T

更新日期：2020-11-21 00:00:00

abstract：:Smith-Lemli-Opitz Syndrome (SLOS) is a developmental disorder (OMIM #270400) caused by autosomal recessive mutations in the Dhcr7 gene, which encodes the enzyme 3β-hydroxysterol-∆7 reductase. SLOS patients present clinically with dysmorphology and neurological, behavioral and cognitive defects, with characteristically...

journal_title：Journal of lipid research

authors： Kanuri B,Fong V,Ponny SR,Tallman KA,Ramachandra Rao S,Porter NA,Fliesler SJ,Patel SB

更新日期：2020-11-17 00:00:00

abstract：:Adiponectin, an adipocyte-derived protein, has anti-atherogenic and anti-diabetic effects, but how it confers the anti-atherogenic effects is not well understood. To study the anti-atherogenic mechanisms of adiponectin, we examined whether it interacts with atherogenic low-density lipoprotein (LDL) to attenuate LDL's ...

journal_title：Journal of lipid research

authors： Kakino A,Fujita Y,Ke LY,Chan HC,Tsai MH,Dai CY,Chen CH,Sawamura T

更新日期：2020-11-03 00:00:00

abstract：:Oxylipins are potent lipid mediators involved in a variety of physiological processes. Their profiling has the potential to provide a wealth of information regarding human health and disease and is a promising technology for translation into clinical applications. However, results generated by independent groups are r...

journal_title：Journal of lipid research

authors： Mainka M,Dalle C,Pétéra M,Dalloux-Chioccioli J,Kampschulte N,Ostermann AI,Rothe M,Bertrand-Michel J,Newman JW,Gladine C,Schebb NH

更新日期：2020-11-01 00:00:00

abstract：:The essential fatty acid DHA (22:6, omega-3 or n-3) is enriched in and required for the membrane biogenesis and function of photoreceptor cells (PRC), synapses, mitochondria, etc. of the CNS. PRC DHA becomes an acyl chain at the sn-2 of phosphatidylcholine (PC), amounting to more than 50% of the PRC outer segment phos...

journal_title：Journal of lipid research

authors： Bazan NG

更新日期：2020-10-26 00:00:00

abstract：:Native interactions between lysophospholipids (LPs) and their cognate LP receptors are difficult to measure because of lipophilicity and/or the adhesive properties of lipids, which contribute to high levels of nonspecific binding in cell membrane preparations. Here, we report development of a free-solution assay (FSA)...

journal_title：Journal of lipid research

authors： Ray M,Nagai K,Kihara Y,Kussrow A,Kammer MN,Frantz A,Bornhop DJ,Chun J

更新日期：2020-08-01 00:00:00

abstract：:Functions of the gut microbiome have a growing number of implications for host metabolic health, with diet being one of the most significant influences on microbiome composition. Compelling links between diet and the gut microbiome suggest key roles for various macronutrients, including lipids, yet how individual clas...

journal_title：Journal of lipid research

authors： Lee MT,Le HH,Johnson EL

更新日期：2020-07-09 00:00:00

abstract：:Bis(monoacylglycero)phosphate (BMP), also known as lysobisphosphatidic acid, is a phospholipid that promotes lipid sorting in late endosomes/lysosomes by activating lipid hydrolases and lipid transfer proteins. Changes in the cellular BMP content therefore reflect an altered metabolic activity of the endolysosomal sys...

journal_title：Journal of lipid research

authors： Grabner GF,Fawzy N,Schreiber R,Pusch LM,Bulfon D,Koefeler H,Eichmann TO,Lass A,Schweiger M,Marsche G,Schoiswohl G,Taschler U,Zimmermann R

更新日期：2020-07-01 00:00:00

abstract：:Oxidized LDL (oxLDL) is a known risk factor for atherogenesis. This study aimed to reveal structural features of oxLDL present in human circulation related to atherosclerosis. When LDL was fractionated on an anion-exchange column, in vivo-oxLDL, detected by the anti-oxidized PC (oxPC) mAb, was recovered in flow-throug...

journal_title：Journal of lipid research

authors： Sawada N,Obama T,Koba S,Takaki T,Iwamoto S,Aiuchi T,Kato R,Kikuchi M,Hamazaki Y,Itabe H

更新日期：2020-06-01 00:00:00

abstract：:Ceramides are the predominant lipids in the stratum corneum (SC) and are crucial components for normal skin barrier function. Although the composition of various ceramide classes in the human SC has been reported, that in mice is still unknown, despite mice being widely used as animal models of skin barrier function. ...

journal_title：Journal of lipid research

authors： Kawana M,Miyamoto M,Ohno Y,Kihara A

更新日期：2020-06-01 00:00:00

abstract：:Membrane-bound proteins have been proposed to mediate the transport of long-chain FA (LCFA) transport through the plasma membrane (PM). These proposals are based largely on reports that PM transport of LCFAs can be blocked by a number of enzymes and purported inhibitors of LCFA transport. Here, using the ratiometric p...

journal_title：Journal of lipid research

authors： Jay AG,Simard JR,Huang N,Hamilton JA

更新日期：2020-05-01 00:00:00

abstract：:Cellular membranes are not homogenous mixtures of proteins; rather, they are segregated into microdomains on the basis of preferential association between specific lipids and proteins. These microdomains, called lipid rafts, are well known for their role in receptor signaling on the plasma membrane (PM) and are essent...

journal_title：Journal of lipid research

authors： Ouweneel AB,Thomas MJ,Sorci-Thomas MG

更新日期：2020-05-01 00:00:00

abstract：:Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and progresses to alcoholic steatohepatitis, fibrosis, and cirrhosis. The severity of hepatic steatosis is highly associated with the developmen...

journal_title：Journal of lipid research

authors： Jeon S,Carr R

更新日期：2020-04-01 00:00:00

abstract：:Xanthophyllomyces dendrorhous is a basidiomycete yeast known as a natural producer of astaxanthin, a carotenoid of commercial interest because of its antioxidant properties. Recent studies indicated that X. dendrorhous has a functional SREBP pathway involved in the regulation of isoprenoid compound biosynthesis, which...

journal_title：Journal of lipid research

authors： Gómez M,Gutiérrez MS,González AM,Gárate-Castro C,Sepúlveda D,Barahona S,Baeza M,Cifuentes V,Alcaíno J

更新日期：2020-02-01 00:00:00

abstract：:Ceramides (Cers) with ultralong (∼32-carbon) chains and ω-esterified linoleic acid, composing a subclass called omega-O-acylceramides (acylCers), are indispensable components of the skin barrier. Normal barriers typically contain acylCer concentrations of ∼10 mol%; diminished concentrations, along with altered or miss...

journal_title：Journal of lipid research

authors： Opálka L,Kováčik A,Pullmannová P,Maixner J,Vávrová K

更新日期：2020-02-01 00:00:00

abstract：:The bile acid (BA) composition in mice is substantially different from that in humans. Chenodeoxycholic acid (CDCA) is an end product in the human liver; however, mouse Cyp2c70 metabolizes CDCA to hydrophilic muricholic acids (MCAs). Moreover, in humans, the gut microbiota converts the primary BAs, cholic acid and CDC...

journal_title：Journal of lipid research

authors： Honda A,Miyazaki T,Iwamoto J,Hirayama T,Morishita Y,Monma T,Ueda H,Mizuno S,Sugiyama F,Takahashi S,Ikegami T

更新日期：2020-01-01 00:00:00

abstract：:Chronic inflammation contributes to cardiovascular disease. Increased levels of the inflammatory cytokine, TNF-α, are often present in conditions associated with cardiovascular disease risk, and TNF-α induces a number of pro-atherogenic effects in macrovascular endothelial cells, including expression of adhesion molec...

journal_title：Journal of lipid research

authors： Jung HS,Shimizu-Albergine M,Shen X,Kramer F,Shao D,Vivekanandan-Giri A,Pennathur S,Tian R,Kanter JE,Bornfeldt KE

更新日期：2020-01-01 00:00:00

abstract：:Lipid metabolism plays an important role in the regulation of cellular homeostasis. However, because it is difficult to measure the actual rates of synthesis and degradation of individual lipid species, lipid compositions are often used as a surrogate to evaluate lipid metabolism even though they provide only static s...

journal_title：Journal of lipid research

authors： Schlame M,Xu Y,Erdjument-Bromage H,Neubert TA,Ren M

更新日期：2020-01-01 00:00:00

abstract：:Dietary lipids are taken up as FAs by the intestinal epithelium and converted by diacylglycerol acyltransferase (DGAT) enzymes into triglycerides, which are packaged in chylomicrons or stored in cytoplasmic lipid droplets (LDs). DGAT1-deficient patients suffer from vomiting, diarrhea, and protein losing enteropathy, i...

journal_title：Journal of lipid research

authors： van Rijn JM,van Hoesel M,de Heus C,van Vugt AHM,Klumperman J,Nieuwenhuis EES,Houwen RHJ,Middendorp S

更新日期：2019-10-01 00:00:00

abstract：:Genetic defects in SAR1B GTPase inhibit chylomicron (CM) trafficking to the Golgi and result in a huge intraenterocyte lipid accumulation with a failure to release CMs and liposoluble vitamins into the blood circulation. The central aim of this study is to test the hypothesis that SAR1B deletion (SAR1B-/- ) disturbs e...

journal_title：Journal of lipid research

authors： Sané A,Ahmarani L,Delvin E,Auclair N,Spahis S,Levy E

更新日期：2019-10-01 00:00:00

abstract：:The de novo ceramide synthesis pathway is essential to human biology and health, but genetic influences remain unexplored. The core function of this pathway is the generation of biologically active ceramide from its precursor, dihydroceramide. Dihydroceramides have diverse, often protective, biological roles; converse...

journal_title：Journal of lipid research

authors： Blackburn NB,Michael LF,Meikle PJ,Peralta JM,Mosior M,McAhren S,Bui HH,Bellinger MA,Giles C,Kumar S,Leandro AC,Almeida M,Weir JM,Mahaney MC,Dyer TD,Almasy L,VandeBerg JL,Williams-Blangero S,Glahn DC,Duggirala R,Ko

更新日期：2019-09-01 00:00:00

abstract：:Chylomicron metabolism is critical for determining plasma levels of triacylglycerols (TAGs) and cholesterol, both of which are risk factors for CVD. The rates of chylomicron secretion and remnant clearance are controlled by intracellular and extracellular factors, including apoC-III. We have previously shown that huma...

journal_title：Journal of lipid research

authors： Li D,Rodia CN,Johnson ZK,Bae M,Muter A,Heussinger AE,Tambini N,Longo AM,Dong H,Lee JY,Kohan AB

更新日期：2019-09-01 00:00:00

abstract：:The combination of daunorubicin (dnr) and cytarabine (Ara-C) is a cornerstone of treatment for acute myelogenous leukemia (AML); resistance to these drugs is a major cause of treatment failure. Ceramide, a sphingolipid (SL), plays a critical role in cancer cell apoptosis in response to chemotherapy. Here, we investiga...

journal_title：Journal of lipid research

authors： Kao LP,Morad SAF,Davis TS,MacDougall MR,Kassai M,Abdelmageed N,Fox TE,Kester M,Loughran TP Jr,Abad JL,Fabrias G,Tan SF,Feith DJ,Claxton DF,Spiegel S,Fisher-Wellman KH,Cabot MC

更新日期：2019-09-01 00:00:00

abstract：:Since the discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9) as an attractive target in the treatment of hypercholesterolemia, multiple anti-PCSK9 therapeutic modalities have been pursued in drug development. The objective of this research is to set the stage for the quantitative benchmarking of two an...

journal_title：Journal of lipid research

authors： Sokolov V,Helmlinger G,Nilsson C,Zhudenkov K,Skrtic S,Hamrén B,Peskov K,Hurt-Camejo E,Jansson-Löfmark R

更新日期：2019-09-01 00:00:00

abstract：:Hypertriglyceridemia results from accumulation of triglyceride (TG)-rich lipoproteins (TRLs) in the circulation and is associated with increased CVD risk. ApoC-III is an apolipoprotein on TRLs and a prominent negative regulator of TG catabolism. We recently established that in vivo apoC-III predominantly inhibits LDL ...

journal_title：Journal of lipid research

authors： Ramms B,Patel S,Nora C,Pessentheiner AR,Chang MW,Green CR,Golden GJ,Secrest P,Krauss RM,Metallo CM,Benner C,Alexander VJ,Witztum JL,Tsimikas S,Esko JD,Gordts PLSM

更新日期：2019-08-01 00:00:00

abstract：:HDL-like particles in human cerebrospinal fluid (CSF) promote the efflux of cholesterol from astrocytes toward the neurons that rely on this supply for their functions. We evaluated whether cell cholesterol efflux capacity of CSF (CSF-CEC) is impaired in Alzheimer's disease (AD) by analyzing AD (n = 37) patients, non-...

journal_title：Journal of lipid research

authors： Marchi C,Adorni MP,Caffarra P,Ronda N,Spallazzi M,Barocco F,Galimberti D,Bernini F,Zimetti F

更新日期：2019-08-01 00:00:00

abstract：:Quantitatively and rapidly analyzing lipids is necessary to elucidate their biological functions. Herein, we developed a quantitative method for various lipid classes using supercritical fluid chromatography (SFC) coupled with a charged aerosol detector (CAD), providing high-throughput data analysis to detect a large ...

journal_title：Journal of lipid research

authors： Takeda H,Takahashi M,Hara T,Izumi Y,Bamba T

更新日期：2019-08-01 00:00:00

abstract：:Abdominal aortic aneurysm (AAA) is an important cause of death in older adults, which has no current drug therapy. Inflammation and abnormal redox status are believed to be key pathogenic mechanisms for AAA. In light of evidence correlating inflammation with aberrant fatty acid profiles, this study compared erythrocyt...

journal_title：Journal of lipid research

authors： Meital LT,Windsor MT,Ramirez Jewell RML,Young P,Schulze K,Magee R,O'Donnell J,Jha P,Perissiou M,Golledge J,Bailey TG,Brooks P,Askew CD,Russell FD

更新日期：2019-06-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is the most common acute leukemia in adults. More than half of older AML patients fail to respond to cytotoxic chemotherapy, and most responders relapse with drug-resistant disease. Failure to achieve complete remission can be partly attributed to the drug resistance advantage of AML blast...

journal_title：Journal of lipid research

authors： Tan SF,Dunton W,Liu X,Fox TE,Morad SAF,Desai D,Doi K,Conaway MR,Amin S,Claxton DF,Wang HG,Kester M,Cabot MC,Feith DJ,Loughran TP Jr

更新日期：2019-06-01 00:00:00

abstract：:In specialized cell types, lysosome-related organelles support regulated secretory pathways, whereas in nonspecialized cells, lysosomes can undergo fusion with the plasma membrane in response to a transient rise in cytosolic calcium. Recent evidence also indicates that lysosome secretion can be controlled transcriptio...

journal_title：Journal of lipid research

authors： Vacca F,Vossio S,Mercier V,Moreau D,Johnson S,Scott CC,Montoya JP,Moniatte M,Gruenberg J

更新日期：2019-04-01 00:00:00

abstract：:Sphingolipids (SLs) have been implicated in numerous important cellular biologies; however, their study has been hindered by the complexities of SL metabolism. Furthermore, enzymes of SL metabolism represent a dynamic and interconnected network in which one metabolite can be transformed into other bioactive SLs throug...

journal_title：Journal of lipid research

authors： Snider JM,Trayssac M,Clarke CJ,Schwartz N,Snider AJ,Obeid LM,Luberto C,Hannun YA

更新日期：2019-04-01 00:00:00

abstract：:Niacin, the first antidyslipidemic drug, has been at the center stage of lipid research for many decades before the discovery of statins. However, to date, despite its remarkable effects on lipid profiles, the clinical outcomes of niacin treatment on cardiac events is still debated. In addition to its historically wel...

journal_title：Journal of lipid research

authors： Romani M,Hofer DC,Katsyuba E,Auwerx J

更新日期：2019-04-01 00:00:00

abstract：:Studies on the effects of longitudinal lipid trajectories on end-stage renal disease (ESRD) development and deaths among patients with chronic kidney disease (CKD) are limited. We conducted a registry-based prospective study using data from a 13-year multidisciplinary pre-ESRD care program. The final study population ...

journal_title：Journal of lipid research

authors： Tsai CW,Huang HC,Chiang HY,Chung CW,Chang SN,Chu PL,Kuo CC

更新日期：2019-03-01 00:00:00

abstract：:Geranylgeranoic acid (GGA) has been reported to induce autophagic cell death via upregulation of lipid-induced unfolded protein response in several human hepatoma-derived cell lines, and its 4,5-didehydro derivative has been developed as a preventive agent against second primary hepatoma in clinical trials. We have pr...

journal_title：Journal of lipid research

authors： Shidoji Y,Tabata Y

更新日期：2019-03-01 00:00:00

abstract：:Very few studies have investigated the interrelations between proprotein convertase subtilisin/kexin type 9 (PCSK9) metabolism, cholesterol synthesis, and cholesterol absorption. We aimed to address this issue in a large clinical trial of 245 patients with hypercholesterolemia. Serum lipids, PCSK9, lathosterol (choles...

journal_title：Journal of lipid research

authors： Silbernagel G,Steiner LK,Hollstein T,Fauler G,Scharnagl H,Stojakovic T,Schumann F,Bölükbasi B,März W,Steinhagen-Thiessen E,Laufs U,Kassner U

更新日期：2019-01-01 00:00:00

abstract：:Mutations in the genes coding for patatin-like phospholipase domain-containing 1 (PNPLA1) and α/β-hydrolase domain-containing 5 (ABHD5), also known as comparative gene identification 58, are causative for ichthyosis, a severe skin barrier disorder. Individuals with mutations in either of these genes show a defect in e...

journal_title：Journal of lipid research

authors： Kien B,Grond S,Haemmerle G,Lass A,Eichmann TO,Radner FPW

更新日期：2018-12-01 00:00:00

abstract：:Neu-Laxova syndrome (NLS) is a very rare autosomal recessive congenital disorder characterized by disturbed development of the central nervous system and the skin and caused by mutations in any of the three genes involved in de novo l-serine biosynthesis: PHGDH, PSAT1, and PSPH l-Serine is essential for the biosynthes...

journal_title：Journal of lipid research

authors： Takeichi T,Okuno Y,Kawamoto A,Inoue T,Nagamoto E,Murase C,Shimizu E,Tanaka K,Kageshita Y,Fukushima S,Kono M,Ishikawa J,Ihn H,Takahashi Y,Akiyama M

更新日期：2018-12-01 00:00:00