Device for evaporation of solvent from small samples.

abstract：:Gluco- and galactocerebrosides can be separated by thin-layer chromatography on Silica Gel G prepared with sodium borate solution instead of water. The most successful developing system was chloroform-methanol-water-15 M NH(4)OH 280:70:6:1. ...

journal_title：Journal of lipid research

authors： Kean EL

更新日期：1966-05-01 00:00:00

abstract：:Membranes of mammalian cells contain lysophosphatidic acid acyltransferase (LPAAT) activities that catalyze the acylation of sn-1-acyl lysophosphatidic acid (lysoPA) to form phosphatidic acid. As the biological roles and biochemical properties of the six known LPAAT isoforms have yet to be fully elucidated, we have ch...

journal_title：Journal of lipid research

authors： Hollenback D,Bonham L,Law L,Rossnagle E,Romero L,Carew H,Tompkins CK,Leung DW,Singer JW,White T

更新日期：2006-03-01 00:00:00

abstract：:Endothelial lipase (EL) is a triglyceride lipase gene family member that has high phospholipase and low triglyceride lipase activity. The aim of this study was to determine whether the phospholipase activity of EL is sufficient to remodel HDLs into small particles and mediate the dissociation of apolipoprotein A-I (ap...

journal_title：Journal of lipid research

authors： Jahangiri A,Rader DJ,Marchadier D,Curtiss LK,Bonnet DJ,Rye KA

更新日期：2005-05-01 00:00:00

abstract：:Lipogenesis in vitro from acetate-1-(14)C was studied in human preputial skin and abdominal skin. Radioactive lipids were separated by column chromatography on Florisil and by thin-layer chromatography on silica gel. Radioactivity was incorporated chiefly into the triglyceride, sterol, and polar lipid fractions, while...

journal_title：Journal of lipid research

authors： Vroman HE,Nemecek RA,Hsia SL

更新日期：1969-09-01 00:00:00

abstract：:In mammals, the apolipoprotein (apo) A-I gene is expressed predominantly in liver and intestine, while in avian species it is expressed in all tissues. Although liver and intestine are the major sites of chicken apoA-I mRNA synthesis, there are appreciable amounts of apoA-I mRNA in kidney, ovary/testes, brain, lung, s...

journal_title：Journal of lipid research

authors： Lamon-Fava S,Sastry R,Ferrari S,Rajavashisth TB,Lusis AJ,Karathanasis SK

更新日期：1992-06-01 00:00:00

abstract：:Subcutaneous fat cells were isolated from genetically obese rats and from rats with obesity produced by hypothalamic lesions. Insulin did not augment the oxidation of fatty acids or their synthesis from glucose-1-(14)C or glucose-1-(3)H by fat cells from either group. Radioactivity from pyruvate-3-(14)C was incorporat...

journal_title：Journal of lipid research

authors： Bray GA

更新日期：1968-11-01 00:00:00

abstract：:Abetalipoproteinemia (ABL) and chylomicron retention disease (CMRD) are extremely rare recessive forms of hypobetalipoproteinemia characterized by intestinal lipid malabsorption and severe vitamin E deficiency. Vitamin E is often supplemented in the form of fat-soluble vitamin E acetate, but fat malabsorption consider...

journal_title：Journal of lipid research

authors： Cuerq C,Henin E,Restier L,Blond E,Drai J,Marçais C,Di Filippo M,Laveille C,Michalski MC,Poinsot P,Caussy C,Sassolas A,Moulin P,Reboul E,Charriere S,Levy E,Lachaux A,Peretti N

更新日期：2018-09-01 00:00:00

abstract：:Genome-wide association (GWA) studies represent a powerful strategy for identifying susceptibility genes for complex diseases in human populations but results must be confirmed and replicated. Because of the close homology between mouse and human genomes, the mouse can be used to add evidence to genes suggested by hum...

journal_title：Journal of lipid research

authors： Leduc MS,Lyons M,Darvishi K,Walsh K,Sheehan S,Amend S,Cox A,Orho-Melander M,Kathiresan S,Paigen B,Korstanje R

更新日期：2011-06-01 00:00:00

abstract：:The inbred C57L strain but not the AKR strain of mice carry Lith genes that determine cholesterol gallstone susceptibility. When C57L mice are fed a lithogenic diet containing 15% fat, 1% cholesterol, and 0.5% cholic acid, gallbladder bile displays rapid cholesterol supersaturation, mucin gel accumulation, increases i...

journal_title：Journal of lipid research

authors： Wang DQ,Lammert F,Paigen B,Carey MC

更新日期：1999-11-01 00:00:00

abstract：:There is unequivocal evidence of an inverse association between plasma high-density lipoprotein (HDL) cholesterol concentrations and the risk of cardiovascular disease, a finding that has led to the hypothesis that HDL protects from atherosclerosis. This review details the experimental evidence for this "HDL hypothesi...

journal_title：Journal of lipid research

authors： Vergeer M,Holleboom AG,Kastelein JJ,Kuivenhoven JA

更新日期：2010-08-01 00:00:00

abstract：:An enzyme-coupled, colorimetric method for the assay of acyl-CoA synthetase is described. Acyl-CoA formed from fatty acid and CoA by acyl-CoA synthetase was dehydrogenated by acyl-CoA oxidase. Hydrogen peroxide produced was then converted into formaldehyde in the presence of methanol by catalase. The formaldehyde reac...

journal_title：Journal of lipid research

authors： Ichihara K,Shibasaki Y

更新日期：1991-10-01 00:00:00

abstract：:Two novel mutations of the low density lipoprotein (LDL)-receptor gene were found in two Italian familial hypercholesterolemia (FH)-heterozygotes. The first mutation was an 18 nucleotide duplication in exon 8 which is preceded by an A-->T transversion. The translation product of the mutant allele was predicted to be a...

journal_title：Journal of lipid research

authors： Patel DD,Lelli N,Garuti R,Li Volti S,Bertolini S,Knight BL,Calandra S

更新日期：1998-07-01 00:00:00

abstract：:The storage of lipids in the form of triglycerides (TGs) and the de novo synthesis (lipogenesis) of fatty acids from nonlipid precursors [de novo lipogenesis (DNL)] are important functions of adipose tissue (AT) that influence whole-body metabolism. Yet, few studies have reported in vivo estimates of adipose lipid kin...

journal_title：Journal of lipid research

authors： White UA,Fitch MD,Beyl RA,Hellerstein MK,Ravussin E

更新日期：2018-09-01 00:00:00

abstract：:We have shown that expression of apolipoprotein (apo) C-III promotes VLDL secretion from transfected McA-RH7777 cells under lipid-rich conditions. To determine structural elements within apoC-III that confer to this function, we contrasted wild-type apoC-III with a mutant Ala23Thr originally identified in hypotriglyce...

journal_title：Journal of lipid research

authors： Sundaram M,Zhong S,Bou Khalil M,Zhou H,Jiang ZG,Zhao Y,Iqbal J,Hussain MM,Figeys D,Wang Y,Yao Z

更新日期：2010-06-01 00:00:00

abstract：:The extent to which the heart can convert alpha-linolenic acid (alpha-LNA, 18:3n-3) to longer chain n-3 PUFAs is not known. Conversion rates can be measured in vivo using radiolabeled alpha-LNA and a kinetic fatty acid model. [1-(14)C]alpha-LNA was infused intravenously for 5 min in unanesthetized rats that had been f...

journal_title：Journal of lipid research

authors： Igarashi M,Ma K,Chang L,Bell JM,Rapoport SI

更新日期：2008-08-01 00:00:00

abstract：:The implication of cholesteryl ester transfer protein (CETP) in the high density lipoprotein (HDL) conversion process was studied by incubating HDL3 with a purified CETP preparation for 24 h at 37 degrees C. At a physiological plasma level, CETP induced a decrease of the HDL3 fraction (8.6 nm diameter) and the appeara...

journal_title：Journal of lipid research

authors： Lagrost L,Gambert P,Dangremont V,Athias A,Lallemant C

更新日期：1990-09-01 00:00:00

abstract：:The phase behavior and temperature-dependent molecular motions of three cholesteryl ethers (caproyl, myristyl, oleyl) and a cholesteryl carbonate (oleyl) were characterized. The properties of each ether were qualitatively similar to, but quantitatively different from, those of the corresponding cholesteryl ester. For ...

journal_title：Journal of lipid research

authors： Croll DH,Sripada PK,Hamilton JA

更新日期：1987-12-01 00:00:00

abstract：:The mixed dyslipidemia phenotype is characterized by elevated triglycerides (TG), low HDL cholesterol (HDL-C), increased ApoB levels, and premature coronary atherosclerosis. Fibrate-statin combination therapy reduces ApoB levels and coronary events in the mixed dyslipidemia population. We sought to identify gene-gene ...

journal_title：Journal of lipid research

authors： Ma L,Ballantyne CM,Belmont JW,Keinan A,Brautbar A

更新日期：2012-11-01 00:00:00

abstract：:AY 9944 is a novel inhibitor of cholesterol biosynthesis which appears to act on the Delta 7-reductase enzyme, interfering with the conversion of 7-dehydrocholesterol to cholesterol. In all tissues studied, with the exception of the lens, there was a reduction in cholesterol and a marked accumulation of 7-dehydrochole...

journal_title：Journal of lipid research

authors： Horlick L

更新日期：1966-01-01 00:00:00

abstract：:Choline kinase catalyzes the phosphorylation of choline, the first step of phospholipid synthesis. Increased phosphorylation of choline is a hallmark characteristic of the malignant phenotype in a variety of neoplasms. However, in hypoxic cancer cells, choline phosphorylation is decreased. To understand the mechanism ...

journal_title：Journal of lipid research

authors： Bansal A,Harris RA,DeGrado TR

更新日期：2012-01-01 00:00:00

abstract：:After crossing floxed stearoyl-CoA desaturase-1 (Scd1fl/fl) mice with LDL receptor-null (ldlr-/-) mice, and then Villin Cre (VilCre) mice, enterocyte Scd1 expression in Scd1fl/fl/ldlr-/-/VilCre mice was reduced 70%. On Western diet (WD), Scd1fl/fl/ldlr-/- mice gained more weight than Scd1fl/fl/ldlr-/-/VilCre mice (P <...

journal_title：Journal of lipid research

authors： Mukherjee P,Hough G,Chattopadhyay A,Grijalva V,O'Connor EI,Meriwether D,Wagner A,Ntambi JM,Navab M,Reddy ST,Fogelman AM

更新日期：2018-10-01 00:00:00

abstract：:Cystic fibrosis (CF) patients and model systems exhibit consistent abnormalities in PUFA metabolism, including increased metabolism of linoleate to arachidonate. Recent studies have connected these abnormalities to increased expression and activity of the Δ6- and Δ5-desaturase enzymes. However, the mechanism connectin...

journal_title：Journal of lipid research

authors： Umunakwe OC,Seegmiller AC

更新日期：2014-07-01 00:00:00

abstract：:Oxidative stress, hepatic steatosis, and mitochondrial dysfunction are key pathophysiological features of nonalcoholic fatty liver disease. A conjugated linoleic acid (CLA) mixture of cis9,trans11 (9,11-CLA) and trans10,cis12 (10,12-CLA) isomers enhanced the antioxidant/detoxifying mechanism via the activation of nucl...

journal_title：Journal of lipid research

authors： Mollica MP,Trinchese G,Cavaliere G,De Filippo C,Cocca E,Gaita M,Della-Gatta A,Marano A,Mazzarella G,Bergamo P

更新日期：2014-05-01 00:00:00

abstract：:This study describes a variant of familial apoA-I deficiency associated with a moderate risk for premature coronary artery disease. The proband, a 25-year-old man of Philippine origin, and his 62-year-old maternal aunt had peripheral corneal opacification, xanthelasma, and planar xanthoma; the aunt had coronary artery...

journal_title：Journal of lipid research

authors： Bekaert ED,Alaupovic P,Knight-Gibson CS,Laux MJ,Pelachyk JM,Norum RA

更新日期：1991-10-01 00:00:00

abstract：:A simple, rapid, inexpensive method for isolating disaturated phosphatidylcholine from adult rat lung has been devised. Total lipids are reacted with osmium tetroxide dissolved in carbon tetrachloride, and the disaturated phosphatidylcholine is isolated on a column of neutral alumina. More than 99% of the fatty acids ...

journal_title：Journal of lipid research

authors： Mason RJ,Nellenbogen J,Clements JA

更新日期：1976-05-01 00:00:00

abstract：:The chemical composition and metabolism of lipoproteins in a population of Benedictine nuns were studied after 5-month periods during which the predominant dietary fats were sunflower oil, peanut oil, palm oil, or milk fats (butter and cream). The population was divided into three groups. The control group (C) include...

journal_title：Journal of lipid research

authors： Baudet MF,Dachet C,Lasserre M,Esteva O,Jacotot B

更新日期：1984-05-01 00:00:00

abstract：:To study the mechanism of alcoholic hypertriglyceridemia, baboons were pair-fed liquid diets containing 50% of energy as ethanol or as additional carbohydrate for 5-16 months. Alcohol-fed animals developed hypertriglyceridemia and early stages of alcoholic injury, namely fatty liver with or without perivenular fibrosi...

journal_title：Journal of lipid research

authors： Savolainen MJ,Baraona E,Leo MA,Lieber CS

更新日期：1986-10-01 00:00:00

abstract：:Phytanic acid (3,7,11,15-tetramethylhexadecanoic acid) is a branched-chain fatty acid derived from dietary sources and broken down in the peroxisome to pristanic acid (2,6,10,14-tetramethylpentadecanoic acid) via alpha-oxidation. Pristanic acid then undergoes beta-oxidation in peroxisomes. Phytanic acid naturally occu...

journal_title：Journal of lipid research

authors： Ferdinandusse S,Rusch H,van Lint AE,Dacremont G,Wanders RJ,Vreken P

更新日期：2002-03-01 00:00:00

abstract：:We describe a method for estimating the total activity of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase (EC 1.1.1.34) in the small intestine of rats. An homogenate of the whole small intestine is prepared rapidly and assayed directly to maximize the yield of enzyme and to minimize opportunity for uncontrolled cha...

journal_title：Journal of lipid research

authors： Young NL,Saudek CD,Crawford SA,Zuckerbrod SL

更新日期：1982-02-01 00:00:00

abstract：:A reliable method for purifying envelope-stripped nuclei from immortalized murine embryonic fibroblasts (iMEFs) was established. Quantitative profiling of the glycerophospholipids (GPLs) in envelope-free iMEF nuclei yields several conclusions. First, we find the endonuclear glycerophospholipidome differs from that of ...

journal_title：Journal of lipid research

authors： Tribble EK,Ivanova PT,Grabon A,Alb JG Jr,Faenza I,Cocco L,Brown HA,Bankaitis VA

更新日期：2016-08-01 00:00:00