Substrate specificity of lysophosphatidic acid acyltransferase beta -- evidence from membrane and whole cell assays.

abstract：:Mixed background SHP(-/-) mice are resistant to diet-induced obesity due to increased energy expenditure caused by enhanced PGC-1α expression in brown adipocytes. However, congenic SHP(-/-) mice on the C57BL/6 background showed normal expression of PGC-1α and other genes involved in brown adipose tissue thermogenesis....

journal_title：Journal of lipid research

authors： Park YJ,Kim SC,Kim J,Anakk S,Lee JM,Tseng HT,Yechoor V,Park J,Choi JS,Jang HC,Lee KU,Novak CM,Moore DD,Lee YK

更新日期：2011-12-01 00:00:00

abstract：:PAF-dependent transacetylase (TA) modifies the functions of platelet-activating factor (PAF), a potent inflammatory lipid, either by transferring the acetyl group from PAF to lysophospholipids (TAL activity), or to sphingosine (TAS activity) or by hydrolyzing PAF (acetylhydrolase activity). In stimulated endothelial c...

journal_title：Journal of lipid research

authors： Balestrieri ML,Castaldo D,Balestrieri C,Quagliuolo L,Giovane A,Servillo L

更新日期：2003-02-01 00:00:00

abstract：:Semi-purified diets supplemented with either a high linoleate (n-6) (safflower) oil or a high alpha-linolenate (n-3) (perilla) oil were fed to mouse mothers and their offspring through 6 weeks of age. The proportions of n-3 and n-6 highly unsaturated fatty acids in brain phospholipids reflected the n-3/n-6 balance of ...

journal_title：Journal of lipid research

authors： Nakashima Y,Yuasa S,Hukamizu Y,Okuyama H,Ohhara T,Kameyama T,Nabeshima T

更新日期：1993-02-01 00:00:00

abstract：:Several studies in humans and animals suggest that LDL particle core enrichment in cholesteryl oleate (CO) is associated with increased atherosclerosis. Diet enrichment with MUFAs enhances LDL CO content. Steroyl O-acyltransferase 2 (SOAT2) is the enzyme that catalyzes the synthesis of much of the CO found in LDL, and...

journal_title：Journal of lipid research

authors： Melchior JT,Sawyer JK,Kelley KL,Shah R,Wilson MD,Hantgan RR,Rudel LL

更新日期：2013-09-01 00:00:00

abstract：:Lipids secreted form the bovine meibomian glands were assigned to following classes: cholesteryl esters (A) (fatty acyl chain lengths from 15 to 27 carbon atoms), 41%; wax esters, 29%; triacylglycerols, 10%; and cholesteryl ester (B) (fatty acyl chain lengths from 14 to 18 carbons), 15%. The remaining 5% consisted of ...

journal_title：Journal of lipid research

authors： Baron C,Blough HA

更新日期：1976-07-01 00:00:00

abstract：:Epidemiological studies in Greenland Eskimos led to the hypothesis that marine oils rich in n-3 fatty acids (also referred to as omega (omega)-3 fatty acids) are hypolipidemic and ultimately antiatherogenic. Metabolically controlled trials in which large amounts of fish oil were fed to normal volunteers and hyperlipid...

journal_title：Journal of lipid research

authors： Harris WS

更新日期：1989-06-01 00:00:00

abstract：:Hormone-sensitive lipase (HSL) catalyzes the rate-limiting step in adipocyte lipolysis. The activity of HSL is thought to be primarily regulated by reversible phosphorylation. However, the regulation of HSL activity by pre-translational mechanisms has been poorly studied. The present studies were undertaken to explore...

journal_title：Journal of lipid research

authors： Large V,Arner P,Reynisdottir S,Grober J,Van Harmelen V,Holm C,Langin D

更新日期：1998-08-01 00:00:00

abstract：:Hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) is the rate-controlling enzyme of cholesterol synthesis, and owing to its biological and pharmacological relevance, researchers have investigated several compounds capable of modulating its activity with the hope of developing new hypocholesterolemic drugs. In particular,...

journal_title：Journal of lipid research

authors： Cuccioloni M,Mozzicafreddo M,Spina M,Tran CN,Falconi M,Eleuteri AM,Angeletti M

更新日期：2011-05-01 00:00:00

abstract：:Serum triglyceride (TG) levels are increased in extremely obese individuals, indicating abnormalities in lipid metabolism and insulin resistance. We carried out a genome scan for serum TG in 320 nuclear families segregating extreme obesity and normal weight. Three hundred eighty-two Marshfield microsatellite markers (...

journal_title：Journal of lipid research

authors： Li WD,Dong C,Li D,Garrigan C,Price RA

更新日期：2005-03-01 00:00:00

abstract：:A report on the effects of primary bile acid ingestion alone or in combination with plant sterols on serum cholesterol levels, biliary lipid secretion, and bile acid metabolism. Biliary bile acid and cholesterol secretion were measured in four patients with type IIa hypercholesterolemia before and after randomized tre...

journal_title：Journal of lipid research

authors： Tangedahl TN,Hofmann AF,Kottke BA

更新日期：1979-01-01 00:00:00

abstract：:Human lysosomal acid lipase/cholesteryl ester hydrolase (hLAL) is essential for the intralysosomal metabolism of cholesteryl esters and triglycerides taken up by receptor-mediated endocytosis of lipoprotein particles. The key role of the enzyme in intracellular lipid homeostasis is illustrated by two lysosomal storage...

journal_title：Journal of lipid research

authors： Lohse P,Maas S,Sewell AC,van Diggelen OP,Seidel D

更新日期：1999-02-01 00:00:00

abstract：:Scavenger receptor class B type I (SR-BI) mediates the selective uptake of HDL cholesteryl esters (CEs) and facilitates the efflux of unesterified cholesterol. SR-BI expression in macrophages presumably plays a role in atherosclerosis. The role of SR-BI for selective CE uptake and cholesterol efflux in macrophages was...

journal_title：Journal of lipid research

authors： Brundert M,Heeren J,Bahar-Bayansar M,Ewert A,Moore KJ,Rinninger F

更新日期：2006-11-01 00:00:00

abstract：:Autosomal dominant Stargardt-like macular dystrophy (STGD3) in humans results from mutations in elongation of very long chain FAs-like 4 (ELOVL4), which leads to vision loss in young adults. ELOVL4 is an integral endoplasmic reticulum (ER) protein that mediates the elongation of very long chain (VLC) FAs. Mutations in...

journal_title：Journal of lipid research

authors： Logan S,Agbaga MP,Chan MD,Brush RS,Anderson RE

更新日期：2014-04-01 00:00:00

abstract：:Interactions of apolipoprotein A-I (apoA-I) with cell membranes appear to be important in the initial steps of reverse cholesterol transport. The objective of this work was to examine the effect of three distinct conformations of apoA-I (lipid-free and in 78 A or 96 A reconstituted high density lipoproteins, rHDL) on ...

journal_title：Journal of lipid research

authors： Tricerri MA,Sanchez SA,Arnulphi C,Durbin DM,Gratton E,Jonas A

更新日期：2002-02-01 00:00:00

abstract：:Ceramide-1-phosphate (C1P) is a novel bioactive sphingolipid formed by the phosphorylation of ceramide catalyzed by ceramide kinase (CERK). In this study, we evaluated the mechanism by which increased C1P during phagocytosis enhances phagocytosis and phagolysosome formation in COS-1 cells expressing hCERK. Stable tran...

journal_title：Journal of lipid research

authors： Hinkovska-Galcheva V,Clark A,VanWay S,Huang JB,Hiraoka M,Abe A,Borofsky M,Kunkel RG,Shanley T,Shayman JA,Lanni F,Petty HR,Boxer LA

更新日期：2008-03-01 00:00:00

abstract：:Deficiency of lysosomal acid lipase (LAL) leads to either Wolman disease (WD) or the more benign cholesteryl ester storage disease (CESD). To identify the molecular basis of the different phenotypes we have characterised the LAL gene mutations in three new patients with LAL deficiency. A patient with WD was homozygote...

journal_title：Journal of lipid research

authors： Pagani F,Pariyarath R,Garcia R,Stuani C,Burlina AB,Ruotolo G,Rabusin M,Baralle FE

更新日期：1998-07-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) is a receptor-active lipid mediator with a broad range of biological effects. Ovarian cancer cells synthesize LPA, which promotes their motility, growth, and survival. We show that a murine homolog of a human protein previously reported to hydrolyze LPA is a highly selective detergent-stimu...

journal_title：Journal of lipid research

authors： Luquain C,Singh A,Wang L,Natarajan V,Morris AJ

更新日期：2003-10-01 00:00:00

abstract：:The diurnal cycle of hepatic HMG CoA reductase activity was studied under conditions of controlled feeding where the percentage of dietary lipid, alone or in combination with 2% cholestyramine, was varied. Cholestyramine caused an increase in HMG CoA reductase activity that began soon after feeding started and peaked ...

journal_title：Journal of lipid research

authors： Goldfarb S,Pitot HC

更新日期：1972-11-01 00:00:00

abstract：:Acyl-CoA-dependent O-acyltransferases catalyze reactions in which fatty acyl-CoAs are joined to acyl acceptors containing free hydroxyl groups to produce neutral lipids. In this report, we characterize a human multifunctional O-acyltransferase (designated MFAT) that belongs to the acyl-CoA:diacylglycerol acyltransfera...

journal_title：Journal of lipid research

authors： Yen CL,Brown CH 4th,Monetti M,Farese RV Jr

更新日期：2005-11-01 00:00:00

abstract：:HDL-like particles in human cerebrospinal fluid (CSF) promote the efflux of cholesterol from astrocytes toward the neurons that rely on this supply for their functions. We evaluated whether cell cholesterol efflux capacity of CSF (CSF-CEC) is impaired in Alzheimer's disease (AD) by analyzing AD (n = 37) patients, non-...

journal_title：Journal of lipid research

authors： Marchi C,Adorni MP,Caffarra P,Ronda N,Spallazzi M,Barocco F,Galimberti D,Bernini F,Zimetti F

更新日期：2019-08-01 00:00:00

abstract：:LCAT plays a key role in the maturation of HDL, as evidenced by low HDL-cholesterol levels in carriers of deleterious mutations in LCAT. However, the role of LCAT in atherosclerosis is unclear. We set out to study this in a prospective study. Plasma LCAT levels, which strongly correlate with LCAT activity, were measur...

journal_title：Journal of lipid research

authors： Holleboom AG,Kuivenhoven JA,Vergeer M,Hovingh GK,van Miert JN,Wareham NJ,Kastelein JJ,Khaw KT,Boekholdt SM

更新日期：2010-02-01 00:00:00

abstract：:Biliary cholesterol secretion is ordinarily tightly coupled to phosphatidylcholine (PC) secretion. Bile PCs are distinct in composition and predominantly composed of molecular species with 16:0 in the sn-1 position and 18:2 and 18:1 in the sn-2 position. In an attempt to acutely change the composition of biliary PCs a...

journal_title：Journal of lipid research

authors： Robins SJ,Fasulo JM,Robins VF,Patton GM

更新日期：1991-06-01 00:00:00

abstract：:Recombinant human pancreatic lipase-related protein 2 (rHPLRP2) was produced in the protease A-deficient yeast Pichia pastoris. A major protein with a molecular mass of 50 kDa was purified from the culture medium using SP-Sepharose and Mono Q chromatography. The protein was found to be highly sensitive to the proteoly...

journal_title：Journal of lipid research

authors： Eydoux C,De Caro J,Ferrato F,Boullanger P,Lafont D,Laugier R,Carrière F,De Caro A

更新日期：2007-07-01 00:00:00

abstract：:Fatty acid binding protein 4 (FABP4), also known as adipocyte FABP or aP2, is secreted from adipocytes in association with lipolysis as a novel adipokine, and elevated serum FABP4 level is associated with obesity, insulin resistance, and atherosclerosis. However, little is known about the modulation of serum FABP4 lev...

journal_title：Journal of lipid research

authors： Furuhashi M,Hiramitsu S,Mita T,Fuseya T,Ishimura S,Omori A,Matsumoto M,Watanabe Y,Hoshina K,Tanaka M,Moniwa N,Yoshida H,Ishii J,Miura T

更新日期：2015-12-01 00:00:00

abstract：:Dietary lipids are taken up as FAs by the intestinal epithelium and converted by diacylglycerol acyltransferase (DGAT) enzymes into triglycerides, which are packaged in chylomicrons or stored in cytoplasmic lipid droplets (LDs). DGAT1-deficient patients suffer from vomiting, diarrhea, and protein losing enteropathy, i...

journal_title：Journal of lipid research

authors： van Rijn JM,van Hoesel M,de Heus C,van Vugt AHM,Klumperman J,Nieuwenhuis EES,Houwen RHJ,Middendorp S

更新日期：2019-10-01 00:00:00

abstract：:We examined the association between rate of cholesterol esterification in plasma depleted of apolipoprotein B-containing lipoproteins (FER(HDL)), atherogenic index of plasma (AIP) [(log (TG/HDL-C)], concentrations, and size of lipoproteins and changes in coronary artery stenosis in participants in the HDL-Atherosclero...

journal_title：Journal of lipid research

authors： Dobiásová M,Frohlich J,Sedová M,Cheung MC,Brown BG

更新日期：2011-03-01 00:00:00

abstract：:Acyl-CoA thioesterase (Acot)2 localizes to the mitochondrial matrix and hydrolyses long-chain fatty acyl-CoA into free FA and CoASH. Acot2 is expressed in highly oxi-dative tissues and is poised to modulate mitochondrial FA oxidation (FAO), yet its biological role is unknown. Using a model of adenoviral Acot2 overexpr...

journal_title：Journal of lipid research

authors： Moffat C,Bhatia L,Nguyen T,Lynch P,Wang M,Wang D,Ilkayeva OR,Han X,Hirschey MD,Claypool SM,Seifert EL

更新日期：2014-12-01 00:00:00

abstract：:Using solid phase systems, the kinetics of binding of monoclonal antibody (LRB 45, IgG2b,kappa) to apoC-I and apoC-I on lipoproteins were investigated. At 25 degrees C, the association constant of LRB 45 antibody to apoC-I (3.56 X 10(6) M-1 X sec-1) was almost three times slower than the association constant LRB 45 an...

journal_title：Journal of lipid research

authors： Wong L

更新日期：1985-07-01 00:00:00

abstract：:LDL receptor-null (LDLR(-/-)) mice on a Western diet (WD) develop endothelial dysfunction and atherosclerosis, which are improved by the apolipoprotein A-I (apoA-I) mimetic peptide D-4F. Focusing on the kidney, LDLR(-/-)mice were fed a WD with D-4F or the inactive control peptide scrambled D-4F (ScD-4F) added to their...

journal_title：Journal of lipid research

authors： Buga GM,Frank JS,Mottino GA,Hakhamian A,Narasimha A,Watson AD,Yekta B,Navab M,Reddy ST,Anantharamaiah GM,Fogelman AM

更新日期：2008-01-01 00:00:00

abstract：:A novel water-soluble polysaccharide fraction, CME-1, with a molecular mass of 27.6 kDa and containing mannose and galactose in a respective ratio of 4:6, was prepared from Cordyceps sinensis mycelia and identified by NMR and GC-MS. In the current study, we examined whether CME-1 has anti-inflammatory effects in RAW26...

journal_title：Journal of lipid research

authors： Wang SH,Yang WB,Liu YC,Chiu YH,Chen CT,Kao PF,Lin CM

更新日期：2011-03-01 00:00:00