Utilization of different fatty acids for hepatic and biliary phosphatidylcholine formation and the effect of changes in phosphatidylcholine molecular species on biliary lipid secretion.

abstract：:The direct effect of apolipoprotein (apo) E on cholesteryl ester transfer protein (CETP) activity was studied using lipoproteins from a subject with apoE deficiency (Atherosclerosis. 1991. 88: 15-20) as a model system. The transfer of cholesteryl ester (CE) from discoidal bilayer particles (DBP) to very low density li...

journal_title：Journal of lipid research

authors： Kinoshita M,Arai H,Fukasawa M,Watanabe T,Tsukamoto K,Hashimoto Y,Inoue K,Kurokawa K,Teramoto T

更新日期：1993-02-01 00:00:00

abstract：:Studies on plasma triglycerides (TG) were performed in 10 nonobese and 16 obese patients with hypothyroidism and in 13 with hyperthyroidism. Nonobese, hypothyroid patients generally had normal levels of TG, but obese patients often had hypertriglyceridemia. In most hypothyroid patients 1-thyroxine treatment lowered pl...

journal_title：Journal of lipid research

authors： Abrams JJ,Grundy SM,Ginsberg H

更新日期：1981-02-01 00:00:00

abstract：:Cholesterol-3-(3)H,4-(14)C was injected intravenously in man and its transformation to cholestanol was studied. From the (3)H: (14)C ratios in cholestanol isolated from blood, evidence for the participation of a ketonic intermediate in the conversion was obtained. In a second subject given cholestanol-3-(3)H,4-(14)C t...

journal_title：Journal of lipid research

authors： Rosenfeld RS,Zumoff B,Hellman L

更新日期：1967-01-01 00:00:00

abstract：:Due to conflicting reports concerning the relationship between phospholipid transfer protein (PLTP) activity and mass in plasma, the protein concentration and activity of PLTP were assessed in fractions isolated by fast protein liquid chromatography from the plasma of healthy normolipidemic individuals. Using both pol...

journal_title：Journal of lipid research

authors： Murdoch SJ,Wolfbauer G,Kennedy H,Marcovina SM,Carr MC,Albers JJ

更新日期：2002-02-01 00:00:00

abstract：:We have developed a simplified and improved high performance liquid chromatography (HPLC) method for the detection and quantitation of tissue lipid using a new laser light-scattering detector (Varex model ELSD II). This detector has a limit of sensitivity of 50 ng for neutral lipid and 200 ng for most phospholipids wi...

journal_title：Journal of lipid research

authors： Lutzke BS,Braughler JM

更新日期：1990-11-01 00:00:00

abstract：:Expression of bile salt export pump (BSEP) is regulated by the bile acid/farnesoid X receptor (FXR) signaling pathway. Two FXR isoforms, FXRα1 and FXRα2, are predominantly expressed in human liver. We previously showed that human BSEP was isoform-dependently regulated by FXR and diminished with altered expression of F...

journal_title：Journal of lipid research

authors： Song X,Chen Y,Valanejad L,Kaimal R,Yan B,Stoner M,Deng R

更新日期：2013-11-01 00:00:00

abstract：:Plasma phospholipid transfer protein (PLTP) interacts with HDL particles and facilitates the transfer of phospholipids from triglyceride (TG)-rich lipoproteins to HDL. Overexpressing human PLTP in mice increases the susceptibility to atherosclerosis. In human plasma, high-active and low-active forms of PLTP exist. To ...

journal_title：Journal of lipid research

authors： Samyn H,Moerland M,van Gent T,van Haperen R,Metso J,Grosveld F,Jauhiainen M,van Tol A,de Crom R

更新日期：2008-12-01 00:00:00

abstract：:A simple, rapid, and sensitive bioluminescence method for measuring primary bile acids has been developed and validated. The method is based on enzymatic dehydrogenation of bile acids using a bacterial 7 alpha-hydroxysteroid dehydrogenase that is co-immobilized on Sepharose 4B beads with NADH:FMN oxidoreductase and a ...

journal_title：Journal of lipid research

authors： Roda A,Kricka LJ,DeLuca M,Hofmann AF

更新日期：1982-12-01 00:00:00

abstract：:Incubation of 125I-labeled very low density lipoprotein (VLDL) with lipoprotein lipase-rich (postheparin) plasma obtained from intact or supradiaphragmatic rats resulted in the transfer of more than 80% of apoprotein C from VLDL to high density lipoprotein (HDL), whereas apoprotein B was associated with lipoprotein of...

journal_title：Journal of lipid research

authors： Eisenberg S,Rachmilewitz D

更新日期：1975-09-01 00:00:00

abstract：:Recombinant human pancreatic lipase-related protein 2 (rHPLRP2) was produced in the protease A-deficient yeast Pichia pastoris. A major protein with a molecular mass of 50 kDa was purified from the culture medium using SP-Sepharose and Mono Q chromatography. The protein was found to be highly sensitive to the proteoly...

journal_title：Journal of lipid research

authors： Eydoux C,De Caro J,Ferrato F,Boullanger P,Lafont D,Laugier R,Carrière F,De Caro A

更新日期：2007-07-01 00:00:00

abstract：:The objectives of this study were to characterize the effects of plasma lipoproteins on prostacyclin (PGI2) production by the Langendorff-perfused rabbit heart, and to determine the mechanism of lipoprotein-induced cardiac PGI2 production. PGI2 production by perfused rabbit hearts was stimulated by injections of rabbi...

journal_title：Journal of lipid research

authors： Van Sickle WA,Wilcox HG,Malik KU,Nasjletti A

更新日期：1986-05-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) is associated with a severe pro-inflammatory response; although decreased plasma cholesterol concentration has been linked to systemic inflammation, any association of phospholipid metabolic pathways with ARDS has not been characterized. Plasma phosphatidylcholine (PC), the m...

journal_title：Journal of lipid research

authors： Dushianthan A,Cusack R,Grocott MPW,Postle AD

更新日期：2018-06-01 00:00:00

abstract：:The human retina is well-known to have unique lipid profiles enriched in long-chain polyunsaturated fatty acids (LC-PUFAs) and very long-chain polyunsaturated fatty acids (VLC-PUFAs) that appear to promote normal retinal structure and function, but the influence of diet on retinal lipid profiles in health and disease ...

journal_title：Journal of lipid research

authors： Gorusupudi A,Liu A,Hageman GS,Bernstein PS

更新日期：2016-03-01 00:00:00

abstract：:Enzymes associated with glycerolipid biosynthesis were examined in microsomal fractions of liver and adipose tissue obtained from swine of various ages. Generally, liver glycerophosphate acyltransferase, phosphatidate phosphohydrolase, diglyceride acyltransferase, and choline phosphotransferase activities were substan...

journal_title：Journal of lipid research

authors： Steffen DG,Phinney G,Brown LJ,Mersmann HJ

更新日期：1979-02-01 00:00:00

abstract：:Loss of function of Niemann-Pick C1 (NPC1) leads to lysosomal free cholesterol storage, resulting in the neurodegenerative disease Niemann-Pick disease type C (NPC). Significant numbers of patients with NPC also suffer from liver disease. Currently, no treatments exist that alter patient outcome, and it is unknown if ...

journal_title：Journal of lipid research

authors： Sayre NL,Rimkunas VM,Graham MJ,Crooke RM,Liscum L

更新日期：2010-08-01 00:00:00

abstract：:The cellular mechanisms responsible for the lipoprotein-mediated stimulation of bile acid synthesis in cultured rat hepatocytes were investigated. Adding 280 micrograms/ml of cholesterol in the form of human or rat low density lipoprotein (LDL) to the culture medium increased bile acid synthesis by 1.8- and 1.6-fold, ...

journal_title：Journal of lipid research

authors： Junker LH,Davis RA

更新日期：1989-12-01 00:00:00

abstract：:Smith-Lemli-Opitz syndrome (SLOS) is a genetic disorder characterized by low plasma cholesterol and high 7-dehydrocholesterol (7-DHC). Synthesis of cholesterol and 7-DHC and its metabolites is regulated by HMG-CoA reductase, whose activity can be measured by 24-h excretion of its product mevalonate. We devised a simpl...

journal_title：Journal of lipid research

authors： Pappu AS,Steiner RD,Connor SL,Flavell DP,Lin DS,Hatcher L,Illingworth DR,Connor WE

更新日期：2002-10-01 00:00:00

abstract：:Animal studies have suggested that angiopoietin-like 4 (Angptl4) regulates adiposity through central and peripheral mechanisms. The aim of this study was to investigate whether serum concentration and adipose tissue expression of Angptl4 are associated with obesity-related parameters in humans. Altogether, 75 dizygoti...

journal_title：Journal of lipid research

authors： Robciuc MR,Naukkarinen J,Ortega-Alonso A,Tyynismaa H,Raivio T,Rissanen A,Kaprio J,Ehnholm C,Jauhiainen M,Pietiläinen KH

更新日期：2011-08-01 00:00:00

abstract：:Very few studies have investigated the interrelations between proprotein convertase subtilisin/kexin type 9 (PCSK9) metabolism, cholesterol synthesis, and cholesterol absorption. We aimed to address this issue in a large clinical trial of 245 patients with hypercholesterolemia. Serum lipids, PCSK9, lathosterol (choles...

journal_title：Journal of lipid research

authors： Silbernagel G,Steiner LK,Hollstein T,Fauler G,Scharnagl H,Stojakovic T,Schumann F,Bölükbasi B,März W,Steinhagen-Thiessen E,Laufs U,Kassner U

更新日期：2019-01-01 00:00:00

abstract：:In this work, we investigated the impact of testosterone deficiency and cholesteryl ester transfer protein (CETP) expression on lipoprotein metabolism and diet-induced atherosclerosis. CETP transgenic mice and nontransgenic (nTg) littermates were studied 4 weeks after bilateral orchidectomy or sham operation. Castrate...

journal_title：Journal of lipid research

authors： Casquero AC,Berti JA,Salerno AG,Bighetti EJ,Cazita PM,Ketelhuth DF,Gidlund M,Oliveira HC

更新日期：2006-07-01 00:00:00

abstract：:Elaborate control mechanisms of intracellular triacylglycerol (TAG) breakdown are critically involved in the maintenance of energy homeostasis. Hypoxia-inducible lipid droplet-associated protein (HILPDA)/hypoxia-inducible gene-2 (Hig-2) has been shown to affect intracellular TAG levels, yet, the underlying molecular m...

journal_title：Journal of lipid research

authors： Padmanabha Das KM,Wechselberger L,Liziczai M,De la Rosa Rodriguez M,Grabner GF,Heier C,Viertlmayr R,Radler C,Lichtenegger J,Zimmermann R,Borst JW,Zechner R,Kersten S,Oberer M

更新日期：2018-03-01 00:00:00

abstract：:De novo synthesis and turnover of endogenous ceramide in cultured skin fibroblasts from patients affected with Farber lipogranulomatosis were studied by biosynthetical labeling of cellular sphingolipids with [14C]serine. The cellular uptake of [14C]serine and incorporation into de novo synthesized ceramide was similar...

journal_title：Journal of lipid research

authors： van Echten-Deckert G,Klein A,Linke T,Heinemann T,Weisgerber J,Sandhoff K

更新日期：1997-12-01 00:00:00

abstract：:Neutral sphingomyelinase-2 (nSMase2) is a key ceramide-producing enzyme in cellular stress responses. While many posttranslational regulators of nSMase2 are known, emerging evidence suggests a more protracted regulation of nSMase2 at the transcriptional level. Previously, we reported that nSMase2 is induced by all-tra...

journal_title：Journal of lipid research

authors： Clarke CJ,Shamseddine AA,Jacob JJ,Khalife G,Burns TA,Hannun YA

更新日期：2016-05-01 00:00:00

abstract：:Phosphorylcholine-1,2-(14)C and choline-1,2-(14)C-labeled cytidine diphosphate choline are incorporated into lecithin by whole homogenates and particulate fractions of rat retina with optimal incorporation of label by the microsomal fraction. The soluble fraction contains a factor(s) which stimulates incorporation of ...

journal_title：Journal of lipid research

authors： Swartz JG,Mitchell JE

更新日期：1970-11-01 00:00:00

abstract：:The effects of intravenous injection of lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNF) were investigated in cynomolgus monkeys (Macaca fascicularis). Injection of 20 micrograms/kg of LPS from E. coli (serotype 055:B5) into cynomolgus monkeys fed a monkey chow diet caused a twofold increase in plasma tr...

journal_title：Journal of lipid research

authors： Ettinger WH,Miller LD,Albers JJ,Smith TK,Parks JS

更新日期：1990-06-01 00:00:00

abstract：:The sterol regulatory element binding protein (SREBP)/SREBP cleavage-activating protein (SCAP) complex regulates the transcription of numerous genes involved in cellular cholesterol metabolism. The CHO mutant, CT60, and its parental cell line, 25RA, possess a gain-of-function mutation in one allele of the SCAP gene th...

journal_title：Journal of lipid research

authors： Maguire JA,Reagan JW Jr

更新日期：2005-09-01 00:00:00

abstract：:Hypertriglyceridemia induces multiple changes in lipoprotein composition. Here we investigate how one of these modifications, triglyceride (TG) enrichment, affects HDL and LDL function when this alteration occurs under conditions in which more polar components can naturally re-equilibrate. TG-enriched lipoproteins wer...

journal_title：Journal of lipid research

authors： Skeggs JW,Morton RE

更新日期：2002-08-01 00:00:00

abstract：:High fatty acid (FA) flux is associated with systemic insulin resistance, and African-American (AA) women tend to be more insulin resistant. We assessed possible depot and race difference in the antilipolytic effect of insulin in adipocytes isolated from abdominal (Abd) and gluteal (Glt) subcutaneous (sc) adipose tiss...

journal_title：Journal of lipid research

authors： Fried SK,Tittelbach T,Blumenthal J,Sreenivasan U,Robey L,Yi J,Khan S,Hollender C,Ryan AS,Goldberg AP

更新日期：2010-05-01 00:00:00

abstract：:The properties of cholesteryl oleate and triolein in mixed monolayers at the air-water interface have been measured between 24 and 37 degrees C. Analysis of force-area curves obtained as a function of the mol fraction of cholesteryl oleate indicates that at relatively low surface pressures these compounds are miscible...

journal_title：Journal of lipid research

authors： Smaby JM,Brockman HL

更新日期：1978-03-01 00:00:00

abstract：:Polyunsaturated fatty acids, including docosahexaenoic acid (DHA, 22:6n-3), modulate immune responses and exert beneficial immunosuppressive effects, but the molecular mechanisms inhibiting T-cell activation are not yet elucidated. Lipid rafts have been shown to play an important role in the compartmentalization and m...

journal_title：Journal of lipid research

authors： Li Q,Wang M,Tan L,Wang C,Ma J,Li N,Li Y,Xu G,Li J

更新日期：2005-09-01 00:00:00