A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters.

abstract：:We have recently reported that the human apolipoprotein A-I (apoA-I) and apolipoprotein C-III (apoC-III) genes are physically linked and that the presence of a DNA insertion in the apoA-I gene is correlated with apoA-I-apoC-III deficiency in patients with premature atherosclerosis. In addition, the presence of a polym...

journal_title：Journal of lipid research

authors： Karathanasis SK,Zannis VI,Breslow JL

更新日期：1985-04-01 00:00:00

abstract：:Cholelithiasis is a multifactorial process, and several mechanisms have been postulated. A decreased expression of the ileal apical sodium-dependent bile acid transporter (ASBT) and of the cytosolic ileal lipid binding protein (ILBP) was recently described in female non-obese patients. The role of the recently identif...

journal_title：Journal of lipid research

authors： Renner O,Harsch S,Strohmeyer A,Schimmel S,Stange EF

更新日期：2008-09-01 00:00:00

abstract：:Infusions of 2-deoxyglucose (2-DG) into intact, adrenalectomized, and adrenalectomized-hypophysectomized dogs caused increases in plasma free fatty acid (FFA) levels which could be reversed by infusing hexamethonium, or prevented by epidural anesthesia or destruction of the thoracic spinal cord. Similar infusions of 2...

journal_title：Journal of lipid research

authors： Goldfien A,Gullixson KS,Hargrove G

更新日期：1966-05-01 00:00:00

abstract：:The sphingomyelin pathway is an important signal transduction system regulating various cellular functions. However, little is known about the effect of sphingomyelin metabolites on vasomotor function. We examined the vascular effects of sphingomyelin, sphingosine, and sphingomyelinase (SPMase) in vitro. In pig corona...

journal_title：Journal of lipid research

authors： Murohara T,Kugiyama K,Ohgushi M,Sugiyama S,Ohta Y,Yasue H

更新日期：1996-07-01 00:00:00

abstract：:Cholesterol-3-(3)H,4-(14)C was injected intravenously in man and its transformation to cholestanol was studied. From the (3)H: (14)C ratios in cholestanol isolated from blood, evidence for the participation of a ketonic intermediate in the conversion was obtained. In a second subject given cholestanol-3-(3)H,4-(14)C t...

journal_title：Journal of lipid research

authors： Rosenfeld RS,Zumoff B,Hellman L

更新日期：1967-01-01 00:00:00

abstract：:Zinc Finger Protein 202 (ZNF202) is a transcriptional repressor that binds elements found predominantly in genes involved in HDL metabolism. We tested the following hypotheses: 1) frequencies of single-nucleotide polymorphisms (SNPs) and haplotypes in ZNF202 differ between individuals with low and high HDL cholesterol...

journal_title：Journal of lipid research

authors： Stene MC,Frikke-Schmidt R,Nordestgaard BG,Tybjaerg-Hansen A

更新日期：2006-05-01 00:00:00

abstract：:The properties of cholesteryl oleate and triolein in mixed monolayers at the air-water interface have been measured between 24 and 37 degrees C. Analysis of force-area curves obtained as a function of the mol fraction of cholesteryl oleate indicates that at relatively low surface pressures these compounds are miscible...

journal_title：Journal of lipid research

authors： Smaby JM,Brockman HL

更新日期：1978-03-01 00:00:00

abstract：:Lysophospholipid acyltransferases (LPATs) incorporate fatty acyl chains into phospholipids via a CoA-dependent mechanism and are important in remodeling phospholipids to generate the molecular species of phospholipids found in cells. These enzymes use one lysophospholipid and one acyl-CoA ester as substrates. Traditio...

journal_title：Journal of lipid research

authors： Martin SA,Gijón MA,Voelker DR,Murphy RC

更新日期：2014-04-01 00:00:00

abstract：:The class B scavenger receptors SR-BI and CD36 exhibit a broad ligand binding specificity. SR-BI is well characterized as a HDL receptor that mediates selective cholesteryl ester uptake from HDL. CD36, a receptor for oxidized LDL, also binds HDL and mediates selective cholesteryl ester uptake, although much less effic...

journal_title：Journal of lipid research

authors： de Beer MC,Castellani LW,Cai L,Stromberg AJ,de Beer FC,van der Westhuyzen DR

更新日期：2004-04-01 00:00:00

abstract：:Extracted tissue phospholipid 31P NMR profiles, obtained from individual porcine lenses subjected to two preservation procedures (acetone desiccation and freeze-drying) and a perchloric acid-extraction procedure, were compared to those from freshly excised lens specimens. Each profile yielded quantitative data on 12 l...

journal_title：Journal of lipid research

authors： Meneses P,Para PF,Glonek T

更新日期：1989-03-01 00:00:00

abstract：:Within the cholesterol biosynthesis cascade, the enzyme 2,3-oxidosqualene cyclase [EC 5.4.99.7] is of special interest due to its dual function: cyclization of 2,3-monoepoxysqualene to lanosterol and 2,3;22,23-diepoxysqualene to oxylanosterol. Further determination of the significance of this enzyme for the intracellu...

journal_title：Journal of lipid research

authors： Mark M,Muller P,Maier R,Eisele B

更新日期：1996-01-01 00:00:00

abstract：:Activation of cultured hepatic stellate cells correlated with an enhanced expression of proteins involved in uptake and storage of fatty acids (FA translocase CD36, Acyl-CoA synthetase 2) and retinol (cellular retinol binding protein type I, CRBP-I; lecithin:retinol acyltransferases, LRAT). The increased expression of...

journal_title：Journal of lipid research

authors： Hellemans K,Rombouts K,Quartier E,Dittié AS,Knorr A,Michalik L,Rogiers V,Schuit F,Wahli W,Geerts A

更新日期：2003-02-01 00:00:00

abstract：:We report on the effect of human apolipoprotein (apo) A-II transgene expression on atherosclerosis susceptibility in two transgenic lines (25.3 and 11.1) whose plasma human apoA-II concentrations (approximately 23 and 96 mg/dl, respectively) span the normal range in humans. After 9 months of an atherogenic diet, 25.3 ...

journal_title：Journal of lipid research

authors： Escolà-Gil JC,Marzal-Casacuberta A,Julve-Gil J,Ishida BY,Ordóñez-Llanos J,Chan L,González-Sastre F,Blanco-Vaca F

更新日期：1998-02-01 00:00:00

abstract：:The diffusion of [2-(14)C]glucose out of liposomes prepared from extracted human erythrocyte lipids was examined. Increased glucose efflux was observed when the lipids were treated with hydrogen peroxide and CuCl(2) before liposome formation, and this phenomenon required both peroxide and metal. Peroxidation of these ...

journal_title：Journal of lipid research

authors： Smolen JE,Shohet SB

更新日期：1974-05-01 00:00:00

abstract：:Cyanidin-3-O-β-glucoside (C3G) (CAS number 7084-24-4), a typical anthocyanin pigment that exists in the human diet, has been reported to have anti-inflammatory properties. However, the effect of C3G on lipopolysaccharide (LPS)-induced mastitis and the molecular mechanisms have not been investigated. In this study, we ...

journal_title：Journal of lipid research

authors： Fu Y,Wei Z,Zhou E,Zhang N,Yang Z

更新日期：2014-06-01 00:00:00

abstract：:Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and progresses to alcoholic steatohepatitis, fibrosis, and cirrhosis. The severity of hepatic steatosis is highly associated with the developmen...

journal_title：Journal of lipid research

authors： Jeon S,Carr R

更新日期：2020-04-01 00:00:00

abstract：:Our goal was to further define the role of LPL gene polymorphisms in coronary heart disease (CHD) risk. We determined the frequencies of three LPL polymorphisms (D9N, N291S, and S447X) in 899 men from the Veterans Affairs HDL Intervention Trial (VA-HIT), a study that examined the potential benefits of increasing HDL w...

journal_title：Journal of lipid research

authors： Brousseau ME,Goldkamp AL,Collins D,Demissie S,Connolly AC,Cupples LA,Ordovas JM,Bloomfield HE,Robins SJ,Schaefer EJ

更新日期：2004-10-01 00:00:00

abstract：:Absorption rates for many biologically important compounds are determined by the relative hydrophobicity of the jejunal microvillus membrane. An estimate of this parameter may be obtained by measuring the incremental change in free energy that occurs when a methylene group partitions into the bilayer form an external ...

journal_title：Journal of lipid research

authors： Meddings JB,Dietschy JM

更新日期：1989-08-01 00:00:00

abstract：:Apoliprotein (apo) B-100-containing very low density lipoprotein (VLDL) particles secreted from the liver accumulate in plasma during alimentary lipemia. To determine whether changes of VLDL composition occur in the postprandial state that may render these lipoproteins more atherogenic, apoE, C-I, C-II, and C-III, and...

journal_title：Journal of lipid research

authors： Björkegren J,Hamsten A,Milne RW,Karpe F

更新日期：1997-02-01 00:00:00

abstract：:The storage of lipids in the form of triglycerides (TGs) and the de novo synthesis (lipogenesis) of fatty acids from nonlipid precursors [de novo lipogenesis (DNL)] are important functions of adipose tissue (AT) that influence whole-body metabolism. Yet, few studies have reported in vivo estimates of adipose lipid kin...

journal_title：Journal of lipid research

authors： White UA,Fitch MD,Beyl RA,Hellerstein MK,Ravussin E

更新日期：2018-09-01 00:00:00

abstract：:Four hours after intraportal injection of retinoic acid-(14)C into bile duct-cannulated rats, less than 10% of the radioactivity was recovered in the liver, intestine, and kidneys. Within 6 hr, 40% of the radioactivity had appeared in bile. When suspensions of retinol-(14)C or retinal were similarly injected, 25-35% o...

journal_title：Journal of lipid research

authors： Zachman RD,Dunagin PE Jr,Olson JA

更新日期：1966-01-01 00:00:00

abstract：:Lipidomics, the mass spectrometry-based comprehensive analysis of lipids, has attracted attention as an analytical approach to provide novel insight into lipid metabolism and to search for biomarkers. However, an ideal method for both comprehensive and quantitative analysis of lipids has not been fully developed. Here...

journal_title：Journal of lipid research

authors： Takeda H,Izumi Y,Takahashi M,Paxton T,Tamura S,Koike T,Yu Y,Kato N,Nagase K,Shiomi M,Bamba T

更新日期：2018-07-01 00:00:00

abstract：:An elevated plasma concentration of lipoprotein (a) [Lp(a)] is an independent risk factor for cardiovascular disease. Life style modification and currently available drugs either fail to effectively lower plasma Lp(a) levels or do not result in clinical benefit. However, lipoprotein apheresis is very efficient in decr...

journal_title：Journal of lipid research

authors： Waldmann E,Parhofer KG

更新日期：2016-10-01 00:00:00

abstract：:These studies examined the proposition that the small particle size of HDL3 in the plasma of hypertriglyceridemic subjects is the consequence of the sequential actions of lipid transfer protein and hepatic lipase on HDL. Incubation of unmodified total HDL or HDL3 in the presence of hepatic lipase resulted in a depleti...

journal_title：Journal of lipid research

authors： Hopkins GJ,Barter PJ

更新日期：1986-12-01 00:00:00

abstract：:The factors involved in shuttling cholesterol among cellular membranes have not been defined. Using amphotericin B selection, we previously isolated Chinese hamster ovary cell mutants expressing defects in intracellular cholesterol transport. Complementation analysis among seven mutants identified one cell line, mutan...

journal_title：Journal of lipid research

authors： Jacobs NL,Andemariam B,Underwood KW,Panchalingam K,Sternberg D,Kielian M,Liscum L

更新日期：1997-10-01 00:00:00

abstract：:Choline glycerophospholipids and ethanolamine glycerophospholipids of ruminant skeletal muscle contain approximately 40% and 65% plasmalogen, respectively. In the 1,2-diacyl-sn-glycero-3-phosphocholine (diacyl CPG), 16:0-18:2(n-6) and 16:0-18:1(n-9) accounted for about 50% of the total molecular species; in the 2-acyl...

journal_title：Journal of lipid research

authors： Scott TW,Ashes JR,Fleck E,Gulati SK

更新日期：1993-05-01 00:00:00

abstract：:We used [2-13C1]glycerol to characterize very low density lipoprotein (VLDL)-triglyceride kinetics and intrahepatic glycerol metabolism in normal men (n = 4) after alcohol (EtOH) ingestion. [2-13C1]glycerol was infused before and after the consumption of 48 g EtOH or a placebo. Three additional subjects also received ...

journal_title：Journal of lipid research

authors： Siler SQ,Neese RA,Parks EJ,Hellerstein MK

更新日期：1998-12-01 00:00:00

abstract：:The increased generation of reactive oxygen species that occurs in the condition of obesity may be responsible for oxidative injury to erythrocyte membranes, which could lead to a decrease in tissue oxygenation. Therefore, we have looked into the effects of obesity on both indexes of oxidative damage and physical-chem...

journal_title：Journal of lipid research

authors： Cazzola R,Rondanelli M,Russo-Volpe S,Ferrari E,Cestaro B

更新日期：2004-10-01 00:00:00

abstract：:The bioactive molecule sphingosine 1-phosphate (S1P) is abundantly stored in platelets and can be released extracellularly. However, although they have high sphingosine (Sph) kinase activity, platelets lack the de novo sphingolipid biosynthesis necessary to provide the substrates. Here, we reveal a generation pathway ...

journal_title：Journal of lipid research

authors： Tani M,Sano T,Ito M,Igarashi Y

更新日期：2005-11-01 00:00:00

abstract：:Distinct isoforms of long-chain acyl-CoA synthetases (ACSLs) may partition fatty acids toward specific metabolic cellular pathways. For each of the five members of the rat ACSL family, we analyzed tissue mRNA distributions, and we correlated the mRNA, protein, and activity of ACSL1 and ACSL4 after fasting and refeedin...

journal_title：Journal of lipid research

authors： Mashek DG,Li LO,Coleman RA

更新日期：2006-09-01 00:00:00