Abstract：
:Our goal was to further define the role of LPL gene polymorphisms in coronary heart disease (CHD) risk. We determined the frequencies of three LPL polymorphisms (D9N, N291S, and S447X) in 899 men from the Veterans Affairs HDL Intervention Trial (VA-HIT), a study that examined the potential benefits of increasing HDL with gemfibrozil in men with established CHD and low high density lipoprotein cholesterol (HDL-C; < or =40 mg/dl), and compared them with those of men without CHD from the Framingham Offspring Study (FOS). In VA-HIT, genotype frequencies for LPL D9N, N291S, and S447X were 5.3, 4.5, and 13.0%, respectively. These values differed from those for men in FOS having an HDL-C of >40, who had corresponding values of 3.2% (P = 0.06), 1.5% (P < 0.01), and 18.2% (P < 0.01). On gemfibrozil, carriers of the LPL N9 allele in VA-HIT had lower levels of large LDL (-32%; P < 0.01) but higher levels of small, dense LDL (+59%; P < 0.003) than did noncarriers. Consequently, mean LDL particle diameter was smaller in LPL N9 carriers than in noncarriers (20.14 +/- 0.87 vs. 20.63 +/- 0.80 nm; P < 0.003). In men with low HDL-C and CHD: 1) the LPL N9 and S291 alleles are more frequent than in CHD-free men with normal HDL-C, whereas the X447 allele is less frequent, and 2) the LPL N9 allele is associated with the LDL subclass response to gemfibrozil.
journal_name
J Lipid Resjournal_title
Journal of lipid researchauthors
Brousseau ME,Goldkamp AL,Collins D,Demissie S,Connolly AC,Cupples LA,Ordovas JM,Bloomfield HE,Robins SJ,Schaefer EJdoi
10.1194/jlr.M400152-JLR200keywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
1885-91issue
10eissn
0022-2275issn
1539-7262pii
M400152-JLR200journal_volume
45pub_type
临床试验,杂志文章abstract：:Inositol lipid kinases have been studied extensively in both plant and animal systems. However, major limitations for in vitro studies of recombinant lipid kinases are the low specific activity and instability of the purified proteins. Our goal was to determine if cyclodextrins would provide an effective substrate del...
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journal_title：Journal of lipid research
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journal_title：Journal of lipid research
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journal_title：Journal of lipid research
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Journal of lipid research
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journal_title：Journal of lipid research
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doi：
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journal_title：Journal of lipid research
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doi：
更新日期：1985-04-01 00:00:00
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doi：
更新日期：1999-08-01 00:00:00
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journal_title：Journal of lipid research
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journal_title：Journal of lipid research
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doi：
更新日期：1998-12-01 00:00:00
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journal_title：Journal of lipid research
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journal_title：Journal of lipid research
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doi：
更新日期：1988-05-01 00:00:00
