Alterations of VLDL composition during alimentary lipemia.

abstract：:Rats were fed a low protein diet deficient in and supplemented with lysine and threonine. Liver lipids contained more lecithin, sphingomyelin, and free fatty acids, and less amino phospholipids in the deficient rats. No variations in fatty acid composition of choline- and ethanolamine-containing phospholipids were fou...

journal_title：Journal of lipid research

authors： Viviani R,Sechi AM,Lenaz G

更新日期：1966-07-01 00:00:00

abstract：:Subcutaneous fat cells were isolated from genetically obese rats and from rats with obesity produced by hypothalamic lesions. Insulin did not augment the oxidation of fatty acids or their synthesis from glucose-1-(14)C or glucose-1-(3)H by fat cells from either group. Radioactivity from pyruvate-3-(14)C was incorporat...

journal_title：Journal of lipid research

authors： Bray GA

更新日期：1968-11-01 00:00:00

abstract：:In mammals, because they share a single synthetic pathway, n-6/n-3 ratios of dietary PUFAs impact tissue arachidonic acid (ARA) and DHA content. Likewise, SNPs in the human fatty acid desaturase (FADS) gene cluster impact tissue ARA and DHA. Here we tested the feasibility of using heterozygous Fads2-null-mice (HET) as...

journal_title：Journal of lipid research

authors： Su H,Zhou D,Pan YX,Wang X,Nakamura MT

更新日期：2016-11-01 00:00:00

abstract：:HDL and its major component, apolipoprotein A-I (apoA-I), play a central role in reverse cholesterol transport. We recently reported the involvement of a glycosylphosphatidylinositol anchor (GPI anchor) in the binding of HDL and apoA-I on human macrophages, and purified an 80 kDa HDL/apoA-I binding protein. In the pre...

journal_title：Journal of lipid research

authors： Matsuyama A,Sakai N,Hiraoka H,Hirano K,Yamashita S

更新日期：2006-01-01 00:00:00

abstract：:The acylation of glycerol-3-phosphate by acyl-CoA is regarded as the first committed step for the synthesis of the lipoidal moiety in glycerolipids. The direct acylation of glycerol in mammalian tissues has not been demonstrated. In this study, lipid biosynthesis in myoblasts and hepatocytes was reassessed by conducti...

journal_title：Journal of lipid research

authors： Lee DP,Deonarine AS,Kienetz M,Zhu Q,Skrzypczak M,Chan M,Choy PC

更新日期：2001-12-01 00:00:00

abstract：:The direct non-endocytotic uptake of cholesteryl esters (CE) from high density lipoprotein (HDL) plays a major role in HDL CE metabolism in rats and rabbits. In vitro evidence indicates it may also play such a role in humans. However, a study in mice (tracing the CE and apoA-I moieties of HDL) concluded that, while se...

journal_title：Journal of lipid research

authors： Khoo JC,Pittman RC,Rubin EM

更新日期：1995-03-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the United States and, indeed, worldwide. It has become a global public health issue. In the United States, the prevalence in the general population is estimated at approximately 20%, while that in the morbidly obese population at approximate...

journal_title：Journal of lipid research

authors： Erickson SK

更新日期：2009-04-01 00:00:00

abstract：:There is a continuous flux of the oxysterol 27-hydroxycholesterol (27-OHC) from the circulation across the blood-brain barrier (BBB) into the brain. The major metabolite of 27-OHC in the brain is 7α-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA). We confirm a recent report describing the presence of this metabolite in cer...

journal_title：Journal of lipid research

authors： Saeed A,Floris F,Andersson U,Pikuleva I,Lövgren-Sandblom A,Bjerke M,Paucar M,Wallin A,Svenningsson P,Björkhem I

更新日期：2014-02-01 00:00:00

abstract：:Prostaglandin (PG)E(2) is relevant in tumor biology, and interactions between tumor and stroma cells dramatically influence tumor progression. We tested the hypothesis that cross-talk between head and neck squamous cell carcinoma (HNSCC) cells and fibroblasts could substantially enhance PGE(2) biosynthesis. We observe...

journal_title：Journal of lipid research

authors： Alcolea S,Antón R,Camacho M,Soler M,Alfranca A,Avilés-Jurado FX,Redondo JM,Quer M,León X,Vila L

更新日期：2012-04-01 00:00:00

abstract：:Niemann-Pick C1-like 1 (NPC1L1) is a recently identified protein that mediates intestinal cholesterol absorption and regulates biliary cholesterol excretion. The itineraries and kinetics of NPC1L1 trafficking remain uncertain. In this study, we have visualized movement of NPC1L1-enhanced green fluorescent protein (NPC...

journal_title：Journal of lipid research

authors： Petersen NH,Faergeman NJ,Yu L,Wüstner D

更新日期：2008-09-01 00:00:00

abstract：:Nucleoredoxin (NRX) is a member of the thioredoxin family of proteins that controls redox homeostasis in cell. Redox homeostasis is a well-known regulator of cell differentiation into various tissue types. We found that NRX expression levels were higher in white adipose tissue of obese ob/ob mice and increased in the ...

journal_title：Journal of lipid research

authors： Bahn YJ,Lee KP,Lee SM,Choi JY,Seo YS,Kwon KS

更新日期：2015-02-01 00:00:00

abstract：:The regulation of hepatic and intestinal 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase and acyl-CoA; cholesterol acyltransferase (ACAT) activities by dietary fish oil was examined in the rabbit. Rabbits were fed 10% menhaden oil or menhaden oil plus 1% cholesterol for 14 days. They were compared with animals fed ...

journal_title：Journal of lipid research

authors： Field FJ,Albright EJ,Mathur SN

更新日期：1987-01-01 00:00:00

abstract：:Ac-hE18A-NH2 is a dual-domain apoE mimetic peptide that possesses the putative receptor binding domain from apoE (LRKLRKRLLR, denoted hE; residues 141-150) covalently attached to lipid-associating peptide 18A. Like apoE, Ac-hE18A-NH2 reduces plasma cholesterol in animal models and exhibits anti-inflammatory properties...

journal_title：Journal of lipid research

authors： Anantharamaiah GM,Garber DW,Goldberg D,Morrel E,Datta G,Palgunachari MN,Register TC,Appt SE,White CR

更新日期：2018-11-01 00:00:00

abstract：:High fatty acid (FA) flux is associated with systemic insulin resistance, and African-American (AA) women tend to be more insulin resistant. We assessed possible depot and race difference in the antilipolytic effect of insulin in adipocytes isolated from abdominal (Abd) and gluteal (Glt) subcutaneous (sc) adipose tiss...

journal_title：Journal of lipid research

authors： Fried SK,Tittelbach T,Blumenthal J,Sreenivasan U,Robey L,Yi J,Khan S,Hollender C,Ryan AS,Goldberg AP

更新日期：2010-05-01 00:00:00

abstract：:The effect of electron transport chain redox status on activity of the mitochondrial Ca(2+)-independent phospholipase A2 (iPLA2) has been examined. When oxidizing NAD-linked substrates, the enzyme is not active unless deenergization occurs. Uncoupler, rotenone, antimycin A, and cyanide are equally effective at upregul...

journal_title：Journal of lipid research

authors： Rauckhorst AJ,Broekemeier KM,Pfeiffer DR

更新日期：2014-05-01 00:00:00

abstract：:Various properties of retinyl ester hydrolysis in the liver and the retinal pigment epithelium (RPE) have been studied, yet the relationship between the retinyl ester hydrolase (REH) activities in these tissues of the same species is not known. In the present study, REH activities in bovine liver and RPE microsomes we...

journal_title：Journal of lipid research

authors： Mata NL,Mata JR,Tsin AT

更新日期：1996-09-01 00:00:00

abstract：:Acetyl-L-carnitine is known as a reservoir of activated acetyl units and as a modulator of metabolic function. The objective of this study was to quantify the fate of the acetyl moiety of acetyl-L-carnitine in lipogenic pathways. Lipogenesis was studied in an adipocyte model, differentiated 3T3-L1 cells, and a hepatom...

journal_title：Journal of lipid research

authors： Lligona-Trulla L,Arduini A,Aldaghlas TA,Calvani M,Kelleher JK

更新日期：1997-07-01 00:00:00

abstract：:Rates of conversion of alpha-linolenic acid (alpha-LNA, 18:3n-3) to docosahexaenoic acid (DHA, 22:6n-3) by the mammalian brain and the brain's ability to upregulate these rates during dietary deprivation of n-3 polyunsaturated fatty acids (PUFAs) are unknown. To answer these questions, we measured conversion coefficie...

journal_title：Journal of lipid research

authors： Igarashi M,DeMar JC Jr,Ma K,Chang L,Bell JM,Rapoport SI

更新日期：2007-05-01 00:00:00

abstract：:Endothelial lipase (EL) is a triglyceride lipase gene family member that has high phospholipase and low triglyceride lipase activity. The aim of this study was to determine whether the phospholipase activity of EL is sufficient to remodel HDLs into small particles and mediate the dissociation of apolipoprotein A-I (ap...

journal_title：Journal of lipid research

authors： Jahangiri A,Rader DJ,Marchadier D,Curtiss LK,Bonnet DJ,Rye KA

更新日期：2005-05-01 00:00:00

abstract：:Supernatant protein factor (SPF) and anionic phospholipids such as phosphatidylglycerol (PG) stimulate squalene epoxidase activity in rat liver microsomes by promoting [3H]squalene uptake as well as substrate translocation (Chin, J., and K. Bloch. 1984. J. Biol. Chem. 259: 11735-11738). This process is postulated to b...

journal_title：Journal of lipid research

authors： Chin J,Bloch K

更新日期：1985-07-01 00:00:00

abstract：:Eubacterium sp. 144 dehydroxylated 16 alpha-hydroxy-progesterone; however, the expected intermediate, delta 16-progesterone, did not accumulate to significant concentrations in the culture medium. Moreover, the final end product of this biotransformation, 17 alpha-progesterone, was produced at a very slow rate. It was...

journal_title：Journal of lipid research

authors： Glass TL,Winter J,Bokkenheuser VD,Hylemon PB

更新日期：1982-02-01 00:00:00

abstract：:Diseases such as obesity, diabetes, and atherosclerosis result from multiple genetic and environmental factors, and importantly, interactions between genetic and environmental factors. Identifying susceptibility genes for these diseases using genetic and genomic technologies is accelerating, and the expectation over t...

journal_title：Journal of lipid research

authors： Schadt EE,Lum PY

更新日期：2006-12-01 00:00:00

abstract：:Neu-Laxova syndrome (NLS) is a very rare autosomal recessive congenital disorder characterized by disturbed development of the central nervous system and the skin and caused by mutations in any of the three genes involved in de novo l-serine biosynthesis: PHGDH, PSAT1, and PSPH l-Serine is essential for the biosynthes...

journal_title：Journal of lipid research

authors： Takeichi T,Okuno Y,Kawamoto A,Inoue T,Nagamoto E,Murase C,Shimizu E,Tanaka K,Kageshita Y,Fukushima S,Kono M,Ishikawa J,Ihn H,Takahashi Y,Akiyama M

更新日期：2018-12-01 00:00:00

abstract：:Exosomes are bioactive vesicles released from multivesicular bodies (MVB) by intact cells and participate in intercellular signaling. We investigated the presence of lipid-related proteins and bioactive lipids in RBL-2H3 exosomes. Besides a phospholipid scramblase and a fatty acid binding protein, the exosomes contain...

journal_title：Journal of lipid research

authors： Subra C,Grand D,Laulagnier K,Stella A,Lambeau G,Paillasse M,De Medina P,Monsarrat B,Perret B,Silvente-Poirot S,Poirot M,Record M

更新日期：2010-08-01 00:00:00

abstract：:Human apolipoprotein E (apoE) is a constituent of plasma very low density and high density lipoproteins and is important in modulating the catabolism of remnants of triglyceride-rich lipoproteins. There are three common isoforms of apoE, designated apoE-2, E-3, and E-4, which are coded by three separate alleles (epsil...

journal_title：Journal of lipid research

authors： Gregg RE,Zech LA,Schaefer EJ,Brewer HB Jr

更新日期：1984-11-01 00:00:00

abstract：:The primary structure of apolipoprotein A-II (apoA-II) isolated from the plasma high density lipoprotein (HDL) fraction of the inbred mouse strain BALB/c is described in this work. The complete 78 amino acid protein sequence was determined by proteolytic fragmentation, gas-phase microsequence analysis, and fast atom b...

journal_title：Journal of lipid research

authors： Miller CG,Lee TD,LeBoeuf RC,Shively JE

更新日期：1987-03-01 00:00:00

abstract：:The objective of this study was to establish a new lipoprotein lipase (LPL) and hepatic lipase (HL) activity assay method. Seventy normal volunteers were recruited. Lipase activities were assayed by measuring the increase in absorbance at 546 nm due to the quinoneine dye. Reaction mixture-1 (R-1) contained dioleoylgly...

journal_title：Journal of lipid research

authors： Imamura S,Kobayashi J,Nakajima K,Sakasegawa S,Nohara A,Noguchi T,Kawashiri MA,Inazu A,Deeb SS,Mabuchi H,Brunzell JD

更新日期：2008-07-01 00:00:00

abstract：:A new polarographic system for measurement of oxygen consumption in vitro has been constructed to minimize different types of errors. The system was built of polyamide-6, Monax glass, stainless steel, and rubber to diminish oxygen leakage and gas capacitance properties. With these materials the system was gas-tight. N...

journal_title：Journal of lipid research

authors： Hallgren P,Korsback S,Sjöström L

更新日期：1986-09-01 00:00:00

abstract：:We used a mouse C57BL/6J×CASA/Rk intercross to map a locus on chromosome 14 that displayed a gender-dependent effect on cholesterol absorption from the intestine. Studies in congenic animals revealed a complex locus with multiple operating genetic determinants resulting in alternating gender-dependent phenotypic effec...

journal_title：Journal of lipid research

authors： Wong WP,Altemus JB,Hester JF,Chan ER,Côté JF,Serre D,Sehayek E

更新日期：2013-03-01 00:00:00

abstract：:Choline kinase catalyzes the phosphorylation of choline, the first step of phospholipid synthesis. Increased phosphorylation of choline is a hallmark characteristic of the malignant phenotype in a variety of neoplasms. However, in hypoxic cancer cells, choline phosphorylation is decreased. To understand the mechanism ...

journal_title：Journal of lipid research

authors： Bansal A,Harris RA,DeGrado TR

更新日期：2012-01-01 00:00:00