Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to diet.

abstract：:Vitamin E (α-tocopherol) is the major lipid-soluble antioxidant in many species. Niemann-Pick type C (NPC) disease is a lysosomal storage disorder caused by mutations in the NPC1 or NPC2 gene, which regulates lipid transport through the endocytic pathway. NPC disease is characterized by massive intracellular accumulat...

journal_title：Journal of lipid research

authors： Ulatowski L,Parker R,Davidson C,Yanjanin N,Kelley TJ,Corey D,Atkinson J,Porter F,Arai H,Walkley SU,Manor D

更新日期：2011-07-01 00:00:00

abstract：:Percent cholesterol absorption was measured in 94 normal subjects aged 17- 80 years while consuming diets generally low in cholesterol (mean intake = 226 +/- 126 mg/day). A new dual stable isotope method was used where a cholesterol tracer containing 6 extra mass units was given intravenously and another tracer with 5...

journal_title：Journal of lipid research

authors： Bosner MS,Lange LG,Stenson WF,Ostlund RE Jr

更新日期：1999-02-01 00:00:00

abstract：:Each abdominal fat depot, such as mesenteric or epididymal, differently contributes to the development of insulin resistance. The aim of this study was to identify the genetic regions that contribute to fat accumulation in epididymal/mesenteric fat and to examine whether or not the genetic regions that affect glucose ...

journal_title：Journal of lipid research

authors： Kobayashi M,Ohno T,Hada N,Fujiyoshi M,Kuga M,Nishimura M,Murai A,Horio F

更新日期：2010-12-01 00:00:00

abstract：:The endocannabinoid 2-arachidonoylglycerol (2-AG) is predominantly biosynthesized by sn-1-diacylglycerol lipase α (DAGL-α) in the CNS. Selective inhibitors of DAGL-α will provide valuable insights in the role of 2-AG in endocannabinoid signaling processes and are potential therapeutics for the treatment of obesity and...

journal_title：Journal of lipid research

authors： van der Wel T,Janssen FJ,Baggelaar MP,Deng H,den Dulk H,Overkleeft HS,van der Stelt M

更新日期：2015-04-01 00:00:00

abstract：:An enzyme (phosphatidyl glycerophosphate phosphatase) that catalyzes the formation of phosphatidyl glycerol from phosphatidyl glycerophosphate has been rendered soluble by treatment of the particulate fraction of E. coli with Triton X-100 in the presence of EDTA, and has been partially purified. The enzyme is specific...

journal_title：Journal of lipid research

authors： Chang YY,Kennedy EP

更新日期：1967-09-01 00:00:00

abstract：:The transport of LDL-derived cholesterol from lysosomes to peroxisomes is facilitated by membrane contacts formed between the lysosomal protein synaptotagmin VII and the peroxisomal lipid phosphatidylinositol 4, 5-bisphosphate [PI(4,5)P2]. Here, we used RNA interference to search for regulators of PI(4,5)P2 and to stu...

journal_title：Journal of lipid research

authors： Hu A,Zhao XT,Tu H,Xiao T,Fu T,Wang Y,Liu Y,Shi XJ,Luo J,Song BL

更新日期：2018-03-01 00:00:00

abstract：:HDL-like particles in human cerebrospinal fluid (CSF) promote the efflux of cholesterol from astrocytes toward the neurons that rely on this supply for their functions. We evaluated whether cell cholesterol efflux capacity of CSF (CSF-CEC) is impaired in Alzheimer's disease (AD) by analyzing AD (n = 37) patients, non-...

journal_title：Journal of lipid research

authors： Marchi C,Adorni MP,Caffarra P,Ronda N,Spallazzi M,Barocco F,Galimberti D,Bernini F,Zimetti F

更新日期：2019-08-01 00:00:00

abstract：:Evidence is given that the heart of the cardiomyopathic UM-X7.1 hamster has a lipid composition different from that of the same tissue isolated from animals of the Syrian hamster parent strain. Also, noncardiac tissues from cardiomyopathic and healthy hamsters exhibit significant compositional differences. On the basi...

journal_title：Journal of lipid research

authors： Vecchini A,Binaglia L,Bibeau M,Minieri M,Carotenuto F,Di Nardo P

更新日期：2001-01-01 00:00:00

abstract：:Polymorphic transformations in two saturated-unsaturated mixed acid triacylglycerols, SOS (sn -1,3-distearoyl-2-oleoylglycerol) and OSO (sn -1,3-dioleoyl-2-stearoylglycerol), have been studied by FT-IR spectroscopy using deuterated specimens in which stearoyl chains are fully deuterated. A reversible phase transition ...

journal_title：Journal of lipid research

authors： Yano J,Sato K,Kaneko F,Small DM,Kodali DR

更新日期：1999-01-01 00:00:00

abstract：:Conventional ideas concerning the unidirectional movement of triacylglycerol from intestinal lumen to lymph with sn-2-monoacylglycerol being the major glyceride-glycerol precursor were challenged by our finding that steady state specific activities of radiolabeled triacylglycerol (glyceryl moiety) in the intestinal mu...

journal_title：Journal of lipid research

authors： Mansbach CM 2nd,Parthasarathy S

更新日期：1982-09-01 00:00:00

abstract：:Studies on plasma triglycerides (TG) were performed in 10 nonobese and 16 obese patients with hypothyroidism and in 13 with hyperthyroidism. Nonobese, hypothyroid patients generally had normal levels of TG, but obese patients often had hypertriglyceridemia. In most hypothyroid patients 1-thyroxine treatment lowered pl...

journal_title：Journal of lipid research

authors： Abrams JJ,Grundy SM,Ginsberg H

更新日期：1981-02-01 00:00:00

abstract：:Small dense LDL (sdLDL) has been reported to be more atherogenic than large buoyant LDL (lbLDL). We examined the metabolism and protein composition of sdLDL and lbLDL in six subjects with combined hyperlipidemia on placebo and rosuvastatin 40 mg/day. ApoB-100 kinetics in triglyceride-rich lipoproteins (TRLs), lbLDL (d...

journal_title：Journal of lipid research

authors： Thongtang N,Diffenderfer MR,Ooi EMM,Barrett PHR,Turner SM,Le NA,Brown WV,Schaefer EJ

更新日期：2017-07-01 00:00:00

abstract：:The regulation of hepatic and intestinal 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase and acyl-CoA; cholesterol acyltransferase (ACAT) activities by dietary fish oil was examined in the rabbit. Rabbits were fed 10% menhaden oil or menhaden oil plus 1% cholesterol for 14 days. They were compared with animals fed ...

journal_title：Journal of lipid research

authors： Field FJ,Albright EJ,Mathur SN

更新日期：1987-01-01 00:00:00

abstract：:Serum lipoproteins of pregnant and puerperal rats were studied by preparative and analytical ultracentrifugation. The concentration for the fraction with density less than 1.019 was markedly elevated in rats during the 3rd wk of gestation and in lactating rats. This fraction showed similar triglyceride fatty acid comp...

journal_title：Journal of lipid research

authors： Bosch V,Camejo G

更新日期：1967-03-01 00:00:00

abstract：:The 3-thia fatty acids, tetradecylthioacetic acid and 3,10-dithiadicarboxylic acid are mitochondrion and peroxisome proliferators. Administration of these promotes an increased transport of endogenous fatty acids to these organelles and a higher capacity of beta-oxidation. Administration of 3-thia fatty acids to rats ...

journal_title：Journal of lipid research

authors： Madsen L,Frøyland L,Dyrøy E,Helland K,Berge RK

更新日期：1998-03-01 00:00:00

abstract：:The role of nuclear membrane phospholipids as targets of phospholipases resulting in the generation of nuclear signaling messengers has received attention. In the present study, we have exploited the utility of electrospray ionization mass spectrometry to determine the phospholipid content of nuclei isolated from perf...

journal_title：Journal of lipid research

authors： Williams SD,Hsu FF,Ford DA

更新日期：2000-10-01 00:00:00

abstract：:Unesterified cholesterol is an essential structural component of the plasma membrane of every cell. During evolution, this membrane came to play an additional, highly specialized role in the central nervous system (CNS) as the major architectural component of compact myelin. As a consequence, in the human the mean con...

journal_title：Journal of lipid research

authors： Dietschy JM,Turley SD

更新日期：2004-08-01 00:00:00

abstract：:Cholesterol 7alpha-hydroxylase, a rate-limiting enzyme for bile acid synthesis, has been implicated in genetic susceptibility to atherosclerosis. The gene, CYP7A1, encoding a protein with this activity, is expressed normally only in hepatocytes and is highly regulated. Our cyp7A1 gene knockout mouse colony, as young a...

journal_title：Journal of lipid research

authors： Erickson SK,Lear SR,Deane S,Dubrac S,Huling SL,Nguyen L,Bollineni JS,Shefer S,Hyogo H,Cohen DE,Shneider B,Sehayek E,Ananthanarayanan M,Balasubramaniyan N,Suchy FJ,Batta AK,Salen G

更新日期：2003-05-01 00:00:00

abstract：:Various properties of retinyl ester hydrolysis in the liver and the retinal pigment epithelium (RPE) have been studied, yet the relationship between the retinyl ester hydrolase (REH) activities in these tissues of the same species is not known. In the present study, REH activities in bovine liver and RPE microsomes we...

journal_title：Journal of lipid research

authors： Mata NL,Mata JR,Tsin AT

更新日期：1996-09-01 00:00:00

abstract：:A new series of analogs of triglycerides has been synthesized, in which the glycerol moiety is replaced by each of the three isomeric cyclopentanetriols. For each of the isomeric cyclopentane-1,2,3-triols (1,2,3/0; DL-1,2/3; and 1,3/2), the tris-homoacyl derivatives of octanoic, decanoic, lauric, myristic, palmitic, s...

journal_title：Journal of lipid research

authors： Hancock AJ,Greenwald SM,Sable HZ

更新日期：1975-07-01 00:00:00

abstract：:We have studied the rate of phospholipid synthesis and turnover in mouse peritoneal macrophages in reaction to cholesterol influx and high density lipoprotein (HDL)-mediated cholesterol efflux, using three different radioactive precursors, 32PO4(3-), [3H]choline, and [14C]oleic acid. The cells were loaded with cholest...

journal_title：Journal of lipid research

authors： Schmitz G,Beuck M,Fischer H,Nowicka G,Robenek H

更新日期：1990-10-01 00:00:00

abstract：:Remnant-like emulsions were prepared with lipid compositions similar to remnants derived from triacylglycerol-rich lipoproteins. When injected into the bloodstream of conscious mice the remnant-like emulsions labeled with cholesteryl[13C]oleate were metabolized in the liver and the appearance of 13CO2 in the breath wa...

journal_title：Journal of lipid research

authors： Martins IJ,Redgrave TG

更新日期：1998-03-01 00:00:00

abstract：:Mature endothelial lipase (EL) is a 68 kDa glycoprotein. In HepG2 cells infected with adenovirus encoding human EL, the mature EL was detectable in the cell lysates and heparin-releasable fractions. In contrast, cell media of these cells contained two EL fragments: an N-terminal 40 kDa fragment and a C-terminal 28 kDa...

journal_title：Journal of lipid research

authors： Gauster M,Hrzenjak A,Schick K,Frank S

更新日期：2005-05-01 00:00:00

abstract：:We evaluated the role of sterol-regulatory element binding protein (SREBP)-1c/peroxisome proliferator activated receptor-gamma (PPARgamma) pathway on heart lipotoxicity in patients with metabolic syndrome (MS) and aortic stenosis (AS). Echocardiographic parameters of heart function and structural alterations of LV spe...

journal_title：Journal of lipid research

authors： Marfella R,Di Filippo C,Portoghese M,Barbieri M,Ferraraccio F,Siniscalchi M,Cacciapuoti F,Rossi F,D'Amico M,Paolisso G

更新日期：2009-11-01 00:00:00

abstract：:To determine the extent and microanatomical distribution of extramyocellular adipocytes associated with skeletal muscle, histological, biochemical, nuclear magnetic resonance proton spectroscopic and microcomputed tomography techniques were employed to analyze skeletal muscle samples from lean and obese Sprague-Dawley...

journal_title：Journal of lipid research

authors： Guo Z,Mishra P,Macura S

更新日期：2001-07-01 00:00:00

abstract：:The diffusion of [2-(14)C]glucose out of liposomes prepared from extracted human erythrocyte lipids was examined. Increased glucose efflux was observed when the lipids were treated with hydrogen peroxide and CuCl(2) before liposome formation, and this phenomenon required both peroxide and metal. Peroxidation of these ...

journal_title：Journal of lipid research

authors： Smolen JE,Shohet SB

更新日期：1974-05-01 00:00:00

abstract：:ABCA12 mutations disrupt the skin barrier and cause harlequin ichthyosis. We previously showed Abca12(-/-) skin has increased glucosylceramide (GlcCer) and correspondingly lower amounts of ceramide (Cer). To examine why loss of ABCA12 leads to accumulation of GlcCer, de novo sphingolipid synthesis was assayed using [(...

journal_title：Journal of lipid research

authors： Haller JF,Cavallaro P,Hernandez NJ,Dolat L,Soscia SJ,Welti R,Grabowski GA,Fitzgerald ML,Freeman MW

更新日期：2014-03-01 00:00:00

abstract：:The enzymic incorporation of choline-1,2-(14)C from CDP-choline-1,2-(14)C into phosphatidylcholine by spinach leaf preparations was characterized. The enzyme catalyzing the incorporation, choline phosphotransferase, had a pH optimum of about 8.0 and required either Mn(2+) or Mg(2+) as cofactor. The saturation concentr...

journal_title：Journal of lipid research

authors： Devor KA,Mudd JB

更新日期：1971-07-01 00:00:00

abstract：:In the present study, we have examined the structure of human low density lipoprotein (LDL) using cryo-electron microscopy. Human LDL particles were analyzed in a vitrified frozen-hydrated condition, without chemical fixation or any form of staining. Hence, the lipoproteins were visualized close to their native state....

journal_title：Journal of lipid research

authors： Van Antwerpen R,Gilkey JC

更新日期：1994-12-01 00:00:00

abstract：:Lipid transfer inhibitor protein (LTIP) is a regulator of cholesteryl ester transfer protein (CETP) function. Factors affecting plasma LTIP levels are poorly understood. In humans, plasma LTIP is elevated in hypercholesterolemia. To define possible mechanisms by which hyperlipidemia modifies LTIP, we investigated the ...

journal_title：Journal of lipid research

authors： Izem L,Morton RE

更新日期：2009-04-01 00:00:00