Cryo-electron microscopy reveals human low density lipoprotein substructure.

abstract：:Cerebrotendinous xanthomatosis (CTX) is a rare, recessively inherited lipid storage disease characterized by a markedly reduced production of chenodeoxycholic acid and an increased formation of 25-hydroxylated bile alcohols and cholestanol. Patients with this disease are known to have mutations in the sterol 27-hydrox...

journal_title：Journal of lipid research

authors： Honda A,Salen G,Matsuzaki Y,Batta AK,Xu G,Leitersdorf E,Tint GS,Erickson SK,Tanaka N,Shefer S

更新日期：2001-02-01 00:00:00

abstract：:This report describes the isolation of sarcosylsarcosine conjugate of ursodeoxycholic acid (UDCA) formed during the synthesis of sarcoUDCA by the mixed anhydride method. The compound was characterized by its chemical ionization mass spectrum. The diamino acid conjugate was formed only when the free amino acid was used...

journal_title：Journal of lipid research

authors： Batta AK,Salen G,Shefer S

更新日期：1989-05-01 00:00:00

abstract：:Investigations of the topography of glycerolipid synthetic enzymes within the transverse plane of microsomal vesicles indicated an exclusive cytoplasmic surface location of active sites. Evidence was derived from studies employing proteases and other impermeant inhibitors, from investigations of latency and substrate ...

journal_title：Journal of lipid research

authors： Bell RM,Ballas LM,Coleman RA

更新日期：1981-03-01 00:00:00

abstract：:In recent years the short-chain fatty acid, 4-phenylbutyrate (PB), has emerged as a promising drug for various clinical conditions. In fact, PB has been Food and Drug Administration-approved for urea cycle disorders since 1996. PB is more potent and less toxic than its metabolite, phenylacetate (PA), and is not just a...

journal_title：Journal of lipid research

authors： Palir N,Ruiter JPN,Wanders RJA,Houtkooper RH

更新日期：2017-05-01 00:00:00

abstract：:Delta-5 and delta-6 desaturases (D5D and D6D) are key enzymes in endogenous synthesis of long-chain PUFAs. In this sample of healthy subjects (n = 310), genotypes of single nucleotide polymorphisms (SNPs) rs174537, rs174561, and rs3834458 in the FADS1-FADS2 gene cluster were strongly associated with proportions of LC-...

journal_title：Journal of lipid research

authors： Al-Hilal M,Alsaleh A,Maniou Z,Lewis FJ,Hall WL,Sanders TA,O'Dell SD,MARINA study team.

更新日期：2013-02-01 00:00:00

abstract：:To examine the validity of the deuterium (D) incorporation technique for measurement of human cholesterol synthesis rates, D uptake from D2O into cholesterol was compared to sterol balance in 13 subjects each under three controlled diet settings. Subjects (age 62 +/- 3.6 yr, body weight 74 +/- 4.0 kg, BMI 27 +/- 1.4) ...

journal_title：Journal of lipid research

authors： Jones PJ,Ausman LM,Croll DH,Feng JY,Schaefer EA,Lichtenstein AH

更新日期：1998-05-01 00:00:00

abstract：:Some commercial preparations of common natural conjugated bile salts contain impurities (e.g., amines, lipids, and calcium) that are likely to affect their physicochemical properties. A method was developed for purifying commercial preparations of sodium salts of glycine- and taurine-conjugated bile acids. The method ...

journal_title：Journal of lipid research

authors： Del Vecchio S,Ostrow JD,Mukerjee P,Ton-Nu HT,Schteingart CD,Hofmann AF,Cerrè C,Roda A

更新日期：1995-12-01 00:00:00

abstract：:Changes in the cellularity of various adipose tissues in growing cattle were analyzed. Fifty male cattle were slaughtered between 15 and 65% of mature weight. The whole adipose mass, separated by dissection, was divided into three parts: subcutaneous, intermuscular, and internal adipose tissues. Lipid content, cell si...

journal_title：Journal of lipid research

authors： Robelin J

更新日期：1981-03-01 00:00:00

abstract：:In promoting oxidation of 0.02 m potassium linoleate in a buffered (pH 7.0) aqueous dispersion at 37 degrees C, ascorbic acid at low concentrations (1.8 x 10(-6) and 1.8 x 10(-5) m) in combination with copper (1.3 x 10(-7) to 1.3 x 10(-3) m) had greater catalytic activity than the additive activity of the two catalyst...

journal_title：Journal of lipid research

authors： Haase G,Dunkley WL

更新日期：1969-09-01 00:00:00

abstract：:Bile acids play important roles in the regulation of lipid, glucose, and energy homeostasis. Recent studies suggest that glucose regulates gene transcription in the liver. The aim of this study was to investigate the potential role of glucose in regulation of bile acid synthesis in human hepatocytes. High glucose stim...

journal_title：Journal of lipid research

authors： Li T,Chanda D,Zhang Y,Choi HS,Chiang JY

更新日期：2010-04-01 00:00:00

abstract：:Neuroinflammation, caused by 6 days of intracerebroventricular infusion of a low dose of lipopolysaccharide (LPS; 0.5 ng/h), stimulates brain arachidonic acid (AA) metabolism in rats, but 6 weeks of lithium pretreatment reduces this effect. To further understand this action of lithium, we measured concentrations of ei...

journal_title：Journal of lipid research

authors： Basselin M,Kim HW,Chen M,Ma K,Rapoport SI,Murphy RC,Farias SE

更新日期：2010-05-01 00:00:00

abstract：:A novel metabolite of d-delta-tocopherol was isolated from the urine of rats given d-3,4-[3H2]-delta-tocopherol intravenously. The metabolite was collected from the urine of rats given d-delta-tocopherol in the same manner as that of the labeled compound. It was found that the metabolites consisted of sulfate conjugat...

journal_title：Journal of lipid research

authors： Chiku S,Hamamura K,Nakamura T

更新日期：1984-01-01 00:00:00

abstract：:The two oxysterols, 27-hydroxycholesterol (27OH) and 24S-hydroxycholesterol (24OH), are both inhibitors of cholesterol synthesis and activators of the liver X receptor (LXR) in vitro. Their role as physiological regulators under in vivo conditions is controversial, however. In the present work, we utilized a previousl...

journal_title：Journal of lipid research

authors： Ali Z,Heverin M,Olin M,Acimovic J,Lövgren-Sandblom A,Shafaati M,Båvner A,Meiner V,Leitersdorf E,Björkhem I

更新日期：2013-04-01 00:00:00

abstract：:Genome-wide association (GWA) studies represent a powerful strategy for identifying susceptibility genes for complex diseases in human populations but results must be confirmed and replicated. Because of the close homology between mouse and human genomes, the mouse can be used to add evidence to genes suggested by hum...

journal_title：Journal of lipid research

authors： Leduc MS,Lyons M,Darvishi K,Walsh K,Sheehan S,Amend S,Cox A,Orho-Melander M,Kathiresan S,Paigen B,Korstanje R

更新日期：2011-06-01 00:00:00

abstract：:In Refsum disease, disorders of peroxisome biogenesis, and rhizomelic chondrodysplasia punctata, pathological accumulation of phytanic acid results from impaired alpha-oxidation of this branched-chain fatty acid. Previous studies from this laboratory indicated that activation of phytanic acid to its CoA derivative pre...

journal_title：Journal of lipid research

authors： Watkins PA,Howard AE,Gould SJ,Avigan J,Mihalik SJ

更新日期：1996-11-01 00:00:00

abstract：:Hypertriglyceridemia induces multiple changes in lipoprotein composition. Here we investigate how one of these modifications, triglyceride (TG) enrichment, affects HDL and LDL function when this alteration occurs under conditions in which more polar components can naturally re-equilibrate. TG-enriched lipoproteins wer...

journal_title：Journal of lipid research

authors： Skeggs JW,Morton RE

更新日期：2002-08-01 00:00:00

abstract：:Rat serum lipoproteins were separated into at least four fractions by agarose-starch gel electrophoresis. The system used was discontinuous in that glycine and sodium barbitone buffer was used in the reservoirs and Tris buffer was used for the gels. The four major bands could be related to the pattern obtained by ultr...

journal_title：Journal of lipid research

authors： Chalvardjian A

更新日期：1971-05-01 00:00:00

abstract：:In this study we employed a capillary gas-liquid chromatographic-mass spectrometric (GLC-MS) method to measure the plasma concentrations of 3-hydroxybutyrate (3-OHB) and 3-hydroxyisobutyrate (3-OHIB) in overnight fasted diabetic subjects and in normal subjects. Plasma contents of 3-hydroxybutyrate measured in this fas...

journal_title：Journal of lipid research

authors： Avogaro A,Bier DM

更新日期：1989-11-01 00:00:00

abstract：:Elongation of very long chain fatty acid-like family member 6 (ELOVL6) is a fatty acyl elongase that performs the initial and rate-limiting condensing reaction required for microsomal elongation of long-chain fatty acids. Our previous in vitro studies suggested that ELOVL6 elongated long-chain saturated fatty acids an...

journal_title：Journal of lipid research

authors： Moon YA,Ochoa CR,Mitsche MA,Hammer RE,Horton JD

更新日期：2014-12-01 00:00:00

abstract：:Agonist-induced lipolysis of adipose fat is robustly inhibited by insulin or by feedback inhibition by the long-chain fatty acids (LCFA) produced during lipolysis. However, the mode of action of LCFA in suppressing adipose lipolysis is not clear. β,β'-Tetramethyl hexadecanedioic acid (Mββ/ EDICA16) is a synthetic LCFA...

journal_title：Journal of lipid research

authors： Kalderon B,Azazmeh N,Azulay N,Vissler N,Valitsky M,Bar-Tana J

更新日期：2012-05-01 00:00:00

abstract：:Recent studies suggest that 7-dehydrocholesterol (7-DHC)-derived oxysterols play important roles in the pathophysiology of Smith-Lemli-Opitz syndrome (SLOS), a metabolic disorder that is caused by defective 3β-hydroxysterol-Δ(7)-reductase (DHCR7). Although 14 oxysterols have been identified as the primary products of ...

journal_title：Journal of lipid research

authors： Xu L,Korade Z,Rosado DA Jr,Mirnics K,Porter NA

更新日期：2013-04-01 00:00:00

abstract：:13C-NMR spectroscopy was used to examine the effect of side chain length on the ionization properties and transmembrane transport rate of 3 alpha,7 alpha-dihydroxy bile acids. When solubilized in taurocholate micelles, [23-13C]nor-chenodeoxycholic acid (nor-CDCA) had a pKa of 6.1, similar to that of CDCA (pKa 6.2), it...

journal_title：Journal of lipid research

authors： Ko J,Hamilton JA,Ton-Nu HT,Schteingart CD,Hofmann AF,Small DM

更新日期：1994-05-01 00:00:00

abstract：:Thyroid hormone lowers serum cholesterol and alters sterol metabolic processes. This laboratory has previously reported increased biliary lipid secretion as an early effect of triiodothyronine (T3) in the rat. To evaluate whether the bile lipid action of T3 is a primary or secondary effect, the isolated-perfused rat l...

journal_title：Journal of lipid research

authors： Gebhard RL,Stone BG,Andreini JP,Duane WC,Evans CD,Prigge W

更新日期：1992-10-01 00:00:00

abstract：:Apolipoprotein (apo)A-IV is synthesized in the small intestine during fat absorption and is incorporated onto the surface of nascent chylomicrons. In circulation, apoA-IV is displaced from the chylomicron surface by high density lipoprotein-associated C and E apolipoproteins; this exchange is critical for activation o...

journal_title：Journal of lipid research

authors： Hockey KJ,Anderson RA,Cook VR,Hantgan RR,Weinberg RB

更新日期：2001-02-01 00:00:00

abstract：:We investigated the formation and pharmacology of prostaglandin E(3) (PGE(3)) derived from fish oil eicosapentaenoic acid (EPA) in human lung cancer A549 cells. Exposure of A549 cells to EPA resulted in the rapid formation and export of PGE(3.) The extracellular ratio of PGE(3) to PGE(2) increased from 0.08 in control...

journal_title：Journal of lipid research

authors： Yang P,Chan D,Felix E,Cartwright C,Menter DG,Madden T,Klein RD,Fischer SM,Newman RA

更新日期：2004-06-01 00:00:00

abstract：:Matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) has been applied primarily to the analysis of glycosphingolipids separated from other complex mixtures by TLC, but it is difficult to obtain quantitative profiling of each glycosphingolipid among the different spots on TLC by MALDI-MS. Thus, the ...

journal_title：Journal of lipid research

authors： Ikeda K,Shimizu T,Taguchi R

更新日期：2008-12-01 00:00:00

abstract：:Oxidized forms of cholesterol (oxysterols) are present in atherosclerotic lesions and may play an active role in lesion development. For example, 7-ketocholesterol (7KC) inhibits cholesterol efflux from macrophage foam cells induced by apolipoprotein A-I (apoA-I). Such oxysterols may promote foam cell formation in ath...

journal_title：Journal of lipid research

authors： Gelissen IC,Rye KA,Brown AJ,Dean RT,Jessup W

更新日期：1999-09-01 00:00:00

abstract：:The isolated perfused mouse liver was utilized to evaluate the relative contribution of various molecules believed to participate in the removal of chylomicron remnants by the liver. Sixty percent of asialofetuin was removed from the perfusate per pass; bovine serum albumin was not removed. Normal mouse livers removed...

journal_title：Journal of lipid research

authors： Yu KC,Jiang Y,Chen W,Cooper AD

更新日期：1999-10-01 00:00:00

abstract：:Smith-Lemli-Opitz Syndrome (SLOS) is a developmental disorder (OMIM #270400) caused by autosomal recessive mutations in the Dhcr7 gene, which encodes the enzyme 3β-hydroxysterol-∆7 reductase. SLOS patients present clinically with dysmorphology and neurological, behavioral and cognitive defects, with characteristically...

journal_title：Journal of lipid research

authors： Kanuri B,Fong V,Ponny SR,Tallman KA,Ramachandra Rao S,Porter NA,Fliesler SJ,Patel SB

更新日期：2020-11-17 00:00:00

abstract：:The ATP binding cassette (ABC) half-transporters ABCG5 and ABCG8 facilitate biliary and intestinal removal of neutral sterols. Here, we identify a binding site for the orphan nuclear receptor liver receptor homolog-1 (LRH-1) at nt 134-142 of the ABCG5/ABCG8 intergenic region necessary for the activity of both the ABCG...

journal_title：Journal of lipid research

authors： Freeman LA,Kennedy A,Wu J,Bark S,Remaley AT,Santamarina-Fojo S,Brewer HB Jr

更新日期：2004-07-01 00:00:00