Effect of a new inhibitor of cholesterol biosynthesis (AY 9944) on serum and tissue sterols in the rat.

abstract：:There is unequivocal evidence of an inverse association between plasma high-density lipoprotein (HDL) cholesterol concentrations and the risk of cardiovascular disease, a finding that has led to the hypothesis that HDL protects from atherosclerosis. This review details the experimental evidence for this "HDL hypothesi...

journal_title：Journal of lipid research

authors： Vergeer M,Holleboom AG,Kastelein JJ,Kuivenhoven JA

更新日期：2010-08-01 00:00:00

abstract：:The concentration of cholesterol carried in low density lipoproteins (LDL-C) is primarily determined by the rate at which LDL-C is produced (Jt) and the rate at which the liver takes up this particle through receptor-dependent transport (Jm). The accumulation of specific dietary fatty acids in the liver profoundly alt...

journal_title：Journal of lipid research

authors： Woollett LA,Daumerie CM,Dietschy JM

更新日期：1994-09-01 00:00:00

abstract：:The resistin gene is expressed in adipocytes and encodes a protein proposed to link obesity and type 2 diabetes. Increased plasma FFA is associated with insulin resistance. We examined the effect of separate FFAs on the expression of resistin mRNA in cultured murine 3T3-L1 adipocytes. The FFAs tested did not increase ...

journal_title：Journal of lipid research

authors： Haugen F,Zahid N,Dalen KT,Hollung K,Nebb HI,Drevon CA

更新日期：2005-01-01 00:00:00

abstract：:Several lipoprotein lipase (LPL) gene polymorphisms have been found associated with fasting lipid levels, but their impact on coronary heart disease (CHD) is less clearly established. We investigated associations of LPL polymorphisms (HindIII, PvuII, Ser447-->Ter) and the newly described mutation Asn291-->Ser with the...

journal_title：Journal of lipid research

authors： Jemaa R,Fumeron F,Poirier O,Lecerf L,Evans A,Arveiler D,Luc G,Cambou JP,Bard JM,Fruchart JC

更新日期：1995-10-01 00:00:00

abstract：:Chronic inflammation contributes to cardiovascular disease. Increased levels of the inflammatory cytokine, TNF-α, are often present in conditions associated with cardiovascular disease risk, and TNF-α induces a number of pro-atherogenic effects in macrovascular endothelial cells, including expression of adhesion molec...

journal_title：Journal of lipid research

authors： Jung HS,Shimizu-Albergine M,Shen X,Kramer F,Shao D,Vivekanandan-Giri A,Pennathur S,Tian R,Kanter JE,Bornfeldt KE

更新日期：2020-01-01 00:00:00

abstract：:Arterial wall lipid retention is believed to be due primarily to ionic interactions between lipoproteins and proteoglycans. Thus, oxidized low density lipoproteins (LDL), with decreased positive charge relative to native LDL, should have decreased interaction with negatively charged proteoglycans. However, oxidized LD...

journal_title：Journal of lipid research

authors： Chang MY,Potter-Perigo S,Wight TN,Chait A

更新日期：2001-05-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) is a receptor-active lipid mediator with a broad range of biological effects. Ovarian cancer cells synthesize LPA, which promotes their motility, growth, and survival. We show that a murine homolog of a human protein previously reported to hydrolyze LPA is a highly selective detergent-stimu...

journal_title：Journal of lipid research

authors： Luquain C,Singh A,Wang L,Natarajan V,Morris AJ

更新日期：2003-10-01 00:00:00

abstract：:In contrast to current methods of bile acid analysis that require the separation of bile acids into different groups prior to their analysis, the HPLC method using a reverse phase column and gradient elution that we developed permits the separation and detection of nonconjugated, glycine-conjugated, and esterified bil...

journal_title：Journal of lipid research

authors： Budai K,Javitt NB

更新日期：1997-09-01 00:00:00

abstract：:Maintaining cellular lipid homeostasis is crucial to oxidative tissues, and it becomes compromised in obesity. Lipid droplets (LD) play a central role in lipid homeostasis by mediating fatty acid (FA) storage in the form of triglyceride, thereby lowering intracellular levels of lipids that mediate cellular lipotoxicit...

journal_title：Journal of lipid research

authors： Wang H,Sreenivasan U,Hu H,Saladino A,Polster BM,Lund LM,Gong DW,Stanley WC,Sztalryd C

更新日期：2011-12-01 00:00:00

abstract：:Bile acids play important roles in the regulation of lipid, glucose, and energy homeostasis. Recent studies suggest that glucose regulates gene transcription in the liver. The aim of this study was to investigate the potential role of glucose in regulation of bile acid synthesis in human hepatocytes. High glucose stim...

journal_title：Journal of lipid research

authors： Li T,Chanda D,Zhang Y,Choi HS,Chiang JY

更新日期：2010-04-01 00:00:00

abstract：:The activity of rat liver microsomal squalene epoxidase is inhibited effectively by digitonin. Concentrations of 0.8 to 1.2 mg/ml of digitonin cause total inhibition of microsomal (0.75 mg protein/ml) squalene epoxidase either in microsomes that were pretreated with digitonin and subsequently washed and subjected to e...

journal_title：Journal of lipid research

authors： Eilenberg H,Klinger E,Przedecki F,Shechter I

更新日期：1989-08-01 00:00:00

abstract：:High fatty acid (FA) flux is associated with systemic insulin resistance, and African-American (AA) women tend to be more insulin resistant. We assessed possible depot and race difference in the antilipolytic effect of insulin in adipocytes isolated from abdominal (Abd) and gluteal (Glt) subcutaneous (sc) adipose tiss...

journal_title：Journal of lipid research

authors： Fried SK,Tittelbach T,Blumenthal J,Sreenivasan U,Robey L,Yi J,Khan S,Hollender C,Ryan AS,Goldberg AP

更新日期：2010-05-01 00:00:00

abstract：:Long-chain acyl-CoA synthetases (ACSLs) catalyze the thioesterification of long-chain FAs into their acyl-CoA derivatives. Purified ACSL4 is an arachidonic acid (20:4)-preferring ACSL isoform, and ACSL4 is therefore a probable regulator of lipid mediator production in intact cells. Eicosanoids play important roles in ...

journal_title：Journal of lipid research

authors： Golej DL,Askari B,Kramer F,Barnhart S,Vivekanandan-Giri A,Pennathur S,Bornfeldt KE

更新日期：2011-04-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the United States and, indeed, worldwide. It has become a global public health issue. In the United States, the prevalence in the general population is estimated at approximately 20%, while that in the morbidly obese population at approximate...

journal_title：Journal of lipid research

authors： Erickson SK

更新日期：2009-04-01 00:00:00

abstract：:An online, two-dimensional (2D) liquid chromatography (LC) quadrupole time-of-flight mass spectrometry (QToF-MS) method was developed for lipid profiling of rat peritoneal surface layers, in which the lipid classes and species could be simultaneously separated in one injection with a significantly increased sensitivit...

journal_title：Journal of lipid research

authors： Nie H,Liu R,Yang Y,Bai Y,Guan Y,Qian D,Wang T,Liu H

更新日期：2010-09-01 00:00:00

abstract：:The differentiation of macrophages into lipid-filled foam cells is a hallmark of the lung granuloma that forms in patients with active tuberculosis (TB). Mycolic acids (MAs), the abundant lipid virulence factors in the cell wall of Mycobacterium tuberculosis (Mtb), can induce this foam phenotype possibly as a way to p...

journal_title：Journal of lipid research

authors： Vermeulen I,Baird M,Al-Dulayymi J,Smet M,Verschoor J,Grooten J

更新日期：2017-04-01 00:00:00

abstract：:Vitamin A-transporting protein in chicken plasma was purified by column chromatography on DEAE-Sephadex and Sephadex G-100; the protein formed a complex of retinol-binding protein (RBP) with prealbumin (PA). The molecular weight of the 1:1 molar complex was estimated to be 76,000 by gel filtration, and the sedimentati...

journal_title：Journal of lipid research

authors： Abe T,Muto Y,Hosoya N

更新日期：1975-05-01 00:00:00

abstract：:The Delta6-desaturase catalyzes key steps in long-chain polyunsaturated fatty acid biosynthesis. Although the gene coding for this enzyme has been isolated in diverse animal species, the protein structure remains poorly characterized. In this work, rat Delta6-desaturase expressed in COS-7 cells was shown to localize i...

journal_title：Journal of lipid research

authors： Guillou H,D'Andrea S,Rioux V,Barnouin R,Dalaine S,Pedrono F,Jan S,Legrand P

更新日期：2004-01-01 00:00:00

abstract：:Native interactions between lysophospholipids (LPs) and their cognate LP receptors are difficult to measure because of lipophilicity and/or the adhesive properties of lipids, which contribute to high levels of nonspecific binding in cell membrane preparations. Here, we report development of a free-solution assay (FSA)...

journal_title：Journal of lipid research

authors： Ray M,Nagai K,Kihara Y,Kussrow A,Kammer MN,Frantz A,Bornhop DJ,Chun J

更新日期：2020-08-01 00:00:00

abstract：:In a previously described method for determining the activity of cerebroside galactosidase, the enzyme preparation was incubated with an emulsion of cerebroside which had been labeled in the galactose moiety. The liberated galactose was separated from the emulsion by liquid-liquid partitioning, but the presence of det...

journal_title：Journal of lipid research

authors： Radin NS,Arora RC

更新日期：1971-03-01 00:00:00

abstract：:Some commercial preparations of common natural conjugated bile salts contain impurities (e.g., amines, lipids, and calcium) that are likely to affect their physicochemical properties. A method was developed for purifying commercial preparations of sodium salts of glycine- and taurine-conjugated bile acids. The method ...

journal_title：Journal of lipid research

authors： Del Vecchio S,Ostrow JD,Mukerjee P,Ton-Nu HT,Schteingart CD,Hofmann AF,Cerrè C,Roda A

更新日期：1995-12-01 00:00:00

abstract：:Supersaturation and rapid nucleation of cholesterol in bile are of key importance in the pathogenesis of cholesterol gallstones. While the effects of bile acids and phospholipids on cholesterol saturation of bile have been extensively studied, their influence on the cholesterol nucleation time has not been compared. W...

journal_title：Journal of lipid research

authors： Jüngst D,Lang T,Huber P,Lange V,Paumgartner G

更新日期：1993-09-01 00:00:00

abstract：:The rate-limiting step in the transit of dietary fat across the intestinal absorptive cell is its exit from the endoplasmic reticulum (ER) in a specialized ER-to-Golgi transport vesicle, the prechylomicron transport vesicle (PCTV). PCTV bud off from the ER membranes and have unique features; they are the largest ER-de...

journal_title：Journal of lipid research

authors： Siddiqi S,Siddiqi SA,Mansbach CM 2nd

更新日期：2010-05-01 00:00:00

abstract：:A modification of the semiautomated assay method of Antonis (1965. J. Lipid Res. 6:307-312) for free fatty acid is presented. Free fatty acids are extracted from serum or plasma into di-n-butyl ether-2-methoxyethanol; the extract is almost free from phospholipids. The acids are analyzed in a portion of extract by a co...

journal_title：Journal of lipid research

authors： Bowyer DE,Cridland JS,King JP

更新日期：1978-02-01 00:00:00

abstract：:Bile acids are a group of molecular species of acidic steroids with peculiar physical-chemical and biological characteristics. At high concentrations they become toxic to mammalian cells, and their presence is pertinent in the pathogenesis of several liver diseases and colon cancer. Bile acid cytoxicity has been relat...

journal_title：Journal of lipid research

authors： Amaral JD,Viana RJ,Ramalho RM,Steer CJ,Rodrigues CM

更新日期：2009-09-01 00:00:00

abstract：:Macrophages contain a neutral cholesteryl ester hydrolase that can be activated by cAMP-dependent protein kinase. Immunological studies strongly suggest that hormone-sensitive lipase (HSL) is probably responsible for the cholesteryl ester hydrolase activity in macrophages; however, due to the very low level of express...

journal_title：Journal of lipid research

authors： Khoo JC,Reue K,Steinberg D,Schotz MC

更新日期：1993-11-01 00:00:00

abstract：:Human apolipoprotein C-I (apoC-I) is an exchangeable apolipoprotein that binds to lipoprotein particles in vivo. In this study, we employed a LC-MS/MS assay to demonstrate that residues 38-51 of apoC-I are significantly protected from proteolysis in the presence of 1,2-dimyristoyl-3-sn-glycero-phosphocholine (DMPC). T...

journal_title：Journal of lipid research

authors： James PF,Dogovski C,Dobson RC,Bailey MF,Goldie KN,Karas JA,Scanlon DB,O'Hair RA,Perugini MA

更新日期：2009-07-01 00:00:00

abstract：:ABCB4, which is specifically expressed on the canalicular membrane of hepatocytes, exports phosphatidylcholine (PC) into bile. Because SM depletion increases cellular PC content and stimulates PC and cholesterol efflux by ABCA1, a key transporter involved in generation of HDL, we predicted that SM depletion also stimu...

journal_title：Journal of lipid research

authors： Zhao Y,Ishigami M,Nagao K,Hanada K,Kono N,Arai H,Matsuo M,Kioka N,Ueda K

更新日期：2015-03-01 00:00:00

abstract：:A gas-liquid chromatographic-mass spectrometric method of determining the position of oxygen atoms on polyfunctional fatty acids has been explored. The method consists of reduction of keto, hydroperoxy, epoxy, and carboxylic acid groups with LiAlH(4) to the corresponding alcohols; trimethylsilylation with bis(trimethy...

journal_title：Journal of lipid research

authors： Esselman WJ,Clagett CO

更新日期：1969-03-01 00:00:00

abstract：:Niacin, the first antidyslipidemic drug, has been at the center stage of lipid research for many decades before the discovery of statins. However, to date, despite its remarkable effects on lipid profiles, the clinical outcomes of niacin treatment on cardiac events is still debated. In addition to its historically wel...

journal_title：Journal of lipid research

authors： Romani M,Hofer DC,Katsyuba E,Auwerx J

更新日期：2019-04-01 00:00:00