Gas--liquid chromatography--mass spectrophotometry of hydroxylated octadecanols derived from hydroxylated stearic acids.

abstract：:We investigated, in the present study, the role of reactive oxygen intermediates (ROI) in the control of macrophage lipoprotein lipase (LPL) secretion. Exposure of murine macrophages to increasing concentrations of hydrogen peroxide (H2O2) resulted in enhanced basal LPL production and mRNA levels. The increase of LPL ...

journal_title：Journal of lipid research

authors： Renier G,Desfaits AC,Lambert A,Mikhail R

更新日期：1996-04-01 00:00:00

abstract：:The increased generation of reactive oxygen species that occurs in the condition of obesity may be responsible for oxidative injury to erythrocyte membranes, which could lead to a decrease in tissue oxygenation. Therefore, we have looked into the effects of obesity on both indexes of oxidative damage and physical-chem...

journal_title：Journal of lipid research

authors： Cazzola R,Rondanelli M,Russo-Volpe S,Ferrari E,Cestaro B

更新日期：2004-10-01 00:00:00

abstract：:Ketone bodies (KBs), acetoacetate and β-hydroxybutyrate (βHB), were considered harmful metabolic by-products when discovered in the mid-19th century in the urine of patients with diabetic ketoacidosis. It took physicians many years to realize that KBs are normal metabolites synthesized by the liver and exported into t...

journal_title：Journal of lipid research

authors： Hashim SA,VanItallie TB

更新日期：2014-09-01 00:00:00

abstract：:Apolipoprotein A-I (apoA-I) induces the translocation of newly synthesized cholesterol as well as caveolin-1 to the cytosolic lipid-protein particle (CLPP) fraction in astrocytes before its appearance in high density lipoprotein generated in the medium (Ito, J., Y. Nagayasu, K. Kato, R. Sato, and S. Yokoyama. 2002. Ap...

journal_title：Journal of lipid research

authors： Ito J,Li H,Nagayasu Y,Kheirollah A,Yokoyama S

更新日期：2004-12-01 00:00:00

abstract：:It is becoming increasingly accepted that removal of cellular cholesterol occurs by at least two pathways, one involving the well-described aqueous diffusion mechanism and another promoted by lipid-free apolipoproteins. We compared the contribution of apolipoprotein-dependent and -independent pathways, taking into con...

journal_title：Journal of lipid research

authors： Mendez AJ

更新日期：1997-09-01 00:00:00

abstract：:We investigated the formation and pharmacology of prostaglandin E(3) (PGE(3)) derived from fish oil eicosapentaenoic acid (EPA) in human lung cancer A549 cells. Exposure of A549 cells to EPA resulted in the rapid formation and export of PGE(3.) The extracellular ratio of PGE(3) to PGE(2) increased from 0.08 in control...

journal_title：Journal of lipid research

authors： Yang P,Chan D,Felix E,Cartwright C,Menter DG,Madden T,Klein RD,Fischer SM,Newman RA

更新日期：2004-06-01 00:00:00

abstract：:Abdominal aortic aneurysm (AAA) is an important cause of death in older adults, which has no current drug therapy. Inflammation and abnormal redox status are believed to be key pathogenic mechanisms for AAA. In light of evidence correlating inflammation with aberrant fatty acid profiles, this study compared erythrocyt...

journal_title：Journal of lipid research

authors： Meital LT,Windsor MT,Ramirez Jewell RML,Young P,Schulze K,Magee R,O'Donnell J,Jha P,Perissiou M,Golledge J,Bailey TG,Brooks P,Askew CD,Russell FD

更新日期：2019-06-01 00:00:00

abstract：:Origins of hyperlipidemia and cholestasis that occur during pregnancy were investigated by examining expression of key elements related to plasma and hepatic cholesterol metabolism during pregnancy, lactation, and post-lactation in the rat model. Among major findings were: during pregnancy, the activities of hepatic 3...

journal_title：Journal of lipid research

authors： Smith JL,Lear SR,Forte TM,Ko W,Massimi M,Erickson SK

更新日期：1998-11-01 00:00:00

abstract：:Measurements of enzymatic activity have demonstrated that lipoprotein lipase (LPL), the principal enzyme responsible for hydrolysis of circulating triglyceride, is present in a number of tissues including brain, kidney, and adrenal gland. To determine the sites of synthesis of LPL in these tissues, in situ hybridizati...

journal_title：Journal of lipid research

authors： Goldberg IJ,Soprano DR,Wyatt ML,Vanni TM,Kirchgessner TG,Schotz MC

更新日期：1989-10-01 00:00:00

abstract：:Hepatocytes express on their surfaces more than one class of receptors capable of mediating the internalization of lipoproteins. However, relatively little is known about the binding characteristics of hepatic receptors for various lipoproteins, about the regulation of the receptors, and about the consequences for int...

journal_title：Journal of lipid research

authors： Tamai T,Patsch W,Lock D,Schonfeld G

更新日期：1983-12-01 00:00:00

abstract：:The vitamin D signal transduction system involves a series of cytochrome P450-containing sterol hydroxylases to generate and degrade the active hormone, 1α,25-dihydroxyvitamin D3, which serves as a ligand for the vitamin D receptor-mediated transcriptional gene expression described in companion articles in this review...

journal_title：Journal of lipid research

authors： Jones G,Prosser DE,Kaufmann M

更新日期：2014-01-01 00:00:00

abstract：:Cystic fibrosis (CF) patients and model systems exhibit consistent abnormalities in PUFA metabolism, including increased metabolism of linoleate to arachidonate. Recent studies have connected these abnormalities to increased expression and activity of the Δ6- and Δ5-desaturase enzymes. However, the mechanism connectin...

journal_title：Journal of lipid research

authors： Umunakwe OC,Seegmiller AC

更新日期：2014-07-01 00:00:00

abstract：:The pathogenesis of aortic valve stenosis (AS) is characterized by the accumulation of LDL-derived cholesterol in the diseased valves. Since LDL particles also contain plant sterols, we investigated whether plant sterols accumulate in aortic valve lesions. Serum samples were collected from 82 patients with severe AS a...

journal_title：Journal of lipid research

authors： Helske S,Miettinen T,Gylling H,Mäyränpää M,Lommi J,Turto H,Werkkala K,Kupari M,Kovanen PT

更新日期：2008-07-01 00:00:00

abstract：:We describe new methods for analyzing the apolipoproteins (apo) of the high density lipoproteins (HDL) of several species by two modes of capillary electrophoresis: size separation using a molecular sieving buffer, and capillary zone electrophoresis (CZE) using neutral coated capillaries. By either mode HDL apos were ...

journal_title：Journal of lipid research

authors： Stocks J,Nanjee MN,Miller NE

更新日期：1998-01-01 00:00:00

abstract：:Cyclophosphamide injection into the fasted rabbit induces a hypertriglyceridemia (4.6 mM vs. 0.8 mM in controls) and a defect of lipoprotein lipase (LPL), as measured in post-heparin plasma (PHP). In contrast, administration of the drug into fed animals tends to increase PHP-LPL. The effects of cyclophosphamide on LPL...

journal_title：Journal of lipid research

authors： Lespine A,Azema C,Gafvels M,Manent J,Dousset N,Chap H,Perret B

更新日期：1993-01-01 00:00:00

abstract：:23-Nor-deoxycholic acid is widely used as internal standard in gas-liquid chromatographic studies of bile acids. Two batches of this compound, submitted to conventional alkaline hydrolysis of bile acid conjugates, were found to be transformed into a product with chromatographic properties different from those of "auth...

journal_title：Journal of lipid research

authors： Attili AF,Angelico M,Capocaccia L,Pièche U,Cantafora A

更新日期：1982-01-01 00:00:00

abstract：:Dietary n-3 PUFAs have been shown to attenuate T-cell-mediated inflammation. To investigate whether dietary n-3 PUFAs promote activation-induced cell death (AICD) in CD4+ T-cells induced in vitro to a polarized T-helper1 (Th1) phenotype, C57BL/6 mice were fed diets containing either 5% corn oil (CO; n-6 PUFA control) ...

journal_title：Journal of lipid research

authors： Switzer KC,Fan YY,Wang N,McMurray DN,Chapkin RS

更新日期：2004-08-01 00:00:00

abstract：:Serum amyloid A (SAA) is an acute phase reactant that can become the predominant apolipoprotein of high density lipoprotein (HDL) during severe inflammatory states. However, the function of SAA is unknown. To study the ability of SAA to form HDL in the absence of apolipoprotein A-I, we expressed the mouse SAA pI 6.15 ...

journal_title：Journal of lipid research

authors： Webb NR,de Beer MC,van der Westhuyzen DR,Kindy MS,Banka CL,Tsukamoto K,Rader DL,de Beer FC

更新日期：1997-08-01 00:00:00

abstract：:Glycosylphosphatidylinositols (GPIs) act as membrane anchors of many eukaryotic cell surface proteins. GPIs in various organisms have a common backbone consisting of ethanolamine phosphate (EtNP), three mannoses (Mans), one non-N-acetylated glucosamine, and inositol phospholipid, whose structure is EtNP-6Manα-2Manα-6M...

journal_title：Journal of lipid research

authors： Kinoshita T,Fujita M

更新日期：2016-01-01 00:00:00

abstract：:The purpose of the present study was to examine the regulation of levels of apolipoprotein B (apoB) mRNA and its protein by cytokines in HepG2 cells. A dose-dependent increase in apoB mRNA levels was observed in the presence of either interleukin-1beta (IL-1beta) or IL-6 alone. This increase occurred as early as 1 h a...

journal_title：Journal of lipid research

authors： Yokoyama K,Ishibashi T,Yi-qiang L,Nagayoshi A,Teramoto T,Maruyama Y

更新日期：1998-01-01 00:00:00

abstract：:A novel water-soluble polysaccharide fraction, CME-1, with a molecular mass of 27.6 kDa and containing mannose and galactose in a respective ratio of 4:6, was prepared from Cordyceps sinensis mycelia and identified by NMR and GC-MS. In the current study, we examined whether CME-1 has anti-inflammatory effects in RAW26...

journal_title：Journal of lipid research

authors： Wang SH,Yang WB,Liu YC,Chiu YH,Chen CT,Kao PF,Lin CM

更新日期：2011-03-01 00:00:00

abstract：:PPARs regulate the expression of genes for energy metabolism in a ligand-dependent manner. PPARs can influence fatty acid oxidation, the level of circulating triglycerides, glucose uptake and insulin sensitivity. Here, we demonstrate that 5-hydroxyeicosapentaenoic acid (HEPE), 8-HEPE, 9-HEPE, 12-HEPE and 18-HEPE (hydr...

journal_title：Journal of lipid research

authors： Yamada H,Oshiro E,Kikuchi S,Hakozaki M,Takahashi H,Kimura K

更新日期：2014-05-01 00:00:00

abstract：:Studies were carried out to determine whether apolipoprotein (apo) A-II, like apoA-I, can recruit phospholipid and cholesterol from cell membranes, thereby forming nascent apoA-II-specific HDL. ApoA-II and apoA-I were purified from plasma and each was incubated with CHO cells at a concentration of 10 micrograms/ml. Li...

journal_title：Journal of lipid research

authors： Forte TM,Bielicki JK,Goth-Goldstein R,Selmek J,McCall MR

更新日期：1995-01-01 00:00:00

abstract：:Fluorescence energy transfer from dehydroergosterol (DHE) to dansylated lecithin (DL) was used to characterize lecithin-cholesterol vesicles in the presence of the bile salt, sodium taurocholate. At lipid concentrations approximating physiological levels, exposure of fluorescently labeled vesicles to the bile salt led...

journal_title：Journal of lipid research

authors： Wrenn SP,Gudheti M,Veleva AN,Kaler EW,Lee SP

更新日期：2001-06-01 00:00:00

abstract：:Monospecific antisera were produced to two chylomicron apoproteins (apoB, apoA-I) and utilized for indirect immunofluorescent localization of these apoproteins within rat intestinal epithelium during normal and impaired lipid absorption. Isolated intestinal epithelial cells prepared after different periods of lipid ab...

journal_title：Journal of lipid research

authors： Glickman RM,Kilgore A,Khorana J

更新日期：1978-02-01 00:00:00

abstract：:Recent discovery and characterization of APOAV suggests a role in metabolism of triglyceride (TG)-rich lipoproteins. Previously, variation at the APOAV locus was shown to modestly influence plasma TGs in normolipidemic samples. The aims of this study were to assess the effects of a polymorphism in APOAV (T-1131C) in t...

journal_title：Journal of lipid research

authors： Aouizerat BE,Kulkarni M,Heilbron D,Drown D,Raskin S,Pullinger CR,Malloy MJ,Kane JP

更新日期：2003-06-01 00:00:00

abstract：:This study has examined the dimeric/oligomeric forms of scavenger receptor class B type I (SR-BI) and its alternatively spliced form, SR-BII, in a diverse group of cells and tissues: i.e., normal and hormonally altered tissues of mice and rats as well as tissues of transgenic animals and genetically altered steroidoge...

journal_title：Journal of lipid research

authors： Reaven E,Cortez Y,Leers-Sucheta S,Nomoto A,Azhar S

更新日期：2004-03-01 00:00:00

abstract：:A method has been developed for rapidly quantitating the cholesterol concentration of normal and certain variant lipoproteins in a large number of patients (over 240 in one week). The method employs a microcomputer interfaced to the vertical autoprofiler (VAP) described earlier (Chung et al. 1981. J. Lipid Res. 22: 10...

journal_title：Journal of lipid research

authors： Cone JT,Segrest JP,Chung BH,Ragland JB,Sabesin SM,Glasscock A

更新日期：1982-08-01 00:00:00

abstract：:Within the cholesterol biosynthesis cascade, the enzyme 2,3-oxidosqualene cyclase [EC 5.4.99.7] is of special interest due to its dual function: cyclization of 2,3-monoepoxysqualene to lanosterol and 2,3;22,23-diepoxysqualene to oxylanosterol. Further determination of the significance of this enzyme for the intracellu...

journal_title：Journal of lipid research

authors： Mark M,Muller P,Maier R,Eisele B

更新日期：1996-01-01 00:00:00

abstract：:Adipose tissue development was studied histochemically and histologically in fetuses from lean and obese sows. At 110 days of gestation, fetuses were removed from Ossabaw (obese-feral) sows and from sows selected for high backfat (obese-domestic) and for low backfat (lean) thickness. Body weights were similar for lean...

journal_title：Journal of lipid research

authors： Hausman GJ,Campion DR,Thomas GB

更新日期：1983-03-01 00:00:00