Hydroxyeicosapentaenoic acids from the Pacific krill show high ligand activities for PPARs.

abstract：:Analytical isoelectric focusing (IEF) has been applied to the study of the apolipoprotein components of rat serum high density and very low density lipoproteins. The apolipoproteins were separated on 7.5% polyacrylamide gels containing 6.8% urea, with a pH gradient of 4-6. The middle molecular weight range apolipoprot...

journal_title：Journal of lipid research

authors： Gidez LI,Swaney JB,Murnane S

更新日期：1977-01-01 00:00:00

abstract：:Black tea is one of the world's most popular beverages, and its health-promoting effects have been intensively investigated. The antiobesity and hypolipidemic effects of black tea have attracted increasing interest, but the mechanisms underlying these phenomena remain unclear. In the present study, the black tea major...

journal_title：Journal of lipid research

authors： Lin CL,Huang HC,Lin JK

更新日期：2007-11-01 00:00:00

abstract：:Two procedures were used to isolate hepatocytic Golgi fractions from rat liver. One procedure yields a light Golgi fraction (GF1 + 2) and the other "intact" stacks of cisternae. Triglyceride fatty acids in nascent very low density lipoproteins (VLDL) were labeled by injection of [3H]palmitate intravenously, and radiol...

journal_title：Journal of lipid research

authors： Hamilton RL,Moorehouse A,Havel RJ

更新日期：1991-03-01 00:00:00

abstract：:Apolipoprotein B (apoB) is a nonexchangeable apolipoprotein. During lipoprotein assembly, it recruits phospholipids and triacylglycerols (TAG) into TAG-rich lipoprotein particles. It remains bound to secreted lipoproteins during lipid metabolism in plasma. The beta1 region (residues 827-1880) of apoB has a high amphip...

journal_title：Journal of lipid research

authors： Wang L,Martin DD,Genter E,Wang J,McLeod RS,Small DM

更新日期：2009-07-01 00:00:00

abstract：:The antitumor effect of daily individual administration of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (2 g/kg body weight) in Balb/c mice bearing a transplantable thymoma was investigated. Mice received oleic acid (control group), EPA and DHA ethyl esters starting 10 days before tumor inoculation. Anal...

journal_title：Journal of lipid research

authors： Calviello G,Palozza P,Di Nicuolo F,Maggiano N,Bartoli GM

更新日期：2000-02-01 00:00:00

abstract：:Vitamin A (VA) is stored in tissues predominantly as retinyl esters (REs), which provide substrate for the production of bioactive retinoids. Retinoic acid (RA), a principal metabolite, has been shown to induce postnatal lung development. To better understand lung RE storage, we compared VA (given as retinyl palmitate...

journal_title：Journal of lipid research

authors： Ross AC,Ambalavanan N,Zolfaghari R,Li NQ

更新日期：2006-08-01 00:00:00

abstract：:Of the six fatty acid elongase (Elovl) subtypes expressed in mammals, adult rat liver expresses four subtypes: Elovl-5 > Elovl-1 = Elovl-2 = Elovl-6. Overnight starvation and fish oil-enriched diets repressed hepatic elongase activity in livers of adult male rats. Diet-induced changes in elongase activity correlate wi...

journal_title：Journal of lipid research

authors： Wang Y,Botolin D,Christian B,Busik J,Xu J,Jump DB

更新日期：2005-04-01 00:00:00

abstract：:ABCA1 plays a key role in the initial lipidation of apoA-I, which generates circulating HDL cholesterol. Whereas it is known that the transcriptional upregulation of ABCA1 promotes HDL formation and reverse cholesterol transport (RCT), it is not known how the inhibition of ABCA1 protein degradation impacts HDL functio...

journal_title：Journal of lipid research

authors： Huang L,Fan B,Ma A,Shaul PW,Zhu H

更新日期：2015-05-01 00:00:00

abstract：:A novel water-soluble polysaccharide fraction, CME-1, with a molecular mass of 27.6 kDa and containing mannose and galactose in a respective ratio of 4:6, was prepared from Cordyceps sinensis mycelia and identified by NMR and GC-MS. In the current study, we examined whether CME-1 has anti-inflammatory effects in RAW26...

journal_title：Journal of lipid research

authors： Wang SH,Yang WB,Liu YC,Chiu YH,Chen CT,Kao PF,Lin CM

更新日期：2011-03-01 00:00:00

abstract：:Trihydroxyoctadecenoic acids (TriHOMEs) are linoleic acid-derived oxylipins with potential physiological relevance in inflammatory processes as well as in maintaining an intact skin barrier. Due to the high number of possible TriHOME isomers with only subtle differences in their physicochemical properties, the stereoc...

journal_title：Journal of lipid research

authors： Fuchs D,Hamberg M,Sköld CM,Wheelock ÅM,Wheelock CE

更新日期：2018-10-01 00:00:00

abstract：:In this study we employed a capillary gas-liquid chromatographic-mass spectrometric (GLC-MS) method to measure the plasma concentrations of 3-hydroxybutyrate (3-OHB) and 3-hydroxyisobutyrate (3-OHIB) in overnight fasted diabetic subjects and in normal subjects. Plasma contents of 3-hydroxybutyrate measured in this fas...

journal_title：Journal of lipid research

authors： Avogaro A,Bier DM

更新日期：1989-11-01 00:00:00

abstract：:Agonist-induced lipolysis of adipose fat is robustly inhibited by insulin or by feedback inhibition by the long-chain fatty acids (LCFA) produced during lipolysis. However, the mode of action of LCFA in suppressing adipose lipolysis is not clear. β,β'-Tetramethyl hexadecanedioic acid (Mββ/ EDICA16) is a synthetic LCFA...

journal_title：Journal of lipid research

authors： Kalderon B,Azazmeh N,Azulay N,Vissler N,Valitsky M,Bar-Tana J

更新日期：2012-05-01 00:00:00

abstract：:Recent studies demonstrate that HDL's ability to promote cholesterol efflux from macrophages associates strongly with cardioprotection in humans independently of HDL-cholesterol (HDL-C) and apoA-I, HDL's major protein. However, the mechanisms that impair cholesterol efflux capacity during vascular disease are unclear....

journal_title：Journal of lipid research

authors： Vaisar T,Tang C,Babenko I,Hutchins P,Wimberger J,Suffredini AF,Heinecke JW

更新日期：2015-08-01 00:00:00

abstract：:Nucleoredoxin (NRX) is a member of the thioredoxin family of proteins that controls redox homeostasis in cell. Redox homeostasis is a well-known regulator of cell differentiation into various tissue types. We found that NRX expression levels were higher in white adipose tissue of obese ob/ob mice and increased in the ...

journal_title：Journal of lipid research

authors： Bahn YJ,Lee KP,Lee SM,Choi JY,Seo YS,Kwon KS

更新日期：2015-02-01 00:00:00

abstract：:In addition to its role in the uptake of apolipoprotein B (apoB)-containing lipoproteins, apoE promotes hepatic very low density lipoprotein-triglyceride (VLDL-TG) production in animal models. However, it is not known if apoE increases the amount of TG per VLDL particle or the number of VLDL particles secreted. VLDL-a...

journal_title：Journal of lipid research

authors： Maugeais C,Tietge UJ,Tsukamoto K,Glick JM,Rader DJ

更新日期：2000-10-01 00:00:00

abstract：:A colony of New Zealand white rabbits has been developed which, when fed a cholesterol-supplemented diet, exhibit unusual resistance to hypercholesterolemia and atherosclerosis, disorders usually observed in normal cholesterol-fed rabbits. When resistant rabbits (RT) were fed a normal low cholesterol diet (ND), their ...

journal_title：Journal of lipid research

authors： Overturf ML,Smith SA,Hewett-Emmett D,Loose-Mitchell DS,Soma MR,Gotto AM Jr,Morrisett JD

更新日期：1989-02-01 00:00:00

abstract：:Dietary n-3 long-chain PUFAs (LC-PUFAs) are associated with improvement in the parameters of the metabolic syndrome (MetS). Glucokinase regulatory protein (GCKR) is a key protein regulating intracellular glucose disposal. Our aim was to investigate: i) the relationship between the GCKR rs1260326 (Pro446Leu) polymorphi...

journal_title：Journal of lipid research

authors： Rousseaux J,Duhamel A,Dumont J,Dallongeville J,Molnar D,Widhalm K,Manios Y,Sjöström M,Kafatos A,Breidenassel C,Gonzales-Gross M,Cuenca-Garcia M,Censi L,Ascensión M,De Henauw S,Moreno LA,Meirhaeghe A,Gottrand F

更新日期：2015-09-01 00:00:00

abstract：:Increased plasma concentrations of apolipoprotein A-IV (apoA-IV) in chronic renal disease suggest a metabolic role of the kidney for this antiatherogenic protein. Therefore, we investigated patients with various forms of proteinuria and found increased serum concentrations of apoA-IV in 124 nephrotic patients compared...

journal_title：Journal of lipid research

authors： Lingenhel A,Lhotta K,Neyer U,Heid IM,Rantner B,Kronenberg MF,König P,von Eckardstein A,Schober M,Dieplinger H,Kronenberg F

更新日期：2006-09-01 00:00:00

abstract：:Cholesterol 7alpha-hydroxylase (CYP7A1) plays a crucial role in cholesterol metabolism and has been implicated in genetic susceptibility to atherosclerosis. Thus, an understanding of its transcriptional regulation is of considerable importance. We evaluated the effect of a common -203A>C polymorphism in the CYP7A1 pro...

journal_title：Journal of lipid research

authors： Lenícek M,Komárek V,Zimolová M,Kovár J,Jirsa M,Lukás M,Vítek L

更新日期：2008-12-01 00:00:00

abstract：:Conditions under which apolipoprotein (apo) A-I dissociates from human high density lipoproteins (HDL) during incubation in vitro have been investigated. Dissociation of apoA-I was demonstrated by non-denaturing gradient gel electrophoresis followed by immunoblotting for apoA-I and by size-exclusion chromatography. It...

journal_title：Journal of lipid research

authors： Liang HQ,Rye KA,Barter PJ

更新日期：1994-07-01 00:00:00

abstract：:A method is described for the determination of mevalonate in ultrafiltrates of blood plasma. The method depends on the phosphorylation of mevalonate with [gamma-32P]ATP and mevalonate kinase to 5-[32P]phosphomevalonate, and the subsequent isolation of the 5-[32P]phosphomevalonate together with known amounts of added 5...

journal_title：Journal of lipid research

authors： Popják G,Boehm G,Parker TS,Edmond J,Edwards PA,Fogelman AM

更新日期：1979-08-01 00:00:00

abstract：:Quantitatively and rapidly analyzing lipids is necessary to elucidate their biological functions. Herein, we developed a quantitative method for various lipid classes using supercritical fluid chromatography (SFC) coupled with a charged aerosol detector (CAD), providing high-throughput data analysis to detect a large ...

journal_title：Journal of lipid research

authors： Takeda H,Takahashi M,Hara T,Izumi Y,Bamba T

更新日期：2019-08-01 00:00:00

abstract：:The rate of peroxidation of unconjugated bilirubin (UCB), catalyzed by horseradish peroxidase (HRP), has been employed by Jacobsen (1969. FEBS Lett. 5: 112-114) to assess the fraction of unbound UCB in the presence of serum albumin. We used this method to examine the interactions of UCB with taurocholate (TC) at pH 8....

journal_title：Journal of lipid research

authors： Rege RV,Webster CC,Ostrow JD

更新日期：1987-06-01 00:00:00

abstract：:In the present study, we have examined the structure of human low density lipoprotein (LDL) using cryo-electron microscopy. Human LDL particles were analyzed in a vitrified frozen-hydrated condition, without chemical fixation or any form of staining. Hence, the lipoproteins were visualized close to their native state....

journal_title：Journal of lipid research

authors： Van Antwerpen R,Gilkey JC

更新日期：1994-12-01 00:00:00

abstract：:Unesterified cholesterol is an essential structural component of the plasma membrane of every cell. During evolution, this membrane came to play an additional, highly specialized role in the central nervous system (CNS) as the major architectural component of compact myelin. As a consequence, in the human the mean con...

journal_title：Journal of lipid research

authors： Dietschy JM,Turley SD

更新日期：2004-08-01 00:00:00

abstract：:The zinc finger protein ZNF202 is a transcriptional repressor that binds to promoter elements predominantly found in genes involved in lipid metabolism. Here we demonstrate that ZNF202 mRNA expression is inversely correlated with ATP binding cassette A1 (ABCA1), ABCG1, and apolipoprotein E (apoE) in human monocytes. U...

journal_title：Journal of lipid research

authors： Langmann T,Schumacher C,Morham SG,Honer C,Heimerl S,Moehle C,Schmitz G

更新日期：2003-05-01 00:00:00

abstract：:Atherogenic mixed dyslipidemia associates with oxidative stress and defective HDL antioxidative function in metabolic syndrome (MetS). The impact of statin treatment on the capacity of HDL to inactivate LDL-derived, redox-active phospholipid hydroperoxides (PCOOHs) in MetS is indeterminate. Insulin-resistant, hypertri...

journal_title：Journal of lipid research

authors： Orsoni A,Thérond P,Tan R,Giral P,Robillard P,Kontush A,Meikle PJ,Chapman MJ

更新日期：2016-11-01 00:00:00

abstract：:Consumption of industrially produced trans fatty acids (IP-TFA) has been positively associated with systemic markers of low-grade inflammation and endothelial dysfunction in cross-sectional studies, but results from intervention studies are inconclusive. Therefore, we conducted a 16 week double-blind parallel interven...

journal_title：Journal of lipid research

authors： Bendsen NT,Stender S,Szecsi PB,Pedersen SB,Basu S,Hellgren LI,Newman JW,Larsen TM,Haugaard SB,Astrup A

更新日期：2011-10-01 00:00:00

abstract：:The effect of microbiological deconjugation of bile acids on total bile acid and neutral sterol fecal excretion by adult male rats has been studied. A screening method utilizing mice allowed selection of a Clostridium perfringens type A strain, which accelerated cholesterol catabolism in mice. When this species of bac...

journal_title：Journal of lipid research

authors： Kellogg TF,Knight PL,Wostmann BS

更新日期：1970-07-01 00:00:00

abstract：:Macrophage infiltration of white adipose tissue (WAT) is implicated in the metabolic complications of obesity. The precipitating event(s) and function(s) of macrophage infiltration into WAT are unknown. We demonstrate that >90% of all macrophages in WAT of obese mice and humans are localized to dead adipocytes, where ...

journal_title：Journal of lipid research

authors： Cinti S,Mitchell G,Barbatelli G,Murano I,Ceresi E,Faloia E,Wang S,Fortier M,Greenberg AS,Obin MS

更新日期：2005-11-01 00:00:00