The n-3 long-chain PUFAs modulate the impact of the GCKR Pro446Leu polymorphism on triglycerides in adolescents.

abstract：:Sebum is a complex lipid mixture that is synthesized in sebaceous glands and excreted on the skin surface. The purpose of this study was the comprehensive detection of the intact lipids that compose sebum. These lipids exist as a broad range of chemical structures and concentrations. Sebum was collected with SebuTape(...

journal_title：Journal of lipid research

authors： Camera E,Ludovici M,Galante M,Sinagra JL,Picardo M

更新日期：2010-11-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) is associated with a severe pro-inflammatory response; although decreased plasma cholesterol concentration has been linked to systemic inflammation, any association of phospholipid metabolic pathways with ARDS has not been characterized. Plasma phosphatidylcholine (PC), the m...

journal_title：Journal of lipid research

authors： Dushianthan A,Cusack R,Grocott MPW,Postle AD

更新日期：2018-06-01 00:00:00

abstract：:Recent studies demonstrate that HDL's ability to promote cholesterol efflux from macrophages associates strongly with cardioprotection in humans independently of HDL-cholesterol (HDL-C) and apoA-I, HDL's major protein. However, the mechanisms that impair cholesterol efflux capacity during vascular disease are unclear....

journal_title：Journal of lipid research

authors： Vaisar T,Tang C,Babenko I,Hutchins P,Wimberger J,Suffredini AF,Heinecke JW

更新日期：2015-08-01 00:00:00

abstract：:Labeled cholesterol esters were incorporated into chylomicrons in vitro by adding an acetone solution of the cholesterol ester to a suspension of washed chylomicrons. The physical and metabolic properties of the added labeled ester were the same as those of cholesterol esters incorporated into chylomicrons in vivo, ex...

journal_title：Journal of lipid research

authors： Quarfordt SH,Goodman DS

更新日期：1966-09-01 00:00:00

abstract：:Little is known of the post-absorptive, metabolic fate of gamma-tocopherol, the major form of vitamin E in North American diets. The objective of this study was to determine the extent of urinary excretion of 2,7, 8-trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman (gamma-CEHC), a recently identified metabolite of gamm...

journal_title：Journal of lipid research

authors： Swanson JE,Ben RN,Burton GW,Parker RS

更新日期：1999-04-01 00:00:00

abstract：:A woman with primary lipoprotein lipase (LPL) deficiency developed marked hypertriglyceridemia, pancreatitis, eruptive xanthomas, and unusual palmar xanthomas during pregnancy. Hypotheses to account for the palmar xanthomas were that oxidative modification of triglyceride (TG)-rich lipoproteins occurred due to increas...

journal_title：Journal of lipid research

authors： Steinberg FM,Tsai EC,Brunzell JD,Chait A

更新日期：1996-05-01 00:00:00

abstract：:Lipid concentrations are heritable traits. Recently, the number of known genetic loci associated with lipid levels in adults increased from 95 to 157. The effects of these 157 loci have not been tested in children. Considering that lipid levels track from childhood to adulthood, we studied to determine whether these v...

journal_title：Journal of lipid research

authors： Latsuzbaia A,Jaddoe VW,Hofman A,Franco OH,Felix JF

更新日期：2016-12-01 00:00:00

abstract：:The initial studies of the metabolism of arachidonic acid (AA) by the cytochrome P450 (P450) hemeproteins sought to: a) elucidate the roles for these enzymes in the metabolism of endogenous pools of the FA, b) identify the P450 isoforms involved in AA epoxidation and ω/ω-1 hydroxylation, and c) explore the biological ...

journal_title：Journal of lipid research

authors： Capdevila JH,Falck JR

更新日期：2018-11-01 00:00:00

abstract：:The ceramide (Cer) and sphingomyelin (SM) species of cultured differentiated rat cerebellar granule cells and human fibroblasts were characterized by electrospray ionization-mass spectrometry. We identified 35 different species of Cer and 18 species of SM in human fibroblasts, and 35 different species of Cer and 9 spe...

journal_title：Journal of lipid research

authors： Valsecchi M,Mauri L,Casellato R,Prioni S,Loberto N,Prinetti A,Chigorno V,Sonnino S

更新日期：2007-02-01 00:00:00

abstract：:This study describes a variant of familial apoA-I deficiency associated with a moderate risk for premature coronary artery disease. The proband, a 25-year-old man of Philippine origin, and his 62-year-old maternal aunt had peripheral corneal opacification, xanthelasma, and planar xanthoma; the aunt had coronary artery...

journal_title：Journal of lipid research

authors： Bekaert ED,Alaupovic P,Knight-Gibson CS,Laux MJ,Pelachyk JM,Norum RA

更新日期：1991-10-01 00:00:00

abstract：:Two new 6-hydroxylated bile acids, 3 beta, 6 alpha, 12 alpha- and 3 beta, 6 beta, 12 alpha-trihydroxy-5 beta-cholanoic acids, were synthesized from deoxycholic acid. In addition, their C-3 epimers, 3 alpha, 6 alpha, 12 alpha- and 3 alpha, 6 beta, 12 alpha-trihydroxy acids, were prepared by a new route. The principal r...

journal_title：Journal of lipid research

authors： Iida T,Tamaru T,Chang FC,Goto J,Nambara T

更新日期：1991-04-01 00:00:00

abstract：:There is a continuous flux of the oxysterol 27-hydroxycholesterol (27-OHC) from the circulation across the blood-brain barrier (BBB) into the brain. The major metabolite of 27-OHC in the brain is 7α-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA). We confirm a recent report describing the presence of this metabolite in cer...

journal_title：Journal of lipid research

authors： Saeed A,Floris F,Andersson U,Pikuleva I,Lövgren-Sandblom A,Bjerke M,Paucar M,Wallin A,Svenningsson P,Björkhem I

更新日期：2014-02-01 00:00:00

abstract：:Two novel mutations of the low density lipoprotein (LDL)-receptor gene were found in two Italian familial hypercholesterolemia (FH)-heterozygotes. The first mutation was an 18 nucleotide duplication in exon 8 which is preceded by an A-->T transversion. The translation product of the mutant allele was predicted to be a...

journal_title：Journal of lipid research

authors： Patel DD,Lelli N,Garuti R,Li Volti S,Bertolini S,Knight BL,Calandra S

更新日期：1998-07-01 00:00:00

abstract：:The properties of cholesteryl oleate and triolein in mixed monolayers at the air-water interface have been measured between 24 and 37 degrees C. Analysis of force-area curves obtained as a function of the mol fraction of cholesteryl oleate indicates that at relatively low surface pressures these compounds are miscible...

journal_title：Journal of lipid research

authors： Smaby JM,Brockman HL

更新日期：1978-03-01 00:00:00

abstract：:Apolipoprotein (apo) B-100, the protein constituent of low density lipoproteins (LDL), is the determinant responsible for LDL binding to the apoB,E(LDL) receptor on cells. The current study was designed to identify the region(s) of apoB-100 that interact with the apoB,E(LDL) receptor. Apolipoprotein B-100 was fragment...

journal_title：Journal of lipid research

authors： Corsini A,Spilman CH,Innerarity TL,Arnold KS,Rall SC Jr,Boyles JK,Mahley RW

更新日期：1987-12-01 00:00:00

abstract：:Rat serum lipoproteins were separated into at least four fractions by agarose-starch gel electrophoresis. The system used was discontinuous in that glycine and sodium barbitone buffer was used in the reservoirs and Tris buffer was used for the gels. The four major bands could be related to the pattern obtained by ultr...

journal_title：Journal of lipid research

authors： Chalvardjian A

更新日期：1971-05-01 00:00:00

abstract：:Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that regulates hepatic low-density lipoprotein receptor (LDLR) levels in humans. PCSK9 has also been shown to regulate the levels of additional membrane-bound proteins in vitro, including the very low-density lipoprotein receptor (VLDLR), apol...

journal_title：Journal of lipid research

authors： Liu M,Wu G,Baysarowich J,Kavana M,Addona GH,Bierilo KK,Mudgett JS,Pavlovic G,Sitlani A,Renger JJ,Hubbard BK,Fisher TS,Zerbinatti CV

更新日期：2010-09-01 00:00:00

abstract：:The interaction of hepatic lipase (HL) with heparan sulfate is critical to the function of this enzyme. The primary amino acid sequence of HL was compared to that of lipoprotein lipase (LPL), a related enzyme that possesses several putative heparin-binding domains. Of the three putative heparin-binding clusters of LPL...

journal_title：Journal of lipid research

authors： Sendak RA,Berryman DE,Gellman G,Melford K,Bensadoun A

更新日期：2000-02-01 00:00:00

abstract：:The genus Acinetobacter is composed of ubiquitous, generally nonpathogen environmental bacteria. Interest concerning these microorganisms has increased during the last 30 years, because some strains, belonging to the so-called A. baumannii-A. calcoaceticus complex, have been implicated in some severe pathological stat...

journal_title：Journal of lipid research

authors： Leone S,Sturiale L,Pessione E,Mazzoli R,Giunta C,Lanzetta R,Garozzo D,Molinaro A,Parrilli M

更新日期：2007-05-01 00:00:00

abstract：:Lipogenesis in vitro from acetate-1-(14)C was studied in human preputial skin and abdominal skin. Radioactive lipids were separated by column chromatography on Florisil and by thin-layer chromatography on silica gel. Radioactivity was incorporated chiefly into the triglyceride, sterol, and polar lipid fractions, while...

journal_title：Journal of lipid research

authors： Vroman HE,Nemecek RA,Hsia SL

更新日期：1969-09-01 00:00:00

abstract：:Since the discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9) as an attractive target in the treatment of hypercholesterolemia, multiple anti-PCSK9 therapeutic modalities have been pursued in drug development. The objective of this research is to set the stage for the quantitative benchmarking of two an...

journal_title：Journal of lipid research

authors： Sokolov V,Helmlinger G,Nilsson C,Zhudenkov K,Skrtic S,Hamrén B,Peskov K,Hurt-Camejo E,Jansson-Löfmark R

更新日期：2019-09-01 00:00:00

abstract：:Lysosphingolipids, which lack the fatty acid moiety of sphingolipids, are known to be accumulated in some variants of sphingolipid storage diseases. Here, we report that lysosphingolipids with naturally occurring stereochemical configurations induce apoptosis in mouse neuroblastoma Neuro2a cells. The intracellular deh...

journal_title：Journal of lipid research

authors： Sueyoshi N,Maehara T,Ito M

更新日期：2001-08-01 00:00:00

abstract：:Matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) has been applied primarily to the analysis of glycosphingolipids separated from other complex mixtures by TLC, but it is difficult to obtain quantitative profiling of each glycosphingolipid among the different spots on TLC by MALDI-MS. Thus, the ...

journal_title：Journal of lipid research

authors： Ikeda K,Shimizu T,Taguchi R

更新日期：2008-12-01 00:00:00

abstract：:Lysophospholipid acyltransferases (LPATs) incorporate fatty acyl chains into phospholipids via a CoA-dependent mechanism and are important in remodeling phospholipids to generate the molecular species of phospholipids found in cells. These enzymes use one lysophospholipid and one acyl-CoA ester as substrates. Traditio...

journal_title：Journal of lipid research

authors： Martin SA,Gijón MA,Voelker DR,Murphy RC

更新日期：2014-04-01 00:00:00

abstract：:Ecdysteroids are potent developmental regulators that control molting, reproduction, and stress response in arthropods. In developing larvae, picogram quantities of individual ecdysteroids and their conjugated forms are present along with milligrams of structural and energy storage lipids. To enhance the specificity a...

journal_title：Journal of lipid research

authors： Lavrynenko O,Nedielkov R,Möller HM,Shevchenko A

更新日期：2013-08-01 00:00:00

abstract：:Smith-Lemli-Opitz Syndrome (SLOS) is a developmental disorder (OMIM #270400) caused by autosomal recessive mutations in the Dhcr7 gene, which encodes the enzyme 3β-hydroxysterol-∆7 reductase. SLOS patients present clinically with dysmorphology and neurological, behavioral and cognitive defects, with characteristically...

journal_title：Journal of lipid research

authors： Kanuri B,Fong V,Ponny SR,Tallman KA,Ramachandra Rao S,Porter NA,Fliesler SJ,Patel SB

更新日期：2020-11-17 00:00:00

abstract：:The group IVA calcium-dependent cytosolic phospholipase A2 (cPLA2α) enzyme directs a complex "eicosanoid storm" that accompanies the tissue response to injury. cPLA2α and its downstream eicosanoid mediators are also implicated in the pathogenesis of fibrosis in many organs, including the kidney. We aimed to determine ...

journal_title：Journal of lipid research

authors： Montford JR,Lehman AMB,Bauer CD,Klawitter J,Klawitter J,Poczobutt JM,Scobey M,Weiser-Evans M,Nemenoff RA,Furgeson SB

更新日期：2018-02-01 00:00:00

abstract：:Bile acids are physiological detergents that generate bile flow and facilitate intestinal absorption and transport of lipids, nutrients, and vitamins. Bile acids also are signaling molecules and inflammatory agents that rapidly activate nuclear receptors and cell signaling pathways that regulate lipid, glucose, and en...

journal_title：Journal of lipid research

authors： Chiang JY

更新日期：2009-10-01 00:00:00

abstract：:Oxidized low density lipoprotein (Ox-LDL) has a plethora of components that are not present in native LDL. Their presence and quantity depends on the nature, type, and extent of oxidation. Lipids esterified to oxidized fatty acids are the major components formed during the early phase of oxidation and these show a num...

journal_title：Journal of lipid research

authors： Parthasarathy S,Santanam N,Ramachandran S,Meilhac O

更新日期：1999-12-01 00:00:00

abstract：:Protein farnesylation is a form of posttranslational modification that occurs in most, if not all, eukaryotic cells. Inhibitors of protein farnesyltransferase (PFTIs) have been developed as anticancer chemotherapeutic agents. Using the knowledge gained from the development of PFTIs for the treatment of cancer, researc...

journal_title：Journal of lipid research

authors： Eastman RT,Buckner FS,Yokoyama K,Gelb MH,Van Voorhis WC

更新日期：2006-02-01 00:00:00