Urinary excretion of 2,7, 8-trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman is a major route of elimination of gamma-tocopherol in humans.

abstract：:The extent to which cholesterol synthesis is modulated in macrophage foam cells by changes in cholesterol influx and efflux was determined using thioglycollate-elicited peritoneal macrophages from normal and cholesterol-fed White Carneau (WC) and Show Racer (SR) pigeons. In peritoneal macrophages from normocholesterol...

journal_title：Journal of lipid research

authors： Nordskog BK,Reagan JW Jr,St Clair RW

更新日期：1999-10-01 00:00:00

abstract：:The hepatic synthesis of sterol was measured in the male Mongolian gerbil (Meriones unguiculatus) in vivo following the administration of [3H]water by monitoring the incorporation of radioactivity into digitonin-precipitable sterol. A diurnal rhythm in cholesterol synthesis was exhibited under conditions of ad libitum...

journal_title：Journal of lipid research

authors： Mercer NJ,Holub BJ

更新日期：1981-07-01 00:00:00

abstract：:Lysophospholipid acyltransferases (LPATs) incorporate fatty acyl chains into phospholipids via a CoA-dependent mechanism and are important in remodeling phospholipids to generate the molecular species of phospholipids found in cells. These enzymes use one lysophospholipid and one acyl-CoA ester as substrates. Traditio...

journal_title：Journal of lipid research

authors： Martin SA,Gijón MA,Voelker DR,Murphy RC

更新日期：2014-04-01 00:00:00

abstract：:Pancreatic triglyceride lipase (PTL) and its protein cofactor, colipase, are required for efficient dietary triglyceride digestion. In addition to PTL, pancreatic acinar cells synthesize two pancreatic lipase related proteins (PLRP1 and PLRP2), which have a high degree of sequence and structural homology with PTL. PLR...

journal_title：Journal of lipid research

authors： Lowe ME

更新日期：2002-12-01 00:00:00

abstract：:Scavenger receptor class B type I (SR-BI) and ABCA1 are structurally dissimilar cell surface proteins that play key roles in HDL metabolism. SR-BI is a receptor that binds HDL with high affinity and mediates both the selective lipid uptake of cholesteryl esters from lipid-rich HDL to cells and the efflux of unesterifi...

journal_title：Journal of lipid research

authors： Nieland TJ,Chroni A,Fitzgerald ML,Maliga Z,Zannis VI,Kirchhausen T,Krieger M

更新日期：2004-07-01 00:00:00

abstract：:Chylomicron remnants have been suggested to be involved in the development of atherosclerosis. To investigate the mechanisms of chylomicron remnant-induced atherosclerosis, we prepared cholesterol (Chol)-containing emulsion particles as models for chylomicron remnants. Chol markedly increased the apolipoprotein E (apo...

journal_title：Journal of lipid research

authors： Sakurai A,Morita SY,Wakita K,Deharu Y,Nakano M,Handa T

更新日期：2005-10-01 00:00:00

abstract：:Mutational inactivation of NPC1 largely blocks the movement of LDL-derived cholesterol from the lysosome to the metabolically active, cytosolic pool of sterol that is the substrate for steroid hormone production. Such a block might, in theory, lead to deficiencies in circulating levels of testosterone, progesterone, a...

journal_title：Journal of lipid research

authors： Xie C,Richardson JA,Turley SD,Dietschy JM

更新日期：2006-05-01 00:00:00

abstract：:Lymph fistula rats with either biliary fistula or pancreaticobiliary fistula were used to measure coenzyme A-independent mucosal cholesterol esterifying activity in the presence and absence of pancreatic exocrine secretion. Efficiency of pancreatic diversion was verified to minimize contamination of mucosal homogenate...

journal_title：Journal of lipid research

authors： Watt SM,Simmonds WJ

更新日期：1981-01-01 00:00:00

abstract：:Cyanidin-3-O-β-glucoside (C3G) (CAS number 7084-24-4), a typical anthocyanin pigment that exists in the human diet, has been reported to have anti-inflammatory properties. However, the effect of C3G on lipopolysaccharide (LPS)-induced mastitis and the molecular mechanisms have not been investigated. In this study, we ...

journal_title：Journal of lipid research

authors： Fu Y,Wei Z,Zhou E,Zhang N,Yang Z

更新日期：2014-06-01 00:00:00

abstract：:Inhibition of Ehrlich ascites carcinoma respiration by aqueous extracts of oxidized linoleic or linolenic acid (aqueous emulsions UV-irradiated, 90 min) was associated entirely with relatively involatile compounds which were both thiobarbituric acid (TBA)-reactive and peroxidase-reactive. Inhibitory compounds were hea...

journal_title：Journal of lipid research

authors： Baker N,Wilson L

更新日期：1966-05-01 00:00:00

abstract：:The effect of inhibiting lysosomal protein degradation on the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase was determined using a mouse mammary cell line (TS-85) which expresses a temperature-sensitive mutation in the ubiquitin degradative pathway. Incubating cells for 18 hr in medium containi...

journal_title：Journal of lipid research

authors： Tanaka RD,Li AC,Fogelman AM,Edwards PA

更新日期：1986-03-01 00:00:00

abstract：:The antitumor effect of daily individual administration of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (2 g/kg body weight) in Balb/c mice bearing a transplantable thymoma was investigated. Mice received oleic acid (control group), EPA and DHA ethyl esters starting 10 days before tumor inoculation. Anal...

journal_title：Journal of lipid research

authors： Calviello G,Palozza P,Di Nicuolo F,Maggiano N,Bartoli GM

更新日期：2000-02-01 00:00:00

abstract：:The objective of this study was to investigate the mobilization of individual fatty acids from human subcutaneous adipose tissue in vivo. Concentrations of individual non-esterified fatty acids were measured in arterialized plasma and in the venous drainage from subcutaneous abdominal adipose tissue in eight normal su...

journal_title：Journal of lipid research

authors： Halliwell KJ,Fielding BA,Samra JS,Humphreys SM,Frayn KN

更新日期：1996-09-01 00:00:00

abstract：:Agonist-induced lipolysis of adipose fat is robustly inhibited by insulin or by feedback inhibition by the long-chain fatty acids (LCFA) produced during lipolysis. However, the mode of action of LCFA in suppressing adipose lipolysis is not clear. β,β'-Tetramethyl hexadecanedioic acid (Mββ/ EDICA16) is a synthetic LCFA...

journal_title：Journal of lipid research

authors： Kalderon B,Azazmeh N,Azulay N,Vissler N,Valitsky M,Bar-Tana J

更新日期：2012-05-01 00:00:00

abstract：:Atherosclerosis is a chronic inflammatory response characterized by the accumulation of cells of innate and acquired immune systems within the intima of the arterial wall. Macrophages are the predominant participant in innate immune responses in atherosclerosis. Protein receptors expressed by macrophages and endotheli...

journal_title：Journal of lipid research

authors： Tobias P,Curtiss LK

更新日期：2005-03-01 00:00:00

abstract：:Inositol lipid kinases have been studied extensively in both plant and animal systems. However, major limitations for in vitro studies of recombinant lipid kinases are the low specific activity and instability of the purified proteins. Our goal was to determine if cyclodextrins would provide an effective substrate del...

journal_title：Journal of lipid research

authors： Davis AJ,Perera IY,Boss WF

更新日期：2004-09-01 00:00:00

abstract：:Biliary lipids (bile salts, phospholipids, cholesterol, plant sterols) were determined in 89 vertebrate species (cartilaginous and bony fish, reptiles, birds, and mammals), and individual phospholipid classes were measured in 35 species. All samples contained conjugated bile salts (C(27) bile alcohol sulfates and/or N...

journal_title：Journal of lipid research

authors： Moschetta A,Xu F,Hagey LR,van Berge-Henegouwen GP,van Erpecum KJ,Brouwers JF,Cohen JC,Bierman M,Hobbs HH,Steinbach JH,Hofmann AF

更新日期：2005-10-01 00:00:00

abstract：:The technique of freeze fracture was used to visualize triglyceride (TG) hydrolysis and the production of lipolytic products (LPs) in vitro and in vivo in the presence of bile salts (BS). Three systems were investigated: pure lipolytic products (oleic acid and monoolein) in the presence of a pure bile salt (taurodeoxy...

journal_title：Journal of lipid research

authors： Rigler MW,Honkanen RE,Patton JS

更新日期：1986-08-01 00:00:00

abstract：:A simplified method for the preparation of the Dittmer-Lester spray for the detection of phospholipids on thin-layer chromatograms is described. ...

journal_title：Journal of lipid research

authors： Vaskovsky VE,Kostetsky EY

更新日期：1968-05-01 00:00:00

abstract：:In this study, we have documented immunochemical properties of apolipoprotein (apo) B-containing particles (LpB) extracted from human atherosclerotic lesions obtained during vascular reconstructive surgery of patients. These properties were compared to those of particles purified from corresponding atherosclerotic pla...

journal_title：Journal of lipid research

authors： Tailleux A,Torpier G,Caron B,Fruchart JC,Fievet C

更新日期：1993-05-01 00:00:00

abstract：:Apart from exhibiting the presence of lipoprotein [a] in its plasma, another interest of the European hedgehog in lipoprotein research lies in the quantitative prominence of a complex spectrum of high density lipoproteins (HDL) and very high density lipoproteins (VHDL) as cholesterol transporters in plasma (Laplaud, P...

journal_title：Journal of lipid research

authors： Sparrow DA,Laplaud PM,Saboureau M,Zhou G,Dolphin PJ,Gotto AM Jr,Sparrow JT

更新日期：1995-03-01 00:00:00

abstract：:At onset of egg-laying in the chicken, plasma levels of apolipoprotein VLDL-II (apoII) increase dramatically, suggesting a function of apoII in yolk deposition of triglyceride-rich lipoproteins. Thus, the possibility that this female-specific homodimeric protein (Mr of subunit, 9500) is recognized by the oocyte recept...

journal_title：Journal of lipid research

authors： Nimpf J,George R,Schneider WJ

更新日期：1988-05-01 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) is present in the blood plasma and acts as a pivotal intercellular signal transmitter in the immune system by recruiting lymphocytes from the thymus and secondary lymphoid tissues. The plasma S1P concentration is maintained by the supply of S1P from erythrocytes. Previously, we showed tha...

journal_title：Journal of lipid research

authors： Kobayashi N,Otsuka M,Yamaguchi A,Nishi T

更新日期：2016-11-01 00:00:00

abstract：:Membranes of mammalian cells contain lysophosphatidic acid acyltransferase (LPAAT) activities that catalyze the acylation of sn-1-acyl lysophosphatidic acid (lysoPA) to form phosphatidic acid. As the biological roles and biochemical properties of the six known LPAAT isoforms have yet to be fully elucidated, we have ch...

journal_title：Journal of lipid research

authors： Hollenback D,Bonham L,Law L,Rossnagle E,Romero L,Carew H,Tompkins CK,Leung DW,Singer JW,White T

更新日期：2006-03-01 00:00:00

abstract：:Hepatic lipase (HL) is a lipolytic enzyme, synthesized by hepatocytes and found localized at the surface of liver sinusoid capillaries. In humans, the enzyme is mostly bound onto heparan-sulfate proteoglycans at the surface of hepatocytes and also of sinusoid endothelial cells. HL shares a number of functional domains...

journal_title：Journal of lipid research

authors： Perret B,Mabile L,Martinez L,Tercé F,Barbaras R,Collet X

更新日期：2002-08-01 00:00:00

abstract：:The genus Acinetobacter is composed of ubiquitous, generally nonpathogen environmental bacteria. Interest concerning these microorganisms has increased during the last 30 years, because some strains, belonging to the so-called A. baumannii-A. calcoaceticus complex, have been implicated in some severe pathological stat...

journal_title：Journal of lipid research

authors： Leone S,Sturiale L,Pessione E,Mazzoli R,Giunta C,Lanzetta R,Garozzo D,Molinaro A,Parrilli M

更新日期：2007-05-01 00:00:00

abstract：:Sphingolipid metabolites function as signaling molecules in mammalian cells, influencing cell proliferation, migration, and death. Recently, sphingolipid signaling has been implicated in the regulation of developmental processes in Drosophila melanogaster. However, biochemical analysis of endogenous Drosophila sphingo...

journal_title：Journal of lipid research

authors： Fyrst H,Herr DR,Harris GL,Saba JD

更新日期：2004-01-01 00:00:00

abstract：:Studies were conducted to explore vitamin A transport in the non-mammalian vertebrates, especially Pisces, Amphibia, and Reptilia, and to isolate and partially characterize piscine retinol-binding protein. Retinol-containing proteins in fresh plasma obtained from bullfrogs and a turtle exhibited similar properties to ...

journal_title：Journal of lipid research

authors： Shidoji Y,Muto Y

更新日期：1977-11-01 00:00:00

abstract：:N-acylethanolamines (NAEs) are a group of lipid mediators synthesized in response to a number of physiological and pathological stimuli. Because of the low tissue concentrations of NAEs, analyses often include liquid extraction followed by solid-phase extraction and subsequent quantitation by LC/MS or GC/MS. Reported ...

journal_title：Journal of lipid research

authors： Skonberg C,Artmann A,Cornett C,Hansen SH,Hansen HS

更新日期：2010-10-01 00:00:00

abstract：:The phospholipase A2(PLA2) activity of peroxiredoxin (Prdx)6 has important physiological roles in the synthesis of lung surfactant and in the repair of peroxidized cell membranes. These functions require the activity of a lysophospholipid acyl transferase as a critical component of the phospholipid remodeling pathway....

journal_title：Journal of lipid research

authors： Fisher AB,Dodia C,Sorokina EM,Li H,Zhou S,Raabe T,Feinstein SI

更新日期：2016-04-01 00:00:00