Thematic review series: The immune system and atherogenesis. Paying the price for pathogen protection: toll receptors in atherogenesis.

abstract：:Ecdysteroids are potent developmental regulators that control molting, reproduction, and stress response in arthropods. In developing larvae, picogram quantities of individual ecdysteroids and their conjugated forms are present along with milligrams of structural and energy storage lipids. To enhance the specificity a...

journal_title：Journal of lipid research

authors： Lavrynenko O,Nedielkov R,Möller HM,Shevchenko A

更新日期：2013-08-01 00:00:00

abstract：:The sphingomyelin pathway is an important signal transduction system regulating various cellular functions. However, little is known about the effect of sphingomyelin metabolites on vasomotor function. We examined the vascular effects of sphingomyelin, sphingosine, and sphingomyelinase (SPMase) in vitro. In pig corona...

journal_title：Journal of lipid research

authors： Murohara T,Kugiyama K,Ohgushi M,Sugiyama S,Ohta Y,Yasue H

更新日期：1996-07-01 00:00:00

abstract：:A method is described for determining the long-chain base content of glycosphingolipids after acid hydrolysis, using the new reagent fluorescamine. The reaction is sensitive and can be used to characterize or measure glycosphingolipids in quantities routinely separated by thin-layer chromatography. ...

journal_title：Journal of lipid research

authors： Kisic A,Rapport MM

更新日期：1974-03-01 00:00:00

abstract：:The skin surface represents our interface with the external environment, and as such, is our first line of defense against microbial colonization and infection. Lipids at the skin surface are thought to underlie at least part of an antimicrobial barrier. Some of these lipids are synthesized in the epidermis and are ca...

journal_title：Journal of lipid research

authors： Drake DR,Brogden KA,Dawson DV,Wertz PW

更新日期：2008-01-01 00:00:00

abstract：:An enzyme (phosphatidyl glycerophosphate phosphatase) that catalyzes the formation of phosphatidyl glycerol from phosphatidyl glycerophosphate has been rendered soluble by treatment of the particulate fraction of E. coli with Triton X-100 in the presence of EDTA, and has been partially purified. The enzyme is specific...

journal_title：Journal of lipid research

authors： Chang YY,Kennedy EP

更新日期：1967-09-01 00:00:00

abstract：:HDL-associated paraoxonase type 1 (PON1) can protect LDL and HDL against oxidative modification in vitro and therefore may protect against cardiovascular disease. We investigated the effects of PON1 levels, activity, and genetic variation on high density lipoprotein-cholesterol (HDL-C) levels, circulating oxidized LDL...

journal_title：Journal of lipid research

authors： van Himbergen TM,Roest M,de Graaf J,Jansen EH,Hattori H,Kastelein JJ,Voorbij HA,Stalenhoef AF,van Tits LJ

更新日期：2005-03-01 00:00:00

abstract：:In a previously described method for determining the activity of cerebroside galactosidase, the enzyme preparation was incubated with an emulsion of cerebroside which had been labeled in the galactose moiety. The liberated galactose was separated from the emulsion by liquid-liquid partitioning, but the presence of det...

journal_title：Journal of lipid research

authors： Radin NS,Arora RC

更新日期：1971-03-01 00:00:00

abstract：:The major high density lipoprotein (HDL) apolipoprotein, apoA-I, was knocked out by gene targeting in ES cells to provide a model for the study of HDL metabolism and its relationship to plasma and tissue cholesterol metabolism. HDL and non-HDL cholesterol (HDL-C) were reduced in apoA-I-deficient mice. Feeding a high f...

journal_title：Journal of lipid research

authors： Plump AS,Azrolan N,Odaka H,Wu L,Jiang X,Tall A,Eisenberg S,Breslow JL

更新日期：1997-05-01 00:00:00

abstract：:The conversion of alpha-linolenate (18:3n-3) to docosahexaenoate (22:6n-3) in the presence of low and high dietary levels of linoleate (18:2n-6) is reported in young rats using [U-13C]-alpha-linolenic acid (18:2n-3*) and high precision gas chromatography-combustion isotope ratio mass spectrometry (GCC-IRMS). After con...

journal_title：Journal of lipid research

authors： Sheaff RC,Su HM,Keswick LA,Brenna JT

更新日期：1995-05-01 00:00:00

abstract：:The intestinal bacterium Eubacterium sp. strain VPI 12708 has been shown to have a bile acid 7 alpha/7 beta-dehydroxylation pathway. A large bile acid inducible (bai) operon encoding at least 9 open reading frames has been cloned and sequenced from this bacterium. The baiE gene from this operon has been subcloned and ...

journal_title：Journal of lipid research

authors： Dawson JA,Mallonee DH,Björkhem I,Hylemon PB

更新日期：1996-06-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the United States and, indeed, worldwide. It has become a global public health issue. In the United States, the prevalence in the general population is estimated at approximately 20%, while that in the morbidly obese population at approximate...

journal_title：Journal of lipid research

authors： Erickson SK

更新日期：2009-04-01 00:00:00

abstract：:Mixed background SHP(-/-) mice are resistant to diet-induced obesity due to increased energy expenditure caused by enhanced PGC-1α expression in brown adipocytes. However, congenic SHP(-/-) mice on the C57BL/6 background showed normal expression of PGC-1α and other genes involved in brown adipose tissue thermogenesis....

journal_title：Journal of lipid research

authors： Park YJ,Kim SC,Kim J,Anakk S,Lee JM,Tseng HT,Yechoor V,Park J,Choi JS,Jang HC,Lee KU,Novak CM,Moore DD,Lee YK

更新日期：2011-12-01 00:00:00

abstract：:Phosphatidylcholine preparations containing saturated and unsaturated molecular species were subjected to KMnO(4)-NaIO(4) oxidation in aqueous acetic acid, which left only disaturated species intact. After the oxidation, the remaining intact phosphatidylcholine was separated by thin-layer chromatography. The procedure...

journal_title：Journal of lipid research

authors： Shimojo T,Abe M,Ota M

更新日期：1974-09-01 00:00:00

abstract：:Our previous studies have shown accumulation of GM2 ganglioside during ethanol-induced neurodegeneration in the developing brain, and GM2 elevation has also been reported in other brain injuries and neurodegenerative diseases. Using GM2/GD2 synthase KO mice lacking GM2/GD2 and downstream gangliosides, the current stud...

journal_title：Journal of lipid research

authors： Saito M,Wu G,Hui M,Masiello K,Dobrenis K,Ledeen RW,Saito M

更新日期：2015-08-01 00:00:00

abstract：:A method for the preparation of 1-alkyl 2-acyl glycero-3-phosphorylcholine, labeled in the 2-position with oleic acid-1-(14)C is described. This method, based on the acylation of a 1-alkyl glycero-3-phosphorylcholine-CdCl(2) complex which is, in turn, formed from 1-alk-1-enyl glycero-3-phosphorylcholine by hydrogenati...

journal_title：Journal of lipid research

authors： Poulos A

更新日期：1970-09-01 00:00:00

abstract：:Lipidomics, the mass spectrometry-based comprehensive analysis of lipids, has attracted attention as an analytical approach to provide novel insight into lipid metabolism and to search for biomarkers. However, an ideal method for both comprehensive and quantitative analysis of lipids has not been fully developed. Here...

journal_title：Journal of lipid research

authors： Takeda H,Izumi Y,Takahashi M,Paxton T,Tamura S,Koike T,Yu Y,Kato N,Nagase K,Shiomi M,Bamba T

更新日期：2018-07-01 00:00:00

abstract：:Effects of serum cholesterol on cholesterol content in the retina are currently unknown. It is also unclear how cholesterol levels are controlled in the retina. High-cholesterol diet and oral administrations of simvastatin were used to modulate serum cholesterol in mice. These treatments only modestly affected cholest...

journal_title：Journal of lipid research

authors： Zheng W,Mast N,Saadane A,Pikuleva IA

更新日期：2015-01-01 00:00:00

abstract：:Loss of function of Niemann-Pick C1 (NPC1) leads to lysosomal free cholesterol storage, resulting in the neurodegenerative disease Niemann-Pick disease type C (NPC). Significant numbers of patients with NPC also suffer from liver disease. Currently, no treatments exist that alter patient outcome, and it is unknown if ...

journal_title：Journal of lipid research

authors： Sayre NL,Rimkunas VM,Graham MJ,Crooke RM,Liscum L

更新日期：2010-08-01 00:00:00

abstract：:Autotaxin (ATX), which is highly expressed and secreted by adipocytes, functions as the key enzyme to generate lysophosphatidic acid (LPA) from lysophosphatidylcholine. Adipose tissue is the main source of circulating ATX that modulates plasma LPA levels. Upregulation of ATX expression in obese patients and mice is cl...

journal_title：Journal of lipid research

authors： Sun S,Wang R,Song J,Guan M,Li N,Zhang X,Zhao Z,Zhang J

更新日期：2017-11-01 00:00:00

abstract：:Rats were fed a low protein diet deficient in and supplemented with lysine and threonine. Liver lipids contained more lecithin, sphingomyelin, and free fatty acids, and less amino phospholipids in the deficient rats. No variations in fatty acid composition of choline- and ethanolamine-containing phospholipids were fou...

journal_title：Journal of lipid research

authors： Viviani R,Sechi AM,Lenaz G

更新日期：1966-07-01 00:00:00

abstract：:Lilly PCSK9 antibody LY3015014 (LY) is a monoclonal antibody (mAb) that neutralizes proprotein convertase subtilisin-kexin type 9 (PCSK9). LY decreases LDL cholesterol in monkeys and, unlike other PCSK9 mAbs, does not cause an accumulation of intact PCSK9 in serum. Comparing the epitope of LY with other clinically tes...

journal_title：Journal of lipid research

authors： Schroeder KM,Beyer TP,Hansen RJ,Han B,Pickard RT,Wroblewski VJ,Kowala MC,Eacho PI

更新日期：2015-11-01 00:00:00

abstract：:In mammals, white adipose tissue (WAT) stores and releases lipids, whereas brown adipose tissue (BAT) oxidizes lipids to fuel thermogenesis. In obese individuals, WAT undergoes profound changes; it expands, becomes dysfunctional, and develops a low-grade inflammatory state. Importantly, BAT content and activity declin...

journal_title：Journal of lipid research

authors： Kotzbeck P,Giordano A,Mondini E,Murano I,Severi I,Venema W,Cecchini MP,Kershaw EE,Barbatelli G,Haemmerle G,Zechner R,Cinti S

更新日期：2018-05-01 00:00:00

abstract：:Oxylipins are potent lipid mediators involved in a variety of physiological processes. Their profiling has the potential to provide a wealth of information regarding human health and disease and is a promising technology for translation into clinical applications. However, results generated by independent groups are r...

journal_title：Journal of lipid research

authors： Mainka M,Dalle C,Pétéra M,Dalloux-Chioccioli J,Kampschulte N,Ostermann AI,Rothe M,Bertrand-Michel J,Newman JW,Gladine C,Schebb NH

更新日期：2020-11-01 00:00:00

abstract：:Lipogenesis in vitro from acetate-1-(14)C was studied in human preputial skin and abdominal skin. Radioactive lipids were separated by column chromatography on Florisil and by thin-layer chromatography on silica gel. Radioactivity was incorporated chiefly into the triglyceride, sterol, and polar lipid fractions, while...

journal_title：Journal of lipid research

authors： Vroman HE,Nemecek RA,Hsia SL

更新日期：1969-09-01 00:00:00

abstract：:Adipose tissue contains one of the largest reservoirs of cholesterol in the body. Adipocyte dysfunction in obesity is associated with intracellular cholesterol accumulation, and alterations in cholesterol homeostasis have been shown to alter glucose metabolism in cultured adipocytes. ABCA1 plays a major role in choles...

journal_title：Journal of lipid research

authors： de Haan W,Bhattacharjee A,Ruddle P,Kang MH,Hayden MR

更新日期：2014-03-01 00:00:00

abstract：:Fatty acid elongases and desaturases play an important role in hepatic and whole body lipid composition. We examined the role that key transcription factors played in the control of hepatic elongase and desaturase expression. Studies with peroxisome proliferator-activated receptor alpha (PPARalpha)-deficient mice esta...

journal_title：Journal of lipid research

authors： Wang Y,Botolin D,Xu J,Christian B,Mitchell E,Jayaprakasam B,Nair MG,Peters JM,Busik JV,Olson LK,Jump DB

更新日期：2006-09-01 00:00:00

abstract：:The recent insight that inflammation contributes to the development of atherosclerosis and type 2 diabetes mellitus constitutes a major breakthrough in understanding the mechanisms underlying these conditions. In addition, it opens the way for new therapeutic approaches that might eventually decrease the prevalence of...

journal_title：Journal of lipid research

authors： Popa C,Netea MG,van Riel PL,van der Meer JW,Stalenhoef AF

更新日期：2007-04-01 00:00:00

abstract：:Although the synthesis pathways of intracellular triacylglycerol (TAG) species have been well elucidated, assessment of the contribution of an individual pathway to TAG pools in different mammalian organs, particularly under pathophysiological conditions, is difficult, although not impossible. Herein, we developed and...

journal_title：Journal of lipid research

authors： Han RH,Wang M,Fang X,Han X

更新日期：2013-04-01 00:00:00

abstract：:Sonication of rat fat cells caused an increase in lipolysis in the absence of lipolytic stimulants (basal lipolysis) and loss of epinephrine responsiveness. Sonication of endogenous lipid droplets from fat cells also induced an increase in lipolysis in the presence of hormone-sensitive lipase (HSL) and loss of epineph...

journal_title：Journal of lipid research

authors： Okuda H,Morimoto C,Tsujita T

更新日期：1994-01-01 00:00:00

abstract：:The role of nuclear membrane phospholipids as targets of phospholipases resulting in the generation of nuclear signaling messengers has received attention. In the present study, we have exploited the utility of electrospray ionization mass spectrometry to determine the phospholipid content of nuclei isolated from perf...

journal_title：Journal of lipid research

authors： Williams SD,Hsu FF,Ford DA

更新日期：2000-10-01 00:00:00