Conversion of alpha-linolenate to docosahexaenoate is not depressed by high dietary levels of linoleate in young rats: tracer evidence using high precision mass spectrometry.

abstract：:The activity of phospholipase A on phosphatidyl choline and phosphatidal choline spread as monolayers on phosphate buffers containing snake venom (Crotalus atrox or Naja naja) was studied by measuring the fall of surface potential as a function of time, pH, film pressure, temperature, and concentrations of phosphate a...

journal_title：Journal of lipid research

authors： Colacicco G,Rapport MM

更新日期：1966-03-01 00:00:00

abstract：:Mutations in the genes coding for patatin-like phospholipase domain-containing 1 (PNPLA1) and α/β-hydrolase domain-containing 5 (ABHD5), also known as comparative gene identification 58, are causative for ichthyosis, a severe skin barrier disorder. Individuals with mutations in either of these genes show a defect in e...

journal_title：Journal of lipid research

authors： Kien B,Grond S,Haemmerle G,Lass A,Eichmann TO,Radner FPW

更新日期：2018-12-01 00:00:00

abstract：:In an attempt to understand the applicability of various animal models to dyslipidemia in humans and to identify improved preclinical models for target discovery and validation for dyslipidemia, we measured comprehensive plasma lipid profiles in 24 models. These included five mouse strains, six other nonprimate specie...

journal_title：Journal of lipid research

authors： Yin W,Carballo-Jane E,McLaren DG,Mendoza VH,Gagen K,Geoghagen NS,McNamara LA,Gorski JN,Eiermann GJ,Petrov A,Wolff M,Tong X,Wilsie LC,Akiyama TE,Chen J,Thankappan A,Xue J,Ping X,Andrews G,Wickham LA,Gai CL,Trinh

更新日期：2012-01-01 00:00:00

abstract：:Six African green monkeys were labeled intravenously with [1,2-(3)H]cholesterol while consuming a cholesterol-free liquid formula diet. The plasma cholesterol specific activity was compared with the specific activity of the biliary cholesterol and bile acids and with the fecal neutral steroids in order to determine wh...

journal_title：Journal of lipid research

authors： Henderson GR,St Clair RW

更新日期：1980-09-01 00:00:00

abstract：:Previous studies have indicated that a G to A substitution at position -76 in the gene encoding apolipoprotein A-I (apoA-I) confers increased plasma high density lipoprotein cholesterol (HDL-C). Increased HDL-C may be a direct consequence of the A allele, or may reflect the action of a locus in linkage disequilibrium ...

journal_title：Journal of lipid research

authors： Barre DE,Guerra R,Verstraete R,Wang Z,Grundy SM,Cohen JC

更新日期：1994-07-01 00:00:00

abstract：:Autosomal recessive polycystic kidney disease (ARPKD) is a severe, monogenetically inherited kidney and liver disease. PCK rats carrying the orthologous mutant gene serve as a model of human disease, and alterations in lipid profiles in PCK rats suggest that defined subsets of lipids may be useful as molecular disease...

journal_title：Journal of lipid research

authors： Ruh H,Salonikios T,Fuchser J,Schwartz M,Sticht C,Hochheim C,Wirnitzer B,Gretz N,Hopf C

更新日期：2013-10-01 00:00:00

abstract：:Choline glycerophospholipids and ethanolamine glycerophospholipids of ruminant skeletal muscle contain approximately 40% and 65% plasmalogen, respectively. In the 1,2-diacyl-sn-glycero-3-phosphocholine (diacyl CPG), 16:0-18:2(n-6) and 16:0-18:1(n-9) accounted for about 50% of the total molecular species; in the 2-acyl...

journal_title：Journal of lipid research

authors： Scott TW,Ashes JR,Fleck E,Gulati SK

更新日期：1993-05-01 00:00:00

abstract：:As microsomal triglyceride transfer protein (MTP) is required for the assembly and secretion of apoB-containing lipoproteins by intestinal epithelial cells, the characterization and regulation of MTP in human intestinal cells, CaCo-2, was studied. CaCo-2 cells express MTP mRNA of 4.2 kb and a 97 kDa subunit of MTP pro...

journal_title：Journal of lipid research

authors： Mathur SN,Born E,Murthy S,Field FJ

更新日期：1997-01-01 00:00:00

abstract：:Adipose differentiation-related protein (ADRP) is a lipid droplet-associated protein that is expressed in various tissues. In mice treated with the peroxisome proliferator-activated receptor alpha (PPARalpha) agonist Wy14,643 (Wy), hepatic mRNA and protein levels of ADRP as well as hepatic triglyceride content increas...

journal_title：Journal of lipid research

authors： Edvardsson U,Ljungberg A,Lindén D,William-Olsson L,Peilot-Sjögren H,Ahnmark A,Oscarsson J

更新日期：2006-02-01 00:00:00

abstract：:In mammals, because they share a single synthetic pathway, n-6/n-3 ratios of dietary PUFAs impact tissue arachidonic acid (ARA) and DHA content. Likewise, SNPs in the human fatty acid desaturase (FADS) gene cluster impact tissue ARA and DHA. Here we tested the feasibility of using heterozygous Fads2-null-mice (HET) as...

journal_title：Journal of lipid research

authors： Su H,Zhou D,Pan YX,Wang X,Nakamura MT

更新日期：2016-11-01 00:00:00

abstract：:We have performed plasma lipid profiling using liquid chromatography electrospray ionization tandem mass spectrometry on a population cohort of more than 1,000 individuals. From 10 μl of plasma we were able to acquire comparative measures of 312 lipids across 23 lipid classes and subclasses including sphingolipids, ph...

journal_title：Journal of lipid research

authors： Weir JM,Wong G,Barlow CK,Greeve MA,Kowalczyk A,Almasy L,Comuzzie AG,Mahaney MC,Jowett JB,Shaw J,Curran JE,Blangero J,Meikle PJ

更新日期：2013-10-01 00:00:00

abstract：:Experimental approaches involving the perfusion of tissues and organs offer the advantage of improved physiological relevance over the use of isolated tissues or cells while at the same time being much more controlled and tissue-specific than studies in vivo. Nevertheless, there have been few metabolic studies perform...

journal_title：Journal of lipid research

authors： Cònsol G,Moles A,Ricart-Jané D,Llobera M

更新日期：2005-08-01 00:00:00

abstract：:Vitamin E (α-tocopherol) is the major lipid-soluble antioxidant in many species. Niemann-Pick type C (NPC) disease is a lysosomal storage disorder caused by mutations in the NPC1 or NPC2 gene, which regulates lipid transport through the endocytic pathway. NPC disease is characterized by massive intracellular accumulat...

journal_title：Journal of lipid research

authors： Ulatowski L,Parker R,Davidson C,Yanjanin N,Kelley TJ,Corey D,Atkinson J,Porter F,Arai H,Walkley SU,Manor D

更新日期：2011-07-01 00:00:00

abstract：:The melanocortin system is an important regulator of energy balance, and melanocortin 4 receptor (MC4R) deficiency is the most common monogenic cause of obesity. We investigated whether the relationship between melanocortin system activity and energy expenditure (EE) is mediated by brown adipose tissue (BAT) activity....

journal_title：Journal of lipid research

authors： Kooijman S,Boon MR,Parlevliet ET,Geerling JJ,van de Pol V,Romijn JA,Havekes LM,Meurs I,Rensen PC

更新日期：2014-10-01 00:00:00

abstract：:The in vivo formation of the sulfate ester of glycolithocholate is a critical step in the elimination of this hepatotoxic bile salt. Rhesus monkeys fed chenodeoxycholate or ursodeoxycholate, the precursors of lithocholate, develop frank cirrhosis in association with accumulation of nonsulfated glycolithocholate in bil...

journal_title：Journal of lipid research

authors： Barnes S,Waldrop R,Crenshaw J,King RJ,Taylor KB

更新日期：1986-11-01 00:00:00

abstract：:We studied the effects of the lecithin:cholesterol acyltransferase reaction on the size and composition of the small spherical high density lipoproteins of patients afflicted with familial lecithin:cholesterol acyltransferase deficiency. We isolated these lipoproteins by preparative ultracentrifugation and rate zonal ...

journal_title：Journal of lipid research

authors： Chen C,Applegate K,King WC,Glomset JA,Norum KR,Gjone E

更新日期：1984-03-01 00:00:00

abstract：:Previous studies have demonstrated that perturbations in barrier function stimulate epidermal lipid synthesis and that this increase can be prevented by occlusive membranes. These observations suggest that epidermal lipid synthesis might be related to barrier function and raised the question whether transcutaneous wat...

journal_title：Journal of lipid research

authors： Grubauer G,Elias PM,Feingold KR

更新日期：1989-03-01 00:00:00

abstract：:A new method for the purification of apolipoprotein H by affinity chromatography followed by continuous-elution electrophoresis is described. It is both simpler and less complicated than the chromatographic and electrophoretic methods usually used. In addition, apolipoprotein H is isolated in a pure, structurally uncl...

journal_title：Journal of lipid research

authors： Gambino R,Ruiu G,Cassader M,Pagano G

更新日期：1996-04-01 00:00:00

abstract：:This study was undertaken to determine the mechanisms that regulate cholesterol synthesis in vivo and to quantitate the relative importance of the liver and extrahepatic tissues as sites for sterol synthesis. Rats were administered [3H]water intravenously and killed 1 hour later. The amount of [3H]water incorporated i...

journal_title：Journal of lipid research

authors： Jeske DJ,Dietschy JM

更新日期：1980-03-01 00:00:00

abstract：:Chemokines are a family of cytokines inducing cell migration and inflammation. Recent reports have implicated the roles of chemokines in cell differentiation. However, little is known about the functional roles of chemokines in adipocytes. Here, we explored gene expression levels of chemokines and chemokine receptors ...

journal_title：Journal of lipid research

authors： Kusuyama J,Komorizono A,Bandow K,Ohnishi T,Matsuguchi T

更新日期：2016-10-01 00:00:00

abstract：:A sensitive and reproducible method has been developed for separation of the major serum lipoproteins from 1 ml or less of human serum by isopycnic density gradient ultracentrifugation. The serum, applied to a step gradient (total volume 12.8 ml), was spun for 48 hr at 38,000 rpm at 10 degrees C and, in each of the fr...

journal_title：Journal of lipid research

authors： Foreman JR,Karlin JB,Edelstein C,Juhn DJ,Rubenstein AH,Scanu AM

更新日期：1977-11-01 00:00:00

abstract：:The differentiation of macrophages into lipid-filled foam cells is a hallmark of the lung granuloma that forms in patients with active tuberculosis (TB). Mycolic acids (MAs), the abundant lipid virulence factors in the cell wall of Mycobacterium tuberculosis (Mtb), can induce this foam phenotype possibly as a way to p...

journal_title：Journal of lipid research

authors： Vermeulen I,Baird M,Al-Dulayymi J,Smet M,Verschoor J,Grooten J

更新日期：2017-04-01 00:00:00

abstract：:Acetyl-L-carnitine is known as a reservoir of activated acetyl units and as a modulator of metabolic function. The objective of this study was to quantify the fate of the acetyl moiety of acetyl-L-carnitine in lipogenic pathways. Lipogenesis was studied in an adipocyte model, differentiated 3T3-L1 cells, and a hepatom...

journal_title：Journal of lipid research

authors： Lligona-Trulla L,Arduini A,Aldaghlas TA,Calvani M,Kelleher JK

更新日期：1997-07-01 00:00:00

abstract：:At 123 K, crystals of cholesteryl cis-9-hexadecenoate (cholesteryl palmitoleate, C45H74O2) are monoclinic, space group P2(1) with cell dimensions a = 12.917(7), b = 8.910(5), c = 34.04(1) A, beta = 94.95(7) degrees [lambda(CuK alpha) = 1.5424 A] having two independent molecules (A and B) per unit cell. The crystal str...

journal_title：Journal of lipid research

authors： Craven BM,Sawzik P

更新日期：1984-08-01 00:00:00

abstract：:In vitro, -polylysine (EPL) strongly inhibited the hydrolysis of trioleoylglycerol emulsified with phosphatidylcholine (PC) and taurocholate by either pancreatic lipase or carboxylester lipase. The EPL concentration required for 50% inhibition of pancreatic lipase, 0.12 microM, was eight times lower than the concentra...

journal_title：Journal of lipid research

authors： Tsujita T,Takaichi H,Takaku T,Aoyama S,Hiraki J

更新日期：2006-08-01 00:00:00

abstract：:Rats were fed a low protein diet deficient in and supplemented with lysine and threonine. Liver lipids contained more lecithin, sphingomyelin, and free fatty acids, and less amino phospholipids in the deficient rats. No variations in fatty acid composition of choline- and ethanolamine-containing phospholipids were fou...

journal_title：Journal of lipid research

authors： Viviani R,Sechi AM,Lenaz G

更新日期：1966-07-01 00:00:00

abstract：:Groups of gerbils were fed purified diets containing either 10 or 20% of safflower, olive, or coconut oil. Each diet was fed without cholesterol and with 0.1 and 0.2% of added cholesterol. The animals were bled after 2, 4, and 8 wk for the determination of the level of serum cholesterol. The major factors affecting th...

journal_title：Journal of lipid research

authors： Hegsted DM,Gallagher A

更新日期：1967-05-01 00:00:00

abstract：:This review presents an overview of mammalian phospholipid synthesis and the cellular locations of the biochemical activities that produce membrane lipid molecular species. The generalized endoplasmic reticulum compartment is a central site for membrane lipid biogenesis, and examples of the emerging relationships betw...

journal_title：Journal of lipid research

authors： Fagone P,Jackowski S

更新日期：2009-04-01 00:00:00

abstract：:Major neutral glycosphingolipid components were extracted from Sporothrix schenckii, a dimorphic fungus exhibiting a hyphal saprophytic phase and a yeast parasitic phase responsible for chronic mycotic infections in mammalian hosts. These components, one from the mycelial form and two from the yeast form, were purifie...

journal_title：Journal of lipid research

authors： Toledo MS,Levery SB,Straus AH,Takahashi HK

更新日期：2000-05-01 00:00:00

abstract：:HDL-associated paraoxonase type 1 (PON1) can protect LDL and HDL against oxidative modification in vitro and therefore may protect against cardiovascular disease. We investigated the effects of PON1 levels, activity, and genetic variation on high density lipoprotein-cholesterol (HDL-C) levels, circulating oxidized LDL...

journal_title：Journal of lipid research

authors： van Himbergen TM,Roest M,de Graaf J,Jansen EH,Hattori H,Kastelein JJ,Voorbij HA,Stalenhoef AF,van Tits LJ

更新日期：2005-03-01 00:00:00