Abstract:
:We have performed plasma lipid profiling using liquid chromatography electrospray ionization tandem mass spectrometry on a population cohort of more than 1,000 individuals. From 10 μl of plasma we were able to acquire comparative measures of 312 lipids across 23 lipid classes and subclasses including sphingolipids, phospholipids, glycerolipids, and cholesterol esters (CEs) in 20 min. Using linear and logistic regression, we identified statistically significant associations of lipid classes, subclasses, and individual lipid species with anthropometric and physiological measures. In addition to the expected associations of CEs and triacylglycerol with age, sex, and body mass index (BMI), ceramide was significantly higher in males and was independently associated with age and BMI. Associations were also observed for sphingomyelin with age but this lipid subclass was lower in males. Lysophospholipids were associated with age and higher in males, but showed a strong negative association with BMI. Many of these lipids have previously been associated with chronic diseases including cardiovascular disease and may mediate the interactions of age, sex, and obesity with disease risk.
journal_name
J Lipid Resjournal_title
Journal of lipid researchauthors
Weir JM,Wong G,Barlow CK,Greeve MA,Kowalczyk A,Almasy L,Comuzzie AG,Mahaney MC,Jowett JB,Shaw J,Curran JE,Blangero J,Meikle PJdoi
10.1194/jlr.P035808subject
Has Abstractpub_date
2013-10-01 00:00:00pages
2898-908issue
10eissn
0022-2275issn
1539-7262pii
jlr.P035808journal_volume
54pub_type
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journal_title:Journal of lipid research
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journal_title:Journal of lipid research
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