Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion.

abstract：:Murine strains susceptible to atherosclerosis provide valuable models to study factors involved in atherogenesis. In some murine models, limited hypercholesterolemia can be achieved and lesions develop primarily in the aortic origin, in the vicinity of the aortic valve. In other models such as LDL receptor-deficient a...

journal_title：Journal of lipid research

authors： Tangirala RK,Rubin EM,Palinski W

更新日期：1995-11-01 00:00:00

abstract：:Familial hypobetalipoproteinemia, a syndrome associated with low plasma cholesterol levels, can be caused by apoB gene mutations. We identified a healthy 42-year-old man whose total plasma cholesterol level was 80 mg/dl. His plasma very low density lipoprotein (VLDL) contained a unique truncated apoB species, apoB-83,...

journal_title：Journal of lipid research

authors： Farese RV Jr,Garg A,Pierotti VR,Vega GL,Young SG

更新日期：1992-04-01 00:00:00

abstract：:A variety of methods are currently used to analyze HL and LPL activities in mice. In search of a simple methodology, we analyzed mouse preheparin and postheparin plasma LPL and HL activities using specific polyclonal antibodies raised in rabbit against rat HL (anti-HL) and in goat against rat LPL (anti-LPL). As an alt...

journal_title：Journal of lipid research

authors： Dallinga-Thie GM,Zonneveld-de Boer AJ,van Vark-van der Zee LC,van Haperen R,van Gent T,Jansen H,De Crom R,van Tol A

更新日期：2007-12-01 00:00:00

abstract：:LCAT plays a key role in the maturation of HDL, as evidenced by low HDL-cholesterol levels in carriers of deleterious mutations in LCAT. However, the role of LCAT in atherosclerosis is unclear. We set out to study this in a prospective study. Plasma LCAT levels, which strongly correlate with LCAT activity, were measur...

journal_title：Journal of lipid research

authors： Holleboom AG,Kuivenhoven JA,Vergeer M,Hovingh GK,van Miert JN,Wareham NJ,Kastelein JJ,Khaw KT,Boekholdt SM

更新日期：2010-02-01 00:00:00

abstract：:We have studied the synthesis, modification, and secretion of rat apoE in primary cultures of neonatal aortic smooth muscle cells and adult rat hepatocytes. The cultures were pulsed with [35S]methionine and the intracellular and secreted apoE were immunoprecipitated and analyzed by two-dimensional isoelectric focusing...

journal_title：Journal of lipid research

authors： Hussain MM,Bucher NL,Faris B,Franzblau C,Zannis VI

更新日期：1988-07-01 00:00:00

abstract：:Severe endothelial abnormalities are a prominent feature in sepsis with cytokines such as tumor necrosis factor (TNF)alpha being implicated in the pathogenesis. As mimic to inflammation, human umbilical vascular endothelial cells (HUVEC) were incubated with TNFalpha for 22 h, in the absence or presence of the omega-6 ...

journal_title：Journal of lipid research

authors： Mayer K,Schmidt R,Muhly-Reinholz M,Bögeholz T,Gokorsch S,Grimminger F,Seeger W

更新日期：2002-06-01 00:00:00

abstract：:Quantitative aspects of the binding of free fatty acid to human erythrocytes were studied by measuring the distribution of various amounts of [1-(14)C]lauric acid between washed human erythrocytes and defatted human plasma albumin. Incubations were done at 37 degrees C in an isotonic phosphate-buffered salt solution. ...

journal_title：Journal of lipid research

authors： Spector AA,Ashbrook JD,Santos EC,Fletcher JE

更新日期：1972-07-01 00:00:00

abstract：:Niacin, the first antidyslipidemic drug, has been at the center stage of lipid research for many decades before the discovery of statins. However, to date, despite its remarkable effects on lipid profiles, the clinical outcomes of niacin treatment on cardiac events is still debated. In addition to its historically wel...

journal_title：Journal of lipid research

authors： Romani M,Hofer DC,Katsyuba E,Auwerx J

更新日期：2019-04-01 00:00:00

abstract：:Lipoproteins internalized by the LDL receptor (LDLR) are released from this receptor in endosomes through a process that involves acid-dependent conformational changes in the receptor ectodomain. How acidic pH promotes this release process is not well understood. Here, we assessed roles for six histidine residues for ...

journal_title：Journal of lipid research

authors： Dong H,Zhao Z,LeBrun DG,Michaely P

更新日期：2017-02-01 00:00:00

abstract：:Elongation of very long chain fatty acids (ELOVL)5 is one of seven mammalian fatty acid condensing enzymes involved in microsomal fatty acid elongation. To determine the in vivo substrates and function of ELOVL5, we generated Elovl5(-/-) mice. Studies using liver microsomal protein from wild-type and knockout mice dem...

journal_title：Journal of lipid research

authors： Moon YA,Hammer RE,Horton JD

更新日期：2009-03-01 00:00:00

abstract：:The bioactive sphingolipid metabolite, ceramide, regulates physiological processes important for inflammation and elevated levels of ceramide have been implicated in IL-1-mediated events. Although much has been learned about ceramide generation by activation of sphingomyelinases in response to IL-1, the contribution o...

journal_title：Journal of lipid research

authors： Cai L,Oyeniran C,Biswas DD,Allegood J,Milstien S,Kordula T,Maceyka M,Spiegel S

更新日期：2016-08-01 00:00:00

abstract：:Cholelithiasis is a multifactorial process, and several mechanisms have been postulated. A decreased expression of the ileal apical sodium-dependent bile acid transporter (ASBT) and of the cytosolic ileal lipid binding protein (ILBP) was recently described in female non-obese patients. The role of the recently identif...

journal_title：Journal of lipid research

authors： Renner O,Harsch S,Strohmeyer A,Schimmel S,Stange EF

更新日期：2008-09-01 00:00:00

abstract：:Acylglycerophosphate acyltransferase 4 (AGPAT4)/lysophosphatidic acid acyltransferase delta catalyzes the formation of phosphatidic acid (PA), a precursor of triacyl-glycerol (TAG). We investigated the effect of Agpat4 gene ablation on white adipose tissue (WAT) after finding consistent expression across depots. Epidi...

journal_title：Journal of lipid research

authors： Mardian EB,Bradley RM,Aristizabal Henao JJ,Marvyn PM,Moes KA,Bombardier E,Tupling AR,Stark KD,Duncan RE

更新日期：2017-10-01 00:00:00

abstract：:Mitochondrial cholesterol is maintained within a narrow range to regulate steroid and oxysterol synthesis and to ensure mitochondrial function. Mitochondria acquire cholesterol through several pathways from different cellular pools. Here we have characterized mitochondrial import of endosomal cholesterol using Chinese...

journal_title：Journal of lipid research

authors： Kennedy BE,Charman M,Karten B

更新日期：2012-12-01 00:00:00

abstract：:apoM is a member of the lipocalin superfamily and circulates in plasma attached to HDL particles. apoM plays a role in cholesterol metabolism and has recently been identified as transporter for the signaling lipid, sphingosine-1-phosphate (S1P), in plasma. S1P is implicated in several inflammatory diseases such as mul...

journal_title：Journal of lipid research

authors： Bosteen MH,Dahlbäck B,Nielsen LB,Christoffersen C

更新日期：2015-03-01 00:00:00

abstract：:Stearoyl-CoA desaturase (SCD) catalyzes the rate-limiting step in the cellular synthesis of monounsaturated fatty acids, mainly oleate (18:1) and palmitoleate (16:1), which are the major monounsaturated fatty acids of membrane phospholipids, cholesteryl esters, waxes, and triglycerides. The mouse expresses three well-...

journal_title：Journal of lipid research

authors： Kim HJ,Miyazaki M,Ntambi JM

更新日期：2002-10-01 00:00:00

abstract：:Lymph fistula rats with either biliary fistula or pancreaticobiliary fistula were used to measure coenzyme A-independent mucosal cholesterol esterifying activity in the presence and absence of pancreatic exocrine secretion. Efficiency of pancreatic diversion was verified to minimize contamination of mucosal homogenate...

journal_title：Journal of lipid research

authors： Watt SM,Simmonds WJ

更新日期：1981-01-01 00:00:00

abstract：:C26 Bile of the 24-nor-5beta-cholestane series were prepared starting from methyl cholate. A Grignard reaction of methyl magnesium iodide with methyl cholate yielded 24-nor-5beta-cholestane-3alpha, 7alpha, 12alpha, 25-tetrol which was dehydrated TO FORM a mixture of 24-nor-5beta-cholest-23-ene-3alpha, 7alpha, 12 alpha...

journal_title：Journal of lipid research

authors： Dayal B,Shefer S,Tint GS,Salen G,Mosbach EH

更新日期：1976-09-01 00:00:00

abstract：:ATP binding cassette transporter G1 (ABCG1) mediates the transport of cellular cholesterol to HDL, and it plays a key role in maintaining macrophage cholesterol homeostasis. During inflammation, HDL undergoes substantial remodeling, acquiring lipid changes and serum amyloid A (SAA) as a major apolipoprotein. In the cu...

journal_title：Journal of lipid research

authors： de Beer MC,Ji A,Jahangiri A,Vaughan AM,de Beer FC,van der Westhuyzen DR,Webb NR

更新日期：2011-02-01 00:00:00

abstract：:In promoting oxidation of 0.02 m potassium linoleate in a buffered (pH 7.0) aqueous dispersion at 37 degrees C, ascorbic acid at low concentrations (1.8 x 10(-6) and 1.8 x 10(-5) m) in combination with copper (1.3 x 10(-7) to 1.3 x 10(-3) m) had greater catalytic activity than the additive activity of the two catalyst...

journal_title：Journal of lipid research

authors： Haase G,Dunkley WL

更新日期：1969-09-01 00:00:00

abstract：:Isolated rat livers were perfused at 37 degrees C with blood-free, defined medium containing delipidized bovine serum albumin (BSA), BSA-oleate, or BSA-palmitate. Very low density lipoproteins (VLDL) were isolated from the perfusate at 12 degrees C and lipid components were extracted and purified. Differential scannin...

journal_title：Journal of lipid research

authors： Hale JE,Schroeder F

更新日期：1981-07-01 00:00:00

abstract：:The Niemann-Pick C1 (NPC1) protein regulates cholesterol transport from late endosomes-lysosomes to other intracellular compartments. In this article, cholesterol transport to caveolin-1 and caveolin-2 containing compartments, such as the trans-Golgi network (TGN) and plasma membrane caveolae, was examined in normal (...

journal_title：Journal of lipid research

authors： Garver WS,Krishnan K,Gallagos JR,Michikawa M,Francis GA,Heidenreich RA

更新日期：2002-04-01 00:00:00

abstract：:Cardiac triacylglycerol (TG) catabolism critically depends on the TG hydrolytic activity of adipose triglyceride lipase (ATGL). Perilipin 5 (Plin5) is expressed in cardiac muscle (CM) and has been shown to interact with ATGL and its coactivator comparative gene identification-58 (CGI-58). Furthermore, ectopic Plin5 ex...

journal_title：Journal of lipid research

authors： Pollak NM,Schweiger M,Jaeger D,Kolb D,Kumari M,Schreiber R,Kolleritsch S,Markolin P,Grabner GF,Heier C,Zierler KA,Rülicke T,Zimmermann R,Lass A,Zechner R,Haemmerle G

更新日期：2013-04-01 00:00:00

abstract：:Apolipoprotein E plays a critical role in plasma lipoprotein clearance. Peptide models of a highly conserved, N-terminal domain of this protein have been shown to increase the binding of low density lipoprotein (LDL) to fibroblast cell surfaces independently of the low density lipoprotein receptor. Here we provide dat...

journal_title：Journal of lipid research

authors： Dominguez SR,Miller-Auer H,Reardon CA,Meredith SC

更新日期：1999-04-01 00:00:00

abstract：:Four different lipolytic preparations have been isolated from rat skeletal muscle. Two of these, provisionally designated monopalmitin lipase (MPL) and monomyristin lipase (MML), are associated with insoluble cellular particulate fractions. The other two enzymes, provisionally designated tricaproin lipase (TCL) and mo...

journal_title：Journal of lipid research

authors： Wallach DP

更新日期：1968-03-01 00:00:00

abstract：:Inositol lipid kinases have been studied extensively in both plant and animal systems. However, major limitations for in vitro studies of recombinant lipid kinases are the low specific activity and instability of the purified proteins. Our goal was to determine if cyclodextrins would provide an effective substrate del...

journal_title：Journal of lipid research

authors： Davis AJ,Perera IY,Boss WF

更新日期：2004-09-01 00:00:00

abstract：:Glycosylphosphatidylinositols (GPIs) act as membrane anchors of many eukaryotic cell surface proteins. GPIs in various organisms have a common backbone consisting of ethanolamine phosphate (EtNP), three mannoses (Mans), one non-N-acetylated glucosamine, and inositol phospholipid, whose structure is EtNP-6Manα-2Manα-6M...

journal_title：Journal of lipid research

authors： Kinoshita T,Fujita M

更新日期：2016-01-01 00:00:00

abstract：:The novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor CP-113,818 has been characterized in vitro against ACAT isolated from liver and intestine from a variety of species including human subjects, and in vivo in cholesterol-fed rats, hamsters, rabbits, and two species of nonhuman primates. CP-113,818 is a pot...

journal_title：Journal of lipid research

authors： Marzetta CA,Savoy YE,Freeman AM,Long CA,Pettini JL,Hagar RE,Inskeep PB,Davis K,Stucchi AF,Nicolosi RJ

更新日期：1994-10-01 00:00:00

abstract：:ABCA1 exports cholesterol and phospholipids from cells by a multistep pathway that involves forming cell surface lipid domains, solubilizing these lipids by apolipoproteins, binding of apolipoproteins to ABCA1, and activating signaling processes. Here we used a mutational analysis approach to evaluate the relationship...

journal_title：Journal of lipid research

authors： Vaughan AM,Tang C,Oram JF

更新日期：2009-02-01 00:00:00

abstract：:The esterification of lysophospholipids contributes to phospholipid synthesis, remodeling, and scavenging. Acyl-CoA-dependent lysophospholipid acyltransferase activity with broad substrate use is mediated by Saccharomyces cerevisiae Lpt1p. We sought to identify Lpt1p active site amino acids besides the histidine conse...

journal_title：Journal of lipid research

authors： Renauer P,Nasiri N,Oelkers P

更新日期：2015-11-01 00:00:00