C26-Analogs of naturally occurring C27 bile alcohols.

abstract：:There is growing evidence of the capacity of vitamin A to regulate the expression of the genetic region that encodes apolipoproteins (apo) A-I, C-III, and A-IV. This region in turn has been proposed to modulate the expression of hyperlipidemia in the commonest genetic form of dyslipidemia, familial combined hyperlipid...

journal_title：Journal of lipid research

authors： Ribalta J,Girona J,Vallvé JC,La Ville AE,Heras M,Masana L

更新日期：1999-03-01 00:00:00

abstract：:Cellular membranes are composed of numerous kinds of glycerophospholipids with different combinations of polar heads at the sn-3 position and acyl moieties at the sn-1 and sn-2 positions, respectively. The glycerophospholipid compositions of different cell types, organelles, and inner/outer plasma membrane leaflets ar...

journal_title：Journal of lipid research

authors： Hishikawa D,Hashidate T,Shimizu T,Shindou H

更新日期：2014-05-01 00:00:00

abstract：:The sterol regulatory element binding protein (SREBP)/SREBP cleavage-activating protein (SCAP) complex regulates the transcription of numerous genes involved in cellular cholesterol metabolism. The CHO mutant, CT60, and its parental cell line, 25RA, possess a gain-of-function mutation in one allele of the SCAP gene th...

journal_title：Journal of lipid research

authors： Maguire JA,Reagan JW Jr

更新日期：2005-09-01 00:00:00

abstract：:The hepatic synthesis of sterol was measured in the male Mongolian gerbil (Meriones unguiculatus) in vivo following the administration of [3H]water by monitoring the incorporation of radioactivity into digitonin-precipitable sterol. A diurnal rhythm in cholesterol synthesis was exhibited under conditions of ad libitum...

journal_title：Journal of lipid research

authors： Mercer NJ,Holub BJ

更新日期：1981-07-01 00:00:00

abstract：:We analyzed Niemann-Pick type C disease 1 (NPC1) gene in 12 patients with Niemann-Pick type C disease by sequencing both cDNA obtained from fibroblasts and genomic DNA. All the patients were compound heterozygotes. We found 15 mutations, eight of which previously unreported. The comparison of cDNA and genomic DNA reve...

journal_title：Journal of lipid research

authors： Tarugi P,Ballarini G,Bembi B,Battisti C,Palmeri S,Panzani F,Di Leo E,Martini C,Federico A,Calandra S

更新日期：2002-11-01 00:00:00

abstract：:PPARs regulate the expression of genes for energy metabolism in a ligand-dependent manner. PPARs can influence fatty acid oxidation, the level of circulating triglycerides, glucose uptake and insulin sensitivity. Here, we demonstrate that 5-hydroxyeicosapentaenoic acid (HEPE), 8-HEPE, 9-HEPE, 12-HEPE and 18-HEPE (hydr...

journal_title：Journal of lipid research

authors： Yamada H,Oshiro E,Kikuchi S,Hakozaki M,Takahashi H,Kimura K

更新日期：2014-05-01 00:00:00

abstract：:LY295427, (3 alpha,4 alpha,5 alpha)-4-(2-propenylcholestan-3-ol), acts through an unknown mechanism to derepress the transcription of the low density lipoprotein (LDL) receptor in the presence of 25-hydroxycholesterol (25-OH chol). Preincubation with LY295427 in Chinese hamster ovary (CHO) cells increased uptake of 25...

journal_title：Journal of lipid research

authors： Bowling N,Matter WF,Gadski RA,McClure DB,Schreyer T,Dawson PA,Vlahos CJ

更新日期：1996-12-01 00:00:00

abstract：:Apheresis is a treatment option for patients with severe hypercholesterolemia and coronary artery disease. It is, however, unknown whether such therapy changes kinetic parameters of lipoprotein metabolism, such as apolipoprotein B (apoB) secretion rates, conversion rates, and fractional catabolic rates (FCR). We studi...

journal_title：Journal of lipid research

authors： Parhofer KG,Barrett PH,Demant T,Richter WO,Schwandt P

更新日期：1996-11-01 00:00:00

abstract：:In vivo single-voxel magnetic resonance spectroscopy (MRS) at 4.7T and ex vivo high-resolution proton magnetic resonance spectroscopy (HR-NMR) at 500 MHz were used to study the composition of adipose tissues in Zucker obese and Zucker lean rats. Lipid composition was characterized by unsaturation and polyunsaturation ...

journal_title：Journal of lipid research

authors： Mosconi E,Fontanella M,Sima DM,Van Huffel S,Fiorini S,Sbarbati A,Marzola P

更新日期：2011-02-01 00:00:00

abstract：:Apolipoprotein A-II (apoA-II) is the second major apolipoprotein following apolipoprotein A-I (apoA-I) in HDL. ApoA-II has multiple physiological functions and can form senile amyloid fibrils (AApoAII) in mice. Most circulating apoA-II is present in lipoprotein A-I/A-II. To study the influence of apoA-I on apoA-II and...

journal_title：Journal of lipid research

authors： Wang Y,Sawashita J,Qian J,Zhang B,Fu X,Tian G,Chen L,Mori M,Higuchi K

更新日期：2011-08-01 00:00:00

abstract：:To study the effect of an unstirred layer (UL), we have investigated the exchange efflux kinetics of anandamide at 0 degrees C, pH 7.3, from albumin-free as well as from albumin-filled human red blood cell ghosts to media of various BSA concentrations ([BSA](o)). The rate constant (k(m)) of unidirectional flux from th...

journal_title：Journal of lipid research

authors： Bojesen IN,Hansen HS

更新日期：2006-03-01 00:00:00

abstract：:Fatty acid compositions of glycerophosphatides of developing chick embryonic brain and liver were compared. In brain, ethanolamine and serine glycerophosphatides contained 30-40% polyunsaturated fatty acids, lecithin almost none (except for arachidonic). In the liver, these acids were equally distributed in the phosph...

journal_title：Journal of lipid research

authors： Miyamoto K,Stephanides LM,Bernsohn J

更新日期：1966-09-01 00:00:00

abstract：:We report the clinical phenotype in three kindreds with familial heterozygous hypobetalipoproteinemia (FHBL) carrying novel truncated apolipoprotein Bs (apoBs) of different sizes (apoB-8.15, apoB-33.4 and apoB-75.7). In D.A. kindred, we found three carriers of a C-deletion in exon 10 leading to the synthesis of apoB-8...

journal_title：Journal of lipid research

authors： Tarugi P,Lonardo A,Gabelli C,Sala F,Ballarini G,Cortella I,Previato L,Bertolini S,Cordera R,Calandra S

更新日期：2001-10-01 00:00:00

abstract：:Circulating triacylglycerol (TG) arises mainly from dietary fat. However, little is known about the entry of dietary fat into the major TG pool, very low-density lipoprotein (VLDL) TG. We used a novel method to study the specific incorporation of dietary fatty acids into postprandial VLDL TG in humans. Eight healthy v...

journal_title：Journal of lipid research

authors： Heath RB,Karpe F,Milne RW,Burdge GC,Wootton SA,Frayn KN

更新日期：2003-11-01 00:00:00

abstract：:Lymph chylomicrons of different sizes are known to be cleared at different rates, but the underlying mechanism for this effect has not been resolved. To investigate the differences in clearance rates between small and large particles, chylomicron-like lipid emulsions labeled with radioactive triolein and cholesteryl o...

journal_title：Journal of lipid research

authors： Martins IJ,Mortimer BC,Miller J,Redgrave TG

更新日期：1996-12-01 00:00:00

abstract：:Wax esters are neutral lipids exhibiting desirable properties for lubrication. Natural sources have traditionally been whales. Additionally some plants produce wax esters in their seed oil. Currently there is no biological source available for long chain length monounsaturated wax esters that are most suited for indus...

journal_title：Journal of lipid research

authors： Heilmann M,Iven T,Ahmann K,Hornung E,Stymne S,Feussner I

更新日期：2012-10-01 00:00:00

abstract：:Cholesterol 7alpha-hydroxylase, a rate-limiting enzyme for bile acid synthesis, has been implicated in genetic susceptibility to atherosclerosis. The gene, CYP7A1, encoding a protein with this activity, is expressed normally only in hepatocytes and is highly regulated. Our cyp7A1 gene knockout mouse colony, as young a...

journal_title：Journal of lipid research

authors： Erickson SK,Lear SR,Deane S,Dubrac S,Huling SL,Nguyen L,Bollineni JS,Shefer S,Hyogo H,Cohen DE,Shneider B,Sehayek E,Ananthanarayanan M,Balasubramaniyan N,Suchy FJ,Batta AK,Salen G

更新日期：2003-05-01 00:00:00

abstract：:Serine palmitoyltransferase (SPT) catalyzes the rate-limiting step of condensation of L-serine and palmitoyl-CoA to form 3-ketodihydrosphingosine (3KDS). Here, we report a HPLC-ESI-MS/MS method to directly quantify 3KDS generated by SPT. With this technique, we were able to detect 3KDS at a level comparable to that of...

journal_title：Journal of lipid research

authors： Ren J,Snider J,Airola MV,Zhong A,Rana NA,Obeid LM,Hannun YA

更新日期：2018-01-01 00:00:00

abstract：:NADPH-dependent lipid peroxidation in liver microsomes, as measured by malondialdehyde formation, decreased by 90% when rats were fed a diet containing 16% coconut oil. This reduction occurred within 1 to 3 days after the rats were placed on this highly saturated diet. The decrease in peroxidation activity was associa...

journal_title：Journal of lipid research

authors： Lokesh BR,Mathur SN,Spector AA

更新日期：1981-08-01 00:00:00

abstract：:The acute-phase response (APR) leads to alterations in lipid metabolism and type II nuclear hormone receptors, which regulate lipid metabolism, are suppressed, in liver, heart, and kidney. Here, we examine the effect of the APR in adipose tissue. In mice, lipopolysaccharide produces a rapid, marked decrease in mRNA le...

journal_title：Journal of lipid research

authors： Lu B,Moser AH,Shigenaga JK,Feingold KR,Grunfeld C

更新日期：2006-10-01 00:00:00

abstract：:Human high density lipoprotein enriched in free cholesterol was obtained by exposing the lipoprotein to lipid dispersions having a free cholesterol/lecithin molar ratio greater than two. The metabolism of cholesterol was studied in tissue culture cells exposed to normal and cholesterol-enriched lipoproteins. Incubatio...

journal_title：Journal of lipid research

authors： Rothblat GH,Arbogast LY,Ray EK

更新日期：1978-03-01 00:00:00

abstract：:In an effort to explore the feasibility of converting a lipase into an esterase by modifying the lid region, we designed and characterized two novel Rhizopus chinensis lipase variants by lid swapping. The substrate specificity of an R. chinensis lipase was successfully modified toward water-soluble substrates, that is...

journal_title：Journal of lipid research

authors： Yu XW,Zhu SS,Xiao R,Xu Y

更新日期：2014-06-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM) is associated with elevated plasma triglyceride levels that normalize after insulin administration. The observation that overexpression of the apoC-III gene in transgenic mice can cause hypertriglyceridemia and other evidence implicating apoC-III in the regulation of triglyce...

journal_title：Journal of lipid research

authors： Chen M,Breslow JL,Li W,Leff T

更新日期：1994-11-01 00:00:00

abstract：:The objective of this study was to investigate the mobilization of individual fatty acids from human subcutaneous adipose tissue in vivo. Concentrations of individual non-esterified fatty acids were measured in arterialized plasma and in the venous drainage from subcutaneous abdominal adipose tissue in eight normal su...

journal_title：Journal of lipid research

authors： Halliwell KJ,Fielding BA,Samra JS,Humphreys SM,Frayn KN

更新日期：1996-09-01 00:00:00

abstract：:Sebaceous glands are intriguing glands that are found throughout the human body except on the palms of the hands and soles of the feet. The true function of these glands has yet to be determined, but there are several theories, including antioxidant effects, antibacterial effects, and transport of pheromones. Sebaceou...

journal_title：Journal of lipid research

authors： Smith KR,Thiboutot DM

更新日期：2008-02-01 00:00:00

abstract：:HDL plays crucial roles at multiple stages of the pathogenesis of atherosclerosis. AMP-activated protein kinase (AMPK) is a therapeutic candidate for the treatment of cardiovascular disease. However, the effect of AMPK activation on HDL functionality has not been established in vivo. We assessed the effects of pharmac...

journal_title：Journal of lipid research

authors： Ma A,Wang J,Yang L,An Y,Zhu H

更新日期：2017-08-01 00:00:00

abstract：:Apolipoprotein (apo)E is well established as a secreted protein that plays an important role in systemic lipoprotein metabolism and vascular wall homeostasis. Recently, endogenous expression of apoE in adipocytes has been shown to play an important role in adipocyte lipoprotein metabolism and gene expression consisten...

journal_title：Journal of lipid research

authors： Yue L,Mazzone T

更新日期：2011-03-01 00:00:00

abstract：:Long-chain fatty acids are the most important substrates for the heart. In addition, they have been shown to affect signalling pathways and gene expression. To explore the effects of long-chain fatty acids on cardiac gene expression, neonatal rat ventricular myocytes were cultured for 48 h with either glucose (10 mm),...

journal_title：Journal of lipid research

authors： van der Lee KA,Vork MM,De Vries JE,Willemsen PH,Glatz JF,Reneman RS,Van der Vusse GJ,Van Bilsen M

更新日期：2000-01-01 00:00:00

abstract：:Labeled cholesterol esters were incorporated into chylomicrons in vitro by adding an acetone solution of the cholesterol ester to a suspension of washed chylomicrons. The physical and metabolic properties of the added labeled ester were the same as those of cholesterol esters incorporated into chylomicrons in vivo, ex...

journal_title：Journal of lipid research

authors： Quarfordt SH,Goodman DS

更新日期：1966-09-01 00:00:00

abstract：:To identify novel fatty acid diol synthases, putative candidate sequences from Penicillium species were analyzed, and hydroxy fatty acid production by crude Penicillium enzyme extracts was assessed. Penicillium chrysogenum was found to produce an unknown dihydroxy fatty acid, a candidate gene implicated in this produc...

journal_title：Journal of lipid research

authors： Shin KC,Seo MJ,Oh DK

更新日期：2016-02-01 00:00:00