Abstract：
:ATP binding cassette transporter G1 (ABCG1) mediates the transport of cellular cholesterol to HDL, and it plays a key role in maintaining macrophage cholesterol homeostasis. During inflammation, HDL undergoes substantial remodeling, acquiring lipid changes and serum amyloid A (SAA) as a major apolipoprotein. In the current study, we investigated whether remodeling of HDL that occurs during acute inflammation impacts ABCG1-dependent efflux. Our data indicate that lipid free SAA acts similarly to apolipoprotein A-I (apoA-I) in mediating sequential efflux from ABCA1 and ABCG1. Compared with normal mouse HDL, acute phase (AP) mouse HDL containing SAA exhibited a modest but significant 17% increase in ABCG1-dependent efflux. Interestingly, AP HDL isolated from mice lacking SAA (SAAKO mice) was even more effective in promoting ABCG1 efflux. Hydrolysis with Group IIA secretory phospholipase A(2) (sPLA(2)-IIA) significantly reduced the ability of AP HDL from SAAKO mice to serve as a substrate for ABCG1-mediated cholesterol transfer, indicating that phospholipid (PL) enrichment, and not the presence of SAA, is responsible for alterations in efflux. AP human HDL, which is not PL-enriched, was somewhat less effective in mediating ABCG1-dependent efflux compared with normal human HDL. Our data indicate that inflammatory remodeling of HDL impacts ABCG1-dependent efflux independent of SAA.
journal_name
J Lipid Resjournal_title
Journal of lipid researchauthors
de Beer MC,Ji A,Jahangiri A,Vaughan AM,de Beer FC,van der Westhuyzen DR,Webb NRdoi
10.1194/jlr.M012328subject
Has Abstractpub_date
2011-02-01 00:00:00pages
345-53issue
2eissn
0022-2275issn
1539-7262pii
jlr.M012328journal_volume
52pub_type
杂志文章abstract：:A strategy has been developed for archaebacterial lipid analysis which provides three times the information to describe archaebacterial isolates and is compatible with simultaneous eubacterial/eukaryotic lipid analysis of environmental samples. Eubacterial and micro-eukaryotic biomass, community structure, and nutriti...
journal_title：Journal of lipid research
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doi：
更新日期：1991-04-01 00:00:00
abstract：:Long-chain fatty acids are the most important substrates for the heart. In addition, they have been shown to affect signalling pathways and gene expression. To explore the effects of long-chain fatty acids on cardiac gene expression, neonatal rat ventricular myocytes were cultured for 48 h with either glucose (10 mm),...
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journal_title：Journal of lipid research
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doi：
更新日期：1967-03-01 00:00:00
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journal_title：Journal of lipid research
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doi：
更新日期：1995-10-01 00:00:00
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journal_title：Journal of lipid research
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doi：
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journal_title：Journal of lipid research
pub_type： 杂志文章
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更新日期：1981-07-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2014-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1194/jlr.M500033-JLR200
更新日期：2005-09-01 00:00:00
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doi：
更新日期：2002-01-01 00:00:00
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journal_title：Journal of lipid research
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doi：10.1194/jlr.M079764
更新日期：2017-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1194/jlr.M056580
更新日期：2015-08-01 00:00:00
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journal_title：Journal of lipid research
pub_type： 杂志文章
doi：10.1194/jlr.M046961
更新日期：2014-12-01 00:00:00
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更新日期：2015-06-01 00:00:00
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journal_title：Journal of lipid research
pub_type： 杂志文章
doi：10.1194/jlr.M009563
更新日期：2010-12-01 00:00:00
abstract：:The chromatographic behavior of 1,2-, 1,3-, 1,4-, and 1,12-long-chain alkane diols and 1-O-alkylglycerols and their derivatives has been compared. Thin-layer chromatography on Silica Gel G gives poor separations of the 1,2-, 1,3-, and 1,4-alkane diols, O-alkylglycerols, and some of their isopropylidene derivatives. Ho...
journal_title：Journal of lipid research
pub_type： 杂志文章
doi：
更新日期：1971-09-01 00:00:00
abstract：:Clostridium absonum was shown to metabolize primary bile acids to give rise to both 7-oxo bile acids and 7 beta-hydroxy (urso) bile acids. At relatively low redox potential (Eh) values, high yields of urso bile acids were achieved (60-75%). If, however, the Eh value of the culture was allowed to rise above approximate...
journal_title：Journal of lipid research
pub_type： 杂志文章
doi：
更新日期：1982-07-01 00:00:00
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journal_title：Journal of lipid research
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doi：10.1194/jlr.M700433-JLR200
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journal_title：Journal of lipid research
pub_type： 杂志文章
doi：
更新日期：1968-01-01 00:00:00
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journal_title：Journal of lipid research
pub_type： 杂志文章
doi：
更新日期：1985-07-01 00:00:00
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journal_title：Journal of lipid research
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doi：
更新日期：1987-10-01 00:00:00
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更新日期：2016-05-01 00:00:00
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journal_title：Journal of lipid research
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doi：
更新日期：2002-04-01 00:00:00
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更新日期：2010-11-01 00:00:00
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journal_title：Journal of lipid research
pub_type： 杂志文章
doi：10.1194/jlr.M022673
更新日期：2012-05-01 00:00:00
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journal_title：Journal of lipid research
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doi：10.1194/jlr.M034579
更新日期：2013-03-01 00:00:00
