Archaebacterial ether lipid diversity analyzed by supercritical fluid chromatography: integration with a bacterial lipid protocol.

abstract：:The human retina is well-known to have unique lipid profiles enriched in long-chain polyunsaturated fatty acids (LC-PUFAs) and very long-chain polyunsaturated fatty acids (VLC-PUFAs) that appear to promote normal retinal structure and function, but the influence of diet on retinal lipid profiles in health and disease ...

journal_title：Journal of lipid research

authors： Gorusupudi A,Liu A,Hageman GS,Bernstein PS

更新日期：2016-03-01 00:00:00

abstract：:Although numerous studies have investigated the relationship between cholesteryl ester transfer protein (CETP) and high density lipoprotein (HDL) remodeling, the relationship between CETP and low density lipoproteins (LDL) is still not fully understood. In the present study, we examined the effect of the inhibition of...

journal_title：Journal of lipid research

authors： Sugano M,Sawada S,Tsuchida K,Makino N,Kamada M

更新日期：2000-01-01 00:00:00

abstract：:A group of polyunsaturated fatty acids called conjugated linoleic acids (CLAs) are found in ruminant products, where the most common isomers are cis9, trans11 (c 9,t11) and trans10, cis12 (t10,c12) CLA. A crude mixture of these isomers has been shown in animal studies to alter body composition by a reduction in body f...

journal_title：Journal of lipid research

authors： Granlund L,Juvet LK,Pedersen JI,Nebb HI

更新日期：2003-08-01 00:00:00

abstract：:Previous in vitro studies have revealed that oxidized low density lipoprotein (OxLDL) has negative effects on the proliferation and activity of endothelial progenitor cells (EPCs). Here, we evaluated the effect of OxLDL on the therapeutic potential of EPCs in ischemia-induced neovascularization. EPCs derived from mobi...

journal_title：Journal of lipid research

authors： Zhou B,Ma FX,Liu PX,Fang ZH,Wang SL,Han ZB,Poon MC,Han ZC

更新日期：2007-03-01 00:00:00

abstract：:The binding of monoacylglycerides of long-chain fatty acids to human serum albumin has been examined using monooleoylglycerol as the ligand. Binding was investigated using changes in tryptophan fluorescence and also the displacement of a variety of well-studied fluorescent ligands from human serum albumin (HSA). Monoo...

journal_title：Journal of lipid research

authors： Thumser AE,Buckland AG,Wilton DC

更新日期：1998-05-01 00:00:00

abstract：:13C nuclear magnetic resonance (NMR) spectra were obtained at 50.3 and 100.5 MHz for methanolic and aqueous mixtures of sodium taurocholate, 1-monocapryloyl-rac-glycerol, and caprylic acid. Distortionless Enhancement by Polarization Transfer (DEPT) was used to improve spectral sensitivity and resolution, and to genera...

journal_title：Journal of lipid research

authors： Wang D,Hadipour NL,Jerlin EA,Stark RE

更新日期：1992-03-01 00:00:00

abstract：:LCAT plays a key role in the maturation of HDL, as evidenced by low HDL-cholesterol levels in carriers of deleterious mutations in LCAT. However, the role of LCAT in atherosclerosis is unclear. We set out to study this in a prospective study. Plasma LCAT levels, which strongly correlate with LCAT activity, were measur...

journal_title：Journal of lipid research

authors： Holleboom AG,Kuivenhoven JA,Vergeer M,Hovingh GK,van Miert JN,Wareham NJ,Kastelein JJ,Khaw KT,Boekholdt SM

更新日期：2010-02-01 00:00:00

abstract：:An enzyme-coupled, colorimetric method for the assay of acyl-CoA synthetase is described. Acyl-CoA formed from fatty acid and CoA by acyl-CoA synthetase was dehydrogenated by acyl-CoA oxidase. Hydrogen peroxide produced was then converted into formaldehyde in the presence of methanol by catalase. The formaldehyde reac...

journal_title：Journal of lipid research

authors： Ichihara K,Shibasaki Y

更新日期：1991-10-01 00:00:00

abstract：:We investigated the role of caveolae in uptake and intracellular trafficking of long chain fatty acids (LCFA) in HepG2 human hepatoma cells. The uptake of [(3)H]oleic acid and [(3)H]stearic acid into HepG2 cells was measured by radioactive assays and internalization of the non-metabolizable fluorescent fatty acid 12-(...

journal_title：Journal of lipid research

authors： Pohl J,Ring A,Stremmel W

更新日期：2002-09-01 00:00:00

abstract：:The aim of this study was to investigate the extent to which inflammation is linked with plasma endothelial lipase (EL) concentrations among healthy sedentary men. Plasma C-reactive protein (CRP) concentrations were measured with a highly sensitive commercial immunoassay, plasma interleukin-6 (IL-6) concentrations wer...

journal_title：Journal of lipid research

authors： Paradis ME,Badellino KO,Rader DJ,Deshaies Y,Couture P,Archer WR,Bergeron N,Lamarche B

更新日期：2006-12-01 00:00:00

abstract：:Genetic defects in SAR1B GTPase inhibit chylomicron (CM) trafficking to the Golgi and result in a huge intraenterocyte lipid accumulation with a failure to release CMs and liposoluble vitamins into the blood circulation. The central aim of this study is to test the hypothesis that SAR1B deletion (SAR1B-/- ) disturbs e...

journal_title：Journal of lipid research

authors： Sané A,Ahmarani L,Delvin E,Auclair N,Spahis S,Levy E

更新日期：2019-10-01 00:00:00

abstract：:Biliary secretion of bile acid glucuronides was studied in control rats and in rats with a congenital defect in hepatobiliary transport of organic anions (GY rats). In control animals, hepatobiliary transport of [3H]lithocholic acid 3-O-glucuronide and [3H]cholic acid 3-O-glucuronide was efficient (greater than 95% in...

journal_title：Journal of lipid research

authors： Kuipers F,Radominska A,Zimniak P,Little JM,Havinga R,Vonk RJ,Lester R

更新日期：1989-12-01 00:00:00

abstract：:AY 9944 is a novel inhibitor of cholesterol biosynthesis which appears to act on the Delta 7-reductase enzyme, interfering with the conversion of 7-dehydrocholesterol to cholesterol. In all tissues studied, with the exception of the lens, there was a reduction in cholesterol and a marked accumulation of 7-dehydrochole...

journal_title：Journal of lipid research

authors： Horlick L

更新日期：1966-01-01 00:00:00

abstract：:Cystic fibrosis (CF) patients and model systems exhibit consistent abnormalities in PUFA metabolism, including increased metabolism of linoleate to arachidonate. Recent studies have connected these abnormalities to increased expression and activity of the Δ6- and Δ5-desaturase enzymes. However, the mechanism connectin...

journal_title：Journal of lipid research

authors： Umunakwe OC,Seegmiller AC

更新日期：2014-07-01 00:00:00

abstract：:A three-step procedure has been developed for the separation of complex mixtures of sterol intermediates in cholesterol biosynthesis. The method has been applied to the separation of sterol intermediates formed from [14C]mevalonate by normal rat hepatocyte culture cells. In Step 1, a short gravity-flow silicic acid co...

journal_title：Journal of lipid research

authors： Hansbury E,Scallen TJ

更新日期：1980-09-01 00:00:00

abstract：:Tritiated dihydrosphingomyelin was injected into rats, and after various time intervals the distribution of radioactivity in various organs and in the blood and urine was determined. The rate of catabolism of the administered dihydrosphingomyelin was relatively rapid, since about one-fifth of the tritium was recovered...

journal_title：Journal of lipid research

authors： Schneider PB,Kennedy EP

更新日期：1968-01-01 00:00:00

abstract：:Lipoprotein (a) [Lp(a)] is a highly atherogenic lipid particle. Although earlier reports suggested that Lp(a) levels are mostly determined by genetic factors, several recent studies have revealed that Lp(a) induction is also caused by chronic inflammation. Therefore, we aimed to examine whether cytokine blockade by mo...

journal_title：Journal of lipid research

authors： Müller N,Schulte DM,Türk K,Freitag-Wolf S,Hampe J,Zeuner R,Schröder JO,Gouni-Berthold I,Berthold HK,Krone W,Rose-John S,Schreiber S,Laudes M

更新日期：2015-05-01 00:00:00

abstract：:Enzymes associated with glycerolipid biosynthesis were examined in microsomal fractions of liver and adipose tissue obtained from swine of various ages. Generally, liver glycerophosphate acyltransferase, phosphatidate phosphohydrolase, diglyceride acyltransferase, and choline phosphotransferase activities were substan...

journal_title：Journal of lipid research

authors： Steffen DG,Phinney G,Brown LJ,Mersmann HJ

更新日期：1979-02-01 00:00:00

abstract：:Adipocyte triglyceride storage provides a reservoir of energy that allows the organism to survive times of nutrient scarcity, but excessive adiposity has emerged as a health problem in many areas of the world. Monoacylglycerol acyltransferase (MGAT) acylates monoacylglycerol to produce diacylglycerol; the penultimate ...

journal_title：Journal of lipid research

authors： Liss KHH,Lutkewitte AJ,Pietka T,Finck BN,Franczyk M,Yoshino J,Klein S,Hall AM

更新日期：2018-09-01 00:00:00

abstract：:The effects of fish oil supplementation (14.5 g n-3 fatty acids/day) on plasma lipoprotein particles in healthy volunteers were assessed by high resolution 13C and 1H nuclear magnetic resonance (NMR) spectroscopy. Resonances not previously observed in the 13C and 1H spectra of plasma and isolated lipoproteins were det...

journal_title：Journal of lipid research

authors： Bell JD,Barnard ML,Parkes HG,Thomas EL,Brennan CH,Cunnane SC,Dagnelie PC

更新日期：1996-08-01 00:00:00

abstract：:The mechanisms involved in the development of alcoholic liver disease (ALD) are not well established. We investigated the involvement of acyl-CoA: diacylglycerol acyltransferase 2 (DGAT2) upregulation in mediating hepatic fat accumulation induced by chronic alcohol consumption. Chronic alcohol feeding caused fatty liv...

journal_title：Journal of lipid research

authors： Wang Z,Yao T,Song Z

更新日期：2010-11-01 00:00:00

abstract：:The central region of apolipoprotein A-I (apoA-I), spanning residues 143--165, has been implicated in lecithin:cholesterol acyltransferase (LCAT) activation and also in high density lipoprotein (HDL) structural rearrangements. To examine the role of individual amino acids in these functions, we constructed, overexpres...

journal_title：Journal of lipid research

authors： Cho KH,Durbin DM,Jonas A

更新日期：2001-03-01 00:00:00

abstract：:Dysregulation of nuclear envelope (NE) assembly results in various cancers; for example, renal and some lung carcinomas ensue due to NE malformation. The NE is a dynamic membrane compartment and its completion during mitosis is a highly regulated process, but the detailed mechanism still remains incompletely understoo...

journal_title：Journal of lipid research

authors： Chung GHC,Domart MC,Peddie C,Mantell J,Mclaverty K,Arabiotorre A,Hodgson L,Byrne RD,Verkade P,Arkill K,Collinson LM,Larijani B

更新日期：2018-08-01 00:00:00

abstract：:A reversed phase high performance liquid chromatographic (HPLC) method was developed for direct profiling and determination of adrenal cholesteryl ester composition. Cholesteryl adrenate and cholesteryl cervonate, which are not commercially available, were synthesized as markers. Lipid extracts of rat adrenal homogena...

journal_title：Journal of lipid research

authors： Cheng B,Kowal J

更新日期：1994-06-01 00:00:00

abstract：:The uropygial gland secretions produced by female mallards (Anas platyrhynchos) throughout the year were analyzed by thin-layer chromatography and combined gas-liquid chromatography and mass spectrometry. Most of the year, the secretion was composed of wax esters. With the beginning of the mating season in the middle ...

journal_title：Journal of lipid research

authors： Kolattukudy PE,Bohnet S,Rogers L

更新日期：1987-05-01 00:00:00

abstract：:A molecular model was built for human lecithin:cholesterol acyltransferase (LCAT) based upon the structural homology between this enzyme and lipases (Peelman et al. 1998. Prot. Sci. 7: 585-597). We proposed that LCAT belongs to the alpha/beta hydrolase fold family, and that the central domain of LCAT consists of a mix...

journal_title：Journal of lipid research

authors： Peelman F,Verschelde JL,Vanloo B,Ampe C,Labeur C,Tavernier J,Vandekerckhove J,Rosseneu M

更新日期：1999-01-01 00:00:00

abstract：:Evidence is given that the heart of the cardiomyopathic UM-X7.1 hamster has a lipid composition different from that of the same tissue isolated from animals of the Syrian hamster parent strain. Also, noncardiac tissues from cardiomyopathic and healthy hamsters exhibit significant compositional differences. On the basi...

journal_title：Journal of lipid research

authors： Vecchini A,Binaglia L,Bibeau M,Minieri M,Carotenuto F,Di Nardo P

更新日期：2001-01-01 00:00:00

abstract：:In specialized cell types, lysosome-related organelles support regulated secretory pathways, whereas in nonspecialized cells, lysosomes can undergo fusion with the plasma membrane in response to a transient rise in cytosolic calcium. Recent evidence also indicates that lysosome secretion can be controlled transcriptio...

journal_title：Journal of lipid research

authors： Vacca F,Vossio S,Mercier V,Moreau D,Johnson S,Scott CC,Montoya JP,Moniatte M,Gruenberg J

更新日期：2019-04-01 00:00:00

abstract：:In mice, the yolk sac appears to play a crucial role in nourishing the developing embryo, especially during embryonic days (E) 7;-10. Lipoprotein synthesis and secretion may be essential for this function: embryos lacking apolipoprotein (apo) B or microsomal triglyceride transfer protein (MTP), both of which participa...

journal_title：Journal of lipid research

authors： Terasawa Y,Cases SJ,Wong JS,Jamil H,Jothi S,Traber MG,Packer L,Gordon DA,Hamilton RL,Farese RV Jr

更新日期：1999-11-01 00:00:00

abstract：:ATP binding cassette transporter G1 (ABCG1) mediates the transport of cellular cholesterol to HDL, and it plays a key role in maintaining macrophage cholesterol homeostasis. During inflammation, HDL undergoes substantial remodeling, acquiring lipid changes and serum amyloid A (SAA) as a major apolipoprotein. In the cu...

journal_title：Journal of lipid research

authors： de Beer MC,Ji A,Jahangiri A,Vaughan AM,de Beer FC,van der Westhuyzen DR,Webb NR

更新日期：2011-02-01 00:00:00