Acute depletion of diacylglycerol from the cis-Golgi affects localized nuclear envelope morphology during mitosis.

abstract：:A simple, rapid, inexpensive method for isolating disaturated phosphatidylcholine from adult rat lung has been devised. Total lipids are reacted with osmium tetroxide dissolved in carbon tetrachloride, and the disaturated phosphatidylcholine is isolated on a column of neutral alumina. More than 99% of the fatty acids ...

journal_title：Journal of lipid research

authors： Mason RJ,Nellenbogen J,Clements JA

更新日期：1976-05-01 00:00:00

abstract：:We report a new genetic defect in the lecithin:cholesterol acyltransferase (LCAT) gene associated with classical clinical and biochemical features of fish eye disease. The 63-year-old Australian female proband also suffers from non-insulin-dependent (type II) diabetes mellitus. She presented with corneal opacities, ma...

journal_title：Journal of lipid research

authors： Contacos C,Sullivan DR,Rye KA,Funke H,Assmann G

更新日期：1996-01-01 00:00:00

abstract：:The kinetics of lecithin exchange between native lipoproteins was characterized for individual molecular species of lecithins of rat mesenteric lymph chylomicrons and rat plasma HDL. Studies were performed in the absence of lipid transfer proteins. Donor (chylomicrons) and acceptor (HDL) particles were present in rati...

journal_title：Journal of lipid research

authors： Patton GM,Robins SJ,Fasulo JM,Clark SB

更新日期：1985-11-01 00:00:00

abstract：:Human monocyte-derived macrophages secrete lipoprotein lipase (LPL) in culture. The regulation of human macrophage LPL production is poorly understood. Since bacterial lipopolysaccharide (LPS) alters production of several macrophage secretory products, its effect on human monocyte-derived macrophage LPL was tested. LP...

journal_title：Journal of lipid research

authors： White JR,Chait A,Klebanoff SJ,Deeb S,Brunzell JD

更新日期：1988-10-01 00:00:00

abstract：:In addition to functioning as detergents that aid digestion of dietary lipids in the intestine, some bile acids have been shown to exhibit antimicrobial activity. However, detailed information on the bactericidal activities of the diverse molecular species of bile acid in humans and rodents is largely unknown. Here, w...

journal_title：Journal of lipid research

authors： Watanabe M,Fukiya S,Yokota A

更新日期：2017-06-01 00:00:00

abstract：:Thioesterase superfamily member 1 (Them1; synonyms acyl-CoA thioesterase 11 and StarD14) is highly expressed in brown adipose tissue and limits energy expenditure in mice. Them1 is a putative fatty acyl-CoA thioesterase that comprises tandem hot dog-fold thioesterase domains and a lipid-binding C-terminal steroidogeni...

journal_title：Journal of lipid research

authors： Han S,Cohen DE

更新日期：2012-12-01 00:00:00

abstract：:Delta-5 and delta-6 desaturases (D5D and D6D) are key enzymes in endogenous synthesis of long-chain PUFAs. In this sample of healthy subjects (n = 310), genotypes of single nucleotide polymorphisms (SNPs) rs174537, rs174561, and rs3834458 in the FADS1-FADS2 gene cluster were strongly associated with proportions of LC-...

journal_title：Journal of lipid research

authors： Al-Hilal M,Alsaleh A,Maniou Z,Lewis FJ,Hall WL,Sanders TA,O'Dell SD,MARINA study team.

更新日期：2013-02-01 00:00:00

abstract：:Deficiency of lysosomal acid lipase (LAL) leads to either Wolman disease (WD) or the more benign cholesteryl ester storage disease (CESD). To identify the molecular basis of the different phenotypes we have characterised the LAL gene mutations in three new patients with LAL deficiency. A patient with WD was homozygote...

journal_title：Journal of lipid research

authors： Pagani F,Pariyarath R,Garcia R,Stuani C,Burlina AB,Ruotolo G,Rabusin M,Baralle FE

更新日期：1998-07-01 00:00:00

abstract：:Sebum is a complex lipid mixture that is synthesized in sebaceous glands and excreted on the skin surface. The purpose of this study was the comprehensive detection of the intact lipids that compose sebum. These lipids exist as a broad range of chemical structures and concentrations. Sebum was collected with SebuTape(...

journal_title：Journal of lipid research

authors： Camera E,Ludovici M,Galante M,Sinagra JL,Picardo M

更新日期：2010-11-01 00:00:00

abstract：:This study examined the in vivo relationship between expression of the HDL receptor scavenger receptor class B (SR-BI) and corresponding structural changes in the rat adrenocortical cell microvillar compartment. Using hormonal stimulation and withdrawal protocols, we were able to manipulate adrenal SR-BI levels and ca...

journal_title：Journal of lipid research

authors： Azhar S,Nomoto A,Reaven E

更新日期：2002-06-01 00:00:00

abstract：:Xanthophyllomyces dendrorhous is a basidiomycete yeast known as a natural producer of astaxanthin, a carotenoid of commercial interest because of its antioxidant properties. Recent studies indicated that X. dendrorhous has a functional SREBP pathway involved in the regulation of isoprenoid compound biosynthesis, which...

journal_title：Journal of lipid research

authors： Gómez M,Gutiérrez MS,González AM,Gárate-Castro C,Sepúlveda D,Barahona S,Baeza M,Cifuentes V,Alcaíno J

更新日期：2020-02-01 00:00:00

abstract：:Incubation of 125I-labeled very low density lipoprotein (VLDL) with lipoprotein lipase-rich (postheparin) plasma obtained from intact or supradiaphragmatic rats resulted in the transfer of more than 80% of apoprotein C from VLDL to high density lipoprotein (HDL), whereas apoprotein B was associated with lipoprotein of...

journal_title：Journal of lipid research

authors： Eisenberg S,Rachmilewitz D

更新日期：1975-09-01 00:00:00

abstract：:A method has been developed for rapidly quantitating the cholesterol concentration of normal and certain variant lipoproteins in a large number of patients (over 240 in one week). The method employs a microcomputer interfaced to the vertical autoprofiler (VAP) described earlier (Chung et al. 1981. J. Lipid Res. 22: 10...

journal_title：Journal of lipid research

authors： Cone JT,Segrest JP,Chung BH,Ragland JB,Sabesin SM,Glasscock A

更新日期：1982-08-01 00:00:00

abstract：:Protein farnesylation is a form of posttranslational modification that occurs in most, if not all, eukaryotic cells. Inhibitors of protein farnesyltransferase (PFTIs) have been developed as anticancer chemotherapeutic agents. Using the knowledge gained from the development of PFTIs for the treatment of cancer, researc...

journal_title：Journal of lipid research

authors： Eastman RT,Buckner FS,Yokoyama K,Gelb MH,Van Voorhis WC

更新日期：2006-02-01 00:00:00

abstract：:Isotopic measurement of biosynthetic rates of lipids in VLDL particles has long posed difficult technical problems. In this review, key methodologic issues and recent technical advances are discussed. A common problem for all biosynthetic measurements is the requirement to measure isotopic labeling of the true intrace...

journal_title：Journal of lipid research

authors： Parks EJ,Hellerstein MK

更新日期：2006-08-01 00:00:00

abstract：:The rate of lipolytic enzyme-catalyzed reactions yielding water-soluble products can be measured by isobaric titration. The method is based upon the measurement of the amount of substrate that must be added to a monalayer to maintain constant surface pressure during the course of the enzymatic reaction. The rate const...

journal_title：Journal of lipid research

authors： Brockman HL,Kézdy FJ,Law JH

更新日期：1975-01-01 00:00:00

abstract：:Prostaglandin (PG)E(2) is relevant in tumor biology, and interactions between tumor and stroma cells dramatically influence tumor progression. We tested the hypothesis that cross-talk between head and neck squamous cell carcinoma (HNSCC) cells and fibroblasts could substantially enhance PGE(2) biosynthesis. We observe...

journal_title：Journal of lipid research

authors： Alcolea S,Antón R,Camacho M,Soler M,Alfranca A,Avilés-Jurado FX,Redondo JM,Quer M,León X,Vila L

更新日期：2012-04-01 00:00:00

abstract：:Phytanic acid (3,7,11,15-tetramethylhexadecanoic acid) is a branched-chain fatty acid derived from dietary sources and broken down in the peroxisome to pristanic acid (2,6,10,14-tetramethylpentadecanoic acid) via alpha-oxidation. Pristanic acid then undergoes beta-oxidation in peroxisomes. Phytanic acid naturally occu...

journal_title：Journal of lipid research

authors： Ferdinandusse S,Rusch H,van Lint AE,Dacremont G,Wanders RJ,Vreken P

更新日期：2002-03-01 00:00:00

abstract：:Bile acids labeled with 3H on the sterol nucleus lose a substantial fraction of label during enterohepatic cycling and conversion to secondary bile acids. We tested the isotopic stability of a side-chain 3H label, [22,23-3H]cholic acid in humans. The 3H-labeled compound was administered simultaneously with [24-14C]cho...

journal_title：Journal of lipid research

authors： Duane WC,Schteingart CD,Ton-Nu HT,Hofmann AF

更新日期：1996-02-01 00:00:00

abstract：:A glycerophospholipid (1-O-tuberculostearoyl-2-O-palmitoyl-sn-glycero-3-phosphoethanolamine) from Mycobacterium tuberculosis was isolated from the reference strain H37Rv. The molecular structure of this tuberculostearoyl [(R)-10-methyloctadecyl] and palmitoyl containing phosphatidylethanolamine (PE) has been resolved....

journal_title：Journal of lipid research

authors： Ter Horst B,Seshadri C,Sweet L,Young DC,Feringa BL,Moody DB,Minnaard AJ

更新日期：2010-05-01 00:00:00

abstract：:We used a mouse C57BL/6J×CASA/Rk intercross to map a locus on chromosome 14 that displayed a gender-dependent effect on cholesterol absorption from the intestine. Studies in congenic animals revealed a complex locus with multiple operating genetic determinants resulting in alternating gender-dependent phenotypic effec...

journal_title：Journal of lipid research

authors： Wong WP,Altemus JB,Hester JF,Chan ER,Côté JF,Serre D,Sehayek E

更新日期：2013-03-01 00:00:00

abstract：:Studies were carried out to determine whether apolipoprotein (apo) A-II, like apoA-I, can recruit phospholipid and cholesterol from cell membranes, thereby forming nascent apoA-II-specific HDL. ApoA-II and apoA-I were purified from plasma and each was incubated with CHO cells at a concentration of 10 micrograms/ml. Li...

journal_title：Journal of lipid research

authors： Forte TM,Bielicki JK,Goth-Goldstein R,Selmek J,McCall MR

更新日期：1995-01-01 00:00:00

abstract：:To examine the validity of the deuterium (D) incorporation technique for measurement of human cholesterol synthesis rates, D uptake from D2O into cholesterol was compared to sterol balance in 13 subjects each under three controlled diet settings. Subjects (age 62 +/- 3.6 yr, body weight 74 +/- 4.0 kg, BMI 27 +/- 1.4) ...

journal_title：Journal of lipid research

authors： Jones PJ,Ausman LM,Croll DH,Feng JY,Schaefer EA,Lichtenstein AH

更新日期：1998-05-01 00:00:00

abstract：:Oligosaccharyl phosphates (OSPs) are hydrolyzed from oligosaccharide-diphosphodolichol (DLO) during protein N-glycosylation by an uncharacterized process. An OSP-generating activity has been reported in vitro, and here we asked if its biochemical characteristics are compatible with a role in endoplasmic reticulum (ER)...

journal_title：Journal of lipid research

authors： Massarweh A,Bosco M,Iatmanen-Harbi S,Tessier C,Auberger N,Busca P,Chantret I,Gravier-Pelletier C,Moore SE

更新日期：2016-06-01 00:00:00

abstract：:During intestinal absorption amino acids must traverse the lipid-rich epithelial cell membrane, possibly in a lipid-soluble form. In a search for such a form, we have determined the ability of lipid extracted from intestinal mucosa to bind valine. After incubation in a valine-containing medium this lipid (defined as t...

journal_title：Journal of lipid research

authors： Reiser S,Christiansen PA

更新日期：1968-09-01 00:00:00

abstract：:The phase behavior and temperature-dependent molecular motions of three cholesteryl ethers (caproyl, myristyl, oleyl) and a cholesteryl carbonate (oleyl) were characterized. The properties of each ether were qualitatively similar to, but quantitatively different from, those of the corresponding cholesteryl ester. For ...

journal_title：Journal of lipid research

authors： Croll DH,Sripada PK,Hamilton JA

更新日期：1987-12-01 00:00:00

abstract：:Distinct isoforms of long-chain acyl-CoA synthetases (ACSLs) may partition fatty acids toward specific metabolic cellular pathways. For each of the five members of the rat ACSL family, we analyzed tissue mRNA distributions, and we correlated the mRNA, protein, and activity of ACSL1 and ACSL4 after fasting and refeedin...

journal_title：Journal of lipid research

authors： Mashek DG,Li LO,Coleman RA

更新日期：2006-09-01 00:00:00

abstract：:The apoproteins of serum lipoproteins and of lipoproteins present in a nonrecirculating perfusate of rat liver were compared by immunochemical, gel electrophoretic, and solubility techniques. Serum and perfusate very low density lipoprotein apoprotein composition were not different. No evidence for the presence of a l...

journal_title：Journal of lipid research

authors： Marsh JB

更新日期：1976-01-01 00:00:00

abstract：:The HDL Atherosclerosis Treatment Study (HATS) demonstrated a clinical benefit in coronary artery disease patients with low HDL cholesterol (HDL-C) levels treated with simvastatin and niacin (S-N) or S-N plus antioxidants (S-N+A) compared with antioxidants alone or placebo. Angiographically documented stenosis regress...

journal_title：Journal of lipid research

authors： Matthan NR,Giovanni A,Schaefer EJ,Brown BG,Lichtenstein AH

更新日期：2003-04-01 00:00:00

abstract：:Mice with a targeted mutation of 3beta-hydroxysterol Delta(7)-reductase (Dhcr7) that cannot convert 7-dehydrocholesterol to cholesterol were used to identify the origin of fetal sterols. Because their heterozygous mothers synthesize cholesterol normally, virtually all sterols found in a Dhcr7 knockout fetus having a D...

journal_title：Journal of lipid research

authors： Tint GS,Yu H,Shang Q,Xu G,Patel SB

更新日期：2006-07-01 00:00:00