SAR1B GTPase is necessary to protect intestinal cells from disorders of lipid homeostasis, oxidative stress, and inflammation.

abstract：:The central region of apolipoprotein A-I (apoA-I), spanning residues 143--165, has been implicated in lecithin:cholesterol acyltransferase (LCAT) activation and also in high density lipoprotein (HDL) structural rearrangements. To examine the role of individual amino acids in these functions, we constructed, overexpres...

journal_title：Journal of lipid research

authors： Cho KH,Durbin DM,Jonas A

更新日期：2001-03-01 00:00:00

abstract：:The selective and reversible adsorption of bovine low density lipoproteins (LDL) by heparin-Sepharose has been exploited as the critical step in a procedure for the preparative isolation of very low density lipoproteins (VLDL)/chylomicrons, LDL, and high density lipoproteins (HDL) from bovine plasma. Molecular size ex...

journal_title：Journal of lipid research

authors： Cordle SR,Clegg RA,Yeaman SJ

更新日期：1985-06-01 00:00:00

abstract：:We analysed the sensitivity to beta-adrenoceptor agonists in epididymal adipose cells from rats submitted to a stress protocol previously reported to induce alterations in sensitivity to catecholamines in cardiac tissue from rats. Food intake and body weight were lower, whereas adipocytes basal lipolysis was higher (c...

journal_title：Journal of lipid research

authors： Farias-Silva E,Grassi-Kassisse DM,Wolf-Nunes V,Spadari-Bratfisch RC

更新日期：1999-09-01 00:00:00

abstract：:The objective of this study was to investigate the mobilization of individual fatty acids from human subcutaneous adipose tissue in vivo. Concentrations of individual non-esterified fatty acids were measured in arterialized plasma and in the venous drainage from subcutaneous abdominal adipose tissue in eight normal su...

journal_title：Journal of lipid research

authors： Halliwell KJ,Fielding BA,Samra JS,Humphreys SM,Frayn KN

更新日期：1996-09-01 00:00:00

abstract：:The hypothesis of lipid domains in cellular plasma membranes is well established. However, direct visualization of the domains has been difficult. Here we report direct visualization of plasma membrane cholesterol microdomains modulated by agents that affect cholesterol trafficking to and from the plasma membrane. The...

journal_title：Journal of lipid research

authors： Kruth HS,Ifrim I,Chang J,Addadi L,Perl-Treves D,Zhang WY

更新日期：2001-09-01 00:00:00

abstract：:The phospholipase A2(PLA2) activity of peroxiredoxin (Prdx)6 has important physiological roles in the synthesis of lung surfactant and in the repair of peroxidized cell membranes. These functions require the activity of a lysophospholipid acyl transferase as a critical component of the phospholipid remodeling pathway....

journal_title：Journal of lipid research

authors： Fisher AB,Dodia C,Sorokina EM,Li H,Zhou S,Raabe T,Feinstein SI

更新日期：2016-04-01 00:00:00

abstract：:Apolipoprotein A-V (apoA-V) first gained attention as a regulator of triglycerides through transgenic mouse studies. Furthermore, peroxisome proliferator-activated receptor alpha (PPARalpha) agonists such as fenofibrate increase apoA-V mRNA expression. Our group recently developed the first assay to quantitate serum a...

journal_title：Journal of lipid research

authors： Schultze AE,Alborn WE,Newton RK,Konrad RJ

更新日期：2005-08-01 00:00:00

abstract：:Subcellular localization of nonesterified cholesterol has been determined in normal human fibroblasts from cultures incubated with human low density lipoprotein (LDL). Nonesterified and esterified cholesterol content of fibroblasts, grown initially in the absence of cholesterol, increased significantly after a 1-hour ...

journal_title：Journal of lipid research

authors： Kruth HS,Blanchette-Mackie J,Avigan J,Gamble W,Vaughan M

更新日期：1982-11-01 00:00:00

abstract：:This review focuses on adipose tissue biology and introduces the concept of adipose tissue plasticity and expandability as key determinants of obesity-associated metabolic dysregulation. This concept is fundamental to our understanding of adipose tissue as a dynamic organ at the center of nutritional adaptation. Here,...

journal_title：Journal of lipid research

authors： Sethi JK,Vidal-Puig AJ

更新日期：2007-06-01 00:00:00

abstract：:We used a mouse C57BL/6J×CASA/Rk intercross to map a locus on chromosome 14 that displayed a gender-dependent effect on cholesterol absorption from the intestine. Studies in congenic animals revealed a complex locus with multiple operating genetic determinants resulting in alternating gender-dependent phenotypic effec...

journal_title：Journal of lipid research

authors： Wong WP,Altemus JB,Hester JF,Chan ER,Côté JF,Serre D,Sehayek E

更新日期：2013-03-01 00:00:00

abstract：:Ceramides are the predominant lipids in the stratum corneum (SC) and are crucial components for normal skin barrier function. Although the composition of various ceramide classes in the human SC has been reported, that in mice is still unknown, despite mice being widely used as animal models of skin barrier function. ...

journal_title：Journal of lipid research

authors： Kawana M,Miyamoto M,Ohno Y,Kihara A

更新日期：2020-06-01 00:00:00

abstract：:The activity of rat liver microsomal squalene epoxidase is inhibited effectively by digitonin. Concentrations of 0.8 to 1.2 mg/ml of digitonin cause total inhibition of microsomal (0.75 mg protein/ml) squalene epoxidase either in microsomes that were pretreated with digitonin and subsequently washed and subjected to e...

journal_title：Journal of lipid research

authors： Eilenberg H,Klinger E,Przedecki F,Shechter I

更新日期：1989-08-01 00:00:00

abstract：:Based on our previous observation that monoclonal antibody anti-apoD-4E11 reacted with several HDL proteins we studied them further with three questions in mind: i) is there common protein polymorphism in healthy individuals? ii) how many proteins are present and what are their characteristics? iii) are they all apoli...

journal_title：Journal of lipid research

authors： Camato R,Marcel YL,Milne RW,Lussier-Cacan S,Weech PK

更新日期：1989-06-01 00:00:00

abstract：:The melanocortin system is an important regulator of energy balance, and melanocortin 4 receptor (MC4R) deficiency is the most common monogenic cause of obesity. We investigated whether the relationship between melanocortin system activity and energy expenditure (EE) is mediated by brown adipose tissue (BAT) activity....

journal_title：Journal of lipid research

authors： Kooijman S,Boon MR,Parlevliet ET,Geerling JJ,van de Pol V,Romijn JA,Havekes LM,Meurs I,Rensen PC

更新日期：2014-10-01 00:00:00

abstract：:The total nitrogen and L-hydroxyproline concentrations of two intra-abdominal and two subcutaneous sites of adipose tissue were measured in male and female Wistar rats. At 100 g body weight the nitrogen concentration of intra-abdominal adipose tissue was slightly lower than that of subcutaneous adipose tissue. As age ...

journal_title：Journal of lipid research

authors： Curtis-Prior PB,Hanley T,Trethewey J,Stewart GA

更新日期：1970-07-01 00:00:00

abstract：:Previous studies have demonstrated that perturbations in barrier function stimulate epidermal lipid synthesis and that this increase can be prevented by occlusive membranes. These observations suggest that epidermal lipid synthesis might be related to barrier function and raised the question whether transcutaneous wat...

journal_title：Journal of lipid research

authors： Grubauer G,Elias PM,Feingold KR

更新日期：1989-03-01 00:00:00

abstract：:The percentage of saturated cholesteryl esters (CEs) synthesized by human LCAT is several times higher than expected from the sn-2 acyl composition of plasma phosphatidylcholine (PC), whereas the synthesis of 20:4 CE and 22:6 CE is much lower than expected. To explain these discrepancies, we proposed that LCAT transfe...

journal_title：Journal of lipid research

authors： Subbaiah PV,Sowa JM,Davidson MH

更新日期：2004-12-01 00:00:00

abstract：:The objectives of this study were to characterize the effects of plasma lipoproteins on prostacyclin (PGI2) production by the Langendorff-perfused rabbit heart, and to determine the mechanism of lipoprotein-induced cardiac PGI2 production. PGI2 production by perfused rabbit hearts was stimulated by injections of rabbi...

journal_title：Journal of lipid research

authors： Van Sickle WA,Wilcox HG,Malik KU,Nasjletti A

更新日期：1986-05-01 00:00:00

abstract：:Several studies indicate that cholesterol esterification is deregulated in cancers. The present study aimed to characterize the role of cholesterol esterification in proliferation and invasion of two tumor cells expressing an activated cholecystokinin 2 receptor (CCK2R). A significant increase in cholesterol esterific...

journal_title：Journal of lipid research

authors： Paillasse MR,de Medina P,Amouroux G,Mhamdi L,Poirot M,Silvente-Poirot S

更新日期：2009-11-01 00:00:00

abstract：:Blood levels of lipoprotein cholesterol and triglycerides (TGs) are highly heritable and are major risk factors for cardiovascular disease (CVD). Approximately 100 lipid-associated loci have been identified in populations of European ancestry. We performed a genome-wide association study of lipid traits in 1,782 Filip...

journal_title：Journal of lipid research

authors： Wu Y,Marvelle AF,Li J,Croteau-Chonka DC,Feranil AB,Kuzawa CW,Li Y,Adair LS,Mohlke KL

更新日期：2013-11-01 00:00:00

abstract：:In breast cancer, 17β-estradiol (E2) plays critical roles mainly by binding to its canonical receptor, estrogen receptor (ER) α66, and eliciting genomic effects. E2 also triggers rapid, nongenomic responses. E2 activates sphingosine kinase 1 (SphK1), increasing sphingosine-1-phosphate (S1P) that binds to its receptors...

journal_title：Journal of lipid research

authors： Maczis MA,Maceyka M,Waters MR,Newton J,Singh M,Rigsby MF,Turner TH,Alzubi MA,Harrell JC,Milstien S,Spiegel S

更新日期：2018-12-01 00:00:00

abstract：:Chiral phase high performance liquid chromatographic resolution of sn-1,2(2,3)- and X-1,3-diacylglycerols generated by partial Grignard degradation from natural triacylglycerols was carried out using a chiral column (25 cm x 4.6 mm i.d.) containing (R)-(+)-1-(1-napthyl)ethylamine polymer chemically bonded to 300A wide...

journal_title：Journal of lipid research

authors： Itabashi Y,Kukis A,Marai L,Takagi T

更新日期：1990-09-01 00:00:00

abstract：:Cellular cholesterol is known to be under homeostatic control in nonsteroidogenic cells, and this intrigued us to understand how such control works in steroidogenic cells that additionally use cholesterol for steroid hormone synthesis. We employed primary culture of rat ovarian granulosa cells to study how steroidogen...

journal_title：Journal of lipid research

authors： Lai WA,Yeh YT,Lee MT,Wu LS,Ke FC,Hwang JJ

更新日期：2013-02-01 00:00:00

abstract：:A method for apolipoprotein (apo) E genotyping was developed using the polymerase chain reaction (PCR) with allele-specific oligonucleotide primers (ASP). Synthetic oligonucleotides with base-pair mismatches at the 3' terminus were used as primers to amplify the apoE gene in subjects previously phenotyped using isoele...

journal_title：Journal of lipid research

authors： Main BF,Jones PJ,MacGillivray RT,Banfield DK

更新日期：1991-01-01 00:00:00

abstract：:Sphingolipid metabolites function as signaling molecules in mammalian cells, influencing cell proliferation, migration, and death. Recently, sphingolipid signaling has been implicated in the regulation of developmental processes in Drosophila melanogaster. However, biochemical analysis of endogenous Drosophila sphingo...

journal_title：Journal of lipid research

authors： Fyrst H,Herr DR,Harris GL,Saba JD

更新日期：2004-01-01 00:00:00

abstract：:Small dense LDL (sdLDL) has been reported to be more atherogenic than large buoyant LDL (lbLDL). We examined the metabolism and protein composition of sdLDL and lbLDL in six subjects with combined hyperlipidemia on placebo and rosuvastatin 40 mg/day. ApoB-100 kinetics in triglyceride-rich lipoproteins (TRLs), lbLDL (d...

journal_title：Journal of lipid research

authors： Thongtang N,Diffenderfer MR,Ooi EMM,Barrett PHR,Turner SM,Le NA,Brown WV,Schaefer EJ

更新日期：2017-07-01 00:00:00

abstract：:Acyl-CoA thioesterase (Acot)2 localizes to the mitochondrial matrix and hydrolyses long-chain fatty acyl-CoA into free FA and CoASH. Acot2 is expressed in highly oxi-dative tissues and is poised to modulate mitochondrial FA oxidation (FAO), yet its biological role is unknown. Using a model of adenoviral Acot2 overexpr...

journal_title：Journal of lipid research

authors： Moffat C,Bhatia L,Nguyen T,Lynch P,Wang M,Wang D,Ilkayeva OR,Han X,Hirschey MD,Claypool SM,Seifert EL

更新日期：2014-12-01 00:00:00

abstract：:A two-step polymerase chain reaction (PCR) method for the rapid detection of the apolipoprotein B(Arg3500----Gln) mutation in a mixture of pooled blood samples is described. In the first step PCR, a short gene fragment surrounding codon 3500 is amplified. Subsequently the reaction product is subjected to a second ampl...

journal_title：Journal of lipid research

authors： Ruzicka V,März W,Russ A,Gross W

更新日期：1992-10-01 00:00:00

abstract：:A simple procedure is described for preparing lyso-GM1, a GM1 derivative that lacks the fatty acid moiety, starting from GM1 ganglioside using a one-pot reaction. Ganglioside deacylation was carried out in KOH/propan-1-ol in the absence of oxygen. The yield of lyso-GM1 under optimal conditions (6 h, 90 degrees C, 0.2 ...

journal_title：Journal of lipid research

authors： Sonnino S,Acquotti D,Kirschner G,Uguaglianza A,Zecca L,Rubino F,Tettamanti G

更新日期：1992-08-01 00:00:00

abstract：:LDL receptor-null (LDLR(-/-)) mice on a Western diet (WD) develop endothelial dysfunction and atherosclerosis, which are improved by the apolipoprotein A-I (apoA-I) mimetic peptide D-4F. Focusing on the kidney, LDLR(-/-)mice were fed a WD with D-4F or the inactive control peptide scrambled D-4F (ScD-4F) added to their...

journal_title：Journal of lipid research

authors： Buga GM,Frank JS,Mottino GA,Hakhamian A,Narasimha A,Watson AD,Yekta B,Navab M,Reddy ST,Anantharamaiah GM,Fogelman AM

更新日期：2008-01-01 00:00:00