Thematic review series: skin lipids. Sebaceous gland lipids: friend or foe?

abstract：:To study the effect of an unstirred layer (UL), we have investigated the exchange efflux kinetics of anandamide at 0 degrees C, pH 7.3, from albumin-free as well as from albumin-filled human red blood cell ghosts to media of various BSA concentrations ([BSA](o)). The rate constant (k(m)) of unidirectional flux from th...

journal_title：Journal of lipid research

authors： Bojesen IN,Hansen HS

更新日期：2006-03-01 00:00:00

abstract：:Vitamin E (α-tocopherol) is the major lipid-soluble antioxidant in many species. Niemann-Pick type C (NPC) disease is a lysosomal storage disorder caused by mutations in the NPC1 or NPC2 gene, which regulates lipid transport through the endocytic pathway. NPC disease is characterized by massive intracellular accumulat...

journal_title：Journal of lipid research

authors： Ulatowski L,Parker R,Davidson C,Yanjanin N,Kelley TJ,Corey D,Atkinson J,Porter F,Arai H,Walkley SU,Manor D

更新日期：2011-07-01 00:00:00

abstract：:Cholesterol efflux (CE) capacity has been inversely associated with atherosclerosis and may provide an insight on inflammation occurring in human immunodeficiency virus (HIV) individuals. We address this by studying CE in HIV patients at different stages of HIV disease progression. In this cross-sectional study, CE fr...

journal_title：Journal of lipid research

authors： Tort O,Escribà T,Egaña-Gorroño L,de Lazzari E,Cofan M,Fernandez E,Gatell JM,Martinez E,Garcia F,Arnedo M

更新日期：2018-11-01 00:00:00

abstract：:At 123 K, crystals of cholesteryl cis-9-hexadecenoate (cholesteryl palmitoleate, C45H74O2) are monoclinic, space group P2(1) with cell dimensions a = 12.917(7), b = 8.910(5), c = 34.04(1) A, beta = 94.95(7) degrees [lambda(CuK alpha) = 1.5424 A] having two independent molecules (A and B) per unit cell. The crystal str...

journal_title：Journal of lipid research

authors： Craven BM,Sawzik P

更新日期：1984-08-01 00:00:00

abstract：:Recombinant human pancreatic lipase-related protein 2 (rHPLRP2) was produced in the protease A-deficient yeast Pichia pastoris. A major protein with a molecular mass of 50 kDa was purified from the culture medium using SP-Sepharose and Mono Q chromatography. The protein was found to be highly sensitive to the proteoly...

journal_title：Journal of lipid research

authors： Eydoux C,De Caro J,Ferrato F,Boullanger P,Lafont D,Laugier R,Carrière F,De Caro A

更新日期：2007-07-01 00:00:00

abstract：:Lipid and cholesterol metabolism in the postprandial phase is associated with both quantitative and qualitative remodeling of HDL particle subspecies that may influence their anti-atherogenic functions in the reverse cholesterol transport pathway. We evaluated the capacity of whole plasma or isolated HDL particles to ...

journal_title：Journal of lipid research

authors： Julia Z,Duchene E,Fournier N,Bellanger N,Chapman MJ,Le Goff W,Guerin M

更新日期：2010-11-01 00:00:00

abstract：:In late-stage atherosclerosis, much of the cholesterol in macrophage foam cells resides within enlarged lysosomes. Similarly, human macrophages incubated in vitro with modified LDLs contain significant amounts of lysosomal free cholesterol and cholesteryl ester (CE), which disrupts lysosomal function similar to macrop...

journal_title：Journal of lipid research

authors： Ullery-Ricewick JC,Cox BE,Griffin EE,Jerome WG

更新日期：2009-10-01 00:00:00

abstract：:The facile synthesis of lithocholic acids sulfates by a procedure that produced the desired products in over 90% yield is described. Lithocholic acid sulfate and glycolithocholic acid sulfate were synthesized by reacting lithocholic acid or glycolithocholic acid with sulfur trioxide-triethylamine complex in dimethylfo...

journal_title：Journal of lipid research

authors： Tserng KY,Klein PD

更新日期：1977-07-01 00:00:00

abstract：:Acetyl-L-carnitine is known as a reservoir of activated acetyl units and as a modulator of metabolic function. The objective of this study was to quantify the fate of the acetyl moiety of acetyl-L-carnitine in lipogenic pathways. Lipogenesis was studied in an adipocyte model, differentiated 3T3-L1 cells, and a hepatom...

journal_title：Journal of lipid research

authors： Lligona-Trulla L,Arduini A,Aldaghlas TA,Calvani M,Kelleher JK

更新日期：1997-07-01 00:00:00

abstract：:Recent studies from our laboratory (Yancey, P.G., and R. W. St. Clair. 1992. Arterioscler. Thromb. 12: 1291-1304) have shown that cultured peritoneal macrophages from White Carneau (WC) pigeons clear cholesteryl esters at a slower rate than do macrophages from Show Racer (SR) pigeons (9% per 24 h vs. 42% per 24 h, res...

journal_title：Journal of lipid research

authors： Yancey PG,St Clair RW

更新日期：1994-12-01 00:00:00

abstract：:A preparation of cerebral microvessels was used to demonstrate the presence of lipoprotein lipase and acid lipase activity in the microvasculature of rabbit brain. Microvessels, consisting predominantly of capillaries, small arterioles, and venules, were islated from rabbit brain. Homogenates were assayed for lipolyti...

journal_title：Journal of lipid research

authors： Brecher P,Kuan HT

更新日期：1979-05-01 00:00:00

abstract：:The ATP binding cassette (ABC) half-transporters ABCG5 and ABCG8 facilitate biliary and intestinal removal of neutral sterols. Here, we identify a binding site for the orphan nuclear receptor liver receptor homolog-1 (LRH-1) at nt 134-142 of the ABCG5/ABCG8 intergenic region necessary for the activity of both the ABCG...

journal_title：Journal of lipid research

authors： Freeman LA,Kennedy A,Wu J,Bark S,Remaley AT,Santamarina-Fojo S,Brewer HB Jr

更新日期：2004-07-01 00:00:00

abstract：:The extent to which the heart can convert alpha-linolenic acid (alpha-LNA, 18:3n-3) to longer chain n-3 PUFAs is not known. Conversion rates can be measured in vivo using radiolabeled alpha-LNA and a kinetic fatty acid model. [1-(14)C]alpha-LNA was infused intravenously for 5 min in unanesthetized rats that had been f...

journal_title：Journal of lipid research

authors： Igarashi M,Ma K,Chang L,Bell JM,Rapoport SI

更新日期：2008-08-01 00:00:00

abstract：:(13)C-Cholesterol was produced with high efficiency by a genetically engineered yeast strain. The method produces ∼ 1 mg of cholesterol per gram of glucose using 100 ml of culture medium. Uniform 94% enrichment where the most abundant product is the fully enriched isotopomer (u-(13)C(27)) is obtained using (u-(13)C(6)...

journal_title：Journal of lipid research

authors： Shivapurkar R,Souza CM,Jeannerat D,Riezman H

更新日期：2011-05-01 00:00:00

abstract：:A sensitive and reproducible method has been developed for separation of the major serum lipoproteins from 1 ml or less of human serum by isopycnic density gradient ultracentrifugation. The serum, applied to a step gradient (total volume 12.8 ml), was spun for 48 hr at 38,000 rpm at 10 degrees C and, in each of the fr...

journal_title：Journal of lipid research

authors： Foreman JR,Karlin JB,Edelstein C,Juhn DJ,Rubenstein AH,Scanu AM

更新日期：1977-11-01 00:00:00

abstract：:Sequence homology indicates the existence of three human cytosolic acyl protein thioesterases, including APT1 that is known to depalmitoylate H- and N-Ras. One of them is the lysophospholipase-like 1 (LYPLAL1) protein that on the one hand is predicted to be closely related to APT1 but on the other hand might also func...

journal_title：Journal of lipid research

authors： Bürger M,Zimmermann TJ,Kondoh Y,Stege P,Watanabe N,Osada H,Waldmann H,Vetter IR

更新日期：2012-01-01 00:00:00

abstract：:Extracts of urine and serum from children with cholestatic liver disease were analyzed by fast atom bombardment (FAB) mass spectrometry. About half of all spectra showed a peak at m/z 657, compatible with the presence of a glucuronidated cholestenediol sulfate. Separation by ion exchange chromatography before and afte...

journal_title：Journal of lipid research

authors： Meng LJ,Griffiths WJ,Nazer H,Yang Y,Sjövall J

更新日期：1997-05-01 00:00:00

abstract：:Oligosaccharyl phosphates (OSPs) are hydrolyzed from oligosaccharide-diphosphodolichol (DLO) during protein N-glycosylation by an uncharacterized process. An OSP-generating activity has been reported in vitro, and here we asked if its biochemical characteristics are compatible with a role in endoplasmic reticulum (ER)...

journal_title：Journal of lipid research

authors： Massarweh A,Bosco M,Iatmanen-Harbi S,Tessier C,Auberger N,Busca P,Chantret I,Gravier-Pelletier C,Moore SE

更新日期：2016-06-01 00:00:00

abstract：:Immunological tolerance is one of the fundamental aspects of the immune system. The CD4(+)CD25(+) regulatory T (Treg) cells have emerged as key players in the development of tolerance to self and foreign antigens. However, little is known about the endogenous factors and mechanisms controlling their suppressive capaci...

journal_title：Journal of lipid research

authors： Yessoufou A,Plé A,Moutairou K,Hichami A,Khan NA

更新日期：2009-12-01 00:00:00

abstract：:The metabolism of chenodeoxycholic acid by Pseudomonas sp. NCIB 10590 under strict anaerobic conditions was studied. A range of unsaturated acidic and neutral metabolites were isolated and identified. The major acidic product was chola-4,6-dien-3-one-24-oic acid whilst the major neutral product was androsta-4,6-dien-3...

journal_title：Journal of lipid research

authors： Owen RW,Hill MJ,Bilton RF

更新日期：1983-09-01 00:00:00

abstract：:Fatty acids (FA) that are utilized for triglyceride (TG) synthesis in the liver and principally from two sources: FA synthesized de novo in the liver and preformed FA. We have measured the contribution from the two sources to very low density lipoprotein (VLDL) TG synthesis individually for palmitate, oleate, stearate...

journal_title：Journal of lipid research

authors： Aarsland A,Wolfe RR

更新日期：1998-06-01 00:00:00

abstract：:Methods were developed for the determination of HMG CoA (3-hydroxy-3-methylglutaryl CoA) reductase activity in subcellular fractions of intestinal mucosa and liver of Wistar strain rats. In the liver, reductase activity was located exclusively in the microsomal fraction. In the intestinal mucosa, activity was found in...

journal_title：Journal of lipid research

authors： Shefer S,Hauser S,Lapar V,Mosbach EH

更新日期：1972-05-01 00:00:00

abstract：:Wax esters are neutral lipids exhibiting desirable properties for lubrication. Natural sources have traditionally been whales. Additionally some plants produce wax esters in their seed oil. Currently there is no biological source available for long chain length monounsaturated wax esters that are most suited for indus...

journal_title：Journal of lipid research

authors： Heilmann M,Iven T,Ahmann K,Hornung E,Stymne S,Feussner I

更新日期：2012-10-01 00:00:00

abstract：:The factors involved in shuttling cholesterol among cellular membranes have not been defined. Using amphotericin B selection, we previously isolated Chinese hamster ovary cell mutants expressing defects in intracellular cholesterol transport. Complementation analysis among seven mutants identified one cell line, mutan...

journal_title：Journal of lipid research

authors： Jacobs NL,Andemariam B,Underwood KW,Panchalingam K,Sternberg D,Kielian M,Liscum L

更新日期：1997-10-01 00:00:00

abstract：:Cystic fibrosis (CF) patients and model systems exhibit consistent abnormalities in PUFA metabolism, including increased metabolism of linoleate to arachidonate. Recent studies have connected these abnormalities to increased expression and activity of the Δ6- and Δ5-desaturase enzymes. However, the mechanism connectin...

journal_title：Journal of lipid research

authors： Umunakwe OC,Seegmiller AC

更新日期：2014-07-01 00:00:00

abstract：:In order to study the metabolic responses of humans consuming a diet moderately high in cholesterol content, we carried out a long-term sterol balance study, up to 25 weeks in duration. Two subjects, one normocholesterolemic and one hypercholesterolemic, were given, in sequence, a very low cholesterol diet and then a ...

journal_title：Journal of lipid research

authors： Lin DS,Connor WE

更新日期：1980-11-01 00:00:00

abstract：:A method is described for the determination of mevalonate in ultrafiltrates of blood plasma. The method depends on the phosphorylation of mevalonate with [gamma-32P]ATP and mevalonate kinase to 5-[32P]phosphomevalonate, and the subsequent isolation of the 5-[32P]phosphomevalonate together with known amounts of added 5...

journal_title：Journal of lipid research

authors： Popják G,Boehm G,Parker TS,Edmond J,Edwards PA,Fogelman AM

更新日期：1979-08-01 00:00:00

abstract：:Four groups of 20 weanling swine each were fed either (a) basal diet, (b) basal plus hydrogenated fat (13% trans), (c) basal plus hydrogenated fat (13% trans) and 0.4% cholesterol, or (d) basal plus beef tallow (all cis). After six months of feeding, the animals were killed and the blood and aortas were removed. Very ...

journal_title：Journal of lipid research

authors： Jackson RL,Morrisett JD,Pownall HJ,Gotto AM Jr,Kamio A,Imai H,Tracy R,Kummerow FA

更新日期：1977-03-01 00:00:00

abstract：:Neu-Laxova syndrome (NLS) is a very rare autosomal recessive congenital disorder characterized by disturbed development of the central nervous system and the skin and caused by mutations in any of the three genes involved in de novo l-serine biosynthesis: PHGDH, PSAT1, and PSPH l-Serine is essential for the biosynthes...

journal_title：Journal of lipid research

authors： Takeichi T,Okuno Y,Kawamoto A,Inoue T,Nagamoto E,Murase C,Shimizu E,Tanaka K,Kageshita Y,Fukushima S,Kono M,Ishikawa J,Ihn H,Takahashi Y,Akiyama M

更新日期：2018-12-01 00:00:00

abstract：:Cellular membranes are not homogenous mixtures of proteins; rather, they are segregated into microdomains on the basis of preferential association between specific lipids and proteins. These microdomains, called lipid rafts, are well known for their role in receptor signaling on the plasma membrane (PM) and are essent...

journal_title：Journal of lipid research

authors： Ouweneel AB,Thomas MJ,Sorci-Thomas MG

更新日期：2020-05-01 00:00:00