Lipoprotein lipase and acid lipase activity in rabbit brain microvessels.

abstract：:Mixed background SHP(-/-) mice are resistant to diet-induced obesity due to increased energy expenditure caused by enhanced PGC-1α expression in brown adipocytes. However, congenic SHP(-/-) mice on the C57BL/6 background showed normal expression of PGC-1α and other genes involved in brown adipose tissue thermogenesis....

journal_title：Journal of lipid research

authors： Park YJ,Kim SC,Kim J,Anakk S,Lee JM,Tseng HT,Yechoor V,Park J,Choi JS,Jang HC,Lee KU,Novak CM,Moore DD,Lee YK

更新日期：2011-12-01 00:00:00

abstract：:Sulfoquinovosyl diglyceride from plant tissues is recovered in sizeable quantities, free from phospholipids and galactolipids. ...

journal_title：Journal of lipid research

authors： Klopfenstein WE,Shigley JW

更新日期：1966-07-01 00:00:00

abstract：:In addition to functioning as detergents that aid digestion of dietary lipids in the intestine, some bile acids have been shown to exhibit antimicrobial activity. However, detailed information on the bactericidal activities of the diverse molecular species of bile acid in humans and rodents is largely unknown. Here, w...

journal_title：Journal of lipid research

authors： Watanabe M,Fukiya S,Yokota A

更新日期：2017-06-01 00:00:00

abstract：:Clostridium absonum was shown to metabolize primary bile acids to give rise to both 7-oxo bile acids and 7 beta-hydroxy (urso) bile acids. At relatively low redox potential (Eh) values, high yields of urso bile acids were achieved (60-75%). If, however, the Eh value of the culture was allowed to rise above approximate...

journal_title：Journal of lipid research

authors： Sutherland JD,Macdonald IA

更新日期：1982-07-01 00:00:00

abstract：:Liver and kidney microsomes have been found to catalyze a rapid decarboxylation of retinoic acid in vitro. The reaction requires NADPH and Fe(2+), and is further stimulated by the presence of pyrophosphate. Thiamine pyrophosphate contained sufficient iron as an impurity to provide strong enhancement of the reaction in...

journal_title：Journal of lipid research

authors： Roberts AB,DeLuca HF

更新日期：1968-07-01 00:00:00

abstract：:ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty acids. There are two known genes encoding the two ACAT enzymes, ACAT1 and ACAT2 (also known as Soat1 and Soat2). In adult humans, ACAT1 is present in most tissues, whereas ACAT2 is localized to enterocytes and hepatocytes. In this...

journal_title：Journal of lipid research

authors： Pramfalk C,Davis MA,Eriksson M,Rudel LL,Parini P

更新日期：2005-09-01 00:00:00

abstract：:The fatty acid composition of human skin fibroblasts grown in 10% dialyzed fetal calf serum can be modified considerably by adding supplemental fatty acids to the culture medium. The degree of modification was dependent on the concentration of added fatty acid over the range tested, 2.5 X 10(-5) to 1 X 10(-4) M. At th...

journal_title：Journal of lipid research

authors： Spector AA,Kiser RE,Denning GM,Koh SW,DeBault LE

更新日期：1979-05-01 00:00:00

abstract：:Familial hypobetalipoproteinemia, a syndrome associated with low plasma cholesterol levels, can be caused by apoB gene mutations. We identified a healthy 42-year-old man whose total plasma cholesterol level was 80 mg/dl. His plasma very low density lipoprotein (VLDL) contained a unique truncated apoB species, apoB-83,...

journal_title：Journal of lipid research

authors： Farese RV Jr,Garg A,Pierotti VR,Vega GL,Young SG

更新日期：1992-04-01 00:00:00

abstract：:The metabolism of chenodeoxycholic acid by Pseudomonas sp. NCIB 10590 under strict anaerobic conditions was studied. A range of unsaturated acidic and neutral metabolites were isolated and identified. The major acidic product was chola-4,6-dien-3-one-24-oic acid whilst the major neutral product was androsta-4,6-dien-3...

journal_title：Journal of lipid research

authors： Owen RW,Hill MJ,Bilton RF

更新日期：1983-09-01 00:00:00

abstract：:Apolipoprotein A-IV (apoA-IV) is involved in the metabolism of chylomicrons and high density lipoproteins. It displays genetic polymorphism due to two co-dominant alleles apoA-IV1 and apoA-IV2. The mutation that causes the polymorphism is a G to T substitution in the third base of codon 360 in the apoA-IV2 allele whic...

journal_title：Journal of lipid research

authors： Tenkanen H

更新日期：1991-03-01 00:00:00

abstract：:Ceramidases catalyze the cleavage of ceramides into sphingosine and fatty acids. Previously, we reported on the use of the RBM14 fluorogenic ceramide analogs to determine acidic ceramidase activity. In this work, we investigated the activity of other amidohydrolases on RBM14 compounds. Both bacterial and human purifie...

journal_title：Journal of lipid research

authors： Casasampere M,Camacho L,Cingolani F,Casas J,Egido-Gabás M,Abad JL,Bedia C,Xu R,Wang K,Canals D,Hannun YA,Mao C,Fabrias G

更新日期：2015-10-01 00:00:00

abstract：:Studies were conducted to explore vitamin A transport in the non-mammalian vertebrates, especially Pisces, Amphibia, and Reptilia, and to isolate and partially characterize piscine retinol-binding protein. Retinol-containing proteins in fresh plasma obtained from bullfrogs and a turtle exhibited similar properties to ...

journal_title：Journal of lipid research

authors： Shidoji Y,Muto Y

更新日期：1977-11-01 00:00:00

abstract：:Sonication of rat fat cells caused an increase in lipolysis in the absence of lipolytic stimulants (basal lipolysis) and loss of epinephrine responsiveness. Sonication of endogenous lipid droplets from fat cells also induced an increase in lipolysis in the presence of hormone-sensitive lipase (HSL) and loss of epineph...

journal_title：Journal of lipid research

authors： Okuda H,Morimoto C,Tsujita T

更新日期：1994-01-01 00:00:00

abstract：:Hepatocytes express on their surfaces more than one class of receptors capable of mediating the internalization of lipoproteins. However, relatively little is known about the binding characteristics of hepatic receptors for various lipoproteins, about the regulation of the receptors, and about the consequences for int...

journal_title：Journal of lipid research

authors： Tamai T,Patsch W,Lock D,Schonfeld G

更新日期：1983-12-01 00:00:00

abstract：:Maintaining cellular lipid homeostasis is crucial to oxidative tissues, and it becomes compromised in obesity. Lipid droplets (LD) play a central role in lipid homeostasis by mediating fatty acid (FA) storage in the form of triglyceride, thereby lowering intracellular levels of lipids that mediate cellular lipotoxicit...

journal_title：Journal of lipid research

authors： Wang H,Sreenivasan U,Hu H,Saladino A,Polster BM,Lund LM,Gong DW,Stanley WC,Sztalryd C

更新日期：2011-12-01 00:00:00

abstract：:Serum amyloid P (SAP) is a common component of human amyloid deposits and has been identified in atherosclerotic lesions. We investigated the extent of the colocalization of SAP with apolipoprotein A-I (apoA-I), apoB, apoC-II, and apoE in human coronary arteries and explored potential roles for SAP in these regions, s...

journal_title：Journal of lipid research

authors： Stewart CR,Haw A 3rd,Lopez R,McDonald TO,Callaghan JM,McConville MJ,Moore KJ,Howlett GJ,O'Brien KD

更新日期：2007-10-01 00:00:00

abstract：:The Delta6-desaturase catalyzes key steps in long-chain polyunsaturated fatty acid biosynthesis. Although the gene coding for this enzyme has been isolated in diverse animal species, the protein structure remains poorly characterized. In this work, rat Delta6-desaturase expressed in COS-7 cells was shown to localize i...

journal_title：Journal of lipid research

authors： Guillou H,D'Andrea S,Rioux V,Barnouin R,Dalaine S,Pedrono F,Jan S,Legrand P

更新日期：2004-01-01 00:00:00

abstract：:Prostaglandin (PG)E(2) is relevant in tumor biology, and interactions between tumor and stroma cells dramatically influence tumor progression. We tested the hypothesis that cross-talk between head and neck squamous cell carcinoma (HNSCC) cells and fibroblasts could substantially enhance PGE(2) biosynthesis. We observe...

journal_title：Journal of lipid research

authors： Alcolea S,Antón R,Camacho M,Soler M,Alfranca A,Avilés-Jurado FX,Redondo JM,Quer M,León X,Vila L

更新日期：2012-04-01 00:00:00

abstract：:The technique of freeze fracture was used to visualize triglyceride (TG) hydrolysis and the production of lipolytic products (LPs) in vitro and in vivo in the presence of bile salts (BS). Three systems were investigated: pure lipolytic products (oleic acid and monoolein) in the presence of a pure bile salt (taurodeoxy...

journal_title：Journal of lipid research

authors： Rigler MW,Honkanen RE,Patton JS

更新日期：1986-08-01 00:00:00

abstract：:In mammals, the esterification of sterols by ACAT plays a critical role in eukaryotic lipid homeostasis. Using the predominant isoform of the yeast ACAT-related enzyme family, Are2p, as a model, we targeted phylogenetically conserved sequences for mutagenesis in order to identify functionally important motifs. Deletio...

journal_title：Journal of lipid research

authors： Guo Z,Cromley D,Billheimer JT,Sturley SL

更新日期：2001-08-01 00:00:00

abstract：:Apolipoprotein A-IV (apoA-IV) has been postulated to be antiatherogenic. Transgenic APOA4/Apoe-/- mice are protected against atherosclerosis, with plasma apoA-IV displaying antioxidant activity in vitro. In humans, there is an inverse relationship between apoA-IV levels and risk of coronary heart disease (CHD). Furthe...

journal_title：Journal of lipid research

authors： Wong WM,Stephens JW,Acharya J,Hurel SJ,Humphries SE,Talmud PJ

更新日期：2004-08-01 00:00:00

abstract：:The pathogenesis of aortic valve stenosis (AS) is characterized by the accumulation of LDL-derived cholesterol in the diseased valves. Since LDL particles also contain plant sterols, we investigated whether plant sterols accumulate in aortic valve lesions. Serum samples were collected from 82 patients with severe AS a...

journal_title：Journal of lipid research

authors： Helske S,Miettinen T,Gylling H,Mäyränpää M,Lommi J,Turto H,Werkkala K,Kupari M,Kovanen PT

更新日期：2008-07-01 00:00:00

abstract：:Lipid transfer inhibitor protein (LTIP) is a regulator of cholesteryl ester transfer protein (CETP) function. Factors affecting plasma LTIP levels are poorly understood. In humans, plasma LTIP is elevated in hypercholesterolemia. To define possible mechanisms by which hyperlipidemia modifies LTIP, we investigated the ...

journal_title：Journal of lipid research

authors： Izem L,Morton RE

更新日期：2009-04-01 00:00:00

abstract：:Genome-wide association (GWA) studies represent a powerful strategy for identifying susceptibility genes for complex diseases in human populations but results must be confirmed and replicated. Because of the close homology between mouse and human genomes, the mouse can be used to add evidence to genes suggested by hum...

journal_title：Journal of lipid research

authors： Leduc MS,Lyons M,Darvishi K,Walsh K,Sheehan S,Amend S,Cox A,Orho-Melander M,Kathiresan S,Paigen B,Korstanje R

更新日期：2011-06-01 00:00:00

abstract：:Male Sprague-Dawley rats were fed diets that contained 20% by weight soybean oil or rapeseed oil (21% and 43% erucic acid) for 7 days. The rapeseed oil diets increased the cardiac triacylglycerol content 5-fold and 25-fold, respectively, above control values. Hearts were removed from the animals and perfused with modi...

journal_title：Journal of lipid research

authors： Stewart LC,Kramer JK,Sauer FD,Clarke K,Wolynetz MS

更新日期：1993-09-01 00:00:00

abstract：:The basic protein protamine strongly inhibited hydrolysis of triolein emulsified with soybean phosphatidylcholine (PC) by pancreatic and carboxylester lipases; 10 micrograms/ml protamine, about 1000 times lower than the concentration of bovine serum albumin for the same effect, inhibited triolein hydrolysis completely...

journal_title：Journal of lipid research

authors： Tsujita T,Matsuura Y,Okuda H

更新日期：1996-07-01 00:00:00

abstract：:Lec9 Chinese hamster ovary cells were found previously to be defective in the synthesis of N-linked glycans. This appeared to be the result of a defect in the synthesis of oligosaccharide lipid and lipid phosphate (Rosenwald, Stanley, and Krag. 1989. Mol. Cell. Biol. 9: 914-924). In this study we analyzed the steady s...

journal_title：Journal of lipid research

authors： Rosenwald AG,Krag SS

更新日期：1990-03-01 00:00:00

abstract：:Human striated muscle samples, from male control and Duchenne muscular dystrophy-affected children, were subjected to cluster-time-of-flight secondary ion mass spectrometry (cluster-ToF-SIMS) imaging using a 25 keV Bi(3)(+) liquid metal ion gun under static SIMS conditions. Spectra and ion density maps, or secondary i...

journal_title：Journal of lipid research

authors： Tahallah N,Brunelle A,De La Porte S,Laprévote O

更新日期：2008-02-01 00:00:00

abstract：:Oxidized forms of cholesterol (oxysterols) are present in atherosclerotic lesions and may play an active role in lesion development. For example, 7-ketocholesterol (7KC) inhibits cholesterol efflux from macrophage foam cells induced by apolipoprotein A-I (apoA-I). Such oxysterols may promote foam cell formation in ath...

journal_title：Journal of lipid research

authors： Gelissen IC,Rye KA,Brown AJ,Dean RT,Jessup W

更新日期：1999-09-01 00:00:00

abstract：:More than 100 proteins necessary for eukaryotic cell growth, differentiation, and morphology require posttranslational modification by the covalent attachment of an isoprenoid lipid (prenylation). Prenylated proteins include members of the Ras, Rab, and Rho families, lamins, CENPE and CENPF, and the gamma subunit of m...

journal_title：Journal of lipid research

authors： Lane KT,Beese LS

更新日期：2006-04-01 00:00:00