HMG CoA reductase of intestinal mucosa and liver of the rat.

abstract：:This report describes the isolation of sarcosylsarcosine conjugate of ursodeoxycholic acid (UDCA) formed during the synthesis of sarcoUDCA by the mixed anhydride method. The compound was characterized by its chemical ionization mass spectrum. The diamino acid conjugate was formed only when the free amino acid was used...

journal_title：Journal of lipid research

authors： Batta AK,Salen G,Shefer S

更新日期：1989-05-01 00:00:00

abstract：:Recent studies suggest: that the epidermis and pilosebaceous epithelium are important sites of de novo sterol synthesis, and that the rate of cutaneous cholesterol synthesis does not change with alterations in circulating sterol levels. Since cutaneous sterols may be important for permeability barrier function, we stu...

journal_title：Journal of lipid research

authors： Menon GK,Feingold KR,Moser AH,Brown BE,Elias PM

更新日期：1985-04-01 00:00:00

abstract：:In an effort tao simulate the effects of insulin on fat cells prepared from fresh adipose tissue, pieces of epididymal adipose tissue were cultured in a medium containing charcoal-treated bovine serum albumin (BSA) with a gas phase of 100% O2. Using this system, the insulin effect on [1-14C]glucose oxidation was retai...

journal_title：Journal of lipid research

authors： Bernstein RS

更新日期：1982-02-01 00:00:00

abstract：:Lipoprotein (a) [Lp(a)] is a highly atherogenic lipid particle. Although earlier reports suggested that Lp(a) levels are mostly determined by genetic factors, several recent studies have revealed that Lp(a) induction is also caused by chronic inflammation. Therefore, we aimed to examine whether cytokine blockade by mo...

journal_title：Journal of lipid research

authors： Müller N,Schulte DM,Türk K,Freitag-Wolf S,Hampe J,Zeuner R,Schröder JO,Gouni-Berthold I,Berthold HK,Krone W,Rose-John S,Schreiber S,Laudes M

更新日期：2015-05-01 00:00:00

abstract：:Leukotriene B4 (LTB4) is a potent lipid mediator of inflammation that acts primarily via a seven-transmembrane-spanning, G-protein-coupled receptor denoted BLT1. Here, we describe the synthesis and characterization of fluorescent analogs of LTB4 that are easy to produce, inexpensive, and without the disadvantages of a...

journal_title：Journal of lipid research

authors： Sabirsh A,Wetterholm A,Bristulf J,Leffler H,Haeggström JZ,Owman C

更新日期：2005-06-01 00:00:00

abstract：:(13)C-Cholesterol was produced with high efficiency by a genetically engineered yeast strain. The method produces ∼ 1 mg of cholesterol per gram of glucose using 100 ml of culture medium. Uniform 94% enrichment where the most abundant product is the fully enriched isotopomer (u-(13)C(27)) is obtained using (u-(13)C(6)...

journal_title：Journal of lipid research

authors： Shivapurkar R,Souza CM,Jeannerat D,Riezman H

更新日期：2011-05-01 00:00:00

abstract：:The sequences necessary for liver-specific expression of the apolipoprotein (apo) E gene have been shown to reside 3' to the gene, within the apoE/C-I/C-II gene cluster, but have not been precisely characterized. Utilizing a transient transfection reporter gene assay based on the apoC-II promoter, we have localized a ...

journal_title：Journal of lipid research

authors： Shachter NS,Zhu Y,Walsh A,Breslow JL,Smith JD

更新日期：1993-10-01 00:00:00

abstract：:Familial hypobetalipoproteinemia (FHBL) exists in three forms: a) FHBL genetically linked to truncated forms of apolipoprotein B (apoB); b) FHBL linked to the apoB gene but with no apoB truncations; and c) FHBL not linked to the apoB gene. Mean production rate (PR) of apoB-100 in FHBL subjects heterozygous for apoB tr...

journal_title：Journal of lipid research

authors： Latour MA,Patterson BW,Pulai J,Chen Z,Schonfeld G

更新日期：1997-03-01 00:00:00

abstract：:High plasma cholesterol levels are found in several metabolic disorders and their reductions are advocated to reduce the risk of atherosclerosis. A way to lower plasma lipids is to curtail lipoprotein production; however, this is associated with steatosis. We previously showed that microRNA (miR)-30c lowers diet-induc...

journal_title：Journal of lipid research

authors： Irani S,Iqbal J,Antoni WJ,Ijaz L,Hussain MM

更新日期：2018-01-01 00:00:00

abstract：:Delta-6 desaturase (D6D) catalyzes the first step in the synthesis of highly unsaturated fatty acids (HUFA) such as arachidonic (AA), docosapentaenoic (DPAn-6), and docosahexaenoic (DHA) acids, as well as the last desaturation of DPAn-6 and DHA. We created D6D-null mice (-/-), which enabled us to study HUFA deficiency...

journal_title：Journal of lipid research

authors： Stroud CK,Nara TY,Roqueta-Rivera M,Radlowski EC,Lawrence P,Zhang Y,Cho BH,Segre M,Hess RA,Brenna JT,Haschek WM,Nakamura MT

更新日期：2009-09-01 00:00:00

abstract：:Enzymes associated with glycerolipid biosynthesis were examined in microsomal fractions of liver and adipose tissue obtained from swine of various ages. Generally, liver glycerophosphate acyltransferase, phosphatidate phosphohydrolase, diglyceride acyltransferase, and choline phosphotransferase activities were substan...

journal_title：Journal of lipid research

authors： Steffen DG,Phinney G,Brown LJ,Mersmann HJ

更新日期：1979-02-01 00:00:00

abstract：:Lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes represent a group of rare genetic disorders of HDL metabolism that have been the subject of a large number of clinical, biochemical, and genetic studies. Of special interest are patients with LCAT-related disorders with severe HDL deficiency and the appa...

journal_title：Journal of lipid research

authors： Kuivenhoven JA,Pritchard H,Hill J,Frohlich J,Assmann G,Kastelein J

更新日期：1997-02-01 00:00:00

abstract：:The lipids of intact human platelets were labeled in vitro with acetate-1-(14)C, and the distribution of radioactivity in individual fatty acids and in lipid classes was examined in platelet subcellular fractions separated by sucrose density gradient ultracentrifugation. The distribution of newly formed fatty acids am...

journal_title：Journal of lipid research

authors： Deykin D

更新日期：1971-01-01 00:00:00

abstract：:Long-chain fatty acids are the most important substrates for the heart. In addition, they have been shown to affect signalling pathways and gene expression. To explore the effects of long-chain fatty acids on cardiac gene expression, neonatal rat ventricular myocytes were cultured for 48 h with either glucose (10 mm),...

journal_title：Journal of lipid research

authors： van der Lee KA,Vork MM,De Vries JE,Willemsen PH,Glatz JF,Reneman RS,Van der Vusse GJ,Van Bilsen M

更新日期：2000-01-01 00:00:00

abstract：:When grown in the presence of bile acids, two strains of Clostridium limosum were found to contain significant amounts of NADP-dependent 7 alpha/7 beta-hydroxysteroid dehydrogenase and NAD-dependent 7 alpha-hydroxysteroid dehydrogenase which were active against conjugated and unconjugated bile acids. No measurable act...

journal_title：Journal of lipid research

authors： Sutherland JD,Williams CN

更新日期：1985-03-01 00:00:00

abstract：:Phytanic acid (3,7,11,15-tetramethylhexadecanoic acid) is a branched-chain fatty acid derived from dietary sources and broken down in the peroxisome to pristanic acid (2,6,10,14-tetramethylpentadecanoic acid) via alpha-oxidation. Pristanic acid then undergoes beta-oxidation in peroxisomes. Phytanic acid naturally occu...

journal_title：Journal of lipid research

authors： Ferdinandusse S,Rusch H,van Lint AE,Dacremont G,Wanders RJ,Vreken P

更新日期：2002-03-01 00:00:00

abstract：:Little is known of the post-absorptive, metabolic fate of gamma-tocopherol, the major form of vitamin E in North American diets. The objective of this study was to determine the extent of urinary excretion of 2,7, 8-trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman (gamma-CEHC), a recently identified metabolite of gamm...

journal_title：Journal of lipid research

authors： Swanson JE,Ben RN,Burton GW,Parker RS

更新日期：1999-04-01 00:00:00

abstract：:The secondary bile acid lithocholic acid (LCA) and its derivatives act as selective modulators of the vitamin D receptor (VDR), although their structures fundamentally differ from that of the natural hormone 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3)]. Here, we have determined the crystal structures of the ligand-binding...

journal_title：Journal of lipid research

authors： Masuno H,Ikura T,Morizono D,Orita I,Yamada S,Shimizu M,Ito N

更新日期：2013-08-01 00:00:00

abstract：:Membrane-bound proteins have been proposed to mediate the transport of long-chain FA (LCFA) transport through the plasma membrane (PM). These proposals are based largely on reports that PM transport of LCFAs can be blocked by a number of enzymes and purported inhibitors of LCFA transport. Here, using the ratiometric p...

journal_title：Journal of lipid research

authors： Jay AG,Simard JR,Huang N,Hamilton JA

更新日期：2020-05-01 00:00:00

abstract：:An improved preparation of proteolipid from bovine brain white matter is described. The product obtained by repeated acetone precipitation is completely soluble in chloroform-methanol and has a fairly constant composition: 35% protein, 40% galactocerebroside, and about 25% phospholipid. ...

journal_title：Journal of lipid research

authors： Cavanna R,Rapport MM

更新日期：1967-01-01 00:00:00

abstract：:Apolipoprotein (apo)E is well established as a secreted protein that plays an important role in systemic lipoprotein metabolism and vascular wall homeostasis. Recently, endogenous expression of apoE in adipocytes has been shown to play an important role in adipocyte lipoprotein metabolism and gene expression consisten...

journal_title：Journal of lipid research

authors： Yue L,Mazzone T

更新日期：2011-03-01 00:00:00

abstract：:Arterial wall lipid retention is believed to be due primarily to ionic interactions between lipoproteins and proteoglycans. Thus, oxidized low density lipoproteins (LDL), with decreased positive charge relative to native LDL, should have decreased interaction with negatively charged proteoglycans. However, oxidized LD...

journal_title：Journal of lipid research

authors： Chang MY,Potter-Perigo S,Wight TN,Chait A

更新日期：2001-05-01 00:00:00

abstract：:Visceral fat has been associated with multiple cardiovascular disease (CVD) risk factors. The aim of this study was to identify anthropometrical measures most closely associated with some well-known CVD risk factors. Because most Asians at risk have normal body mass index (BMI) according to Western standards, we studi...

journal_title：Journal of lipid research

authors： Jang Y,Kim OY,Ryu HJ,Kim JY,Song SH,Ordovas JM,Lee JH

更新日期：2003-12-01 00:00:00

abstract：:In this study we employed a capillary gas-liquid chromatographic-mass spectrometric (GLC-MS) method to measure the plasma concentrations of 3-hydroxybutyrate (3-OHB) and 3-hydroxyisobutyrate (3-OHIB) in overnight fasted diabetic subjects and in normal subjects. Plasma contents of 3-hydroxybutyrate measured in this fas...

journal_title：Journal of lipid research

authors： Avogaro A,Bier DM

更新日期：1989-11-01 00:00:00

abstract：:In addition to functioning as detergents that aid digestion of dietary lipids in the intestine, some bile acids have been shown to exhibit antimicrobial activity. However, detailed information on the bactericidal activities of the diverse molecular species of bile acid in humans and rodents is largely unknown. Here, w...

journal_title：Journal of lipid research

authors： Watanabe M,Fukiya S,Yokota A

更新日期：2017-06-01 00:00:00

abstract：:Rab GTPases require special machinery for protein prenylation, which include Rab escort protein (REP) and Rab geranylgeranyl transferase (RGGT). The current model of Rab geranylgeranylation proposes that REP binds Rab and presents it to RGGT. After geranylgeranylation of Rab C-terminal cysteines, REP delivers the pren...

journal_title：Journal of lipid research

authors： Leung KF,Baron R,Seabra MC

更新日期：2006-03-01 00:00:00

abstract：:Expression of bile salt export pump (BSEP) is regulated by the bile acid/farnesoid X receptor (FXR) signaling pathway. Two FXR isoforms, FXRα1 and FXRα2, are predominantly expressed in human liver. We previously showed that human BSEP was isoform-dependently regulated by FXR and diminished with altered expression of F...

journal_title：Journal of lipid research

authors： Song X,Chen Y,Valanejad L,Kaimal R,Yan B,Stoner M,Deng R

更新日期：2013-11-01 00:00:00

abstract：:Oxidized LDL (oxLDL) is a known risk factor for atherogenesis. This study aimed to reveal structural features of oxLDL present in human circulation related to atherosclerosis. When LDL was fractionated on an anion-exchange column, in vivo-oxLDL, detected by the anti-oxidized PC (oxPC) mAb, was recovered in flow-throug...

journal_title：Journal of lipid research

authors： Sawada N,Obama T,Koba S,Takaki T,Iwamoto S,Aiuchi T,Kato R,Kikuchi M,Hamazaki Y,Itabe H

更新日期：2020-06-01 00:00:00

abstract：:The major net flux of cholesterol in the intact animal or human is from the peripheral organs to the liver. This flux is made up of cholesterol that is either synthesized in these peripheral tissues or taken up as lipoprotein cholesterol. This study investigates whether it is the concentration of apolipoprotein (apo) ...

journal_title：Journal of lipid research

authors： Jolley CD,Woollett LA,Turley SD,Dietschy JM

更新日期：1998-11-01 00:00:00

abstract：:Dysregulation of nuclear envelope (NE) assembly results in various cancers; for example, renal and some lung carcinomas ensue due to NE malformation. The NE is a dynamic membrane compartment and its completion during mitosis is a highly regulated process, but the detailed mechanism still remains incompletely understoo...

journal_title：Journal of lipid research

authors： Chung GHC,Domart MC,Peddie C,Mantell J,Mclaverty K,Arabiotorre A,Hodgson L,Byrne RD,Verkade P,Arkill K,Collinson LM,Larijani B

更新日期：2018-08-01 00:00:00