Circulating oxidized LDL, increased in patients with acute myocardial infarction, is accompanied by heavily modified HDL.

abstract：:Biliary amphipathic anionic polypeptide (APF) the major protein of the pigment-lipoprotein complex in bile, and calcium-binding protein (CBP) from gallstones are both small (less than 10 kDa), highly acidic, amphipathic proteins present in bile and closely associated also with pigmented areas in human gallstones. Poly...

journal_title：Journal of lipid research

authors： Domingo N,Grosclaude J,Bekaert ED,Mège D,Chapman MJ,Shimizu S,Ayrault-Jarrier M,Ostrow JD,Lafont H

更新日期：1992-10-01 00:00:00

abstract：:Abetalipoproteinemia (ABL) and chylomicron retention disease (CMRD) are extremely rare recessive forms of hypobetalipoproteinemia characterized by intestinal lipid malabsorption and severe vitamin E deficiency. Vitamin E is often supplemented in the form of fat-soluble vitamin E acetate, but fat malabsorption consider...

journal_title：Journal of lipid research

authors： Cuerq C,Henin E,Restier L,Blond E,Drai J,Marçais C,Di Filippo M,Laveille C,Michalski MC,Poinsot P,Caussy C,Sassolas A,Moulin P,Reboul E,Charriere S,Levy E,Lachaux A,Peretti N

更新日期：2018-09-01 00:00:00

abstract：:ABCA12 mutations disrupt the skin barrier and cause harlequin ichthyosis. We previously showed Abca12(-/-) skin has increased glucosylceramide (GlcCer) and correspondingly lower amounts of ceramide (Cer). To examine why loss of ABCA12 leads to accumulation of GlcCer, de novo sphingolipid synthesis was assayed using [(...

journal_title：Journal of lipid research

authors： Haller JF,Cavallaro P,Hernandez NJ,Dolat L,Soscia SJ,Welti R,Grabowski GA,Fitzgerald ML,Freeman MW

更新日期：2014-03-01 00:00:00

abstract：:We previously reported that a eucaloric, low fat, liquid formula diet enriched in simple carbohydrate markedly increased the synthesis of fatty acids in lean volunteers. To examine the diet sensitivity of obese subjects, 7 obese and 12 lean volunteers were given two eucaloric low fat solid food diets enriched in simpl...

journal_title：Journal of lipid research

authors： Hudgins LC,Hellerstein MK,Seidman CE,Neese RA,Tremaroli JD,Hirsch J

更新日期：2000-04-01 00:00:00

abstract：:Leukotriene B4 (LTB4) is a potent lipid mediator of inflammation that acts primarily via a seven-transmembrane-spanning, G-protein-coupled receptor denoted BLT1. Here, we describe the synthesis and characterization of fluorescent analogs of LTB4 that are easy to produce, inexpensive, and without the disadvantages of a...

journal_title：Journal of lipid research

authors： Sabirsh A,Wetterholm A,Bristulf J,Leffler H,Haeggström JZ,Owman C

更新日期：2005-06-01 00:00:00

abstract：:This study was undertaken to develop techniques for measuring absolute rates of sterol synthesis in extrahepatic tissues in vitro and to estimate the magnitude of the errors inherent in the use of various 14C-labeled substrates for such measurements. Initial studies showed that significant errors were introduced when ...

journal_title：Journal of lipid research

authors： Andersen JM,Dietschy JM

更新日期：1979-08-01 00:00:00

abstract：:Among the family of phospholipases A2 (PLA2s) are the Ca(2+)-independent PLA2s (iPLA2s) and they are designated group VI iPLA2s. In relation to secretory and cytosolic PLA2s, the iPLA2s are more recently described and details of their expression and roles in biological functions are rapidly emerging. The iPLA2s or pat...

journal_title：Journal of lipid research

authors： Ramanadham S,Ali T,Ashley JW,Bone RN,Hancock WD,Lei X

更新日期：2015-09-01 00:00:00

abstract：:The genus Acinetobacter is composed of ubiquitous, generally nonpathogen environmental bacteria. Interest concerning these microorganisms has increased during the last 30 years, because some strains, belonging to the so-called A. baumannii-A. calcoaceticus complex, have been implicated in some severe pathological stat...

journal_title：Journal of lipid research

authors： Leone S,Sturiale L,Pessione E,Mazzoli R,Giunta C,Lanzetta R,Garozzo D,Molinaro A,Parrilli M

更新日期：2007-05-01 00:00:00

abstract：:The role of very low density lipoproteins (VLDL) in the energy metabolism of conscious, 24-hr fasted rats was studied. VLDL labeled with [2-3H]glycerol and [1-14C]palmitate were infused into the rats, along with [1-13C]palmitate bound to albumin and d-8-glycerol, and various metabolic factors were assessed. The rates ...

journal_title：Journal of lipid research

authors： Wolfe RR,Durkot MJ

更新日期：1985-02-01 00:00:00

abstract：:Isotopic measurement of biosynthetic rates of lipids in VLDL particles has long posed difficult technical problems. In this review, key methodologic issues and recent technical advances are discussed. A common problem for all biosynthetic measurements is the requirement to measure isotopic labeling of the true intrace...

journal_title：Journal of lipid research

authors： Parks EJ,Hellerstein MK

更新日期：2006-08-01 00:00:00

abstract：:To investigate the relative turnover of esterified polyunsaturated fatty acids in diacylglycerophospholipids and plasmalogens in isolated cardiac myocytes, we characterized the phospholipid composition and distribution of radiolabel in different phospholipid classes and in individual molecular species of diradyl choli...

journal_title：Journal of lipid research

authors： DaTorre SD,Creer MH

更新日期：1991-07-01 00:00:00

abstract：:Tetradecylthioacetic acid (TTA), which cannot be beta-oxidized, exerts growth-limiting properties in glioma cells. In order to investigate the importance of modulated lipid metabolism and alterations in mitochondrial properties in this cell death process, we incubated glioma cells both with TTA and the oxidizable fatt...

journal_title：Journal of lipid research

authors： Berge K,Tronstad KJ,Bohov P,Madsen L,Berge RK

更新日期：2003-01-01 00:00:00

abstract：:Adiponectin, an adipocyte-derived protein, has anti-atherogenic and anti-diabetic effects, but how it confers the anti-atherogenic effects is not well understood. To study the anti-atherogenic mechanisms of adiponectin, we examined whether it interacts with atherogenic low-density lipoprotein (LDL) to attenuate LDL's ...

journal_title：Journal of lipid research

authors： Kakino A,Fujita Y,Ke LY,Chan HC,Tsai MH,Dai CY,Chen CH,Sawamura T

更新日期：2020-11-03 00:00:00

abstract：:Reduced white adipose tissue (WAT) LPL activity delays plasma clearance of TG-rich lipoproteins (TRLs). We reported the secretion of apoC-I, an LPL inhibitor, from WAT ex vivo in women. Therefore we hypothesized that WAT-secreted apoC-I associates with reduced WAT LPL activity and TRL clearance. WAT apoC-I secretion a...

journal_title：Journal of lipid research

authors： Cyr Y,Wassef H,Bissonnette S,Lamantia V,Davignon J,Faraj M

更新日期：2016-06-01 00:00:00

abstract：:Ceramides (Cers) with ultralong (∼32-carbon) chains and ω-esterified linoleic acid, composing a subclass called omega-O-acylceramides (acylCers), are indispensable components of the skin barrier. Normal barriers typically contain acylCer concentrations of ∼10 mol%; diminished concentrations, along with altered or miss...

journal_title：Journal of lipid research

authors： Opálka L,Kováčik A,Pullmannová P,Maixner J,Vávrová K

更新日期：2020-02-01 00:00:00

abstract：:Triacylglycerols (TG) are the major storage form of energy in eukaryotic organisms and are synthesized primarily by acyl CoA:1,2-diacylglycerol acyltransferase (DGAT) enzymes. In vitro DGAT activity has previously been quantified by measuring the incorporation of either radiolabeled fatty acyl CoA or diacylglycerol (D...

journal_title：Journal of lipid research

authors： McFie PJ,Stone SJ

更新日期：2011-09-01 00:00:00

abstract：:Nine even-numbered saturated (C4 to C20) and two unsaturated (C18:1, C18:2) cholesterol alkyl ethers were studied by differential scanning calorimetry, polarizing microscopy, and X-ray powder diffraction. Seven of the nine saturated ethers examined melt into stable liquid crystal mesophases. Mesophase transition tempe...

journal_title：Journal of lipid research

authors： Deckelbaum RJ,Halperin G,Atkinson D

更新日期：1983-05-01 00:00:00

abstract：:The inverse relationship between plasma levels of high density lipoprotein (HDL) and coronary heart disease rates has suggested that HDL might influence body stores of cholesterol. Therefore, we have investigated potential relationships between the parameters of body cholesterol metabolism and the plasma levels of HDL...

journal_title：Journal of lipid research

authors： Blum CB,Dell RB,Palmer RH,Ramakrishnan R,Seplowitz AH,Goodman DS

更新日期：1985-09-01 00:00:00

abstract：:We have previously shown that expression of a human apoE cDNA in J774 macrophages enhances cholesterol efflux to HDL3. We have also shown that endogenous apoE expression produces a cell surface pool of apoE associated with proteoglycans. In this series of experiments, we first demonstrate the presence of a cell surfac...

journal_title：Journal of lipid research

authors： Lin CY,Lucas M,Mazzone T

更新日期：1998-02-01 00:00:00

abstract：:Based on our previous observation that monoclonal antibody anti-apoD-4E11 reacted with several HDL proteins we studied them further with three questions in mind: i) is there common protein polymorphism in healthy individuals? ii) how many proteins are present and what are their characteristics? iii) are they all apoli...

journal_title：Journal of lipid research

authors： Camato R,Marcel YL,Milne RW,Lussier-Cacan S,Weech PK

更新日期：1989-06-01 00:00:00

abstract：:Legume consumption appears to lower serum cholesterol and to increase cholesterol saturation of bile, but the mechanisms of these effects have not been established. We studied nine human subjects on a metabolic ward during two randomly ordered 6-7 week periods: one during consumption of a control diet and the other du...

journal_title：Journal of lipid research

authors： Duane WC

更新日期：1997-06-01 00:00:00

abstract：:Liver and kidney microsomes have been found to catalyze a rapid decarboxylation of retinoic acid in vitro. The reaction requires NADPH and Fe(2+), and is further stimulated by the presence of pyrophosphate. Thiamine pyrophosphate contained sufficient iron as an impurity to provide strong enhancement of the reaction in...

journal_title：Journal of lipid research

authors： Roberts AB,DeLuca HF

更新日期：1968-07-01 00:00:00

abstract：:The objectives of this study were to characterize the effects of plasma lipoproteins on prostacyclin (PGI2) production by the Langendorff-perfused rabbit heart, and to determine the mechanism of lipoprotein-induced cardiac PGI2 production. PGI2 production by perfused rabbit hearts was stimulated by injections of rabbi...

journal_title：Journal of lipid research

authors： Van Sickle WA,Wilcox HG,Malik KU,Nasjletti A

更新日期：1986-05-01 00:00:00

abstract：:The hepatic synthesis of sterol was measured in the male Mongolian gerbil (Meriones unguiculatus) in vivo following the administration of [3H]water by monitoring the incorporation of radioactivity into digitonin-precipitable sterol. A diurnal rhythm in cholesterol synthesis was exhibited under conditions of ad libitum...

journal_title：Journal of lipid research

authors： Mercer NJ,Holub BJ

更新日期：1981-07-01 00:00:00

abstract：:Acyl-CoA-dependent O-acyltransferases catalyze reactions in which fatty acyl-CoAs are joined to acyl acceptors containing free hydroxyl groups to produce neutral lipids. In this report, we characterize a human multifunctional O-acyltransferase (designated MFAT) that belongs to the acyl-CoA:diacylglycerol acyltransfera...

journal_title：Journal of lipid research

authors： Yen CL,Brown CH 4th,Monetti M,Farese RV Jr

更新日期：2005-11-01 00:00:00

abstract：:For the last 30 years fibrates have been widely prescribed to treat human dyslipidemia. However, the primary mechanism by which they lower plasma lipid levels is still unknown. Studies with transgenic mice have suggested that changes in apoC-III expression levels have a dramatic influence on plasma triglyceride levels...

journal_title：Journal of lipid research

authors： Haubenwallner S,Essenburg AD,Barnett BC,Pape ME,DeMattos RB,Krause BR,Minton LL,Auerbach BJ,Newton RS,Leff T

更新日期：1995-12-01 00:00:00

abstract：:The aim of this study was to investigate the extent to which inflammation is linked with plasma endothelial lipase (EL) concentrations among healthy sedentary men. Plasma C-reactive protein (CRP) concentrations were measured with a highly sensitive commercial immunoassay, plasma interleukin-6 (IL-6) concentrations wer...

journal_title：Journal of lipid research

authors： Paradis ME,Badellino KO,Rader DJ,Deshaies Y,Couture P,Archer WR,Bergeron N,Lamarche B

更新日期：2006-12-01 00:00:00

abstract：:Hepatic steatosis is one of the most common liver disorders in the general population. The main cause of hepatic steatosis is nonalcoholic fatty liver disease (NAFLD), representing the hepatic component of the metabolic syndrome, which is characterized by type 2 diabetes, obesity, and dyslipidemia. Insulin resistance ...

journal_title：Journal of lipid research

authors： Hooper AJ,Adams LA,Burnett JR

更新日期：2011-04-01 00:00:00

abstract：:The effects of polyunsaturated fatty acids (PUFA) on the structure of recombinant high density lipoprotein (rHDL) was investigated using homogeneous particles containing phosphatidylcholine (PC), [3H]cholesterol, and apolipoprotein A-I (apoA-I). The PC component of the rHDL contained sn -1 16:0 and sn -2 18:1 (POPC), ...

journal_title：Journal of lipid research

authors： Huggins KW,Curtiss LK,Gebre AK,Parks JS

更新日期：1998-12-01 00:00:00

abstract：:A new method for the purification of apolipoprotein H by affinity chromatography followed by continuous-elution electrophoresis is described. It is both simpler and less complicated than the chromatographic and electrophoretic methods usually used. In addition, apolipoprotein H is isolated in a pure, structurally uncl...

journal_title：Journal of lipid research

authors： Gambino R,Ruiu G,Cassader M,Pagano G

更新日期：1996-04-01 00:00:00