Abstract:
:HDL-associated paraoxonase type 1 (PON1) can protect LDL and HDL against oxidative modification in vitro and therefore may protect against cardiovascular disease. We investigated the effects of PON1 levels, activity, and genetic variation on high density lipoprotein-cholesterol (HDL-C) levels, circulating oxidized LDL (OxLDL), subclinical inflammation [high-sensitive C-reactive protein (Hs-CRP)], and carotid atherosclerosis. PON1 genotypes (L55M, Q192R, -107C/T, -162A/G, -824G/A, and -907G/C) were determined in 302 patients with familial hypercholesterolemia. PON1 activity was monitored by the hydrolysis rate of paraoxon, diazoxon, and phenyl acetate. PON1 levels, OxLDL, and Hs-CRP were determined using an immunoassay. The genetic variants of PON1 that were associated with high levels and activity of the enzyme were associated with higher HDL-C levels (P values for trend: 0.008, 0.020, 0.042, and 0.037 for L55M, Q192R, -107C/T, and -907G/C, respectively). In addition to the PON1 genotype, there was also a positive correlation between PON1 levels and activity and HDL-C (PON1 levels: r = 0.37, P < 0.001; paraoxonase activity: r = 0.23, P = 0.01; diazoxonase activity: r = 0.29, P < 0.001; arylesterase activity: r = 0.19, P = 0.03). Our observations support the hypothesis that both PON1 levels and activity preserve HDL-C in plasma.
journal_name
J Lipid Resjournal_title
Journal of lipid researchauthors
van Himbergen TM,Roest M,de Graaf J,Jansen EH,Hattori H,Kastelein JJ,Voorbij HA,Stalenhoef AF,van Tits LJdoi
10.1194/jlr.M400052-JLR200keywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
445-51issue
3eissn
0022-2275issn
1539-7262pii
M400052-JLR200journal_volume
46pub_type
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journal_title:Journal of lipid research
pub_type: 杂志文章,评审
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journal_title:Journal of lipid research
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更新日期:1971-09-01 00:00:00
abstract::Our previous studies have shown accumulation of GM2 ganglioside during ethanol-induced neurodegeneration in the developing brain, and GM2 elevation has also been reported in other brain injuries and neurodegenerative diseases. Using GM2/GD2 synthase KO mice lacking GM2/GD2 and downstream gangliosides, the current stud...
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journal_title:Journal of lipid research
pub_type: 杂志文章
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journal_title:Journal of lipid research
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journal_title:Journal of lipid research
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journal_title:Journal of lipid research
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
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journal_title:Journal of lipid research
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
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journal_title:Journal of lipid research
pub_type: 杂志文章
doi:10.1194/jlr.M900040-JLR200
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journal_title:Journal of lipid research
pub_type: 杂志文章
doi:10.1194/jlr.M400377-JLR200
更新日期:2005-02-01 00:00:00
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journal_title:Journal of lipid research
pub_type: 杂志文章
doi:10.1194/jlr.M400064-JLR200
更新日期:2004-07-01 00:00:00
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journal_title:Journal of lipid research
pub_type: 杂志文章,评审
doi:10.1194/jlr.R600026-JLR200
更新日期:2006-12-01 00:00:00
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journal_title:Journal of lipid research
pub_type: 杂志文章
doi:10.1194/jlr.P015867
更新日期:2011-08-01 00:00:00
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journal_title:Journal of lipid research
pub_type: 杂志文章
doi:10.1194/jlr.M600344-JLR200
更新日期:2007-02-01 00:00:00
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journal_title:Journal of lipid research
pub_type: 杂志文章
doi:10.1194/jlr.M079764
更新日期:2017-11-01 00:00:00
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journal_title:Journal of lipid research
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journal_title:Journal of lipid research
pub_type: 杂志文章
doi:10.1194/jlr.M600051-JLR200
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journal_title:Journal of lipid research
pub_type: 杂志文章
doi:
更新日期:2001-08-01 00:00:00
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journal_title:Journal of lipid research
pub_type: 杂志文章
doi:10.1194/jlr.D500007-JLR200
更新日期:2005-07-01 00:00:00
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journal_title:Journal of lipid research
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Journal of lipid research
pub_type: 杂志文章
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更新日期:1999-10-01 00:00:00
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journal_title:Journal of lipid research
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doi:10.1194/jlr.M800429-JLR200
更新日期:2009-04-01 00:00:00
abstract::The absorption and distribution of deuterated trans- and cis-13-octadecenoic acid (13t-18:1 and 13c-18:1) in plasma lipids were compared to deuterated cis-9-octadecenoic acid (9c-18:1) in two young adult male subjects. A mixture of triglycerides was fed in a multiple-labeled experiment where each triglyceride containe...
journal_title:Journal of lipid research
pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00
abstract::Protein palmitoylation refers to the posttranslational addition of a 16 carbon fatty acid to the side chain of cysteine, forming a thioester linkage. This acyl modification is readily reversible, providing a potential regulatory mechanism to mediate protein-membrane interactions and subcellular trafficking of proteins...
journal_title:Journal of lipid research
pub_type: 杂志文章,评审
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更新日期:2006-06-01 00:00:00
abstract::In Tangier disease, absence of ATP binding cassette transporter A1 (ABCA1) results in reduced plasma HDL and elevated triglyceride (TG) levels. We hypothesized that hepatocyte ABCA1 regulates VLDL TG secretion through nascent HDL production. Silencing of ABCA1 expression in oleate-stimulated rat hepatoma cells resulte...
journal_title:Journal of lipid research
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更新日期:2010-04-01 00:00:00
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journal_title:Journal of lipid research
pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
abstract::Gangliosides and sulfatides (STs) are acidic glycosphingolipids (GSLs) that have one or more sialic acids or sulfate substituents, in addition to neutral sugars, attached to the C-1 hydroxyl group of the ceramide long chain base. TLC is a widely employed and convenient technique for separation and characterization of ...
journal_title:Journal of lipid research
pub_type: 杂志文章
doi:10.1194/jlr.D046128
更新日期:2014-04-01 00:00:00
abstract::Recent studies suggest: that the epidermis and pilosebaceous epithelium are important sites of de novo sterol synthesis, and that the rate of cutaneous cholesterol synthesis does not change with alterations in circulating sterol levels. Since cutaneous sterols may be important for permeability barrier function, we stu...
journal_title:Journal of lipid research
pub_type: 杂志文章
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更新日期:1985-04-01 00:00:00