Incorporation of deuterium-labeled trans- and cis-13-octadecenoic acids in human plasma lipids.

abstract：:4F is an anti-inflammatory, apolipoprotein A-I (apoA-I)-mimetic peptide that is active in vivo at nanomolar concentrations in the presence of a large molar excess of apoA-I. Physiologic concentrations ( approximately 35 microM) of human apoA-I did not inhibit the production of LDL-induced monocyte chemotactic activity...

journal_title：Journal of lipid research

authors： Van Lenten BJ,Wagner AC,Jung CL,Ruchala P,Waring AJ,Lehrer RI,Watson AD,Hama S,Navab M,Anantharamaiah GM,Fogelman AM

更新日期：2008-11-01 00:00:00

abstract：:The properties of cholesteryl oleate and triolein in mixed monolayers at the air-water interface have been measured between 24 and 37 degrees C. Analysis of force-area curves obtained as a function of the mol fraction of cholesteryl oleate indicates that at relatively low surface pressures these compounds are miscible...

journal_title：Journal of lipid research

authors： Smaby JM,Brockman HL

更新日期：1978-03-01 00:00:00

abstract：:Subcutaneous fat cells were isolated from genetically obese rats and from rats with obesity produced by hypothalamic lesions. Insulin did not augment the oxidation of fatty acids or their synthesis from glucose-1-(14)C or glucose-1-(3)H by fat cells from either group. Radioactivity from pyruvate-3-(14)C was incorporat...

journal_title：Journal of lipid research

authors： Bray GA

更新日期：1968-11-01 00:00:00

abstract：:Fatty acid translocase (FAT/CD36) is a membrane protein putatively involved in the transmembrane transport of long-chain fatty acids. We tested the hypothesis that expression of this protein in H9c2, a rat heart cell line normally not expressing FAT, would increase cellular palmitate uptake. We were able to stably tra...

journal_title：Journal of lipid research

authors： Van Nieuwenhoven FA,Luiken JJ,De Jong YF,Grimaldi PA,Van der Vusse GJ,Glatz JF

更新日期：1998-10-01 00:00:00

abstract：:We studied the biogenesis of apolipoprotein B (apoB) in primary hepatocytes isolated from hamster liver, an animal model with striking resemblance to humans in lipoprotein metabolism. Hamster hepatocytes were found to assemble and secrete apoB-containing lipoproteins at a density of VLDL. Intracellular mechanisms of a...

journal_title：Journal of lipid research

authors： Taghibiglou C,Rudy D,Van Iderstine SC,Aiton A,Cavallo D,Cheung R,Adeli K

更新日期：2000-04-01 00:00:00

abstract：:In Refsum disease, disorders of peroxisome biogenesis, and rhizomelic chondrodysplasia punctata, pathological accumulation of phytanic acid results from impaired alpha-oxidation of this branched-chain fatty acid. Previous studies from this laboratory indicated that activation of phytanic acid to its CoA derivative pre...

journal_title：Journal of lipid research

authors： Watkins PA,Howard AE,Gould SJ,Avigan J,Mihalik SJ

更新日期：1996-11-01 00:00:00

abstract：:The bile acid (BA) composition in mice is substantially different from that in humans. Chenodeoxycholic acid (CDCA) is an end product in the human liver; however, mouse Cyp2c70 metabolizes CDCA to hydrophilic muricholic acids (MCAs). Moreover, in humans, the gut microbiota converts the primary BAs, cholic acid and CDC...

journal_title：Journal of lipid research

authors： Honda A,Miyazaki T,Iwamoto J,Hirayama T,Morishita Y,Monma T,Ueda H,Mizuno S,Sugiyama F,Takahashi S,Ikegami T

更新日期：2020-01-01 00:00:00

abstract：:Apolipoprotein E plays a critical role in plasma lipoprotein clearance. Peptide models of a highly conserved, N-terminal domain of this protein have been shown to increase the binding of low density lipoprotein (LDL) to fibroblast cell surfaces independently of the low density lipoprotein receptor. Here we provide dat...

journal_title：Journal of lipid research

authors： Dominguez SR,Miller-Auer H,Reardon CA,Meredith SC

更新日期：1999-04-01 00:00:00

abstract：:Although the synthesis pathways of intracellular triacylglycerol (TAG) species have been well elucidated, assessment of the contribution of an individual pathway to TAG pools in different mammalian organs, particularly under pathophysiological conditions, is difficult, although not impossible. Herein, we developed and...

journal_title：Journal of lipid research

authors： Han RH,Wang M,Fang X,Han X

更新日期：2013-04-01 00:00:00

abstract：:A relatively rapid procedure is described for the spectrophotometric determination of total tocopherol in red blood cells (RBC) based on a modification of the original Emmerie-Engel reaction. The critical feature in this method is the presence of a large amount of an added antioxidant, pyrogallol or ascorbic acid, dur...

journal_title：Journal of lipid research

authors： Kayden HJ,Chow CK,Bjornson LK

更新日期：1973-09-01 00:00:00

abstract：:Lipid concentrations are heritable traits. Recently, the number of known genetic loci associated with lipid levels in adults increased from 95 to 157. The effects of these 157 loci have not been tested in children. Considering that lipid levels track from childhood to adulthood, we studied to determine whether these v...

journal_title：Journal of lipid research

authors： Latsuzbaia A,Jaddoe VW,Hofman A,Franco OH,Felix JF

更新日期：2016-12-01 00:00:00

abstract：:A qualitative iodometric test for lipoxygenase activity is described. The sensitive method is useful for rapidly screening large numbers of samples, as from a chromatography column or after enzyme inactivation treatment in food processing. ...

journal_title：Journal of lipid research

authors： Wallace JM

更新日期：1972-03-01 00:00:00

abstract：:Macrophages and arterial chondroitin sulfate proteoglycans (CSPG) are probably associated with extracellular and intracellular lipoprotein deposition during atherogenesis. We found that human arterial CSPG can be used to select subclasses from low density lipoprotein (LDL) with different structural properties and capa...

journal_title：Journal of lipid research

authors： Hurt-Camejo E,Camejo G,Rosengren B,Lopez F,Wiklund O,Bondjers G

更新日期：1990-08-01 00:00:00

abstract：:The CYP27A gene encodes a mitochondrial cytochrome P450 enzyme, sterol 27-hydroxylase, that is expressed in many different tissues and plays an important role in cholesterol and bile acid metabolism. In humans, CYP27A deficiency leads to cerebrotendinous xanthomatosis. To gain insight into the roles of CYP27A in the r...

journal_title：Journal of lipid research

authors： Dubrac S,Lear SR,Ananthanarayanan M,Balasubramaniyan N,Bollineni J,Shefer S,Hyogo H,Cohen DE,Blanche PJ,Krauss RM,Batta AK,Salen G,Suchy FJ,Maeda N,Erickson SK

更新日期：2005-01-01 00:00:00

abstract：:Lipid-containing deposits within the swim bladders of Coryphaenoides acrolepis and Antimora rostrata were investigated. Lipid analysis of this material, which was quite uniform from the two species, yielded the following data: neutral lipids, 36.0-41.7%; phospholipids, 53.6-56.7%; and glycolipids, 4.3-8.9%. Cholestero...

journal_title：Journal of lipid research

authors： Patton S,Thomas AJ

更新日期：1971-05-01 00:00:00

abstract：:The mechanisms involved in the development of alcoholic liver disease (ALD) are not well established. We investigated the involvement of acyl-CoA: diacylglycerol acyltransferase 2 (DGAT2) upregulation in mediating hepatic fat accumulation induced by chronic alcohol consumption. Chronic alcohol feeding caused fatty liv...

journal_title：Journal of lipid research

authors： Wang Z,Yao T,Song Z

更新日期：2010-11-01 00:00:00

abstract：:We previously have shown that LDL-R354, a truncated low density lipoprotein (LDL) receptor, is a calcium binding protein. LDL-R354 is composed of the ligand binding domain and repeat A of the EGF precursor homology domain of the full-length human LDL receptor. We also found that Ca2+ was required for the interaction b...

journal_title：Journal of lipid research

authors： Dirlam-Schatz KA,Attie AD

更新日期：1998-02-01 00:00:00

abstract：:In this study, we examined effects of retinol deficiency and three retinoids, all-trans-retinoic acid, 13-cis-retinoic acid, and etretin, the aromatic derivative of retinoic acid on nuclear retinoic acid receptor isoforms alpha, beta, and gamma mRNA in rat adipose tissue. Retinol deficiency caused an almost 50% decrea...

journal_title：Journal of lipid research

authors： Riaz-ul-Haq,Chytil F

更新日期：1992-03-01 00:00:00

abstract：:The tear film covers the anterior eye and the precise balance of its various constituting components is critical for maintaining ocular health. The composition of the tear film amphiphilic lipid sublayer, in particular, has largely remained a matter of contention due to the limiting concentrations of these lipid amphi...

journal_title：Journal of lipid research

authors： Lam SM,Tong L,Duan X,Petznick A,Wenk MR,Shui G

更新日期：2014-02-01 00:00:00

abstract：:Loss of function of Niemann-Pick C1 (NPC1) leads to lysosomal free cholesterol storage, resulting in the neurodegenerative disease Niemann-Pick disease type C (NPC). Significant numbers of patients with NPC also suffer from liver disease. Currently, no treatments exist that alter patient outcome, and it is unknown if ...

journal_title：Journal of lipid research

authors： Sayre NL,Rimkunas VM,Graham MJ,Crooke RM,Liscum L

更新日期：2010-08-01 00:00:00

abstract：:A variety of methods are currently used to analyze HL and LPL activities in mice. In search of a simple methodology, we analyzed mouse preheparin and postheparin plasma LPL and HL activities using specific polyclonal antibodies raised in rabbit against rat HL (anti-HL) and in goat against rat LPL (anti-LPL). As an alt...

journal_title：Journal of lipid research

authors： Dallinga-Thie GM,Zonneveld-de Boer AJ,van Vark-van der Zee LC,van Haperen R,van Gent T,Jansen H,De Crom R,van Tol A

更新日期：2007-12-01 00:00:00

abstract：:We propose a simple mathematical model to account for the coupling of secretion rates of bile salts, lecithin, and cholesterol into bile. The model assumes that: 1) molecules of "biliary" lecithin and cholesterol enter a functional compartment located in the endoplasmic reticulum of the hepatocyte from which they are ...

journal_title：Journal of lipid research

authors： Mazer NA,Carey MC

更新日期：1984-09-01 00:00:00

abstract：:Prostaglandin (PG)E(2) is relevant in tumor biology, and interactions between tumor and stroma cells dramatically influence tumor progression. We tested the hypothesis that cross-talk between head and neck squamous cell carcinoma (HNSCC) cells and fibroblasts could substantially enhance PGE(2) biosynthesis. We observe...

journal_title：Journal of lipid research

authors： Alcolea S,Antón R,Camacho M,Soler M,Alfranca A,Avilés-Jurado FX,Redondo JM,Quer M,León X,Vila L

更新日期：2012-04-01 00:00:00

abstract：:Achilles tendon xanthomas are associated with increased cardiovascular risk in patients with familial hypercholesterolemia (FH). Oxidized low density lipoprotein (OxLDL), the antibodies against OxLDL, and the LDL-associated phospholipase A(2) (Lp-PLA(2)) may play important roles in atherogenesis. We investigated the p...

journal_title：Journal of lipid research

authors： Tsouli SG,Kiortsis DN,Lourida ES,Xydis V,Tsironis LD,Argyropoulou MI,Elisaf M,Tselepis AD

更新日期：2006-10-01 00:00:00

abstract：:The Smith-Lemli-Opitz syndrome (SLOS) is a congenital birth defect syndrome caused by a deficiency of 3beta-hydroxysterol Delta(7)-reductase, the final enzyme in the cholesterol biosynthetic pathway. The patients have reduced plasma and tissue cholesterol concentrations with the accumulation of 7-dehydrocholesterol an...

journal_title：Journal of lipid research

authors： Honda A,Salen G,Shefer S,Batta AK,Honda M,Xu G,Tint GS,Matsuzaki Y,Shoda J,Tanaka N

更新日期：1999-08-01 00:00:00

abstract：:Dietary n-3 long-chain PUFAs (LC-PUFAs) are associated with improvement in the parameters of the metabolic syndrome (MetS). Glucokinase regulatory protein (GCKR) is a key protein regulating intracellular glucose disposal. Our aim was to investigate: i) the relationship between the GCKR rs1260326 (Pro446Leu) polymorphi...

journal_title：Journal of lipid research

authors： Rousseaux J,Duhamel A,Dumont J,Dallongeville J,Molnar D,Widhalm K,Manios Y,Sjöström M,Kafatos A,Breidenassel C,Gonzales-Gross M,Cuenca-Garcia M,Censi L,Ascensión M,De Henauw S,Moreno LA,Meirhaeghe A,Gottrand F

更新日期：2015-09-01 00:00:00

abstract：:Abdominal aortic aneurysm (AAA) is an important cause of death in older adults, which has no current drug therapy. Inflammation and abnormal redox status are believed to be key pathogenic mechanisms for AAA. In light of evidence correlating inflammation with aberrant fatty acid profiles, this study compared erythrocyt...

journal_title：Journal of lipid research

authors： Meital LT,Windsor MT,Ramirez Jewell RML,Young P,Schulze K,Magee R,O'Donnell J,Jha P,Perissiou M,Golledge J,Bailey TG,Brooks P,Askew CD,Russell FD

更新日期：2019-06-01 00:00:00

abstract：:Cerebrotendinous xanthomatosis (CTX) is a treatable neurodegenerative metabolic disorder of bile acid synthesis in which symptoms can be prevented if treatment with chenodeoxycholic acid supplementation is initiated early in life, making CTX an excellent candidate for newborn screening. We developed a new dried blood ...

journal_title：Journal of lipid research

authors： Vaz FM,Bootsma AH,Kulik W,Verrips A,Wevers RA,Schielen PC,DeBarber AE,Huidekoper HH

更新日期：2017-05-01 00:00:00

abstract：:In vitro studies show that docosahexaenoic acid (DHA) can be released from membrane phospholipid by Ca(2+)-independent phospholipase A(2) (iPLA(2)), Ca(2+)-independent plasmalogen PLA(2) or secretory PLA(2 (sPLA2)), but not by Ca(2+)-dependent cytosolic PLA(2) (cPLA2), which selectively releases arachidonic acid (AA)....

journal_title：Journal of lipid research

authors： Ramadan E,Rosa AO,Chang L,Chen M,Rapoport SI,Basselin M

更新日期：2010-08-01 00:00:00

abstract：:The role of very low density lipoproteins (VLDL) in the energy metabolism of conscious, 24-hr fasted rats was studied. VLDL labeled with [2-3H]glycerol and [1-14C]palmitate were infused into the rats, along with [1-13C]palmitate bound to albumin and d-8-glycerol, and various metabolic factors were assessed. The rates ...

journal_title：Journal of lipid research

authors： Wolfe RR,Durkot MJ

更新日期：1985-02-01 00:00:00