Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation.

abstract：:N-acylethanolamines (NAEs) are a group of lipid mediators synthesized in response to a number of physiological and pathological stimuli. Because of the low tissue concentrations of NAEs, analyses often include liquid extraction followed by solid-phase extraction and subsequent quantitation by LC/MS or GC/MS. Reported ...

journal_title：Journal of lipid research

authors： Skonberg C,Artmann A,Cornett C,Hansen SH,Hansen HS

更新日期：2010-10-01 00:00:00

abstract：:Apolipoprotein (apo)A-IV is synthesized in the small intestine during fat absorption and is incorporated onto the surface of nascent chylomicrons. In circulation, apoA-IV is displaced from the chylomicron surface by high density lipoprotein-associated C and E apolipoproteins; this exchange is critical for activation o...

journal_title：Journal of lipid research

authors： Hockey KJ,Anderson RA,Cook VR,Hantgan RR,Weinberg RB

更新日期：2001-02-01 00:00:00

abstract：:Choline glycerophospholipids and ethanolamine glycerophospholipids of ruminant skeletal muscle contain approximately 40% and 65% plasmalogen, respectively. In the 1,2-diacyl-sn-glycero-3-phosphocholine (diacyl CPG), 16:0-18:2(n-6) and 16:0-18:1(n-9) accounted for about 50% of the total molecular species; in the 2-acyl...

journal_title：Journal of lipid research

authors： Scott TW,Ashes JR,Fleck E,Gulati SK

更新日期：1993-05-01 00:00:00

abstract：:An in vitro assay to study lipolysis of very low density lipoproteins (VLDL) by heparan sulfate proteoglycan (HSPG-bound lipoprotein lipase (LPL) was developed. Optimal conditions for VLDL lipolysis by HSPG-bound LPL were obtained by incubating plastic wells with 0.5 microg HSPG and 1.5 microg LPL, subsequently. Contr...

journal_title：Journal of lipid research

authors： de Man FH,de Beer F,van der Laarse A,Smelt AH,Havekes LM

更新日期：1997-12-01 00:00:00

abstract：:A-C1 protein is the product of a tumor suppressor gene negatively regulating the oncogene Ras and belongs to the HRASLS (HRAS-like suppressor) subfamily. We recently found that four members of this subfamily expressed in human tissues function as phospholipid-metabolizing enzymes. Here we examined a possible enzyme ac...

journal_title：Journal of lipid research

authors： Shinohara N,Uyama T,Jin XH,Tsuboi K,Tonai T,Houchi H,Ueda N

更新日期：2011-11-01 00:00:00

abstract：:Accumulation of foam cells in the neointima represents a key event in atherosclerosis. We previously demonstrated that Tanshinone IIA (Tan), a lipophilic bioactive compound extracted from Salvia miltiorrhiza Bunge, inhibits experimental atherogenesis, yet the detailed mechanisms are not fully understood. In this study...

journal_title：Journal of lipid research

authors： Liu Z,Wang J,Huang E,Gao S,Li H,Lu J,Tian K,Little PJ,Shen X,Xu S,Liu P

更新日期：2014-02-01 00:00:00

abstract：:A gas-liquid chromatographic-mass spectrometric method of determining the position of oxygen atoms on polyfunctional fatty acids has been explored. The method consists of reduction of keto, hydroperoxy, epoxy, and carboxylic acid groups with LiAlH(4) to the corresponding alcohols; trimethylsilylation with bis(trimethy...

journal_title：Journal of lipid research

authors： Esselman WJ,Clagett CO

更新日期：1969-03-01 00:00:00

abstract：:Autosomal dominant Stargardt-like macular dystrophy (STGD3) in humans results from mutations in elongation of very long chain FAs-like 4 (ELOVL4), which leads to vision loss in young adults. ELOVL4 is an integral endoplasmic reticulum (ER) protein that mediates the elongation of very long chain (VLC) FAs. Mutations in...

journal_title：Journal of lipid research

authors： Logan S,Agbaga MP,Chan MD,Brush RS,Anderson RE

更新日期：2014-04-01 00:00:00

abstract：:High plasma cholesterol levels are found in several metabolic disorders and their reductions are advocated to reduce the risk of atherosclerosis. A way to lower plasma lipids is to curtail lipoprotein production; however, this is associated with steatosis. We previously showed that microRNA (miR)-30c lowers diet-induc...

journal_title：Journal of lipid research

authors： Irani S,Iqbal J,Antoni WJ,Ijaz L,Hussain MM

更新日期：2018-01-01 00:00:00

abstract：:Cyclophosphamide injection into the fasted rabbit induces a hypertriglyceridemia (4.6 mM vs. 0.8 mM in controls) and a defect of lipoprotein lipase (LPL), as measured in post-heparin plasma (PHP). In contrast, administration of the drug into fed animals tends to increase PHP-LPL. The effects of cyclophosphamide on LPL...

journal_title：Journal of lipid research

authors： Lespine A,Azema C,Gafvels M,Manent J,Dousset N,Chap H,Perret B

更新日期：1993-01-01 00:00:00

abstract：:Neu-Laxova syndrome (NLS) is a very rare autosomal recessive congenital disorder characterized by disturbed development of the central nervous system and the skin and caused by mutations in any of the three genes involved in de novo l-serine biosynthesis: PHGDH, PSAT1, and PSPH l-Serine is essential for the biosynthes...

journal_title：Journal of lipid research

authors： Takeichi T,Okuno Y,Kawamoto A,Inoue T,Nagamoto E,Murase C,Shimizu E,Tanaka K,Kageshita Y,Fukushima S,Kono M,Ishikawa J,Ihn H,Takahashi Y,Akiyama M

更新日期：2018-12-01 00:00:00

abstract：:The accurate quantitation of high density lipoproteins has recently assumed greater importance in view of studies suggesting their negative correlation with coronary heart disease. High density lipoproteins may be estimated by measuring cholesterol in the plasma fraction of d > 1.063 g/ml. A more practical approach is...

journal_title：Journal of lipid research

authors： Warnick GR,Albers JJ

更新日期：1978-01-01 00:00:00

abstract：:Cigarette smokers have reduced levels of plasma high density lipoprotein (HDL) compared to nonsmokers and are at risk of premature cardiovascular disease. Previous work from this laboratory has shown that exposure of human plasma to gas-phase cigarette smoke (CS) inhibited the activity of lecithin:cholesterol acyltran...

journal_title：Journal of lipid research

authors： Bielicki JK,McCall MR,van den Berg JJ,Kuypers FA,Forte TM

更新日期：1995-02-01 00:00:00

abstract：:We have shown that expression of apolipoprotein (apo) C-III promotes VLDL secretion from transfected McA-RH7777 cells under lipid-rich conditions. To determine structural elements within apoC-III that confer to this function, we contrasted wild-type apoC-III with a mutant Ala23Thr originally identified in hypotriglyce...

journal_title：Journal of lipid research

authors： Sundaram M,Zhong S,Bou Khalil M,Zhou H,Jiang ZG,Zhao Y,Iqbal J,Hussain MM,Figeys D,Wang Y,Yao Z

更新日期：2010-06-01 00:00:00

abstract：:Previously, our laboratory demonstrated that ceramide-1-phosphate (C1P) specifically activated group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) in vitro. In this study, we investigated the chain length specificity of this interaction. C1P with an acyl-chain of >or=6 carbons efficiently activated cPLA(2)alpha in v...

journal_title：Journal of lipid research

authors： Wijesinghe DS,Subramanian P,Lamour NF,Gentile LB,Granado MH,Bielawska A,Szulc Z,Gomez-Munoz A,Chalfant CE

更新日期：2009-10-01 00:00:00

abstract：:Glycosylphosphatidylinositols (GPIs) act as membrane anchors of many eukaryotic cell surface proteins. GPIs in various organisms have a common backbone consisting of ethanolamine phosphate (EtNP), three mannoses (Mans), one non-N-acetylated glucosamine, and inositol phospholipid, whose structure is EtNP-6Manα-2Manα-6M...

journal_title：Journal of lipid research

authors： Kinoshita T,Fujita M

更新日期：2016-01-01 00:00:00

abstract：:The objectives of this study were to characterize the effects of plasma lipoproteins on prostacyclin (PGI2) production by the Langendorff-perfused rabbit heart, and to determine the mechanism of lipoprotein-induced cardiac PGI2 production. PGI2 production by perfused rabbit hearts was stimulated by injections of rabbi...

journal_title：Journal of lipid research

authors： Van Sickle WA,Wilcox HG,Malik KU,Nasjletti A

更新日期：1986-05-01 00:00:00

abstract：:In specialized cell types, lysosome-related organelles support regulated secretory pathways, whereas in nonspecialized cells, lysosomes can undergo fusion with the plasma membrane in response to a transient rise in cytosolic calcium. Recent evidence also indicates that lysosome secretion can be controlled transcriptio...

journal_title：Journal of lipid research

authors： Vacca F,Vossio S,Mercier V,Moreau D,Johnson S,Scott CC,Montoya JP,Moniatte M,Gruenberg J

更新日期：2019-04-01 00:00:00

abstract：:Cyanidin-3-O-β-glucoside (C3G) (CAS number 7084-24-4), a typical anthocyanin pigment that exists in the human diet, has been reported to have anti-inflammatory properties. However, the effect of C3G on lipopolysaccharide (LPS)-induced mastitis and the molecular mechanisms have not been investigated. In this study, we ...

journal_title：Journal of lipid research

authors： Fu Y,Wei Z,Zhou E,Zhang N,Yang Z

更新日期：2014-06-01 00:00:00

abstract：:ABCB4, which is specifically expressed on the canalicular membrane of hepatocytes, exports phosphatidylcholine (PC) into bile. Because SM depletion increases cellular PC content and stimulates PC and cholesterol efflux by ABCA1, a key transporter involved in generation of HDL, we predicted that SM depletion also stimu...

journal_title：Journal of lipid research

authors： Zhao Y,Ishigami M,Nagao K,Hanada K,Kono N,Arai H,Matsuo M,Kioka N,Ueda K

更新日期：2015-03-01 00:00:00

abstract：:Subnormal HDL-cholesterol (HDL-C) and apolipoprotein (apo)AI levels are characteristic of familial hypercholesterolemia (FH), reflecting perturbed intravascular metabolism with compositional anomalies in HDL particles, including apoE enrichment. Does LDL-apheresis, which reduces HDL-cholesterol, apoAI, and apoE by ads...

journal_title：Journal of lipid research

authors： Orsoni A,Saheb S,Levels JH,Dallinga-Thie G,Atassi M,Bittar R,Robillard P,Bruckert E,Kontush A,Carrié A,Chapman MJ

更新日期：2011-12-01 00:00:00

abstract：:Small angle X-ray diffraction was used to examine arterial smooth muscle cell (SMC) plasma membranes isolated from control and cholesterol-fed (2%) atherosclerotic rabbits. A microsomal membrane enriched with plasma membrane obtained from animals fed cholesterol for up to 13 weeks showed a progressive elevation in the...

journal_title：Journal of lipid research

authors： Tulenko TN,Chen M,Mason PE,Mason RP

更新日期：1998-05-01 00:00:00

abstract：:We propose a simple mathematical model to account for the coupling of secretion rates of bile salts, lecithin, and cholesterol into bile. The model assumes that: 1) molecules of "biliary" lecithin and cholesterol enter a functional compartment located in the endoplasmic reticulum of the hepatocyte from which they are ...

journal_title：Journal of lipid research

authors： Mazer NA,Carey MC

更新日期：1984-09-01 00:00:00

abstract：:During intestinal absorption amino acids must traverse the lipid-rich epithelial cell membrane, possibly in a lipid-soluble form. In a search for such a form, we have determined the ability of lipid extracted from intestinal mucosa to bind valine. After incubation in a valine-containing medium this lipid (defined as t...

journal_title：Journal of lipid research

authors： Reiser S,Christiansen PA

更新日期：1968-09-01 00:00:00

abstract：:Insulin resistance (IR) is associated with elevated plasma levels of triglyceride-rich lipoproteins (TRLs) of intestinal origin. However, the mechanisms underlying the overaccumulation of apolipoprotein (apo)B-48-containing TRLs in individuals with IR are not yet fully understood. This study examined the relationships...

journal_title：Journal of lipid research

authors： Couture P,Tremblay AJ,Kelly I,Lemelin V,Droit A,Lamarche B

更新日期：2014-01-01 00:00:00

abstract：:The hypothesis of lipid domains in cellular plasma membranes is well established. However, direct visualization of the domains has been difficult. Here we report direct visualization of plasma membrane cholesterol microdomains modulated by agents that affect cholesterol trafficking to and from the plasma membrane. The...

journal_title：Journal of lipid research

authors： Kruth HS,Ifrim I,Chang J,Addadi L,Perl-Treves D,Zhang WY

更新日期：2001-09-01 00:00:00

abstract：:Triglyceride-rich very low density lipoproteins (VLDL) are the major lipoprotein in perfusates of normal guinea pig livers. Their component apoprotein B is mainly B-100 together with some B-95. This apoprotein is actively synthesized, as are C apoproteins and small amounts of apoprotein E. Only trace amounts of interm...

journal_title：Journal of lipid research

authors： Guo LS,Hamilton RL,Ostwald R,Havel RJ

更新日期：1982-05-01 00:00:00

abstract：:Apolipoproteins, such as apolipoprotein A-I (apoA-I), can stimulate cholesterol efflux from cells expressing the ATP binding cassette transporter A1 (ABCA1). The nature of the molecular interaction between these cholesterol acceptors and ABCA1 is controversial, and models suggesting a direct protein-protein interactio...

journal_title：Journal of lipid research

authors： Fitzgerald ML,Morris AL,Chroni A,Mendez AJ,Zannis VI,Freeman MW

更新日期：2004-02-01 00:00:00

abstract：:Several studies have documented the presence of Lp[a] in nonhuman primates. However, data are lacking in great apes such as the chimpanzee. We have studied the quantitative distribution of Lp[a], as well as the frequency of apo[a] phenotypes, in a population of chimpanzees living in Gabon. Monoclonal antibody 14A12, d...

journal_title：Journal of lipid research

authors： Doucet C,Huby T,Chapman J,Thillet J

更新日期：1994-02-01 00:00:00

abstract：:Geranylgeranoic acid (GGA) has been reported to induce autophagic cell death via upregulation of lipid-induced unfolded protein response in several human hepatoma-derived cell lines, and its 4,5-didehydro derivative has been developed as a preventive agent against second primary hepatoma in clinical trials. We have pr...

journal_title：Journal of lipid research

authors： Shidoji Y,Tabata Y

更新日期：2019-03-01 00:00:00