Incorporation of labeled cholesterol esters into chylomicrons in vitro.

abstract：:Lipogenesis in vitro from acetate-1-(14)C was studied in human preputial skin and abdominal skin. Radioactive lipids were separated by column chromatography on Florisil and by thin-layer chromatography on silica gel. Radioactivity was incorporated chiefly into the triglyceride, sterol, and polar lipid fractions, while...

journal_title：Journal of lipid research

authors： Vroman HE,Nemecek RA,Hsia SL

更新日期：1969-09-01 00:00:00

abstract：:Leukotrienes (LTs) play major roles in lung immune responses, and LTD4 is the most potent agonist for cysteinyl LT1, leading to bronchoconstriction and tissue remodeling. Here, we studied LT crosstalk between myeloid cells and pulmonary epithelial cells. Monocytic cells (Mono Mac 6 cell line, primary dendritic cells) ...

journal_title：Journal of lipid research

authors： Lukic A,Ji J,Idborg H,Samuelsson B,Palmberg L,Gabrielsson S,Rådmark O

更新日期：2016-09-01 00:00:00

abstract：:A study was conducted to determine the levels of cellular retinol-binding protein (CRBP) mRNA and protein in various tissues of the rat, to explore relationship between CRBP mRNA and protein levels in different tissues, and to examine the effects of changes in retinol nutritional status on the tissue distribution and ...

journal_title：Journal of lipid research

authors： Rajan N,Blaner WS,Soprano DR,Suhara A,Goodman DS

更新日期：1990-05-01 00:00:00

abstract：:The apoE gene exhibits two common polymorphisms that have been associated with both coronary artery disease and Alzheimer's disease. The polymorphisms create the three allelic isoforms E2, E3, and E4 which are encoded by Cys;-Cys, Cys;-Arg, and Arg;-Arg at amino acid positions 112 and 158, respectively. Numerous metho...

journal_title：Journal of lipid research

authors： Bolla MK,Wood N,Humphries SE

更新日期：1999-12-01 00:00:00

abstract：:Senescence-accelerated mouse-prone (SAMP1; SAMP1@Umz) is an animal model of senile amyloidosis with apolipoprotein A-II (apoA-II) amyloid fibril (AApoAII) deposits. This study was undertaken to investigate the effects of dietary fats on AApoAII deposits in SAMP1 mice when purified diets containing 4% fat as butter, sa...

journal_title：Journal of lipid research

authors： Umezawa M,Tatematsu K,Korenaga T,Fu X,Matushita T,Okuyama H,Hosokawa M,Takeda T,Higuchi K

更新日期：2003-04-01 00:00:00

abstract：:Diet-induced changes in high density lipoprotein (HDL) density and size were studied in patas monkeys. When the animals were switched from a moderate fat-low cholesterol diet to a high fat-high cholesterol (HFHC) diet, the plasma apoA-I levels increased initially in all of the animals. The apoA-I levels remained eleva...

journal_title：Journal of lipid research

authors： Melchior GW,Baker HN,Abee CR,Roheim PS

更新日期：1984-09-01 00:00:00

abstract：:The effect of microbiological deconjugation of bile acids on total bile acid and neutral sterol fecal excretion by adult male rats has been studied. A screening method utilizing mice allowed selection of a Clostridium perfringens type A strain, which accelerated cholesterol catabolism in mice. When this species of bac...

journal_title：Journal of lipid research

authors： Kellogg TF,Knight PL,Wostmann BS

更新日期：1970-07-01 00:00:00

abstract：:ABCA1 plays a key role in the initial lipidation of apoA-I, which generates circulating HDL cholesterol. Whereas it is known that the transcriptional upregulation of ABCA1 promotes HDL formation and reverse cholesterol transport (RCT), it is not known how the inhibition of ABCA1 protein degradation impacts HDL functio...

journal_title：Journal of lipid research

authors： Huang L,Fan B,Ma A,Shaul PW,Zhu H

更新日期：2015-05-01 00:00:00

abstract：:In this article we report the effects of low and high fat diets on the arterial thrombosis tendency in rats. The animal system used was the aorta loop model, in which we compared the effect of saturated (hardened coconut oil, HCO) and unsaturated (sunflower seed oil, SSO; corn oil, CO) fatty acids on the arterial thro...

journal_title：Journal of lipid research

authors： Schurgers LJ,Vermeer C

更新日期：2001-07-01 00:00:00

abstract：:Recent studies suggest: that the epidermis and pilosebaceous epithelium are important sites of de novo sterol synthesis, and that the rate of cutaneous cholesterol synthesis does not change with alterations in circulating sterol levels. Since cutaneous sterols may be important for permeability barrier function, we stu...

journal_title：Journal of lipid research

authors： Menon GK,Feingold KR,Moser AH,Brown BE,Elias PM

更新日期：1985-04-01 00:00:00

abstract：:Delta-6 desaturase (D6D) catalyzes the first step in the synthesis of highly unsaturated fatty acids (HUFA) such as arachidonic (AA), docosapentaenoic (DPAn-6), and docosahexaenoic (DHA) acids, as well as the last desaturation of DPAn-6 and DHA. We created D6D-null mice (-/-), which enabled us to study HUFA deficiency...

journal_title：Journal of lipid research

authors： Stroud CK,Nara TY,Roqueta-Rivera M,Radlowski EC,Lawrence P,Zhang Y,Cho BH,Segre M,Hess RA,Brenna JT,Haschek WM,Nakamura MT

更新日期：2009-09-01 00:00:00

abstract：:The surface behavior of a series of cholesteryl esters was studied in mixtures with a model phospholipid, 1-palmitoyl-2-oleoyl phosphatidylcholine. The cholesteryl esters were representative of the predominant forms occurring naturally and qualitative similarities in their phase behavior permits generalization of thei...

journal_title：Journal of lipid research

authors： Smaby JM,Brockman HL

更新日期：1987-09-01 00:00:00

abstract：:The secondary bile acid lithocholic acid (LCA) and its derivatives act as selective modulators of the vitamin D receptor (VDR), although their structures fundamentally differ from that of the natural hormone 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3)]. Here, we have determined the crystal structures of the ligand-binding...

journal_title：Journal of lipid research

authors： Masuno H,Ikura T,Morizono D,Orita I,Yamada S,Shimizu M,Ito N

更新日期：2013-08-01 00:00:00

abstract：:Macrophages and arterial chondroitin sulfate proteoglycans (CSPG) are probably associated with extracellular and intracellular lipoprotein deposition during atherogenesis. We found that human arterial CSPG can be used to select subclasses from low density lipoprotein (LDL) with different structural properties and capa...

journal_title：Journal of lipid research

authors： Hurt-Camejo E,Camejo G,Rosengren B,Lopez F,Wiklund O,Bondjers G

更新日期：1990-08-01 00:00:00

abstract：:Familial dysbetalipoproteinemia (FD) is a genetic disorder associated with impaired postprandial lipid clearance. The effect of adding bezafibrate to standard lipid-lowering therapy on postprandial and fasting lipid levels in patients with FD is unknown. In this randomized placebo-controlled double-blind crossover tri...

journal_title：Journal of lipid research

authors： Koopal C,Marais AD,Westerink J,van der Graaf Y,Visseren FLJ

更新日期：2017-11-01 00:00:00

abstract：:The sphingomyelin pathway is an important signal transduction system regulating various cellular functions. However, little is known about the effect of sphingomyelin metabolites on vasomotor function. We examined the vascular effects of sphingomyelin, sphingosine, and sphingomyelinase (SPMase) in vitro. In pig corona...

journal_title：Journal of lipid research

authors： Murohara T,Kugiyama K,Ohgushi M,Sugiyama S,Ohta Y,Yasue H

更新日期：1996-07-01 00:00:00

abstract：:Adipocyte triglyceride storage provides a reservoir of energy that allows the organism to survive times of nutrient scarcity, but excessive adiposity has emerged as a health problem in many areas of the world. Monoacylglycerol acyltransferase (MGAT) acylates monoacylglycerol to produce diacylglycerol; the penultimate ...

journal_title：Journal of lipid research

authors： Liss KHH,Lutkewitte AJ,Pietka T,Finck BN,Franczyk M,Yoshino J,Klein S,Hall AM

更新日期：2018-09-01 00:00:00

abstract：:This work describes the molecular mechanisms of fatty acid and hormonal modulations of the retinoid X receptor alpha (RXRalpha) in rat liver cells. We examined the effects of different fatty acids (myristic, stearic, oleic, linolenic, and arachidonic acids, EPA, and the peroxisomal proliferator TTA) and several hormon...

journal_title：Journal of lipid research

authors： Steineger HH,Arntsen BM,Spydevold O,Sørensen HN

更新日期：1998-04-01 00:00:00

abstract：:The storage of lipids in the form of triglycerides (TGs) and the de novo synthesis (lipogenesis) of fatty acids from nonlipid precursors [de novo lipogenesis (DNL)] are important functions of adipose tissue (AT) that influence whole-body metabolism. Yet, few studies have reported in vivo estimates of adipose lipid kin...

journal_title：Journal of lipid research

authors： White UA,Fitch MD,Beyl RA,Hellerstein MK,Ravussin E

更新日期：2018-09-01 00:00:00

abstract：:The quantitative isolation of total glycosphingolipids from crude lipid extracts without contamination from other lipid classes is described. The method consists of (a) acetylation of total lipids with pyridine and acetic anhydride, (b) separation of acetylated glycolipids from nonglycolipids on a magnesia-silica gel ...

journal_title：Journal of lipid research

authors： Saito T,Hakomori SI

更新日期：1971-03-01 00:00:00

abstract：:The aim of this study was to investigate the extent to which inflammation is linked with plasma endothelial lipase (EL) concentrations among healthy sedentary men. Plasma C-reactive protein (CRP) concentrations were measured with a highly sensitive commercial immunoassay, plasma interleukin-6 (IL-6) concentrations wer...

journal_title：Journal of lipid research

authors： Paradis ME,Badellino KO,Rader DJ,Deshaies Y,Couture P,Archer WR,Bergeron N,Lamarche B

更新日期：2006-12-01 00:00:00

abstract：:Genetic defects in SAR1B GTPase inhibit chylomicron (CM) trafficking to the Golgi and result in a huge intraenterocyte lipid accumulation with a failure to release CMs and liposoluble vitamins into the blood circulation. The central aim of this study is to test the hypothesis that SAR1B deletion (SAR1B-/- ) disturbs e...

journal_title：Journal of lipid research

authors： Sané A,Ahmarani L,Delvin E,Auclair N,Spahis S,Levy E

更新日期：2019-10-01 00:00:00

abstract：:The effects of polyunsaturated fatty acids (PUFA) on the structure of recombinant high density lipoprotein (rHDL) was investigated using homogeneous particles containing phosphatidylcholine (PC), [3H]cholesterol, and apolipoprotein A-I (apoA-I). The PC component of the rHDL contained sn -1 16:0 and sn -2 18:1 (POPC), ...

journal_title：Journal of lipid research

authors： Huggins KW,Curtiss LK,Gebre AK,Parks JS

更新日期：1998-12-01 00:00:00

abstract：:Quantitatively and rapidly analyzing lipids is necessary to elucidate their biological functions. Herein, we developed a quantitative method for various lipid classes using supercritical fluid chromatography (SFC) coupled with a charged aerosol detector (CAD), providing high-throughput data analysis to detect a large ...

journal_title：Journal of lipid research

authors： Takeda H,Takahashi M,Hara T,Izumi Y,Bamba T

更新日期：2019-08-01 00:00:00

abstract：:Studies were conducted to explore vitamin A transport in the non-mammalian vertebrates, especially Pisces, Amphibia, and Reptilia, and to isolate and partially characterize piscine retinol-binding protein. Retinol-containing proteins in fresh plasma obtained from bullfrogs and a turtle exhibited similar properties to ...

journal_title：Journal of lipid research

authors： Shidoji Y,Muto Y

更新日期：1977-11-01 00:00:00

abstract：:Paraoxonase-1 (PON1) is known to be associated with high density lipoproteins. We optimized buffer conditions to obtain quantitative recovery of PON1 (arylesterase) activity and analyzed the distribution of PON1 in mice using a combination of size-exclusion chromatography and ultracentrifugation. Size-exclusion chroma...

journal_title：Journal of lipid research

authors： Connelly PW,Maguire GF,Draganov DI

更新日期：2004-03-01 00:00:00

abstract：:Ceramides play an essential role in modulating immune signaling pathways and proinflammatory cytokine production in response to infectious pathogens, stress stimuli, or chemotherapeutic drugs. In this study, we demonstrated that Aggregatibacter actinomycetemcomitans, the pathogen for aggressive periodontitis, induced ...

journal_title：Journal of lipid research

authors： Yu H,Valerio M,Bielawski J

更新日期：2013-01-01 00:00:00

abstract：:Lipid droplet (LD) coating proteins are essential for the formation and stability of intracellular LDs. Plin2 is an abundant LD coating protein in skeletal muscle, but its importance for muscle function is unclear. We show that myotubes established from Plin2-/- mice contain reduced content of LDs and accumulate less ...

journal_title：Journal of lipid research

authors： Feng YZ,Lund J,Li Y,Knabenes IK,Bakke SS,Kase ET,Lee YK,Kimmel AR,Thoresen GH,Rustan AC,Dalen KT

更新日期：2017-11-01 00:00:00

abstract：:4F is an anti-inflammatory, apolipoprotein A-I (apoA-I)-mimetic peptide that is active in vivo at nanomolar concentrations in the presence of a large molar excess of apoA-I. Physiologic concentrations ( approximately 35 microM) of human apoA-I did not inhibit the production of LDL-induced monocyte chemotactic activity...

journal_title：Journal of lipid research

authors： Van Lenten BJ,Wagner AC,Jung CL,Ruchala P,Waring AJ,Lehrer RI,Watson AD,Hama S,Navab M,Anantharamaiah GM,Fogelman AM

更新日期：2008-11-01 00:00:00

abstract：:Human apolipoprotein C-I (apoC-I) is an exchangeable apolipoprotein that binds to lipoprotein particles in vivo. In this study, we employed a LC-MS/MS assay to demonstrate that residues 38-51 of apoC-I are significantly protected from proteolysis in the presence of 1,2-dimyristoyl-3-sn-glycero-phosphocholine (DMPC). T...

journal_title：Journal of lipid research

authors： James PF,Dogovski C,Dobson RC,Bailey MF,Goldie KN,Karas JA,Scanlon DB,O'Hair RA,Perugini MA

更新日期：2009-07-01 00:00:00