PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain.

abstract：:The reversibility and regression of histological and biochemical findings in a mouse model of Gaucher disease (4L/PS-NA) was evaluated using a liver-enriched activator protein promoter control of a tetracycline-controlled transcriptional activation-responsive human acid beta-glucosidase (hGCase) transgenic system. 4L/...

journal_title：Journal of lipid research

authors： Sun Y,Quinn B,Xu YH,Leonova T,Witte DP,Grabowski GA

更新日期：2006-10-01 00:00:00

abstract：:The apolipoprotein (apo) B-100-specific monoclonal antibody MB47 has been widely used in lipoprotein metabolism and atherosclerosis research. When bound to apoB-100 on low density lipoproteins (LDL), antibody MB47 completely blocks the binding of LDL to the LDL receptor. The epitope for antibody MB47 has previously be...

journal_title：Journal of lipid research

authors： Young SG,Koduri RK,Austin RK,Bonnet DJ,Smith RS,Curtiss LK

更新日期：1994-03-01 00:00:00

abstract：:Vitamin E (α-tocopherol) is the major lipid-soluble antioxidant in many species. Niemann-Pick type C (NPC) disease is a lysosomal storage disorder caused by mutations in the NPC1 or NPC2 gene, which regulates lipid transport through the endocytic pathway. NPC disease is characterized by massive intracellular accumulat...

journal_title：Journal of lipid research

authors： Ulatowski L,Parker R,Davidson C,Yanjanin N,Kelley TJ,Corey D,Atkinson J,Porter F,Arai H,Walkley SU,Manor D

更新日期：2011-07-01 00:00:00

abstract：:A simplified method for the preparation of the Dittmer-Lester spray for the detection of phospholipids on thin-layer chromatograms is described. ...

journal_title：Journal of lipid research

authors： Vaskovsky VE,Kostetsky EY

更新日期：1968-05-01 00:00:00

abstract：:Epoxyeicosatrienoic acids were isolated and purified from female rabbit kidneys. They were identified as a group, prior to resolution, by packed column gas-liquid chromatography-mass spectroscopic techniques as their methyl esters as well as their trimethylsilyl bromohydrin methyl esters. Initial capillary gas-liquid ...

journal_title：Journal of lipid research

authors： Falck JR,Schueler VJ,Jacobson HR,Siddhanta AK,Pramanik B,Capdevila J

更新日期：1987-07-01 00:00:00

abstract：:Oxidized forms of cholesterol (oxysterols) are present in atherosclerotic lesions and may play an active role in lesion development. For example, 7-ketocholesterol (7KC) inhibits cholesterol efflux from macrophage foam cells induced by apolipoprotein A-I (apoA-I). Such oxysterols may promote foam cell formation in ath...

journal_title：Journal of lipid research

authors： Gelissen IC,Rye KA,Brown AJ,Dean RT,Jessup W

更新日期：1999-09-01 00:00:00

abstract：:Prostaglandin (PG)E(2) is relevant in tumor biology, and interactions between tumor and stroma cells dramatically influence tumor progression. We tested the hypothesis that cross-talk between head and neck squamous cell carcinoma (HNSCC) cells and fibroblasts could substantially enhance PGE(2) biosynthesis. We observe...

journal_title：Journal of lipid research

authors： Alcolea S,Antón R,Camacho M,Soler M,Alfranca A,Avilés-Jurado FX,Redondo JM,Quer M,León X,Vila L

更新日期：2012-04-01 00:00:00

abstract：:Lipid peroxidation is a common event in health and is greatly accelerated in pro-inflammatory settings such as hypercholesterolemia. Consequently, oxidation-specific epitopes are generated, which are pro-inflammatory and immunogenic, leading to both adaptive and innate responses. Because innate immune mechanisms use c...

journal_title：Journal of lipid research

authors： Hartvigsen K,Chou MY,Hansen LF,Shaw PX,Tsimikas S,Binder CJ,Witztum JL

更新日期：2009-04-01 00:00:00

abstract：:We investigated, in the present study, the role of reactive oxygen intermediates (ROI) in the control of macrophage lipoprotein lipase (LPL) secretion. Exposure of murine macrophages to increasing concentrations of hydrogen peroxide (H2O2) resulted in enhanced basal LPL production and mRNA levels. The increase of LPL ...

journal_title：Journal of lipid research

authors： Renier G,Desfaits AC,Lambert A,Mikhail R

更新日期：1996-04-01 00:00:00

abstract：:Seven Z-octadecenoic acids having the double bond located in positions 6Z to 13Z were photooxidized. The resulting hydroperoxy-E-octadecenoic acids [HpOME(E)] were resolved by chiral phase-HPLC-MS, and the absolute configurations of the enantiomers were determined by gas chromatographic analysis of diastereoisomeric d...

journal_title：Journal of lipid research

authors： Oliw EH,Wennman A,Hoffmann I,Garscha U,Hamberg M,Jernerén F

更新日期：2011-11-01 00:00:00

abstract：:Previous findings with various murine tumor cell lines suggest an association between ganglioside GM3 and cell cohesive properties. The influence of GM3 on cohesion was studied in two mouse brain tumor cell lines: ependymoblastoma (EPEN) and CT-2A. In culture, the EPEN cells grow as islands and contain GM3 as the only...

journal_title：Journal of lipid research

authors： Bai H,Seyfried TN

更新日期：1997-01-01 00:00:00

abstract：:HDL-associated paraoxonase type 1 (PON1) can protect LDL and HDL against oxidative modification in vitro and therefore may protect against cardiovascular disease. We investigated the effects of PON1 levels, activity, and genetic variation on high density lipoprotein-cholesterol (HDL-C) levels, circulating oxidized LDL...

journal_title：Journal of lipid research

authors： van Himbergen TM,Roest M,de Graaf J,Jansen EH,Hattori H,Kastelein JJ,Voorbij HA,Stalenhoef AF,van Tits LJ

更新日期：2005-03-01 00:00:00

abstract：:When grown in the presence of bile acids, two strains of Clostridium limosum were found to contain significant amounts of NADP-dependent 7 alpha/7 beta-hydroxysteroid dehydrogenase and NAD-dependent 7 alpha-hydroxysteroid dehydrogenase which were active against conjugated and unconjugated bile acids. No measurable act...

journal_title：Journal of lipid research

authors： Sutherland JD,Williams CN

更新日期：1985-03-01 00:00:00

abstract：:Vitamin E is a naturally occurring fat-soluble antioxidant which has been proposed as a treatment for both primary and secondary protection against cardiovascular (CV) events. Promising data from observational epidemiological studies associating higher vitamin E dietary intake with lower risk of CV events have not bee...

journal_title：Journal of lipid research

authors： Vardi M,Levy NS,Levy AP

更新日期：2013-09-01 00:00:00

abstract：:Humans and mice lacking angiopoietin-like protein 3 (ANGPTL3) have pan-hypolipidemia. ANGPTL3 inhibits two intravascular lipases, LPL and endothelial lipase, and the low plasma TG and HDL-cholesterol levels in ANGPTL3 deficiency reflect increased activity of these enzymes. The mechanism responsible for the low LDL-cho...

journal_title：Journal of lipid research

authors： Wang Y,Gusarova V,Banfi S,Gromada J,Cohen JC,Hobbs HH

更新日期：2015-07-01 00:00:00

abstract：:In a previously described method for determining the activity of cerebroside galactosidase, the enzyme preparation was incubated with an emulsion of cerebroside which had been labeled in the galactose moiety. The liberated galactose was separated from the emulsion by liquid-liquid partitioning, but the presence of det...

journal_title：Journal of lipid research

authors： Radin NS,Arora RC

更新日期：1971-03-01 00:00:00

abstract：:In order to study the metabolic responses of humans consuming a diet moderately high in cholesterol content, we carried out a long-term sterol balance study, up to 25 weeks in duration. Two subjects, one normocholesterolemic and one hypercholesterolemic, were given, in sequence, a very low cholesterol diet and then a ...

journal_title：Journal of lipid research

authors： Lin DS,Connor WE

更新日期：1980-11-01 00:00:00

abstract：:Decreased HDL-cholesterol (HDL-C) and familial combined hyperlipidemia (FCHL) are the two most common familial dyslipidemias predisposing to premature coronary heart disease (CHD). These dyslipidemias share many phenotypic features, suggesting a partially overlapping molecular pathogenesis. This was supported by our p...

journal_title：Journal of lipid research

authors： Lilja HE,Suviolahti E,Soro-Paavonen A,Hiekkalinna T,Day A,Lange K,Sobel E,Taskinen MR,Peltonen L,Perola M,Pajukanta P

更新日期：2004-10-01 00:00:00

abstract：:Sonication of rat fat cells caused an increase in lipolysis in the absence of lipolytic stimulants (basal lipolysis) and loss of epinephrine responsiveness. Sonication of endogenous lipid droplets from fat cells also induced an increase in lipolysis in the presence of hormone-sensitive lipase (HSL) and loss of epineph...

journal_title：Journal of lipid research

authors： Okuda H,Morimoto C,Tsujita T

更新日期：1994-01-01 00:00:00

abstract：:The effects of fish oil supplementation (14.5 g n-3 fatty acids/day) on plasma lipoprotein particles in healthy volunteers were assessed by high resolution 13C and 1H nuclear magnetic resonance (NMR) spectroscopy. Resonances not previously observed in the 13C and 1H spectra of plasma and isolated lipoproteins were det...

journal_title：Journal of lipid research

authors： Bell JD,Barnard ML,Parkes HG,Thomas EL,Brennan CH,Cunnane SC,Dagnelie PC

更新日期：1996-08-01 00:00:00

abstract：:We analysed the sensitivity to beta-adrenoceptor agonists in epididymal adipose cells from rats submitted to a stress protocol previously reported to induce alterations in sensitivity to catecholamines in cardiac tissue from rats. Food intake and body weight were lower, whereas adipocytes basal lipolysis was higher (c...

journal_title：Journal of lipid research

authors： Farias-Silva E,Grassi-Kassisse DM,Wolf-Nunes V,Spadari-Bratfisch RC

更新日期：1999-09-01 00:00:00

abstract：:AY 9944 is a novel inhibitor of cholesterol biosynthesis which appears to act on the Delta 7-reductase enzyme, interfering with the conversion of 7-dehydrocholesterol to cholesterol. In all tissues studied, with the exception of the lens, there was a reduction in cholesterol and a marked accumulation of 7-dehydrochole...

journal_title：Journal of lipid research

authors： Horlick L

更新日期：1966-01-01 00:00:00

abstract：:Thermal and lyotropic phase behavior was studied by X-ray diffraction and differential scanning calorimetry for a diether phosphonolipid analog (DEPN-8) of the major lung surfactant glycerophospholipid dipalmitoyl phosphatidylcholine (DPPC). DEPN-8 differs in an ether, rather than an ester, bond at the acyl chain-back...

journal_title：Journal of lipid research

authors： Skita V,Chester DW,Oliver CJ,Turcotte JG,Notter RH

更新日期：1995-05-01 00:00:00

abstract：:HDL-like particles in human cerebrospinal fluid (CSF) promote the efflux of cholesterol from astrocytes toward the neurons that rely on this supply for their functions. We evaluated whether cell cholesterol efflux capacity of CSF (CSF-CEC) is impaired in Alzheimer's disease (AD) by analyzing AD (n = 37) patients, non-...

journal_title：Journal of lipid research

authors： Marchi C,Adorni MP,Caffarra P,Ronda N,Spallazzi M,Barocco F,Galimberti D,Bernini F,Zimetti F

更新日期：2019-08-01 00:00:00

abstract：:To assess the relationship between cholesterol synthesis and feedback inhibition of bile acid synthesis, we studied seven normal human subjects taking three different doses of chenodiol, 0, 5, and 15 mg/kg per day: once while taking no lovastatin and again while taking lovastatin 80 mg/day. Lovastatin and both doses o...

journal_title：Journal of lipid research

authors： Hanson DS,Duane WC

更新日期：1994-08-01 00:00:00

abstract：:The lipids of rat milk, the contents of 9-- 10-day-old rat stomach and intestine, lymph, plasma, and liver were quantitated and their fatty acids were analyzed. Rat milk consists of 97% triacylglycerols, of which 35% of the fatty acids are of medium chain length (C8-C12). However, stomach triacylglycerols show a 25% r...

journal_title：Journal of lipid research

authors： Fernando-Warnakulasuriya GJ,Staggers JE,Frost SC,Wells MA

更新日期：1981-05-01 00:00:00

abstract：:We measured plasma markers of cholesterol synthesis (lathosterol) and absorption (campesterol, sitosterol, and cholestanol) in order to compare the effects of maximal doses of rosuvastatin with atorvastatin and investigate the basis for the significant individual variation in lipid lowering response to statin therapy....

journal_title：Journal of lipid research

authors： van Himbergen TM,Matthan NR,Resteghini NA,Otokozawa S,Ai M,Stein EA,Jones PH,Schaefer EJ

更新日期：2009-04-01 00:00:00

abstract：:Exosomes are bioactive vesicles released from multivesicular bodies (MVB) by intact cells and participate in intercellular signaling. We investigated the presence of lipid-related proteins and bioactive lipids in RBL-2H3 exosomes. Besides a phospholipid scramblase and a fatty acid binding protein, the exosomes contain...

journal_title：Journal of lipid research

authors： Subra C,Grand D,Laulagnier K,Stella A,Lambeau G,Paillasse M,De Medina P,Monsarrat B,Perret B,Silvente-Poirot S,Poirot M,Record M

更新日期：2010-08-01 00:00:00

abstract：:Scavenger receptor class B type I (SR-BI) has been identified as a functional HDL binding protein that can mediate the selective uptake of cholesteryl ester (CE) from HDL. To quantify the in vivo role of SR-BI in the process of selective uptake, HDL was labeled with cholesteryl ether ([(3)H] CEt-HDL) and (125)I-tyrami...

journal_title：Journal of lipid research

authors： Out R,Hoekstra M,Spijkers JA,Kruijt JK,van Eck M,Bos IS,Twisk J,Van Berkel TJ

更新日期：2004-11-01 00:00:00

abstract：:CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) catalyzes the rate-controlling reaction of the CDP-ethanolamine (Kennedy) pathway. We have previously established that Pcyt2 is encoded by a single gene that can be alternatively spliced from an internal exon into two transcripts, designated Pcyt2alpha and Pcyt2beta...

journal_title：Journal of lipid research

authors： Tie A,Bakovic M

更新日期：2007-10-01 00:00:00