Post-transcriptional regulation of retroviral vector-transduced low density lipoprotein receptor activity.

abstract：:The major high density lipoprotein (HDL) apolipoprotein, apoA-I, was knocked out by gene targeting in ES cells to provide a model for the study of HDL metabolism and its relationship to plasma and tissue cholesterol metabolism. HDL and non-HDL cholesterol (HDL-C) were reduced in apoA-I-deficient mice. Feeding a high f...

journal_title：Journal of lipid research

authors： Plump AS,Azrolan N,Odaka H,Wu L,Jiang X,Tall A,Eisenberg S,Breslow JL

更新日期：1997-05-01 00:00:00

abstract：:Neuroinflammation, caused by 6 days of intracerebroventricular infusion of a low dose of lipopolysaccharide (LPS; 0.5 ng/h), stimulates brain arachidonic acid (AA) metabolism in rats, but 6 weeks of lithium pretreatment reduces this effect. To further understand this action of lithium, we measured concentrations of ei...

journal_title：Journal of lipid research

authors： Basselin M,Kim HW,Chen M,Ma K,Rapoport SI,Murphy RC,Farias SE

更新日期：2010-05-01 00:00:00

abstract：:In this study, we investigated the hypothesis that regulatory T cells (T(reg)) are involved in the immunomodulatory effects of statins on rheumatoid arthritis (RA) patients. The 12-week study cohort consisted of 55 RA patients and 42 control subjects allocated to either a group treated with atorvastatin (AT) (20 mg/da...

journal_title：Journal of lipid research

authors： Tang TT,Song Y,Ding YJ,Liao YH,Yu X,Du R,Xiao H,Yuan J,Zhou ZH,Liao MY,Yao R,Jevallee H,Shi GP,Cheng X

更新日期：2011-05-01 00:00:00

abstract：:The time course of the clearance from the blood and the tissue localization of [14C]L-glucosylceramide, a nonmetabolizable enantiomorph of D-glucosylceramide that accumulates in Gaucher's disease, has been determined. 14C-labeled L-glucosylceramide injected intravenously in the form of micelles or liposomes is rapidly...

journal_title：Journal of lipid research

authors： Tokoro T,Gal AE,Gallo LL,Brady RO

更新日期：1987-08-01 00:00:00

abstract：:The mixed dyslipidemia phenotype is characterized by elevated triglycerides (TG), low HDL cholesterol (HDL-C), increased ApoB levels, and premature coronary atherosclerosis. Fibrate-statin combination therapy reduces ApoB levels and coronary events in the mixed dyslipidemia population. We sought to identify gene-gene ...

journal_title：Journal of lipid research

authors： Ma L,Ballantyne CM,Belmont JW,Keinan A,Brautbar A

更新日期：2012-11-01 00:00:00

abstract：:Lipid and cholesterol metabolism in the postprandial phase is associated with both quantitative and qualitative remodeling of HDL particle subspecies that may influence their anti-atherogenic functions in the reverse cholesterol transport pathway. We evaluated the capacity of whole plasma or isolated HDL particles to ...

journal_title：Journal of lipid research

authors： Julia Z,Duchene E,Fournier N,Bellanger N,Chapman MJ,Le Goff W,Guerin M

更新日期：2010-11-01 00:00:00

abstract：:Adipocyte triglyceride storage provides a reservoir of energy that allows the organism to survive times of nutrient scarcity, but excessive adiposity has emerged as a health problem in many areas of the world. Monoacylglycerol acyltransferase (MGAT) acylates monoacylglycerol to produce diacylglycerol; the penultimate ...

journal_title：Journal of lipid research

authors： Liss KHH,Lutkewitte AJ,Pietka T,Finck BN,Franczyk M,Yoshino J,Klein S,Hall AM

更新日期：2018-09-01 00:00:00

abstract：:Apart from exhibiting the presence of lipoprotein [a] in its plasma, another interest of the European hedgehog in lipoprotein research lies in the quantitative prominence of a complex spectrum of high density lipoproteins (HDL) and very high density lipoproteins (VHDL) as cholesterol transporters in plasma (Laplaud, P...

journal_title：Journal of lipid research

authors： Sparrow DA,Laplaud PM,Saboureau M,Zhou G,Dolphin PJ,Gotto AM Jr,Sparrow JT

更新日期：1995-03-01 00:00:00

abstract：:This study describes a variant of familial apoA-I deficiency associated with a moderate risk for premature coronary artery disease. The proband, a 25-year-old man of Philippine origin, and his 62-year-old maternal aunt had peripheral corneal opacification, xanthelasma, and planar xanthoma; the aunt had coronary artery...

journal_title：Journal of lipid research

authors： Bekaert ED,Alaupovic P,Knight-Gibson CS,Laux MJ,Pelachyk JM,Norum RA

更新日期：1991-10-01 00:00:00

abstract：:Groups of gerbils were fed purified diets containing either 10 or 20% of safflower, olive, or coconut oil. Each diet was fed without cholesterol and with 0.1 and 0.2% of added cholesterol. The animals were bled after 2, 4, and 8 wk for the determination of the level of serum cholesterol. The major factors affecting th...

journal_title：Journal of lipid research

authors： Hegsted DM,Gallagher A

更新日期：1967-05-01 00:00:00

abstract：:Murine strains susceptible to atherosclerosis provide valuable models to study factors involved in atherogenesis. In some murine models, limited hypercholesterolemia can be achieved and lesions develop primarily in the aortic origin, in the vicinity of the aortic valve. In other models such as LDL receptor-deficient a...

journal_title：Journal of lipid research

authors： Tangirala RK,Rubin EM,Palinski W

更新日期：1995-11-01 00:00:00

abstract：:Two procedures were used to isolate hepatocytic Golgi fractions from rat liver. One procedure yields a light Golgi fraction (GF1 + 2) and the other "intact" stacks of cisternae. Triglyceride fatty acids in nascent very low density lipoproteins (VLDL) were labeled by injection of [3H]palmitate intravenously, and radiol...

journal_title：Journal of lipid research

authors： Hamilton RL,Moorehouse A,Havel RJ

更新日期：1991-03-01 00:00:00

abstract：:C26 Bile of the 24-nor-5beta-cholestane series were prepared starting from methyl cholate. A Grignard reaction of methyl magnesium iodide with methyl cholate yielded 24-nor-5beta-cholestane-3alpha, 7alpha, 12alpha, 25-tetrol which was dehydrated TO FORM a mixture of 24-nor-5beta-cholest-23-ene-3alpha, 7alpha, 12 alpha...

journal_title：Journal of lipid research

authors： Dayal B,Shefer S,Tint GS,Salen G,Mosbach EH

更新日期：1976-09-01 00:00:00

abstract：:There is growing evidence of the capacity of vitamin A to regulate the expression of the genetic region that encodes apolipoproteins (apo) A-I, C-III, and A-IV. This region in turn has been proposed to modulate the expression of hyperlipidemia in the commonest genetic form of dyslipidemia, familial combined hyperlipid...

journal_title：Journal of lipid research

authors： Ribalta J,Girona J,Vallvé JC,La Ville AE,Heras M,Masana L

更新日期：1999-03-01 00:00:00

abstract：:Type 1 diabetes mellitus is a devastating disorder affecting both glucose and lipid metabolism. Using the nonobese diabetic (NOD) mouse model, we found that diabetic mice had a liver-specific increase in steady state mRNA levels for enzymes involved in oxidation of fatty acids. Increased mRNA abundance was observed in...

journal_title：Journal of lipid research

authors： Kurtz DM,Tian L,Gower BA,Nagy TR,Pinkert CA,Wood PA

更新日期：2000-12-01 00:00:00

abstract：:The ceramide (Cer) and sphingomyelin (SM) species of cultured differentiated rat cerebellar granule cells and human fibroblasts were characterized by electrospray ionization-mass spectrometry. We identified 35 different species of Cer and 18 species of SM in human fibroblasts, and 35 different species of Cer and 9 spe...

journal_title：Journal of lipid research

authors： Valsecchi M,Mauri L,Casellato R,Prioni S,Loberto N,Prinetti A,Chigorno V,Sonnino S

更新日期：2007-02-01 00:00:00

abstract：:Oxidized forms of cholesterol (oxysterols) are present in atherosclerotic lesions and may play an active role in lesion development. For example, 7-ketocholesterol (7KC) inhibits cholesterol efflux from macrophage foam cells induced by apolipoprotein A-I (apoA-I). Such oxysterols may promote foam cell formation in ath...

journal_title：Journal of lipid research

authors： Gelissen IC,Rye KA,Brown AJ,Dean RT,Jessup W

更新日期：1999-09-01 00:00:00

abstract：:The metabolism of chenodeoxycholic acid by Pseudomonas sp. NCIB 10590 under strict anaerobic conditions was studied. A range of unsaturated acidic and neutral metabolites were isolated and identified. The major acidic product was chola-4,6-dien-3-one-24-oic acid whilst the major neutral product was androsta-4,6-dien-3...

journal_title：Journal of lipid research

authors： Owen RW,Hill MJ,Bilton RF

更新日期：1983-09-01 00:00:00

abstract：:Niemann-Pick C1-like 1 (NPC1L1) is a recently identified protein that mediates intestinal cholesterol absorption and regulates biliary cholesterol excretion. The itineraries and kinetics of NPC1L1 trafficking remain uncertain. In this study, we have visualized movement of NPC1L1-enhanced green fluorescent protein (NPC...

journal_title：Journal of lipid research

authors： Petersen NH,Faergeman NJ,Yu L,Wüstner D

更新日期：2008-09-01 00:00:00

abstract：:In vitro studies show that docosahexaenoic acid (DHA) can be released from membrane phospholipid by Ca(2+)-independent phospholipase A(2) (iPLA(2)), Ca(2+)-independent plasmalogen PLA(2) or secretory PLA(2 (sPLA2)), but not by Ca(2+)-dependent cytosolic PLA(2) (cPLA2), which selectively releases arachidonic acid (AA)....

journal_title：Journal of lipid research

authors： Ramadan E,Rosa AO,Chang L,Chen M,Rapoport SI,Basselin M

更新日期：2010-08-01 00:00:00

abstract：:Lipogenesis in vitro from acetate-1-(14)C was studied in human preputial skin and abdominal skin. Radioactive lipids were separated by column chromatography on Florisil and by thin-layer chromatography on silica gel. Radioactivity was incorporated chiefly into the triglyceride, sterol, and polar lipid fractions, while...

journal_title：Journal of lipid research

authors： Vroman HE,Nemecek RA,Hsia SL

更新日期：1969-09-01 00:00:00

abstract：:Our previous studies have shown accumulation of GM2 ganglioside during ethanol-induced neurodegeneration in the developing brain, and GM2 elevation has also been reported in other brain injuries and neurodegenerative diseases. Using GM2/GD2 synthase KO mice lacking GM2/GD2 and downstream gangliosides, the current stud...

journal_title：Journal of lipid research

authors： Saito M,Wu G,Hui M,Masiello K,Dobrenis K,Ledeen RW,Saito M

更新日期：2015-08-01 00:00:00

abstract：:Previous studies have shown that antibodies to cubulin, a receptor on the yolk sac that binds high density lipoproteins (HDL) and cobalamin, induce fetal abnormalities. Mice with markedly low concentrations of plasma HDL-cholesterol (HDL-C) give birth to healthy pups, however. To establish whether maternal HDL-C has a...

journal_title：Journal of lipid research

authors： McConihay JA,Honkomp AM,Granholm NA,Woollett LA

更新日期：2000-03-01 00:00:00

abstract：:A study was conducted to determine the levels of cellular retinol-binding protein (CRBP) mRNA and protein in various tissues of the rat, to explore relationship between CRBP mRNA and protein levels in different tissues, and to examine the effects of changes in retinol nutritional status on the tissue distribution and ...

journal_title：Journal of lipid research

authors： Rajan N,Blaner WS,Soprano DR,Suhara A,Goodman DS

更新日期：1990-05-01 00:00:00

abstract：:The accurate quantitation of high density lipoproteins has recently assumed greater importance in view of studies suggesting their negative correlation with coronary heart disease. High density lipoproteins may be estimated by measuring cholesterol in the plasma fraction of d > 1.063 g/ml. A more practical approach is...

journal_title：Journal of lipid research

authors： Warnick GR,Albers JJ

更新日期：1978-01-01 00:00:00

abstract：:Effects of serum cholesterol on cholesterol content in the retina are currently unknown. It is also unclear how cholesterol levels are controlled in the retina. High-cholesterol diet and oral administrations of simvastatin were used to modulate serum cholesterol in mice. These treatments only modestly affected cholest...

journal_title：Journal of lipid research

authors： Zheng W,Mast N,Saadane A,Pikuleva IA

更新日期：2015-01-01 00:00:00

abstract：:Niemann-Pick type C1 disease (NPC1) is an autosomal recessive lysosomal storage disorder characterized by neonatal jaundice, hepatosplenomegaly, and progressive neurodegeneration. The present study provides the lipid profiles, mutations, and corresponding associations with the biochemical phenotype obtained from NPC1 ...

journal_title：Journal of lipid research

authors： Garver WS,Jelinek D,Meaney FJ,Flynn J,Pettit KM,Shepherd G,Heidenreich RA,Vockley CM,Castro G,Francis GA

更新日期：2010-02-01 00:00:00

abstract：:Smith-Lemli-Opitz Syndrome (SLOS) is a developmental disorder (OMIM #270400) caused by autosomal recessive mutations in the Dhcr7 gene, which encodes the enzyme 3β-hydroxysterol-∆7 reductase. SLOS patients present clinically with dysmorphology and neurological, behavioral and cognitive defects, with characteristically...

journal_title：Journal of lipid research

authors： Kanuri B,Fong V,Ponny SR,Tallman KA,Ramachandra Rao S,Porter NA,Fliesler SJ,Patel SB

更新日期：2020-11-17 00:00:00

abstract：:Biliary amphipathic anionic polypeptide (APF) the major protein of the pigment-lipoprotein complex in bile, and calcium-binding protein (CBP) from gallstones are both small (less than 10 kDa), highly acidic, amphipathic proteins present in bile and closely associated also with pigmented areas in human gallstones. Poly...

journal_title：Journal of lipid research

authors： Domingo N,Grosclaude J,Bekaert ED,Mège D,Chapman MJ,Shimizu S,Ayrault-Jarrier M,Ostrow JD,Lafont H

更新日期：1992-10-01 00:00:00

abstract：:The phospholipase A2(PLA2) activity of peroxiredoxin (Prdx)6 has important physiological roles in the synthesis of lung surfactant and in the repair of peroxidized cell membranes. These functions require the activity of a lysophospholipid acyl transferase as a critical component of the phospholipid remodeling pathway....

journal_title：Journal of lipid research

authors： Fisher AB,Dodia C,Sorokina EM,Li H,Zhou S,Raabe T,Feinstein SI

更新日期：2016-04-01 00:00:00