Abstract:
:The rates of acid-catalyzed hydrolysis of a hypermodified nucleoside, wyosine and its 5'-monophosphate were determined at various pH, temperature and buffer concentrations. The results show that despite distinct differences in structure and the glycosyl bond stability, the hydrolysis of wyosine proceeds via cleavage of the C-N bond by A-1 mechanism, analogously to simple nucleosides. Unlike majority of other monophosphates studied so far, wyosine 5'-monophosphate is not more stable than respective nucleoside.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Golankiewicz B,Zielonacka-Lis E,Folkman Wdoi
10.1093/nar/13.7.2443subject
Has Abstractpub_date
1985-04-11 00:00:00pages
2443-9issue
7eissn
0305-1048issn
1362-4962journal_volume
13pub_type
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