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Systematic screening of CTCF binding partners identifies that BHLHE40 regulates CTCF genome-wide distribution and long-range chromatin interactions.

Abstract：

:CTCF plays a pivotal role in mediating chromatin interactions, but it does not do so alone. A number of factors have been reported to co-localize with CTCF and regulate CTCF loops, but no comprehensive analysis of binding partners has been performed. This prompted us to identify CTCF loop participants and regulators by co-localization analysis with CTCF. We screened all factors that had ChIP-seq data in humans by co-localization analysis with human super conserved CTCF (hscCTCF) binding sites, and identified many new factors that overlapped with hscCTCF binding sites. Combined with CTCF loop information, we observed that clustered factors could promote CTCF loops. After in-depth mining of each factor, we found that many factors might have the potential to promote CTCF loops. Our data further demonstrated that BHLHE40 affected CTCF loops by regulating CTCF binding. Together, this study revealed that many factors have the potential to participate in or regulate CTCF loops, and discovered a new role for BHLHE40 in modulating CTCF loop formation.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Hu G,Dong X,Gong S,Song Y,Hutchins AP,Yao H

doi

10.1093/nar/gkaa705

subject

Has Abstract

pub_date

2020-09-25 00:00:00

pages

9606-9620

issue

17

eissn

0305-1048

issn

1362-4962

pii

5901079

journal_volume

48

pub_type

杂志文章

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