Abstract:
:A simple, two-step method is described for the synthesis of the 5'-pyro- and triphosphate derivatives of 3'-5' ApA, ApG, GpA and GpG. The readily accessible 2'(3')-5' ApA, ApG, GpA and GpG were converted in one step to the corresponding 5'-phosphoramidate derivatives which were then transformed to the 5'-pyro- and triphosphates. CD spectra of 3'-5' pn GpG (n = 0,1,2 or 3) derivatives, measured at pH 1, indicated stabilization of the (syn) G+p (anti)G conformation by the 5'-phosphate groups.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Tomasz J,Simoncsits A,Kajtár M,Krug RM,Shatkin AJdoi
10.1093/nar/5.8.2945subject
Has Abstractpub_date
1978-08-01 00:00:00pages
2945-57issue
8eissn
0305-1048issn
1362-4962journal_volume
5pub_type
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