Abstract:
:Translatome reprogramming is a primary determinant of protein levels during stimuli adaptation. This raises the question: what are the translatome remodelers that reprogram protein output to activate biochemical adaptations. Here, we identify a translational pathway that represses metabolism to safeguard genome integrity. A system-wide MATRIX survey identified the ancient eIF5A as a pH-regulated translation factor that responds to fermentation-induced acidosis. TMT-pulse-SILAC analysis identified several pH-dependent proteins, including the mTORC1 suppressor Tsc2 and the longevity regulator Sirt1. Sirt1 operates as a pH-sensor that deacetylates nuclear eIF5A during anaerobiosis, enabling the cytoplasmic export of eIF5A/Tsc2 mRNA complexes for translational engagement. Tsc2 induction inhibits mTORC1 to suppress cellular metabolism and prevent acidosis-induced DNA damage. Depletion of eIF5A or Tsc2 leads to metabolic re-initiation and proliferation, but at the expense of incurring substantial DNA damage. We suggest that eIF5A operates as a translatome remodeler that suppresses metabolism to shield the genome.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Balukoff NC,Ho JJD,Theodoridis PR,Wang M,Bokros M,Llanio LM,Krieger JR,Schatz JH,Lee Sdoi
10.1038/s41467-020-19602-2subject
Has Abstractpub_date
2020-11-13 00:00:00pages
5755issue
1issn
2041-1723pii
10.1038/s41467-020-19602-2journal_volume
11pub_type
杂志文章abstract::A prerequisite to myelination of peripheral axons by Schwann cells (SCs) is SC differentiation, and recent evidence indicates that reprogramming from a glycolytic to oxidative metabolism occurs during cellular differentiation. Whether this reprogramming is essential for SC differentiation, and the genes that regulate ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5993
更新日期:2014-09-26 00:00:00
abstract::The central issues for understanding iron (Fe)-based superconductors are the symmetry and structure of the superconducting gap. So far the experimental data and theoretical models have been highly controversial. Some experiments favor two or more constant or nearly constant gaps, others indicate strong anisotropy and ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1115
更新日期:2010-11-16 00:00:00
abstract::It is well known that high-risk human papilloma virus (HR-HPV) infection is strongly associated with cervical cancer and E7 was identified as one of the key initiators in HPV-mediated carcinogenesis. Here we show that lactate dehydrogenase A (LDHA) preferably locates in the nucleus in HPV16-positive cervical tumors du...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06841-7
更新日期:2018-10-24 00:00:00
abstract::Fibronectin fibrils within the extracellular matrix play central roles in physiological and pathological processes, yet many structural details about their hierarchical and molecular assembly remain unknown. Here we combine site-specific protein labelling with single-molecule localization by stepwise photobleaching or...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8275
更新日期:2015-06-04 00:00:00
abstract::Photocatalysis has not found widespread industrial adoption, in spite of decades of active research, because the challenges associated with catalyst illumination and turnover outweigh the touted advantages of replacing heat with light. A demonstration that light can control product selectivity in complex chemical reac...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14542
更新日期:2017-02-23 00:00:00
abstract::Nanoporous frameworks are polymeric materials built from rigid molecules, which give rise to their nanoporous structures with applications in gas sorption and storage, catalysis and others. Conceptually new applications could emerge, should these beneficial properties be manipulated by external stimuli in a reversible...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4588
更新日期:2014-04-07 00:00:00
abstract::Wilms tumor gene on the X chromosome (WTX) is a putative tumor suppressor gene in Wilms tumor, but its expression and functions in other tumors are unclear. Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in women and the second leading cause in men in the United States. We demonstrated tha...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07998-x
更新日期:2019-01-10 00:00:00
abstract::The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal epithelial cells (PECs) invade glomerular capillaries, thereby promoting injury and kidney failure. Here we show...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11013-2
更新日期:2019-07-24 00:00:00
abstract::The development of transistors with high gain is essential for applications ranging from switching elements and drivers to transducers for chemical and biological sensing. Organic transistors have become well-established based on their distinct advantages, including ease of fabrication, synthetic freedom for chemical ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3133
更新日期:2013-01-01 00:00:00
abstract::Little is known about how our brains dynamically adapt for efficient functioning. Most previous work has focused on analyzing changes in co-fluctuations between a set of brain regions over several temporal segments of the data. We argue that by collapsing data in space or time, we stand to lose useful information abou...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03664-4
更新日期:2018-04-11 00:00:00
abstract::Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a gene mapping approach) results using summary data (S-PrediXcan) and show its accuracy and general robustness to misspecified reference sets. We ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03621-1
更新日期:2018-05-08 00:00:00
abstract::Mechanical signals play many roles in cell and developmental biology. Several mechanotransduction pathways have been uncovered, but the mechanisms identified so far only address the perception of stress intensity. Mechanical stresses are tensorial in nature, and thus provide dual mechanical information: stress magnitu...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/s41467-019-10207-y
更新日期:2019-05-29 00:00:00
abstract::Despite the fundamental importance of efficient and selective synthesis of widely useful alkylarenes, the direct catalytic C(sp2)-H alkylation of unactivated arenes with a readily available alkyl halide remains elusive. Here, we report the catalytic C(sp2)-H alkylation reactions of unactivated arenes with alkyl bromid...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19038-8
更新日期:2020-10-19 00:00:00
abstract::Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity in clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognostication. Pooling data from seven studies incorporating 842 cases identifies two genomic loca...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20822-9
更新日期:2021-01-28 00:00:00
abstract::The early diversification of animals (∼ 630 Ma), and their development into both motile and macroscopic forms (∼ 575-565 Ma), has been linked to stepwise increases in the oxygenation of Earth's surface environment. However, establishing such a linkage between oxygen and evolution for the later Cambrian 'explosion' (54...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8142
更新日期:2015-05-18 00:00:00
abstract::Oxygen vacancies, especially their distribution, are directly coupled to the electromagnetic properties of oxides and related emergent functionalities that have implications for device applications. Here using a homoepitaxial strontium titanate thin film, we demonstrate a controlled manipulation of the oxygen vacancy ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00710-5
更新日期:2017-09-20 00:00:00
abstract::Tibetan wheat is grown under environmental constraints at high-altitude conditions, but its underlying adaptation mechanism remains unknown. Here, we present a draft genome sequence of a Tibetan semi-wild wheat (Triticum aestivum ssp. tibetanum Shao) accession Zang1817 and re-sequence 245 wheat accessions, including w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18738-5
更新日期:2020-10-08 00:00:00
abstract::The nasal cellular epigenome may serve as biomarker of airway disease and environmental response. Here we collect nasal swabs from the anterior nares of 547 children (mean-age 12.9 y), and measure DNA methylation (DNAm) with the Infinium MethylationEPIC BeadChip. We perform nasal Epigenome-Wide Association analyses (E...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11058-3
更新日期:2019-07-12 00:00:00
abstract::Ufuk Günesdogan was incorrectly associated with Center for Genetic Analysis of Behaviour, National Institute for Physiological Sciences, 5-1 Higashiyama Myodaiji, Okazaki, Aichi 444-8787, Japan and Toshihiro Kobayashi was incorrectly associated with Department of Developmental Biology, University of Göttingen, Götting...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-07765-y
更新日期:2018-12-11 00:00:00
abstract::Bacteria release membrane vesicles (MVs) that play important roles in various biological processes. However, the mechanisms of MV formation in Gram-positive bacteria are unclear, as these cells possess a single cytoplasmic membrane that is surrounded by a thick cell wall. Here we use live cell imaging and electron cry...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00492-w
更新日期:2017-09-07 00:00:00
abstract::COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral drugs or vaccines were developed against the closely related coronavirus, SARS-CoV-1 or MERS-CoV, despite previous zoonotic outbreaks. To identify starting points for such therapeutics, we performed a large-scale screen of electro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18709-w
更新日期:2020-10-07 00:00:00
abstract::In all of the diverse areas of science where waves play an important role, one of the most fundamental solutions of the corresponding wave equation is a stationary wave with constant intensity. The most familiar example is that of a plane wave propagating in free space. In the presence of any Hermitian potential, a wa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8257
更新日期:2015-07-08 00:00:00
abstract::Crosstalk between inflammatory signalling pathways and receptor tyrosine kinases has been revealed as an indicator of cancer malignant progression. In the present study, we focus on EphA2 receptor tyrosine kinase, which is overexpressed in many human cancers. It has been reported that ligand-independent phosphorylatio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8679
更新日期:2015-07-09 00:00:00
abstract::The Montreal Protocol has succeeded in limiting major ozone-depleting substance emissions, and consequently stratospheric ozone concentrations are expected to recover this century. However, there is a large uncertainty in the rate of regional ozone recovery in the Northern Hemisphere. Here we identify a Eurasia-North ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02565-2
更新日期:2018-01-15 00:00:00
abstract::CD4(+) Th17 are heterogeneous in terms of cytokine production and capacity to initiate autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE). Here we demonstrate that experimental priming of encephalitogenic Th cells expressing RORγt and T-bet and producing IL-17A, IFN-γ and GM-CSF but not IL-10...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11541
更新日期:2016-05-18 00:00:00
abstract::Non-aromatic nitrogen- and oxygen-containing heterocycles such as piperidines and pyrans are prevalent components of natural products and pharmaceutical drugs. Although it has been a workhorse as a synthetic method for assembling unsaturated sp(2)-hybridized substrates, transition metal-catalysed cross-coupling chemis...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6474
更新日期:2014-11-18 00:00:00
abstract::An accurate description of the interaction of intense hard X-ray pulses with heavy atoms, which is crucial for many applications of free-electron lasers, represents a hitherto unresolved challenge for theory because of the enormous number of electronic configurations and relativistic effects, which need to be taken in...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06745-6
更新日期:2018-10-10 00:00:00
abstract::Integrating epigenetic data with genome-wide association study (GWAS) results can reveal disease mechanisms. The genome sequence itself also shapes the epigenome, with CpG density and transcription factor binding sites (TFBSs) strongly encoding the DNA methylome. Therefore, genetic polymorphism impacts on the observed...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01586-1
更新日期:2018-01-02 00:00:00
abstract::Defects can greatly influence the properties of oxide materials; however, facile defect engineering of oxides at room temperature remains challenging. The generation of defects in oxides is difficult to control by conventional chemical reduction methods that usually require high temperatures and are time consuming. He...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03765-0
更新日期:2018-04-03 00:00:00
abstract::The original version of this article contained an error in the spelling of Juan Pedro Martinez-Barbera, which was incorrectly given as Juan Pedro Martinez Barbera. This error has now been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-05718-z
更新日期:2018-08-02 00:00:00