Induced hypothyroidism alters articular cartilage in skeletally immature miniature swine.

abstract：PURPOSE:Experimental measurements of bone mineral density distributions (BMDDs) enable a determination of secondary mineralization kinetics in bone, but the maximum degree of mineralization and how this maximum is approached remain uncertain. We thus test computationally different hypotheses on late stages of bone mine...

journal_title：Connective tissue research

authors： Buenzli PR,Lerebours C,Roschger A,Roschger P,Weinkamer R

更新日期：2018-12-01 00:00:00

abstract：:Degeneration of the intervertebral discs, a natural progression of the aging process, is strongly implicated as a cause of low back pain. Aggrecan is the major structural proteoglycan in the extracellular matrix of the intervertebral disc. It is large, possessing numerous glycosaminoglycan chains and the ability to fo...

journal_title：Connective tissue research

authors： Wei Q,Zhang X,Zhou C,Ren Q,Zhang Y

更新日期：2019-05-01 00:00:00

abstract：:Oriented fibers, arising from the self assembly of collagen, may be produced from in vitro fibrillogenesis of soluble collagen with gradients of fibrillogenic potential. These gradients may be introduced by either concentration gradients of pronase-treated collagen or of arginine which, in turn, create concentration g...

journal_title：Connective tissue research

authors： Ghosh S,Comper WD

更新日期：1988-01-01 00:00:00

abstract：:Sea urchin's teeth from four families of order Echinoida and from orders Temnopleuroida, Arbacioida and Cidaroida were studied with synchrotron X-ray diffraction. The high and very high Mg calcite phases of the teeth, i.e. the first and second stage mineral constituents, respectively, have the same crystallographic or...

journal_title：Connective tissue research

authors： Stock SR,Ignatiev K,Lee PL,Almer JD

更新日期：2014-08-01 00:00:00

abstract：:Fitting children and infants who have osteogenesis imperfecta (OI) with braces has posed substantial problems of implementation and patient management For the past twelve years bracing has been an important component of a patient research and management program conducted at the National Institutes of Health. By using ...

journal_title：Connective tissue research

authors： Weintrob JC

更新日期：1995-01-01 00:00:00

abstract：:These studies examined the effects of heat-inactivated horse serum, insulin, triiodothyronine (T3), and thyroxine (T4), individually and in combination, on collagen and proteoglycan synthesis by primary cell cultures of articular chondrocytes from immature male rabbits. Insulin concentrations of 25 to 100 ng/ml (4.4 t...

journal_title：Connective tissue research

authors： Glade MJ,Kanwar YS,Stern PH

更新日期：1994-01-01 00:00:00

abstract：:Solutions of type I acid soluble collagen were studied in light and electron microscopy at concentrations over 40 mg/ml. Banded patterns spontaneously emerge in samples observed between crossed polars between slide and coverslip. The textures are interpreted as precholesteric, appearing at the transition between the i...

journal_title：Connective tissue research

authors： Giraud-Guille MM,Besseau L

更新日期：1998-01-01 00:00:00

abstract：:Parietal yolk sacs isolated from 14.5-day rat embryos and incubated in vitro with either [14C]proline, [3H]mannose or 3H-labeled amino acid mixture synthesized and secreted basement membrane collagenous and noncollagenous glycoprotein components with relative molecular weights of 350,000 (350K), 220,000 (220K), 185,00...

journal_title：Connective tissue research

authors： Clark CC,Kefalides NA

更新日期：1982-01-01 00:00:00

abstract：:Transforming growth factor beta-1 (TGF beta-1) is a multifunctional growth factor that is expressed in numerous cell types. It has been shown to induce secretion of dentin extracellular matrix components associated with primary dentinogenesis and to play a role in tertiary or reparative dentinogenesis. In this study, ...

journal_title：Connective tissue research

authors： Unterbrink A,O'Sullivan M,Chen S,MacDougall M

更新日期：2002-01-01 00:00:00

abstract：:Many organisms from a wide variety of taxa produce amorphous calcium carbonate (ACC), despite the fact that it is inherently unstable and relatively soluble in its pure state. These properties also make it difficult to detect and characterize ACC. Raman spectroscopy is a particularly useful method for investigating AC...

journal_title：Connective tissue research

authors： Weiner S,Levi-Kalisman Y,Raz S,Addadi L

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:This study proposes to evaluate, by means of microtomographic analysis, the topical potential of raloxifene combined with BioGran® through the sonochemical method in the repair of critical bone defects in the calvaria of rats. The hypothesis was that the homogenization of Raloxifene to Biogran at the 20% conc...

journal_title：Connective tissue research

authors： Lisboa-Filho PN,Gomes-Ferreira PHS,Batista FRS,Momesso GAC,Faverani LP,Okamoto R

更新日期：2018-12-01 00:00:00

abstract：:For many years we have investigated the earliest crystal formations of different developing hard tissues (matrix vesicle, bone, dentine, enamel, etc.) by different electron microscopic measurements. It was observed that primarily Ca-phosphate (apatite) "chains," composed of nanometer sized particles (dots, islands), e...

journal_title：Connective tissue research

authors： Höhling HJ,Arnold S,Barckhaus RH,Plate U,Wiesmann HP

更新日期：1995-01-01 00:00:00

abstract：:The desmoplastic response to breast carcinoma is being studied. The stimulation of stromal cell proliferation by a preformed breast tumor matrix was shown. An additional mechanism for stimulating scleroprotein deposition is described here. On a per-cell basis, the synthesis of collagen and elastin was increased by 50%...

journal_title：Connective tissue research

authors： Kao RT,Hall J,Stern R

更新日期：1986-01-01 00:00:00

abstract：:Positive effects on the tensile characteristics of swine digital extensors were found following twelve months of exercise training. Compared to sedentary controls, the tendons from the exercised animals became stronger as a material and exhibited hypertrophy. These biomechanical results were supported by biochemical a...

journal_title：Connective tissue research

authors： Woo SL,Ritter MA,Amiel D,Sanders TM,Gomez MA,Kuei SC,Garfin SR,Akeson WH

更新日期：1980-01-01 00:00:00

abstract：:Since hyaluronan anchors the proteoglycan-rich pericellular matrix to chondrocytes, hyaluronan-cell interactions may direct cartilage matrix assembly. To test this hypothesis, the competitive binding of hyaluronan hexasaccharides for native hyaluronan during matrix assembly, accumulation and retention in embryonic car...

journal_title：Connective tissue research

authors： Maleski MP,Knudson CB

更新日期：1996-01-01 00:00:00

abstract：:Although bone is a nanocomposite of mineral and collagen, mineral has been the more elusive component of study. A standard for bone mineral is clearly needed. We hypothesized that the most natural, least-processed bone mineral could be retrieved from the most highly mineralized bone. We therefore studied the rostrum o...

journal_title：Connective tissue research

authors： Li Z,Pasteris JD,Novack D

更新日期：2013-01-01 00:00:00

abstract：AIM:To investigate the effect of extracellular matrix (ECM) proteins on characteristics of mesenchymal stem cells (MSCs) and tendon-derived cells (TDCs). MATERIALS AND METHODS:MSCs and TDCs, cultured in a monolayer (2D) or hydrogels (3D), with or without ECM protein supplementation, and on a non-viable native tendon (...

journal_title：Connective tissue research

authors： Clements LE,Garvican ER,Dudhia J,Smith RK

更新日期：2016-11-01 00:00:00

abstract：:The pharmacokinetics of desmosine following a 5 mg intravenous dose was determined in five sheep. The biological half-life (t 1/2 beta) of desmosine varied between 81-489 min. Urinary recovery of unchanged desmosine indicated that the compound is not extensively metabolized and that the primary route of elimination is...

journal_title：Connective tissue research

authors： Verma PS,Hoyt RF Jr,Jackson AJ,Phillips YY

更新日期：1984-01-01 00:00:00

abstract：:The experiments described herein tested the effects of CaCl2 and ZnCl2, added at various concentrations in the culture medium, upon the synthesis of collagen and proteoglycan by adult and fetal (articular, epiphyseal and hypertrophic) bovine chondrocytes maintained in high density multilayer cultures. CaCl2 concentrat...

journal_title：Connective tissue research

authors： Koyano Y,Hejna M,Flechtenmacher J,Schmid TM,Thonar EJ,Mollenhauer J

更新日期：1996-01-01 00:00:00

abstract：:Depolymerization of Ch-4-S, Ch-6-S, HA and HP was observed by gel filtration after treatment with 2-10 N NaOH or Ba(OH)2 in the presence of NaBH4 at 80-83 degrees for 1-5 hr. Depolymerized products were isolated after these treatments. 4-Deoxy-alpha-L-threo-4-enohexopyranosyluronic acid residue as the nonreducing end ...

journal_title：Connective tissue research

authors： Hirano S,Ishigami M,Koga Y

更新日期：1975-01-01 00:00:00

abstract：:Activation of protein kinase C (PKC) can upregulate tooth eruption molecules such as osteoprotegerin (OPG) and vascular endothelial growth factor (VEGF). In this study, we examined the in vivo gene expression of classic isoforms of PKC in the dental follicle of postnatal rats. The expression level of PKC-alpha was sig...

journal_title：Connective tissue research

authors： Yao S,Wise G

更新日期：2004-01-01 00:00:00

abstract：:Effects of applied hydrostatic pressure on transmembrane potentials were investigated in sheep articular chondrocytes and human skin fibroblasts in non-confluent monolayer cultures. Resting potentials in chondrocytes (about -12 mv) and in fibroblasts (about -15 mV) were increased and decreased respectively by over 40%...

journal_title：Connective tissue research

authors： Wright MO,Stockwell RA,Nuki G

更新日期：1992-01-01 00:00:00

abstract：:The relationship between structural changes and hyaluronic acid (HA) content in muscular atrophy is unknown. The objective of our study was to conduct multifaceted evaluations of the change in muscle extensibility in muscular atrophy, in terms of morphological aspects as well as from a biochemical viewpoint, including...

journal_title：Connective tissue research

authors： Ishikawa T,Shimizu M,Mikawa Y,Zhu BL,Quan L,Li DR,Zhao D,Maeda H

更新日期：2005-01-01 00:00:00

abstract：:The eggshell is an highly ordered structure deposited in the distal oviduct and composed of calcium carbonate and an organic matrix which is believed to influence its fabric. We have identified ovotransferrin as an 80 kDa matrix protein observed at high concentration in the uterine fluid at the initial stage of shell ...

journal_title：Connective tissue research

authors： Gautron J,Hincke MT,Panheleux M,Garcia-Ruiz JM,Boldicke T,Nys Y

更新日期：2001-01-01 00:00:00

abstract：:The in-vitro fluoride treatment technique has been introduced to investigate the composite behavior of bone tissue. Bone tissue with different mechanical properties can be obtained by varying the concentration, pH and immersion time in fluoride ion solutions. The chemical and physical changes in intact pieces of bone ...

journal_title：Connective tissue research

authors： Kotha SP,DePaula CA,Koike K,Pan Y,Ohno M,Abjornson C,Rangarajan S,Guzelsu N

更新日期：2002-01-01 00:00:00

abstract：:In the absence of ascorbic acid, confluent human skin fibroblasts incubated in 0.5% serum-supplemented medium had one-third of the level of lysyl hydroxylase activity of cells incubated in media containing high serum concentrations (5-20%). This difference appeared to be due to a decline in the enzyme activity followi...

journal_title：Connective tissue research

authors： Murad S,Sivarajah A,Pinnell SR

更新日期：1985-01-01 00:00:00

abstract：:EMDOGAIN is derived from porcine developing enamel matrix and has been shown to facilitate regeneration of the periodontium, although its mechanism of action is unknown. The aim of the present study was to identify enamel matrix proteins and proteolytic enzymes present in EMDOGAIN and compare them with those extracted...

journal_title：Connective tissue research

authors： Maycock J,Wood SR,Brookes SJ,Shore RC,Robinson C,Kirkham J

更新日期：2002-01-01 00:00:00

abstract：:The crystal ghosts represent a crystal associated organic material which is stained by acidic phosphotungstic acid, periodic acid-silver methenamine and periodic acid-thiosemicarbazide-osmium, and is reactive with cations and with colloidal iron at pH 2.0, and unreactive after methylation and saponification. These res...

journal_title：Connective tissue research

authors： Bonucci E,Silvestrini G,di Grezia R

更新日期：1989-01-01 00:00:00

abstract：:Growth factors were historically defined as molecules produced by the body to regulate cell growth and proliferation. After the identification of their receptors and the intracellular signaling machinery they activate, it is now clear that they are involved in the regulation of multiple processes essential for develop...

journal_title：Connective tissue research

authors： Oehrl W,Panayotou G

更新日期：2008-01-01 00:00:00

abstract：:Volume and morphology of chondrocytes in osteoarthritic human hip joint articular cartilage were characterized, and their relationship to tissue structure and function was determined. Human osteochondral articular cartilage samples (n=16) were obtained from the femoral heads of nine patients undergoing total hip arthr...

journal_title：Connective tissue research

authors： Huttu MR,Puhakka J,Mäkelä JT,Takakubo Y,Tiitu V,Saarakkala S,Konttinen YT,Kiviranta I,Korhonen RK

更新日期：2014-08-01 00:00:00