Cell-tissue interactions in osteoarthritic human hip joint articular cartilage.

abstract：:The purpose of this study was to examine the hypoxic and inflammatory conditions after immobilization in the joint capsule of rat knees. The unilateral knee joints of adult male rats were immobilized with an internal fixator (Im group) for 1 day, 3 days, and 1, 2, 4, 8, and 16 weeks. Sham-operated animals had holes dr...

journal_title：Connective tissue research

authors： Yabe Y,Hagiwara Y,Suda H,Ando A,Onoda Y,Tsuchiya M,Hatori K,Itoi E

更新日期：2013-01-01 00:00:00

abstract：:The paper reviews the changes in ameloblast ultrastructure, concomitant with the changes in its functions across the major stages of amelogenesis. It describes the mechanisms associated with the major events in biosynthesis and degradation of the major enamel proteins (amelogenins and tuftelin/enamelins) and with the ...

journal_title：Connective tissue research

authors： Deutsch D,Catalano-Sherman J,Dafni L,David S,Palmon A

更新日期：1995-01-01 00:00:00

abstract：:A transmission electron microscope study of carbonate apatite crystals isolated from bone and mineralizing tendon, as well as those produced synthetically under approximated-physiological conditions, shows that they are thin irregular shaped plates. Electron diffraction patterns of individual crystals confirm that the...

journal_title：Connective tissue research

authors： Moradian-Oldak J,Weiner S,Addadi L,Landis WJ,Traub W

更新日期：1991-01-01 00:00:00

abstract：:Recently our laboratory has reported, in a lacerated flexor tendon model, that the "early turnover" phase of the repair process extends for a longer period of time in vivo than previously documented. The extensive turnover of the collagenous matrix was consistent with the presence of collagenolytic activity in repairi...

journal_title：Connective tissue research

authors： Russell JE,Manske PR

更新日期：1989-01-01 00:00:00

abstract：:Part of the hyaluronic acid (HA) synthesized in peripheral tissues enters the blood circulation through the lymph. It is rapidly taken up by the endothelial cells in the liver (half-life in blood is 2.5-5.5 minutes) and degraded. Pure primary cultures of liver endothelial cells were obtained by a newly developed techn...

journal_title：Connective tissue research

authors： Laurent TC,Dahl IM,Dahl LB,Engström-Laurent A,Eriksson S,Fraser JR,Granath KA,Laurent C,Laurent UB,Lilja K

更新日期：1986-01-01 00:00:00

abstract：:To study the glycosylation of glomerular basement membrane collagen (GBMC) in diabetes, kidneys were obtained at autopsy from 5 patients with insulin-requiring diabetes of long duration and diabetic complications, and from 5 control subjects. Glomeruli were prepared by sieving and collagen was isolated by limited peps...

journal_title：Connective tissue research

authors： Uitto J,Perejda AJ,Grant GA,Rowold EA,Kilo C,Williamson JR

更新日期：1982-01-01 00:00:00

abstract：:This investigation is devoted to the study of the viscoelastic behavior of human abdominal fascia from the umbilical region. Seventeen samples 10 mm wide and up to 70 mm long were cut along the primary fiber direction (group FL) or perpendicular to it (group FT) and subjected to relaxation tests. The viscoelastic resp...

journal_title：Connective tissue research

authors： Kirilova M

更新日期：2012-01-01 00:00:00

abstract：:The expression of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) by human vascular smooth muscle cells (SMC) was monitored as a function of the phenotypic modulation in vitro. Cell phenotype was manipulated by varying serum concentration and cell density. Synthetic phenotype was characterized by a minim...

journal_title：Connective tissue research

authors： Kato S,Yasukawa H,Fujii T,Yamaguchi M,Miyagi N,Okamoto K,Wada Y,Miyamoto T,Morimatsu M,Fox JC

更新日期：2000-01-01 00:00:00

abstract：:Purpose: Non-pathological child cortical bone (NPCCB) studies can provide clinicians with vital information and insights. However, assessing the anisotropic elastic properties of NPCCB remains a challenge for the biomechanical engineering community. For the first time, this paper provides elastic moduli values for NPC...

journal_title：Connective tissue research

authors： Semaan M,Karam E,Baron C,Pithioux M

更新日期：2019-07-01 00:00:00

abstract：:Size measurements of dispersed rat bone crystals show that with age a greater proportion exceeds 400 A in length. The surface fractures of more heavily mineralized bones tend to be smooth and stepped, whereas those of less mineralized bones are fibrous. These observations combined with information reported elsewhere o...

journal_title：Connective tissue research

authors： Weiner S,Traub W

更新日期：1989-01-01 00:00:00

abstract：:The effect of I- and C1- on the enzymatic degradation of elastin pancreatic elastase has been studied. At low halide concentrations both ions show a marked stimulation of elastolysis, I- being significantly more effective than Cl-. Kinetic plots of enzyme activity indicate that anions enhance the susceptibility of the...

journal_title：Connective tissue research

authors： Winkler RH

更新日期：1978-01-01 00:00:00

abstract：:Heparin treated and aldehyde crosslinked rat aorta segments were implanted in infrarenal aorta of homologous rats. One year following aortic replacement, the subendothelial scar and the prosthetic remnants were excised. The scar and the host intima-media were incubated with 3H-valine for 4 h and extracted with 5 M gua...

journal_title：Connective tissue research

authors： Moczar M,Bessou JP,Loisance D

更新日期：1983-01-01 00:00:00

abstract：:Although intervertebral disc (IVD) degeneration is one of most common causes of morbidity, its etiology remains unclear. In healthy discs, the rates of synthesis and breakdown of the extracelluar matrix (ECM) are in equilibrium because of intricate regulation by growth factors and catabolic cytokines. Important among ...

journal_title：Connective tissue research

authors： Cho H,Lee S,Park SH,Huang J,Hasty KA,Kim SJ

更新日期：2013-01-01 00:00:00

abstract：:This study investigated the in vivo formation of engineering cartilage within living or devitalized cartilage discs using reflectance mode confocal microscopy and conventional light microscopy. Pig articular chondrocytes were suspended in fibrin glue and placed between two cartilage discs. Four experimental groups wer...

journal_title：Connective tissue research

authors： Peretti GM,Campo-Ruiz V,Gonzalez S,Randolph MA,Wei Xu J,Morse KR,Roses RE,Yaremchuk MJ

更新日期：2006-01-01 00:00:00

abstract：:TGF beta modulates the growth and differentiation of various cell types, in part by regulating the production of extracellular matrix proteins. In rat osteoblast-like cells TGF beta stimulates the production of collagen, osteopontin and osteonectin. On the other hand, TGF beta inhibits the production of osteocalcin, o...

journal_title：Connective tissue research

authors： Noda M,Rodan GA

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:Tissue engineering and regenerative medicine approaches have the potential to overcome the challenges associated with current treatment strategies for meniscus injuries. 3D-Bioplotted scaffolds are promising, but have not demonstrated the ability to guide the formation of aligned collagenous matrix in vivo, whi...

journal_title：Connective tissue research

authors： Warren PB,Huebner P,Spang JT,Shirwaiker RA,Fisher MB

更新日期：2017-01-01 00:00:00

abstract：:Two overlapping clones encompassing 8.5 kb of the human elastin gene were isolated from two genomic libraries constructed by partial digestion with either HaeIII/AluI or Sau3A and contained in lambda Charon 4A or EMBL3, respectively. The 6 kb of DNA comprising the most 3' portion of the gene were sequenced demonstrati...

journal_title：Connective tissue research

authors： Indik Z,Yoon K,Morrow SD,Cicila G,Rosenbloom J,Rosenbloom J,Ornstein-Goldstein N

更新日期：1987-01-01 00:00:00

abstract：:Ameloblastic tissue samples from unerupted bone molars were used to prepare subcellular enamel protein kinase preparations, nuclear + plasma membrane, cytosolic and microsomal, and used in in vitro phosphorylation of purified 20 kDa bovine amelogenin in the presence of 32P-ATP. Both cytosolic and microsomal preparatio...

journal_title：Connective tissue research

authors： Salih E,Huang JC,Strawich E,Gouverneur M,Glimcher MJ

更新日期：1998-01-01 00:00:00

abstract：AIM:To investigate the effect of extracellular matrix (ECM) proteins on characteristics of mesenchymal stem cells (MSCs) and tendon-derived cells (TDCs). MATERIALS AND METHODS:MSCs and TDCs, cultured in a monolayer (2D) or hydrogels (3D), with or without ECM protein supplementation, and on a non-viable native tendon (...

journal_title：Connective tissue research

authors： Clements LE,Garvican ER,Dudhia J,Smith RK

更新日期：2016-11-01 00:00:00

abstract：:A method is described for accurate and reproducible determination of wet and dry weights of small articular cartilage samples. The water content of the articular cartilage samples before and after treatment with selective degradative enzymes and "artificial fibrillation" was determined. It was found that the water con...

journal_title：Connective tissue research

authors： Simon WH,Wohl DL

更新日期：1982-01-01 00:00:00

abstract：:Stimulation of the cholinergic inflammatory pathway can attenuate collagen-induced arthritis (CIA) and inhibit synovitis by Janus kinase (JAK) 2 and signal transducer and activator of transcription (STAT) 3 signaling. Suppressor of cytokine signaling (SOCS) protein can also regulate the inflammatory processes and acti...

journal_title：Connective tissue research

authors： Li T,Wu S,Li S,Bai X,Luo H,Zuo X

更新日期：2018-05-01 00:00:00

abstract：AIM:miR-155 is a pro-inflammatory or anti-inflammatory factor depending on the cell type in which it is expressed. miR-155 controls apoptosis and matrix degradation in nucleus pulposus (NP) cells in vitro. The aim of this study is to explore the effect of miR-155 in vivo and further investigate the mechanism of miR-155...

journal_title：Connective tissue research

authors： Zhou J,Liang A,Hong J,Sun J,Lin X,Peng Y,Wang X,Sun S,Xiao D,Xu K,Ye W

更新日期：2019-03-01 00:00:00

abstract：:The diameter of collagen fibrils has been measured in electron micrographs of the tunica media and adventitia of the common carotid artery of 14 rats (19,262 counts). The fibrils of the media were measured in each of its three interlamellar spaces. The mean fibril diameters in the innermost space and the middle space ...

journal_title：Connective tissue research

authors： Buck RC

更新日期：1987-01-01 00:00:00

abstract：:Abnormal polyanion metabolism in cultured fibroblasts from patients with pseudoxanthoma elasticum (PXE) was studied by incubating normal and PXE fibroblasts in culture medium containing 35SO4 for 96 hr and measuring differences in secreted 35SO4-labelled proteoglycans (35S-PG). PXE medium contained less high molecular...

journal_title：Connective tissue research

authors： Gordon SG,Overland M,Foley J

更新日期：1978-01-01 00:00:00

abstract：:Epithelial-mesenchymal interactions are required for tissue growth and gene expression patterns during odontogenesis. We showed previously that Sonic hedgehog (SHH) is detectable in both dental epithelium and mesenchyme, while Shh transcripts are present in dental epithelium only, suggesting that SHH functions as an a...

journal_title：Connective tissue research

authors： Wu C,Shimo T,Liu M,Pacifici M,Koyama E

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:Experimental measurements of bone mineral density distributions (BMDDs) enable a determination of secondary mineralization kinetics in bone, but the maximum degree of mineralization and how this maximum is approached remain uncertain. We thus test computationally different hypotheses on late stages of bone mine...

journal_title：Connective tissue research

authors： Buenzli PR,Lerebours C,Roschger A,Roschger P,Weinkamer R

更新日期：2018-12-01 00:00:00

abstract：:Human skin fibroblasts cultured with 4-methylumbelliferone (MU), a hyaluronan synthesis inhibitor, produce a hyaluronan-deficient extracellular matrix (See [9]). Our present study investigated the effects of MU on proteoglycan, which is the other main component of the extracellular matrix, and interacts with hyalurona...

journal_title：Connective tissue research

authors： Funahashi M,Nakamura T,Kakizaki I,Mizunuma H,Endo M

更新日期：2009-01-01 00:00:00

abstract：:This study aims to elucidate the feasible geometry of the scaffolds in bone and periodontal tissue engineering. Several biomaterials with different geometries are compared in terms of their patterns of ectopic BMP-induced chondrogenesis and osteogenesis. The materials include a honeycomb-shaped hydroxyapatite (HCHAP) ...

journal_title：Connective tissue research

authors： Kuboki Y,Jin Q,Kikuchi M,Mamood J,Takita H

更新日期：2002-01-01 00:00:00

abstract：:Radiation therapy is one of the routine treatment modalities for cancer patients. Ionizing radiation (IR) can induce bone loss, and consequently increases the risk of fractures with delayed and nonunion of the bone in the cancer patients who receive radiotherapy. The orchestrated bone remodeling can be disrupted due t...

journal_title：Connective tissue research

authors： Zhang J,Qiu X,Xi K,Hu W,Pei H,Nie J,Wang Z,Ding J,Shang P,Li B,Zhou G

更新日期：2018-11-01 00:00:00

abstract：:Two populations of primary osteoblasts and the cloned murine osteoblast cell line MC3T3 were activated with osteotropic agents and the conditioned media tested for the presence of macrophage colony stimulating factor (M-CSF). Differences in ability of the three populations to secrete the cytokine as well as in the eff...

journal_title：Connective tissue research

authors： Horowitz MC,Einhorn TA,Philbrick W,Jilka RL

更新日期：1989-01-01 00:00:00