Abstract：
:This investigation is devoted to the study of the viscoelastic behavior of human abdominal fascia from the umbilical region. Seventeen samples 10 mm wide and up to 70 mm long were cut along the primary fiber direction (group FL) or perpendicular to it (group FT) and subjected to relaxation tests. The viscoelastic response of the tissue at three different strain levels (4%, 5%, and 6%) was investigated. The relaxation curves were fitted using a two-stage decaying exponential form. The following parameters were determined: initial stress σ(0), relaxation times τ(1) and τ(2), stress reduction Δσ, initial relaxation modulus E and equilibrium relaxation modulus E(eq), as well as the ratio E/E(eq). Fiber orientation and strain levels were varied to determine their influence on the viscoelastic properties of fascia. The results highlight the inherent viscoelastic mechanical properties of umbilical fascia. The values of the viscoelastic parameters determined for the longitudinal and transverse directions varied markedly. Significant differences were found between the two groups FL and FT for the initial stress at 5% and 6% strain (p < 0.038) and for the initial and equilibrium moduli at the 6% strain level (p < 0.046). The stress reduction in samples from the FL group (45-55%) was less than that in samples from the FT group (37-54%), but this difference was not significant (p > 0.388). The influence of strain level on the parameter values was not statistically significant (p > 0.121). The nonlinear response of the tissue was demonstrated over the chosen strain range.
journal_name
Connect Tissue Resjournal_title
Connective tissue researchauthors
Kirilova Mdoi
10.3109/03008207.2011.604452subject
Has Abstractpub_date
2012-01-01 00:00:00pages
21-8issue
1eissn
0300-8207issn
1607-8438journal_volume
53pub_type
杂志文章abstract：:In our previous developmental study on skin we reported that correlations existed between the collagen fibril diameter distribution, glycosaminoglycan content and composition, and mechanical role. In this work we present new but related electron microscope data on the ultrastructure of skins from flounder, marlin, cod...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.3109/03008208709006977
更新日期：1987-01-01 00:00:00
abstract：PURPOSE:Treatment of meniscal injury is important for osteoarthritis (OA) prevention. Meniscus cells are divided between inner and outer cells, which have different characteristics and vascularity. We evaluated the effects of hyaluronic acid (HA) on the proliferation and migration of human inner and outer meniscus cell...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.1080/03008207.2018.1465053
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:The presence of genetic variants in uric acid (UA) transporters can be associated with hyperuricemia, and therefore with an increased risk of monosodium urate (MSU) crystal precipitation. The inflammatory process triggered by these crystals leads to cartilage damage, which, in turn, could promote knee osteoa...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.1080/03008207.2018.1483359
更新日期：2019-05-01 00:00:00
abstract：:The matrix metalloproteinases collagenase (MMP-1) and stromelysin (MMP-3) are often coordinately expressed, and their promoters contain similar regulatory elements, including an AP-1 site at about -70. There are, however, additional sequences including an adjacent ETS site at about -90 in both promoters, and a NIP (nu...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.3109/03008209709160231
更新日期：1997-01-01 00:00:00
abstract：:Bone sialoprotein is a 34 kDa phosphorylated and sulphated glycoprotein that is essentially unique to mineralizing connective tissues. Recent studies on the developmental expression of BSP mRNA and the temporo-spatial appearance of the protein during bone formation in vivo and in vitro have demonstrated that BSP is ex...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.3109/03008209609029171
更新日期：1996-01-01 00:00:00
abstract：:The structural and immunological properties of the glycosaminoglycans and the core proteins of bovine nasal cartilage proteoglycan and the proteoglycans produced by rabbit articular chondrocytes in spinner and monolayer culture were compared. Culture medium with 35SO4- or 3H-serine-labeled proteoglycan was mixed with ...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.3109/03008208309004860
更新日期：1983-01-01 00:00:00
abstract：:Heparin treated and aldehyde crosslinked rat aorta segments were implanted in infrarenal aorta of homologous rats. One year following aortic replacement, the subendothelial scar and the prosthetic remnants were excised. The scar and the host intima-media were incubated with 3H-valine for 4 h and extracted with 5 M gua...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.3109/03008208309005609
更新日期：1983-01-01 00:00:00
abstract：:STR/ort mice develop a naturally occurring osteoarthritis (OA) of the knee joints. However, the evaluation of early OA changes has been difficult due to variability caused by gender, individual differences, and differences between the right and left lower limbs. The objective of this study was to analyze the variabili...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.1080/03008200902836065
更新日期：2009-01-01 00:00:00
abstract：:Bioprinting is a promising tool to fabricate organized cartilage. This study aimed to investigate the printability of gelatin-methacryloyl/gellan gum (gelMA/gellan) hydrogels with and without methacrylated hyaluronic acid (HAMA), and to explore (zone-specific) chondrogenesis of chondrocytes, articular cartilage progen...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.1080/03008207.2018.1553960
更新日期：2020-03-01 00:00:00
abstract：:Laminin promotes adhesion of various cell types via multiple interactions with cell surface components. We have used a laminin domain involved in adhesion of melanoma cells, peptide F9 (Charonis et al., J. Cell Biol. 107:1253 [( 1988]), to examine its specific interaction with cell surface components. Cells were surfa...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.3109/03008209109152435
更新日期：1991-01-01 00:00:00
abstract：:Cumulative damage to long-lived connective tissue proteins play a key role in the development of age-related human diseases such as cardiovascular stiffening and age-related macular degeneration. The processes that result in the accumulation of increasingly insoluble, undigestible damaged collagen are only partially k...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.1080/03008200600721569
更新日期：2006-01-01 00:00:00
abstract：:The fibrous collagens form the structural basis of all mammalian connective tissues, including the vasculature, dermis, bones, tendons, cartilage, and those tissues that support organs such as the heart, kidneys, liver, and lungs. The helical structure of collagen has been extensively studied but in addition to its he...
journal_title：Connective tissue research
pub_type： 杂志文章,评审
doi：10.3109/03008207.2010.511353
更新日期：2011-02-01 00:00:00
abstract：:The purpose of this investigation is to evaluate enamel thickness in extant and extinct hominoids. The material used in this study spans the evolutionary history of this group, from 20 million years ago to the present. The objectives of this investigation are to test three hypotheses: (1) the Loading Hypothesis: loadi...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.3109/03008209809023927
更新日期：1998-01-01 00:00:00
abstract：:Human skin fibroblasts cultured with 4-methylumbelliferone (MU), a hyaluronan synthesis inhibitor, produce a hyaluronan-deficient extracellular matrix (See [9]). Our present study investigated the effects of MU on proteoglycan, which is the other main component of the extracellular matrix, and interacts with hyalurona...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.1080/03008200802684615
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVE:We investigated whether COMP may modify cartilage metabolism and play a role as an endogenous disease aggravating factor in OA. MATERIALS AND METHODS:Full-length and momomeric COMP was recombinantly expressed in human embryonic kidney cells and purified it via affinity chromatography. Purified COMP was used ...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.3109/03008207.2014.951440
更新日期：2014-10-01 00:00:00
abstract：:Anterior cruciate ligament (ACL) has poor healing ability and an injured ACL would induce the degeneration of other intra-articular connective tissues. However, the coordinated expression and activities of matrix metalloproteinase (MMPs) in intra-articular tissues induced by ACL rupture were poorly understood. With a ...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：:Bone sialoprotein (BSP) and osteopontin (OPN) are two extracellular bone matrix proteins that have the ability to modulate the growth of hydroxyapatite in vitro. Studies of BSP/OPN hydroxyapatite interactions in the past have been directed toward the identification of essential structural elements that allow these two...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.3109/03008209609029217
更新日期：1996-01-01 00:00:00
abstract：:The protein components of biomineralized structures (matrix proteins) are believed to modulate crystal nucleation and growth, and thereby influence the shape and strength of the final structure. The chicken eggshell contains a complex array of distinct matrix proteins. One of these was found to have similar molecular ...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.3109/03008209509010814
更新日期：1995-01-01 00:00:00
abstract：:Quantitative levels of mRNAs coding for elastin, types I and III procollagen and gamma-actin were measured in porcine vascular material following balloon catheterization. A balloon catheter was introduced into the thoracic aorta and jugular vein of 3-6 week old pigs; following distention and six days of postoperative ...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.3109/03008208809008059
更新日期：1988-01-01 00:00:00
abstract：:Human aortic smooth muscle cells (AoSMCs) change their extracellular matrix composition during aging, with direct effects on cellular events and cell migration. For example, active matrix metalloproteinase-2 (MMP-2) is synthesized only by young AoSMCs, whereas aged cells produce only the inactive zymogen form. The pro...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.1080/03008200802143141
更新日期：2008-01-01 00:00:00
abstract：:A detailed analysis of the D-period and axial electron density distribution of cornea and tendon collagen was carried out by means of X-ray diffraction and electron microscopy. Ultrastructural observations were made on replicas of freeze fractured and deep-etched specimens. Synchrotron radiation was used to obtain hig...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.3109/03008208609001985
更新日期：1986-01-01 00:00:00
abstract：:Vascular smooth muscle cells (VSMC)s are characterized by their acute growth inhibition by heparin and heparan sulfates; however, recently the isolation of VSMCs which display greatly diminished sensitivity to the antiproliferative action of heparin have been reported. These heparin resistant (HR) VSMCs have been deri...
journal_title：Connective tissue research
pub_type： 杂志文章,评审
doi：10.3109/03008209809028903
更新日期：1998-01-01 00:00:00
abstract：:Depolymerization of Ch-4-S, Ch-6-S, HA and HP was observed by gel filtration after treatment with 2-10 N NaOH or Ba(OH)2 in the presence of NaBH4 at 80-83 degrees for 1-5 hr. Depolymerized products were isolated after these treatments. 4-Deoxy-alpha-L-threo-4-enohexopyranosyluronic acid residue as the nonreducing end ...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.3109/03008207509152343
更新日期：1975-01-01 00:00:00
abstract：:During cloning of the rat incisor phosphophoryn gene, several clones were identified with a PP antibody. One of the clones (2PP) was shown to encode a PP denoted as dentin matrix protein 2, DMP2. We have now sequenced another clone, which appears to be bifunctional, or at minimum, has two distinct domains. The 5' regi...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.3109/03008209909005277
更新日期：1999-01-01 00:00:00
abstract：:To study the glycosylation of glomerular basement membrane collagen (GBMC) in diabetes, kidneys were obtained at autopsy from 5 patients with insulin-requiring diabetes of long duration and diabetic complications, and from 5 control subjects. Glomeruli were prepared by sieving and collagen was isolated by limited peps...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.3109/03008208209008054
更新日期：1982-01-01 00:00:00
abstract：:This study investigated the in vivo formation of engineering cartilage within living or devitalized cartilage discs using reflectance mode confocal microscopy and conventional light microscopy. Pig articular chondrocytes were suspended in fibrin glue and placed between two cartilage discs. Four experimental groups wer...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.1080/03008200600809935
更新日期：2006-01-01 00:00:00
abstract：:We determined the feasibility of using scaffolds of adenoviral human BMP2 gene (AdBMP2)-modified human bone marrow mesenchymal stem cells (hBMSCs) and antigen-free bovine cancellous bone (BCB) to construct bone tissue. hMSCs were infected with AdBMP-2. Expression of BMP-2 and alkaline phosphatase confirmed successful ...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.3109/03008200903318295
更新日期：2010-08-01 00:00:00
abstract：:Monoclonal antibodies (mAbs) (4F2 and 7E12) were prepared against heparan sulfate proteoglycan (HSPG) isolated from bovine glomeruli. Enzyme linked immunosorbent assays (ELISA) and immunoblotting demonstrated that the mABs reacted with HSPG. Indirect immunofluorescence (IF) showed that the mAbs stained renal basement ...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.3109/03008208809019069
更新日期：1988-01-01 00:00:00
abstract：:The effect of intra-bone injection of differentiated rat bone marrow mesenchymal stem cells (BMMSCs) into the femur of osteoporotic female rats was studied. Osteoporosis was induced in Wistar female rats by bilateral ovariectomy. Then, 0.75 million BMMSCs isolated from healthy rats were injected into the femurs of ost...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.3109/03008201003597049
更新日期：2010-12-01 00:00:00
abstract：:Statoconia are calcium carbonate inclusions in the lumen of the gravity-sensing organ, the statocyst, of Aplysia californica. The aim of the present study was to examine the role of carbonic anhydrase and urease in statoconia mineralization in vitro. The experiments were performed using a previously described culture ...
journal_title：Connective tissue research
pub_type： 杂志文章
doi：10.3109/03008209609029206
更新日期：1996-01-01 00:00:00
