Abstract:
:Due to the rise of multidrug-resistant infections in humans, phage therapy is gaining renewed attention in Western medicine. Despite the increasing number of publications focussed on the isolation, characterization and in vitro performance of different phages, there is still a lack of concise pre-clinical information to guide the application of phage therapy in clinical practice. Nevertheless, over the last decade, efforts have been made to conduct more detailed studies of the in vivo efficacy of phages. Here, we review the most relevant in vivo studies performed in the last decade covering phage efficacy in both preclinical and clinical trials. We compare different routes of administration, dosage effect and different animal models of distinct types of infections. Moreover, insights into case studies and results from clinical trials are presented. Challenges and limitations of phage use as evidenced by the current state of research are also discussed in order to improve both the trustworthiness and success of the implementation of phage therapy.
journal_name
Crit Rev Microbioljournal_title
Critical reviews in microbiologyauthors
Melo LDR,Oliveira H,Pires DP,Dabrowska K,Azeredo Jdoi
10.1080/1040841X.2020.1729695subject
Has Abstractpub_date
2020-02-01 00:00:00pages
78-99issue
1eissn
1040-841Xissn
1549-7828journal_volume
46pub_type
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