Abstract:
:Both coagulation and fibrinolysis are tightly connected with the innate immune system. Infection and inflammation cause profound alterations in the otherwise well-controlled balance between coagulation and fibrinolysis. Many pathogenic bacteria directly exploit the host's hemostatic system to increase their virulence. Here, we review the capacity of bacteria to activate plasminogen. The resulting proteolytic activity allows them to breach tissue barriers and evade innate immune defense, thus promoting bacterial spreading. Yersinia pestis, streptococci of group A, C and G and Staphylococcus aureus produce a specific bacterial plasminogen activator. Moreover, surface plasminogen receptors play an established role in pneumococcal, borrelial and group B streptococcal infections. This review summarizes the mechanisms of bacterial activation of host plasminogen and the role of the fibrinolytic system in infections caused by these pathogens.
journal_name
Crit Rev Microbioljournal_title
Critical reviews in microbiologyauthors
Peetermans M,Vanassche T,Liesenborghs L,Lijnen RH,Verhamme Pdoi
10.3109/1040841X.2015.1080214subject
Has Abstractpub_date
2016-11-01 00:00:00pages
866-82issue
6eissn
1040-841Xissn
1549-7828journal_volume
42pub_type
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