Bacterial pathogens activate plasminogen to breach tissue barriers and escape from innate immunity.

Abstract:

:Both coagulation and fibrinolysis are tightly connected with the innate immune system. Infection and inflammation cause profound alterations in the otherwise well-controlled balance between coagulation and fibrinolysis. Many pathogenic bacteria directly exploit the host's hemostatic system to increase their virulence. Here, we review the capacity of bacteria to activate plasminogen. The resulting proteolytic activity allows them to breach tissue barriers and evade innate immune defense, thus promoting bacterial spreading. Yersinia pestis, streptococci of group A, C and G and Staphylococcus aureus produce a specific bacterial plasminogen activator. Moreover, surface plasminogen receptors play an established role in pneumococcal, borrelial and group B streptococcal infections. This review summarizes the mechanisms of bacterial activation of host plasminogen and the role of the fibrinolytic system in infections caused by these pathogens.

journal_name

Crit Rev Microbiol

authors

Peetermans M,Vanassche T,Liesenborghs L,Lijnen RH,Verhamme P

doi

10.3109/1040841X.2015.1080214

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

866-82

issue

6

eissn

1040-841X

issn

1549-7828

journal_volume

42

pub_type

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