Botulism diagnostics: from clinical symptoms to in vitro assays.

Abstract:

:Botulinum neurotoxin (BoNT), which cause the deadly neuroparalytic disease, botulism, is the most toxic substance known to man. BoNT can be used as potential bioterrorism agents, and therefore, pose great threat to national security and public health. Rapid and sensitive detection of BoNTs using molecular and biochemical techniques is an essential component in the diagnosis of botulism, and is yet to be achieved. The most sensitive and widely accepted assay method for BoNTs is mouse bioassay, which takes 4 days to complete. This clearly can not meet the need for clinical diagnosis of botulism, botulinum detection in field conditions, and screening of large scale samples. Consequently, the clinical diagnosis of botulism relies on the clinical symptom development, thus limiting the effectiveness of antitoxin treatment. In response to this critical need, many in vitro methods for BoNT detection are under development. This review is focused on recently developed in vitro detection methods for BoNTs, and emerging new technologies with potential for sensitive and rapid in vitro diagnostics for botulism.

journal_name

Crit Rev Microbiol

authors

Cai S,Singh BR,Sharma S

doi

10.1080/10408410701364562

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

109-25

issue

2

eissn

1040-841X

issn

1549-7828

pii

779373661

journal_volume

33

pub_type

杂志文章,评审
  • From papyrus to compact disc: the microbial deterioration of documentary heritage.

    abstract::Highly significant evidence of the intellectual and cultural efforts of the human race is contained in documents. They take many forms, from papyri through paper to modern magnetic media and optical records. These items are mainly made of organic materials many of which contain polymers, which span from cellulose and ...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.1080/10408410490884766

    authors: Cappitelli F,Sorlini C

    更新日期:2005-01-01 00:00:00

  • Bacterial pathogens activate plasminogen to breach tissue barriers and escape from innate immunity.

    abstract::Both coagulation and fibrinolysis are tightly connected with the innate immune system. Infection and inflammation cause profound alterations in the otherwise well-controlled balance between coagulation and fibrinolysis. Many pathogenic bacteria directly exploit the host's hemostatic system to increase their virulence....

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.3109/1040841X.2015.1080214

    authors: Peetermans M,Vanassche T,Liesenborghs L,Lijnen RH,Verhamme P

    更新日期:2016-11-01 00:00:00

  • Molecular aspects of fungal dimorphism.

    abstract::The approach to this article will be the review of experimental developments achieved in recent years in the fields of biochemistry, molecular biology, ultrastructure, etc. and that have suggested models and hypothesis in order to understand the regulation of the molecular mechanisms involved in fungal differentiation...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.3109/10408418409105474

    authors: San-Blas G,San-Blas F

    更新日期:1984-01-01 00:00:00

  • Peptide conversations in Gram-positive bacteria.

    abstract::Within Gram-positive bacteria, the expression of target genes is controlled at the population level via signaling peptides, also known as pheromones. Pheromones control a wide range of functions, including competence, virulence, and others that remain unknown. Until now, their role in bacterial gene regulation has pro...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.3109/1040841X.2014.948804

    authors: Monnet V,Juillard V,Gardan R

    更新日期:2016-05-01 00:00:00

  • Recent advances on topical antimicrobials for skin and soft tissue infections and their safety concerns.

    abstract::Antimicrobial resistance of disease-related microorganisms is considered a worldwide prevalent and serious issue which increases the failure of treatment outcomes and leads to high mortality. Considering that the increased resistance to systemic antimicrobial therapy often needs of the use of more toxic agents, topica...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.1080/1040841X.2017.1313811

    authors: Lam PL,Lee KKH,Wong RSM,Cheng GYM,Bian ZX,Chui CH,Gambari R

    更新日期:2018-02-01 00:00:00

  • Marine microorganisms as potential biofactories for synthesis of metallic nanoparticles.

    abstract::The use of marine microorganisms as potential biofactories for green synthesis of metallic nanoparticles is a relatively new field of research with considerable prospects. This method is eco-friendly, time saving, and inexpensive and can be easily scaled up for large-scale synthesis. The increasing need to develop sim...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.3109/1040841X.2015.1137860

    authors: Manivasagan P,Nam SY,Oh J

    更新日期:2016-11-01 00:00:00

  • Taxonomy of Aureobasidium spp. and biosynthesis and regulation of their extracellular polymers.

    abstract::The genus Aureobasidium spp. have been divided into three species, A. pullulans. A. leucospermi and A. proteae, and A. pullulans has been known to have five varieties. However, after analysis of many strains of this yeast isolated from different environments, they do not belong to any of the three species or the five ...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.3109/1040841X.2013.826176

    authors: Li Y,Chi Z,Wang GY,Wang ZP,Liu GL,Lee CF,Ma ZC,Chi ZM

    更新日期:2015-06-01 00:00:00

  • Bacterial separation and concentration from complex sample matrices: a review.

    abstract::The use of many rapid detection technologies could be expanded if the bacteria were separated, concentrated, and purified from the sample matrix before detection. Specific advantages of bacterial concentration might include facilitating the detection of multiple bacterial strains; removal of matrix-associated assay in...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.1080/10408410490266410

    authors: Stevens KA,Jaykus LA

    更新日期:2004-01-01 00:00:00

  • The acetone-butanol-ethanol fermentation.

    abstract::Renewed interest in the acetone-butanol-ethanol (ABE) fermentation as a route for industrial production of butanol has been evident since the oil crisis of the 1970s. The present review includes an historical recap of the traditional industrial process and culturing practices useful in maintaining viable solvent-produ...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.3109/10408418809104464

    authors: Awang GM,Jones GA,Ingledew WM

    更新日期:1988-01-01 00:00:00

  • Pneumococcal surface adhesin A (PsaA): a review.

    abstract::Pneumococcal surface adhesin A (PsaA) is a surface-exposed common 37-kilodalton multi-functional lipoprotein detected on all known serotypes of Streptococcus pneumoniae. This lipoprotein belongs to the ABC-type transport protein complex that transports Mn2+; it is also an adhesin that plays a major role in pneumococca...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.1080/10408410802275352

    authors: Rajam G,Anderton JM,Carlone GM,Sampson JS,Ades EW

    更新日期:2008-01-01 00:00:00

  • The adenylate cyclase toxins.

    abstract::Cyclic AMP is a ubiquitous messenger that integrates many processes of the cell. Diverse families of adenylate cyclases and phosphodiesterases stringently regulate the intracellular concentration of cAMP. Any alteration in the cytosolic concentration of cAMP has a profound effect on the various processes of the cell. ...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.1080/10408410490468795

    authors: Ahuja N,Kumar P,Bhatnagar R

    更新日期:2004-01-01 00:00:00

  • Verifying compliance to the biological and toxin weapons convention.

    abstract::There are difficult technical problems inherent in verifying compliance to the Biological Weapons and Toxin Convention (BWC) that are making it difficult to reach international agreement on a verification protocol. A compliance regime will most likely involve the formation of an Organization for the Prevention of Biol...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.1080/10408419891294262

    authors: Zilinskas RA

    更新日期:1998-01-01 00:00:00

  • Microbial transmission from mother to child: improving infant intestinal microbiota development by identifying the obstacles.

    abstract::Industrialisation has introduced several lifestyle changes and medical advancements but their impact on intestinal microbiota acquisition is often overlooked. Even though these consequential changes in the microbiota could contribute to the disease burden that accompanies industrialisation, such as obesity and atopic ...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.1080/1040841X.2019.1680601

    authors: Van Daele E,Knol J,Belzer C

    更新日期:2019-01-01 00:00:00

  • Normal flora and bacterial vaginosis in pregnancy: an overview.

    abstract::The female genital tract is an intricate, yet balanced ecosystem that hosts a variety of different residential microflora. The physiological changes that occur during pregnancy may disrupt this balanced ecosystem and predispose women to a potentially pathogenic microbiota. Bacteria that are associated with bacterial v...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.3109/1040841X.2014.954522

    authors: Redelinghuys MJ,Ehlers MM,Dreyer AW,Kock MM

    更新日期:2016-05-01 00:00:00

  • Is gonococcal disease preventable? The importance of understanding immunity and pathogenesis in vaccine development.

    abstract::Gonorrhea is a major, global public health problem for which there is no vaccine. The continuing emergence of antibiotic-resistant strains raises concerns that untreatable Neisseria gonorrhoeae may become widespread in the near future. Consequently, there is an urgent need for increased efforts towards the development...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.3109/1040841X.2015.1105782

    authors: Edwards JL,Jennings MP,Apicella MA,Seib KL

    更新日期:2016-11-01 00:00:00

  • Alicyclobacillus spp. in the fruit juice industry: history, characteristics, and current isolation/detection procedures.

    abstract::The first Alicyclobacillus spp. was isolated in 1982, and was originally thought to be strictly limited to thermophilic and acidic environments. Two years later, another Alicyclobacillus sp., A. acidoterrestris, was identified as the causative agent in spoilage of commercially pasteurized apple juice. Subsequent studi...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.1080/10408410490435089

    authors: Chang SS,Kang DH

    更新日期:2004-01-01 00:00:00

  • Antibiotic adjuvants: an alternative approach to overcome multi-drug resistant Gram-negative bacteria.

    abstract::Antibiotic resistance in Gram-negative pathogens has emerged and constituted a global crisis, thereby novel antibiotics and other anti-infective strategies are urgently needed. However, the growing gap between clinical need and drug innovation, coupled with the membrane permeability barrier in Gram-negative bacteria r...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.1080/1040841X.2019.1599813

    authors: Liu Y,Li R,Xiao X,Wang Z

    更新日期:2019-05-01 00:00:00

  • The immunology of mycobacterial infections.

    abstract::Mycobacteria are endowed with substances that profoundly affect the immune system. Leprosy and tuberculosis exemplify broad spectra of useful and detrimental immune responses of mycobacterial infections that range from intense potentiation to severe specific adn nonspecific suppression of humoral and cellular immune e...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.3109/10408418209104488

    authors: Chaparas SD

    更新日期:1982-01-01 00:00:00

  • Nanotechnology and water treatment: applications and emerging opportunities.

    abstract::Nanotechnology, the engineering and art of manipulating matter at the nanoscale (1-100 nm), offers the potential of novel nanomaterials for treatment of surface water, groundwater, and wastewater contaminated by toxic metal ions, organic and inorganic solutes, and microorganisms. Due to their unique activity toward re...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.1080/10408410701710442

    authors: Theron J,Walker JA,Cloete TE

    更新日期:2008-01-01 00:00:00

  • The proteasome of the differently-diverged eukaryote Giardia lamblia and its role in remodeling of the microtubule-based cytoskeleton.

    abstract::Giardia lamblia is the causative agent of the diarrheal disease giardiasis, against which only a limited number of drugs are currently available. Increasing reports of resistance to these drugs makes it necessary to identify new cellular targets for designing the next generation of anti-giardial drugs. Towards this go...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.1080/1040841X.2016.1262814

    authors: Ray A,Sarkar S

    更新日期:2017-08-01 00:00:00

  • Identification of brucella species and biotypes using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

    abstract::Brucellosis is a worldwide zoonosis causing reproductive failures in livestock and a severe multi-organ disease in humans. The genus Brucella is divided into seven species and various biotypes differing in pathogenicity and host specificity. Although Brucella spp. represent a highly homogenous group of bacteria, RFLPs...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.1080/10408410500304041

    authors: Al Dahouk S,Tomaso H,Prenger-Berninghoff E,Splettstoesser WD,Scholz HC,Neubauer H

    更新日期:2005-01-01 00:00:00

  • mazEF-mediated programmed cell death in bacteria: "what is this?".

    abstract::Toxin-antitoxin (TA) systems consist of a bicistronic operon, encoding a toxin and an antitoxin. They are widely distributed in the prokaryotic kingdom, often in multiple numbers. TAs are implicated in contradicting phenomena of persistence and programmed cell death (PCD) in bacteria. mazEF TA system, one of the widel...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.3109/1040841X.2013.804030

    authors: Ramisetty BC,Natarajan B,Santhosh RS

    更新日期:2015-02-01 00:00:00

  • The multi-omics promise in context: from sequence to microbial isolate.

    abstract::The numbers and diversity of microbes in ecosystems within and around us is unmatched, yet most of these microorganisms remain recalcitrant to in vitro cultivation. Various high-throughput molecular techniques, collectively termed multi-omics, provide insights into the genomic structure and metabolic potential as well...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.1080/1040841X.2017.1332003

    authors: Gutleben J,Chaib De Mares M,van Elsas JD,Smidt H,Overmann J,Sipkema D

    更新日期:2018-03-01 00:00:00

  • Recent developments in therapeutic applications of Cyanobacteria.

    abstract::The cyanobacteria (blue-green algae) are photosynthetic prokaryotes having applications in human health with numerous biological activities and as a dietary supplement. It is used as a food supplement because of its richness in nutrients and digestibility. Many cyanobacteria (Microcystis sp, Anabaena sp, Nostoc sp, Os...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.3109/1040841X.2014.957640

    authors: Raja R,Hemaiswarya S,Ganesan V,Carvalho IS

    更新日期:2016-05-01 00:00:00

  • Immunoregulation of dermatophytosis.

    abstract::Dermatophytoses are superficial infections caused by a group of fungi, the dermatophytes, which invade keratinized tissue of skin, hair, and nails in humans and animals. The importance of normal immune function in resistance to dermatophytoses is substantiated by an increased susceptibility to chronic infection seen i...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.3109/10408418909104472

    authors: Calderon RA

    更新日期:1989-01-01 00:00:00

  • Cell surface engineering of microorganisms towards adsorption of heavy metals.

    abstract::Heavy metal contamination has become a worldwide environmental concern due to its toxicity, non-degradability and food-chain bioaccumulation. Conventional physical and chemical treatment methods for heavy metal removal have disadvantages such as cost-intensiveness, incomplete removal, secondary pollution and the lack ...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.3109/1040841X.2013.813898

    authors: Li PS,Tao HC

    更新日期:2015-06-01 00:00:00

  • Enteroaggregative Escherichia coli heat-stable enterotoxin 1 (EAST1): a new toxin with an old twist.

    abstract::Enteroaggregative Escherichia coli heat-stable enterotoxin 1 (EAST1) is a small protein that was first detected more than a decade ago in an enteroaggregative E. coli (EAEC) strain isolated from the stools of a diarrheic child. The EAST1 gene, astA, is not solely present in EAEC, but also in other categories of diarrh...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.1080/1040-840291046687

    authors: Ménard LP,Dubreuil JD

    更新日期:2002-01-01 00:00:00

  • Implication of virulence factors in Escherichia coil O157:H7 pathogenesis.

    abstract::Since the first documented outbreak of hemorrhagic colitis caused by Escherichia coli O157:H7 in 1982, numerous publications have demonstrated or proposed putative components implicated in the pathogenesis of this gastrointestinal infection. Indeed, Escherichia coli O157:H7 pathogenesis is linked to several potential ...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.1080/713608014

    authors: LeBlanc JJ

    更新日期:2003-01-01 00:00:00

  • Pheromones among the procaryotes.

    abstract::A pheromone is a chemical excreted by an organism into the environment that acts to elicit a specific response from other organisms of the same species. The importance of pheromones in the life cycle of various species of mammals, insects, and fungi is well known. In the past decade, it has become apparent that pherom...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.3109/10408418609108741

    authors: Stephens K

    更新日期:1986-01-01 00:00:00

  • Genomic tools to profile antibiotic mode of action.

    abstract::The increasing emergence of antimicrobial multiresistant bacteria is of great concern to public health. While these bacteria are becoming an ever more prominent cause of nosocomial and community-acquired infections worldwide, the antibiotic discovery pipeline has been stalled in the last few years with very few effort...

    journal_title:Critical reviews in microbiology

    pub_type: 杂志文章,评审

    doi:10.3109/1040841X.2013.866073

    authors: Cardona ST,Selin C,Gislason AS

    更新日期:2015-01-01 00:00:00