Main Symptomatic Treatment Targets in Suspected and Early Psychosis: New Insights From Network Analysis.

abstract：:The role of negative cognition and effect in maintaining psychotic symptoms is increasingly recognized but has yet to be substantiated though longitudinal analysis. Based on an a priori theoretical model, we hypothesized that negative cognition and depressed mood play a direct causal role in maintaining paranoia in pe...

journal_title：Schizophrenia bulletin

authors： Fowler D,Hodgekins J,Garety P,Freeman D,Kuipers E,Dunn G,Smith B,Bebbington PE

更新日期：2012-09-01 00:00:00

abstract：:Every year numerous reports on antipsychotic drug trials are being published in neuropsychiatric journals, adding new information to our knowledge in the field. The information however is often hard for the reader to interpret, sometimes contradictory to comparable available studies and leaves more questions open than...

journal_title：Schizophrenia bulletin

authors： Leucht S,Heres S,Hamann J,Kane JM

更新日期：2008-03-01 00:00:00

abstract：:At the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) New Approaches Conference, a discussion group focused on directions for future research that are critical to enhancing our understanding of the distinctions among key cognitive domains that have relevance for the development of c...

journal_title：Schizophrenia bulletin

authors： Nuechterlein KH,Robbins TW,Einat H

更新日期：2005-10-01 00:00:00

abstract：:Increased latency of stimulus encoding is presented as a central deficit in schizophrenia cognition. Encoding, here, entails the internal representation of presenting stimuli in a format facilitating their implementation in other cognitive processes, such as those taking place in working memory. Historical roots of su...

journal_title：Schizophrenia bulletin

authors： Neufeld RW

更新日期：2007-07-01 00:00:00

abstract：:Genome-wide association studies (GWASs) have identified >100 susceptibility loci for schizophrenia (SCZ) and demonstrated that SCZ is a polygenic disorder determined by numerous genetic variants but with small effect size. We conducted a GWAS in the Japanese (JPN) population (a) to detect novel SCZ-susceptibility gene...

journal_title：Schizophrenia bulletin

authors： Ikeda M,Takahashi A,Kamatani Y,Momozawa Y,Saito T,Kondo K,Shimasaki A,Kawase K,Sakusabe T,Iwayama Y,Toyota T,Wakuda T,Kikuchi M,Kanahara N,Yamamori H,Yasuda Y,Watanabe Y,Hoya S,Aleksic B,Kushima I,Arai H,Takaki

更新日期：2019-06-18 00:00:00

abstract：:This meta-analytic review sought to answer questions concerning the role of psychosocial treatments in the comprehensive management of patients with schizophrenia. The review focused on the effects of combining psychosocial treatment with somatic treatment. Findings demonstrated the additive and supplementary effects ...

journal_title：Schizophrenia bulletin

authors： Mojtabai R,Nicholson RA,Carpenter BN

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Insight into the neural mechanisms underlying the shared and disparate features of schizophrenia (SZ) and bipolar disorder (BD) is limited. The amygdala and prefrontal cortex (PFC) appear to have crucial roles in SZ and BD, yet abnormalities appear to manifest differently in the 2 disorders. METHODS:Eightee...

journal_title：Schizophrenia bulletin

authors： Liu H,Tang Y,Womer F,Fan G,Lu T,Driesen N,Ren L,Wang Y,He Y,Blumberg HP,Xu K,Wang F

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:In light of the evidence for brain white matter (WM) abnormalities in schizophrenia, study of normal WM maturation in adolescence may provide critical insights relevant to the neurodevelopment of the disorder. Voxel-wise diffusion tensor imaging (DTI) studies have consistently demonstrated increases in fract...

journal_title：Schizophrenia bulletin

authors： Peters BD,Szeszko PR,Radua J,Ikuta T,Gruner P,DeRosse P,Zhang JP,Giorgio A,Qiu D,Tapert SF,Brauer J,Asato MR,Khong PL,James AC,Gallego JA,Malhotra AK

更新日期：2012-11-01 00:00:00

abstract：:Schizophrenia elevates the risk for aggressive behavior and violent crime, and different approaches have been used to manage this problem. The results of such treatments vary. One reason for this variation is that aggressive behavior in schizophrenia is heterogeneous in origin. This heterogeneity has usually not been ...

journal_title：Schizophrenia bulletin

authors： Volavka J,Citrome L

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:Cross-sectional studies have shown associations between 22q11.2 deletion syndrome and schizophrenia. However, large-scale prospective studies have been lacking. We, therefore, conducted the first large-scale population based study on the risk of being diagnosed with schizophrenia in persons identified with 22...

journal_title：Schizophrenia bulletin

authors： Vangkilde A,Olsen L,Hoeffding LK,Pedersen CB,Mortensen PB,Werge T,Trabjerg B

更新日期：2016-05-01 00:00:00

abstract：:Considerable research has documented the stigmatization of people with mental illnesses and its negative consequences. Recently it has been shown that stigma may also seriously affect families of psychiatric patients, but little empirical research has addressed this problem. We examine perceptions of and reactions to ...

journal_title：Schizophrenia bulletin

authors： Phelan JC,Bromet EJ,Link BG

更新日期：1998-01-01 00:00:00

abstract：:Catatonia is a central aspect of schizophrenia spectrum disorders (SSD) and most likely associated with abnormalities in affective, motor, and sensorimotor brain regions. However, contributions of different cortical features to the pathophysiology of catatonia in SSD are poorly understood. Here, T1-weighted structural...

journal_title：Schizophrenia bulletin

authors： Hirjak D,Kubera KM,Northoff G,Fritze S,Bertolino AL,Topor CE,Schmitgen MM,Wolf RC

更新日期：2019-10-24 00:00:00

abstract：:Staff members from nine mental health agencies were trained in psychiatric rehabilitation technology. The trainers then received intensive followup to assist them in implementing the technology in their own agencies. Evaluation of the impact of the "training of trainers" strategy suggested that mental health workers w...

journal_title：Schizophrenia bulletin

authors： Rogers ES,Cohen BF,Danley KS,Hutchinson D,Anthony WA

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Many people with schizophrenia smoke cannabis, and it is unclear why a large proportion do so and if the effects are harmful or beneficial. It is also unclear what the best method is to allow people with schizophrenia to alter their cannabis intake. OBJECTIVES:To assess the effects of specific psychological...

journal_title：Schizophrenia bulletin

authors： Pushpa-Rajah JA,McLoughlin BC,Gillies D,Rathbone J,Variend H,Kalakouti E,Kyprianou K

更新日期：2015-03-01 00:00:00

abstract：:Psychotic patients with a lifetime history of cannabis use generally show better cognitive functioning than other psychotic patients. Some authors suggest that cannabis-using patients may have been less cognitively impaired and less socially withdrawn in their premorbid life. Using a dataset comprising 948 patients wi...

journal_title：Schizophrenia bulletin

authors： Ferraro L,La Cascia C,Quattrone D,Sideli L,Matranga D,Capuccio V,Tripoli G,Gayer-Anderson C,Morgan C,Sami MB,Sham P,de Haan L,Velthorst E,Jongsma HE,Kirkbride JB,Rutten BPF,Richards AL,Roldan L,Arango C,Bernardo M,

更新日期：2020-04-10 00:00:00

abstract：:Randomized controlled trials for antipsychotic drugs have a variety of design features suited to diverse purposes. Efficacy (or explanatory) trials seek to establish if a drug can reduce psychotic symptoms under ideal circumstances. To isolate drug effects, researchers enroll carefully selected patients. Specialized r...

journal_title：Schizophrenia bulletin

authors： Stroup TS,Geddes JR

更新日期：2008-03-01 00:00:00

abstract：:The present article reports findings on intelligence and personality functioning during the school period and at adolescence in a sample of kibbutz and urban Israeli children at risk for schizophrenia, as measured by a standard psychological test battery. On the first round of testing it was found that the index subje...

journal_title：Schizophrenia bulletin

authors： Sohlberg SC

更新日期：1985-01-01 00:00:00

abstract：:Schizotypal disorder is characterized by odd behavior and attenuated forms of schizophrenic features without the manifestation of overt and sustained psychoses. Past studies suggest that schizotypal disorder shares biological and psychological commonalties with schizophrenia. Structural magnetic resonance imaging (MRI...

journal_title：Schizophrenia bulletin

authors： Takayanagi Y,Sasabayashi D,Takahashi T,Furuichi A,Kido M,Nishikawa Y,Nakamura M,Noguchi K,Suzuki M

更新日期：2020-02-26 00:00:00

abstract：:Clinical descriptions of perceptual and attentional anomalies in schizophrenia emphasize phenomena such as flooding, or inundation, by sensory stimuli. A failure of sensory "gating" mechanisms in the brain is hypothesized to account for these symptoms, and this hypothesis has led to a marked interest in their putative...

journal_title：Schizophrenia bulletin

authors： Bunney WE Jr,Hetrick WP,Bunney BG,Patterson JV,Jin Y,Potkin SG,Sandman CA

更新日期：1999-01-01 00:00:00

abstract：:The left superior temporal sulcus (STS) plays an important role in integrating audiovisual information and is functionally connected to disparate regions of the brain. For the integration of gesture information in an abstract sentence context (metaphoric gestures), intact connectivity between the left STS and the infe...

journal_title：Schizophrenia bulletin

authors： Straube B,Green A,Sass K,Kircher T

更新日期：2014-07-01 00:00:00

abstract：:This article examines the factors that influence antipsychotic use among youth treated in public inpatient facilities. By combining data from 11 focus groups, a survey of 43 researchers and clinicians, and a chart review of 100 closed patient charts, we investigated the interplay between physicians' and staff members'...

journal_title：Schizophrenia bulletin

authors： Pappadopulos E,Jensen PS,Schur SB,MacIntyre JC 2nd,Ketner S,Van Orden K,Sverd J,Sardana S,Woodlock D,Schweitzer R,Rube D

更新日期：2002-01-01 00:00:00

abstract：:A series of human and animal investigations has suggested that altered expression and function of the alpha7-nicotinic cholinergic receptor may be responsible for the auditory sensory gating deficit characterized in schizophrenia patients and their relatives as diminished suppression of an auditory-evoked response (P5...

journal_title：Schizophrenia bulletin

authors： Adler LE,Olincy A,Waldo M,Harris JG,Griffith J,Stevens K,Flach K,Nagamoto H,Bickford P,Leonard S,Freedman R

更新日期：1998-01-01 00:00:00

abstract：:The success of the biological revolution in our understanding of schizophrenia, along with the lack of convincing evidence for the efficacy of global approaches to individual psychotherapy with schizophrenia, has led to the virtual disappearance of research and theory in this area. However, it seems timely to reexamin...

journal_title：Schizophrenia bulletin

authors： Coursey RD

更新日期：1989-01-01 00:00:00

abstract：:We have previously reported on typically paranoid schizophrenic patients who attempted to see the President or other prominent American political figures based on hallucinations or delusional beliefs. By obtaining arrest records on these White House Cases (WHCs), we were able to determine which individuals had murder ...

journal_title：Schizophrenia bulletin

authors： Shore D,Filson CR,Johnson WE

更新日期：1988-01-01 00:00:00

abstract：:The prevalence and demographic and clinical correlates of lifetime substance use disorders were examined in a cohort of 325 recently hospitalized psychiatric patients (53% schizophrenia or schizoaffective disorder). Alcohol use was the most common type of substance use disorder, followed by cannabis and cocaine use. U...

journal_title：Schizophrenia bulletin

authors： Mueser KT,Yarnold PR,Rosenberg SD,Swett C Jr,Miles KM,Hill D

更新日期：2000-01-01 00:00:00

abstract：:This research studied hypotheses that positive thought disorder in schizophrenia is influenced by patients' not taking in immediate target contextual material, thereby losing vital cues that guide thought processes. We assessed 164 acute inpatients (including 55 schizophrenia and 31 bipolar disorder patients), using s...

journal_title：Schizophrenia bulletin

authors： Harrow M,Green KE,Sands JR,Jobe TH,Goldberg JF,Kaplan KJ,Martin EM

更新日期：2000-01-01 00:00:00

abstract：:Childhood trauma (CT) has been identified as a potential risk factor for the onset of psychotic disorders. However, to date, there is limited consensus with respect to which symptoms may ensue after exposure to trauma in early life, and whether specific pathways may account for these associations. The aim of the prese...

journal_title：Schizophrenia bulletin

authors： Isvoranu AM,van Borkulo CD,Boyette LL,Wigman JT,Vinkers CH,Borsboom D,Group Investigators.

更新日期：2017-01-01 00:00:00

abstract：:The authors describe an easily administered scale being developed to assess the rejecting feelings of family respondents toward former mental patients who return to live with their families. Based upon a sample of 133 discharged mental patients and family members, the scale demonstrates a moderately high reliability (...

journal_title：Schizophrenia bulletin

authors： Kreisman DE,Simmens SJ,Joy VD

更新日期：1979-01-01 00:00:00

abstract：:Cognitive-behavioral therapy for psychosis is described. It draws on the cognitive models and therapy approach of Beck and colleagues, combined with an application of stress-vulnerability models of schizophrenia and cognitive models of psychotic symptoms. There is encouraging evidence for the efficacy of this approach...

journal_title：Schizophrenia bulletin

authors： Garety PA,Fowler D,Kuipers E

更新日期：2000-01-01 00:00:00

abstract：:The normal developmental series of brains in the Yakovlev Collection has been examined to explore the possibility that various brain regions implicated in schizophrenia may show changes in myelination during late adolescence, a period coinciding with the appearance of early symptoms of this disorder. The prefrontal, c...

journal_title：Schizophrenia bulletin

authors： Benes FM

更新日期：1989-01-01 00:00:00