Abstract:
:Tumor-associated macrophages affect tumor progression and resistance to immune checkpoint therapy. Here, we identify the chemokine signal regulator FROUNT as a target to control tumor-associated macrophages. The low level FROUNT expression in patients with cancer correlates with better clinical outcomes. Frount-deficiency markedly reduces tumor progression and decreases macrophage tumor-promoting activity. FROUNT is highly expressed in macrophages, and its myeloid-specific deletion impairs tumor growth. Further, the anti-alcoholism drug disulfiram (DSF) acts as a potent inhibitor of FROUNT. DSF interferes with FROUNT-chemokine receptor interactions via direct binding to a specific site of the chemokine receptor-binding domain of FROUNT, leading to inhibition of macrophage responses. DSF monotherapy reduces tumor progression and decreases macrophage tumor-promoting activity, as seen in the case of Frount-deficiency. Moreover, co-treatment with DSF and an immune checkpoint antibody synergistically inhibits tumor growth. Thus, inhibition of FROUNT by DSF represents a promising strategy for macrophage-targeted cancer therapy.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Terashima Y,Toda E,Itakura M,Otsuji M,Yoshinaga S,Okumura K,Shand FHW,Komohara Y,Takeda M,Kokubo K,Chen MC,Yokoi S,Rokutan H,Kofuku Y,Ohnishi K,Ohira M,Iizasa T,Nakano H,Okabe T,Kojima H,Shimizu A,Kanegasaki S,doi
10.1038/s41467-020-14338-5subject
Has Abstractpub_date
2020-01-30 00:00:00pages
609issue
1issn
2041-1723pii
10.1038/s41467-020-14338-5journal_volume
11pub_type
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