当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > Comparative Transcriptome Analysis of the Molecular Mechanism of the Hairy Roots of Brassica campestris L. in Response to Cadmium Stress.

Comparative Transcriptome Analysis of the Molecular Mechanism of the Hairy Roots of Brassica campestris L. in Response to Cadmium Stress.

Abstract：

:Brassica campestris L., a hyperaccumulator of cadmium (Cd), is considered a candidate plant for efficient phytoremediation. The hairy roots of Brassica campestris L are chosen here as a model plant system to investigate the response mechanism of Brassica campestris L. to Cd stress. High-throughput sequencing technology is used to identify genes related to Cd tolerance. A total of 2394 differentially expressed genes (DEGs) are identified by RNA-Seq analysis, among which 1564 genes are up-regulated, and 830 genes are down-regulated. Data from the gene ontology (GO) analysis indicate that DEGs are mainly involved in metabolic processes. Glutathione metabolism, in which glutathione synthetase and glutathione S-transferase are closely related to Cd stress, is identified in the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. A Western blot shows that glutathione synthetase and glutathione S-transferase are involved in Cd tolerance. These results provide a preliminary understanding of the Cd tolerance mechanism of Brassica campestris L. and are, hence, of particular importance to the future development of an efficient phytoremediation process based on hairy root cultures, genetic modification, and the subsequent regeneration of the whole plant.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Sun Y,Lu Q,Cao Y,Wang M,Cheng X,Yan Q

doi

10.3390/ijms21010180

subject

Has Abstract

pub_date

2019-12-26 00:00:00

issue

1

issn

1422-0067

pii

ijms21010180

journal_volume

21

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • P1G10, the Proteolytic Fraction from Vasconcellea cundinamarcensis, Stimulates Tissue Repair after Acute Exposure to Ultraviolet B Radiation.

    abstract：BACKGROUND:P1G10 is a cysteine proteolytic fraction from Vasconcellea cundinamarcensis latex, obtained by chromatographic separation on Sephadex-G10 and ultrafiltration. This fraction enhances healing in different models of skin lesions, and displays a protective/healing effect against gastric ulcers, where it was sugg...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20184373

    authors： Freitas KM,Silva ACAE,Veloso ES,Ferreira Ê,Barcelos LS,Caliari MV,Salas CE,Lopes MTP

    更新日期：2019-09-06 00:00:00

  • Mechanistic Insight of Na/K-ATPase Signaling and HO-1 into Models of Obesity and Nonalcoholic Steatohepatitis.

    abstract：:Obesity is a multifaceted pathophysiological condition that has been associated with lipid accumulation, adipocyte dysfunction, impaired mitochondrial biogenesis and an altered metabolic profile. Redox imbalance and excessive release of inflammatory mediators have been intricately linked in obesity-associated phenotyp...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21010087

    authors： Pratt R,Lakhani HV,Zehra M,Desauguste R,Pillai SS,Sodhi K

    更新日期：2019-12-21 00:00:00

  • Perillyl Alcohol and Its Drug-Conjugated Derivatives as Potential Novel Methods of Treating Brain Metastases.

    abstract：:Metastasis to the central nervous system remains difficult to treat, and such patients are faced with a dismal prognosis. The blood-brain barrier (BBB), despite being partially compromised within malignant lesions in the brain, still retains much of its barrier function and prevents most chemotherapeutic agents from e...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms17091463

    authors： Chen TC,Da Fonseca CO,Schönthal AH

    更新日期：2016-09-02 00:00:00

  • Phenotypic Screen with the Human Secretome Identifies FGF16 as Inducing Proliferation of iPSC-Derived Cardiac Progenitor Cells.

    abstract：:Paracrine factors can induce cardiac regeneration and repair post myocardial infarction by stimulating proliferation of cardiac cells and inducing the anti-fibrotic, antiapoptotic, and immunomodulatory effects of angiogenesis. Here, we screened a human secretome library, consisting of 923 growth factors, cytokines, an...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20236037

    authors： Jennbacken K,Wågberg F,Karlsson U,Eriksson J,Magnusson L,Chimienti M,Ricchiuto P,Bernström J,Ding M,Ross-Thriepland D,Xue Y,Peiris D,Aastrup T,Tegel H,Hober S,Sivertsson Å,Uhlén M,Strömstedt PE,Davies R,Holmberg Sch

    更新日期：2019-11-30 00:00:00

  • Supraspliceosomes at defined functional states portray the pre-assembled nature of the pre-mRNA processing machine in the cell nucleus.

    abstract：:When isolated from mammalian cell nuclei, all nuclear pre-mRNAs are packaged in multi-subunit large ribonucleoprotein complexes-supraspliceosomes-composed of four native spliceosomes interconnected by the pre-mRNA. Supraspliceosomes contain all five spliceosomal U snRNPs, together with other splicing factors, and are ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms150711637

    authors： Kotzer-Nevo H,de Lima Alves F,Rappsilber J,Sperling J,Sperling R

    更新日期：2014-06-30 00:00:00

  • Identification of Differentially Expressed Micrornas Associate with Glucose Metabolism in Different Organs of Blunt Snout Bream (Megalobrama amblycephala).

    abstract：:Blunt snout bream (Megalobrama amblycephala) is a widely favored herbivorous fish species and is a frequentlyused fish model for studying the metabolism physiology. This study aimed to provide a comprehensive illustration of the mechanisms of a high-starch diet (HSD) induced lipid metabolic disorder by identifying mic...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18061161

    authors： Miao LH,Lin Y,Pan WJ,Huang X,Ge XP,Ren MC,Zhou QL,Liu B

    更新日期：2017-05-31 00:00:00

  • Stimulation of Peritoneal Mesothelial Cells to Secrete Matrix Metalloproteinase-9 (MMP-9) by TNF-α: A Role in the Invasion of Gastric Carcinoma Cells.

    abstract：:It has recently been recognized that inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), upregulate the secretion of matrix metalloproteinase-9 (MMP-9) from cancer cells and thereby promote peritoneal dissemination. In this study, we found that TNF-α also stimulated peritoneal mesothelial cells to secrete...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19123961

    authors： Oku T,Shimada K,Kenmotsu H,Ando Y,Kurisaka C,Sano R,Tsuiji M,Hasegawa S,Fukui T,Tsuji T

    更新日期：2018-12-09 00:00:00

  • Extracts of Magnolia Species-Induced Prevention of Diabetic Complications: A Brief Review.

    abstract：:Diabetic complications are the major cause of mortality for the patients with diabetes. Oxidative stress and inflammation have been recognized as important contributors for the development of many diabetic complications, such as diabetic nephropathy, hepatopathy, cardiomyopathy, and other cardiovascular diseases. Seve...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms17101629

    authors： Zhao X,Li F,Sun W,Gao L,Kim KS,Kim KT,Cai L,Zhang Z,Zheng Y

    更新日期：2016-09-24 00:00:00

  • Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence.

    abstract：:Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that govern the expression of genes responsible for energy metabolism, cellular development, and differentiation. Their crucial biological roles dictate the significance of PPAR-targeting synthetic ligands in medical research and drug discovery....

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20205055

    authors： Cheng HS,Tan WR,Low ZS,Marvalim C,Lee JYH,Tan NS

    更新日期：2019-10-11 00:00:00

  • Fibrin-Enhanced Canonical Wnt Signaling Directs Plasminogen Expression in Cementoblasts.

    abstract：:Cementum is a mineralized layer on the tooth's root surface and facilitates the biomechanical anchoring of fibrous connective tissues as a part of tooth-supportive complexes. Previously, we observed that OCCM30 cementoblasts cultured on fibrin matrices underwent apoptosis due to fibrin degradation through the expressi...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18112380

    authors： Rahman SU,Park CH,Baek JH,Ryoo HM,Woo KM

    更新日期：2017-11-09 00:00:00

  • Insertion of Telomeric Repeats in the Human and Horse Genomes: An Evolutionary Perspective.

    abstract：:Interstitial telomeric sequences (ITSs) are short stretches of telomeric-like repeats (TTAGGG)n at nonterminal chromosomal sites. We previously demonstrated that, in the genomes of primates and rodents, ITSs were inserted during the repair of DNA double-strand breaks. These conclusions were derived from sequence compa...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21082838

    authors： Santagostino M,Piras FM,Cappelletti E,Del Giudice S,Semino O,Nergadze SG,Giulotto E

    更新日期：2020-04-18 00:00:00

  • HuR-regulated mRNAs associated with nuclear hnRNP A1-RNP complexes.

    abstract：:Post-transcriptional regulatory networks are dependent on the interplay of many RNA-binding proteins having a major role in mRNA processing events in mammals. We have been interested in the concerted action of the two RNA-binding proteins hnRNP A1 and HuR, both stable components of immunoselected hnRNP complexes and h...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms141020256

    authors： Papadodima O,Chatziioannou A,Patrinou-Georgoula M,Kolisis FN,Pletsa V,Guialis A

    更新日期：2013-10-11 00:00:00

  • Production of MCM-41 Nanoparticles with Control of Particle Size and Structural Properties: Optimizing Operational Conditions during Scale-Up.

    abstract：:The synthesis of Mobil Composition of Matter 41 (MCM-41) mesoporous silica nanoparticles (MSNs) of controlled sizes and porous structure has been performed at laboratory and pilot plant scales. Firstly, the effects of the main operating conditions (TEOS -Tetraethyl ortosilicate- addition rate, nanoparticle maturation ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21217899

    authors： Castillo RR,de la Torre L,García-Ochoa F,Ladero M,Vallet-Regí M

    更新日期：2020-10-24 00:00:00

  • Pre-Clinical Drug Testing in 2D and 3D Human In Vitro Models of Glioblastoma Incorporating Non-Neoplastic Astrocytes: Tunneling Nano Tubules and Mitochondrial Transfer Modulates Cell Behavior and Therapeutic Respons.

    abstract：:The role of astrocytes in the glioblastoma (GBM) microenvironment is poorly understood; particularly with regard to cell invasion and drug resistance. To assess this role of astrocytes in GBMs we established an all human 2D co-culture model and a 3D hyaluronic acid-gelatin based hydrogel model (HyStem™-HP) with differ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20236017

    authors： Civita P,M Leite D,Pilkington GJ

    更新日期：2019-11-29 00:00:00

  • The Tumor Microenvironment of Primitive and Metastatic Breast Cancer: Implications for Novel Therapeutic Strategies.

    abstract：:Breast cancer evolves thanks to a dense and close interaction with the surrounding tumor microenvironment (TME). Fibroblasts, leukocytes, blood and lymphatic endothelial cells and extracellular matrix are the constituents of this entity, and they synergistically play a pivotal role in all of the stages of breast cance...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21218102

    authors： Zarrilli G,Businello G,Dieci MV,Paccagnella S,Carraro V,Cappellesso R,Miglietta F,Griguolo G,Guarneri V,Lo Mele M,Fassan M

    更新日期：2020-10-30 00:00:00

  • Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds.

    abstract：: Adenosine monophosphate-activated protein kinase (AMPK) is an important energy sensor which is activated by increases in adenosine monophosphate (AMP)/adenosine triphosphate (ATP) ratio and/or adenosine diphosphate (ADP)/ATP ratio, and increases different metabolic pathways such as fatty acid oxidation, glucose trans...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18020288

    authors： Marín-Aguilar F,Pavillard LE,Giampieri F,Bullón P,Cordero MD

    更新日期：2017-01-29 00:00:00

  • Identification of a plastid-localized bifunctional nerolidol/linalool synthase in relation to linalool biosynthesis in young grape berries.

    abstract：:Monoterpenoids are a diverse class of natural products and contribute to the important varietal aroma of certain Vitis vinifera grape cultivars. Among the typical monoterpenoids, linalool exists in almost all grape varieties. A gene coding for a nerolidol/linalool (NES/LINS) synthase was evaluated in the role of linal...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms151221992

    authors： Zhu BQ,Cai J,Wang ZQ,Xu XQ,Duan CQ,Pan QH

    更新日期：2014-12-01 00:00:00

  • Thrombocytosis and Effects of IL-6 Knock-Out in a Colitis-Associated Cancer Model.

    abstract：:There is an increasing number of studies showing that thrombocytosis-accompanying a variety of solid tumors including colorectal cancer (CRC)-is associated with shorter survival and earlier development of metastases. The mechanisms of cancer-associated thrombocytosis are not completely understood yet. The aim of our s...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21176218

    authors： Josa V,Ferenczi S,Szalai R,Fuder E,Kuti D,Horvath K,Hegedus N,Kovacs T,Bagamery G,Juhasz B,Winkler Z,Veres DS,Zrubka Z,Mathe D,Baranyai Z

    更新日期：2020-08-27 00:00:00

  • Repellent and Antifeedant Activities of Citral-Derived Lactones against the Peach Potato Aphid.

    abstract：:Citral is well known for its antimicrobial, antifungal, and insecticidal activities. Natural sesquiterpene α-methylenelactones also exhibit a broad spectrum of biological activities. The aim of the study was to explore the effect of structural changes to citral molecules on citral behavior-modifying activity towards M...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21218029

    authors： Dancewicz K,Szumny A,Wawrzeńczyk C,Gabryś B

    更新日期：2020-10-28 00:00:00

  • Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons.

    abstract：:Cystic fibrosis (CF) is caused by mutations in the gene encoding the transmembrane conductance regulator (CFTR) protein. Some CF patients are compound heterozygous or homozygous for nonsense mutations in the CFTR gene. This implies the presence in the transcript of premature termination codons (PTCs) responsible for a...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21134781

    authors： Melfi R,Cancemi P,Chiavetta R,Barra V,Lentini L,Di Leonardo A

    更新日期：2020-07-06 00:00:00

  • In vitro efficacy of Myxococcus fulvus ANSM068 to biotransform aflatoxin B₁.

    abstract：:Aflatoxin B(1) (AFB(1)) is commonly found in cereals and animal feeds and causes a significant threat to the food industry and animal production. Several microbial isolates with high AFB(1) transformation ability have been identified in our previous studies. The aim of this research was to characterize one of those is...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms11104063

    authors： Guan S,Zhao L,Ma Q,Zhou T,Wang N,Hu X,Ji C

    更新日期：2010-10-20 00:00:00

  • Bevacizumab for Patients with Recurrent Multifocal Glioblastomas.

    abstract：:In patients with glioblastoma, antiangiogenic therapy with bevacizumab (BEV) has been shown to improve progression-free survival (PFS), but not overall survival (OS). Especially in patients with an unusual infiltrative phenotype as seen in multifocal glioblastoma, the use of BEV therapy is still more controversial. Th...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18112469

    authors： Burger MC,Breuer S,Cieplik HC,Harter PN,Franz K,Bähr O,Steinbach JP

    更新日期：2017-11-20 00:00:00

  • Targeting Actomyosin Contractility Suppresses Malignant Phenotypes of Acute Myeloid Leukemia Cells.

    abstract：:Actomyosin-mediated contractility is required for the majority of force-driven cellular events such as cell division, adhesion, and migration. Under pathological conditions, the role of actomyosin contractility in malignant phenotypes of various solid tumors has been extensively discussed, but the pathophysiological r...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21103460

    authors： Chang F,Kong SJ,Wang L,Choi BK,Lee H,Kim C,Kim JM,Park K

    更新日期：2020-05-14 00:00:00

  • Experimental Model Systems for Understanding Human Axonal Injury Responses.

    abstract：:Neurons are structurally unique and have dendrites and axons that are vulnerable to injury. Some neurons in the peripheral nervous system (PNS) can regenerate their axons after injuries. However, most neurons in the central nervous system (CNS) fail to do so, resulting in irreversible neurological disorders. To unders...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms22020474

    authors： Lee B,Cho Y

    更新日期：2021-01-06 00:00:00

  • Experimental construction of BMP2 and VEGF gene modified tissue engineering bone in vitro.

    abstract：:The purpose of this study was to investigate the feasibility and advantages of constructing a novel tissue engineering bone, using β-tricalcium phosphate (β-TCP) and rat bone marrow mesenchymal stem cells (MSCs), modified with human bone morphogenetic protein 2 gene (hBMP2) and human vascular endothelial growth factor...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms12031744

    authors： Jiang J,Fan CY,Zeng BF

    更新日期：2011-01-01 00:00:00

  • Loss of Dystroglycan Drives Cellular Senescence via Defective Mitosis-Mediated Genomic Instability.

    abstract：:Nuclear β-dystroglycan (β-DG) is involved in the maintenance of nuclear architecture and function. Nonetheless, its relevance in defined nuclear processes remains to be determined. In this study we generated a C2C12 cell-based DG-null model using CRISPR-Cas9 technology to provide insights into the role of β-DG on nucl...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21144961

    authors： Jimenez-Gutierrez GE,Mondragon-Gonzalez R,Soto-Ponce LA,Gómez-Monsiváis WL,García-Aguirre I,Pacheco-Rivera RA,Suárez-Sánchez R,Brancaccio A,Magaña JJ,C R Perlingeiro R,Cisneros B

    更新日期：2020-07-14 00:00:00

  • Novel Nanocomposite Inhibiting Caries at the Enamel Restoration Margins in an In Vitro Saliva-Derived Biofilm Secondary Caries Model.

    abstract：:Secondary caries often occurs at the tooth-composite margins. This study developed a novel bioactive composite containing DMAHDM (dimethylaminohexadecyl methacrylate) and NACP (nanoparticles of amorphous calcium phosphate), inhibiting caries at the enamel restoration margins in an in vitro saliva-derived biofilm secon...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21176369

    authors： Zhou W,Peng X,Zhou X,Bonavente A,Weir MD,Melo MAS,Imazato S,Oates TW,Cheng L,Xu HHK

    更新日期：2020-09-02 00:00:00

  • The Regulation and Function of the L-Type Amino Acid Transporter 1 (LAT1) in Cancer.

    abstract：:The progression of cancer is associated with increases in amino acid uptake by cancer cells. Upon their entry into cells through specific transporters, exogenous amino acids are used to synthesize proteins, nucleic acids and lipids and to generate ATP. The essential amino acid leucine is also important for maintaining...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19082373

    authors： Salisbury TB,Arthur S

    更新日期：2018-08-12 00:00:00

  • Renaissance Distribution for Statistically Failed Experiments.

    abstract：:Much of the experimental data, especially in life sciences, is considered to be useless if it demonstrates a large standard deviation from the mean value. The Renaissance distribution, as presented in this study, allows one to extract true values from such statistical data with large noise. To obtain proof of the Rena...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20133250

    authors： Popov R,Shankara GK,von Bojničić-Kninski C,Nesterov-Mueller A

    更新日期：2019-07-02 00:00:00

  • Cytoprotective Effect of the UCP2-SIRT3 Signaling Pathway by Decreasing Mitochondrial Oxidative Stress on Cerebral Ischemia-Reperfusion Injury.

    abstract：:Recovered blood supply after cerebral ischemia for a certain period of time fails to restore brain function, with more severe dysfunctional problems developing, called cerebral ischemia-reperfusion injury (CIR). CIR involves several extremely complex pathophysiological processes in which the interactions between key f...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18071599

    authors： Su J,Liu J,Yan XY,Zhang Y,Zhang JJ,Zhang LC,Sun LK

    更新日期：2017-07-24 00:00:00