Abstract：
:Actomyosin-mediated contractility is required for the majority of force-driven cellular events such as cell division, adhesion, and migration. Under pathological conditions, the role of actomyosin contractility in malignant phenotypes of various solid tumors has been extensively discussed, but the pathophysiological relevance in hematopoietic malignancies has yet to be elucidated. In this study, we found enhanced actomyosin contractility in diverse acute myeloid leukemia (AML) cell lines represented by highly expressed non-muscle myosin heavy chain A (NMIIA) and increased phosphorylation of the myosin regulatory light chain. Genetic and pharmacological inhibition of actomyosin contractility induced multivalent malignancy- suppressive effects in AML cells. In this context, perturbed actomyosin contractility enhances AML cell apoptosis through cytokinesis failure and aryl hydrocarbon receptor activation. Moreover, leukemic oncogenes were downregulated by the YAP/TAZ-mediated mechanotransduction pathway. Our results provide a theoretical background for targeting actomyosin contractility to suppress the malignancy of AML cells.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Chang F,Kong SJ,Wang L,Choi BK,Lee H,Kim C,Kim JM,Park Kdoi
10.3390/ijms21103460subject
Has Abstractpub_date
2020-05-14 00:00:00issue
10issn
1422-0067pii
ijms21103460journal_volume
21pub_type
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journal_title：International journal of molecular sciences
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